The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series
- Autores
- Dias, Tamiris T.; Tauro, Laura Beatriz; Macêdo, Lara E. N.; Brito, Liz O.; Ribeiro, Victor H. O.; Santos, Cleiton S.; Jacob-Nascimento, Leile C.; Vilas-Boas, Letícia S.; Amado, Caio; Barbosa, Paula S.; Reis, Joice N.; Soares Campos, Gubio; Ribeiro, Guilherme S.; Siqueira, Isadora C.; Silva, Luciano K.; Reis, Mitermayer G.
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Recently, different arboviruses became endemic in Brazil mostlycausing acute febrile illnesses, however, neurological manifestations have alsobeen reported. This study aimed to investigate which viruses were involved inthe meningitis etiology and the contribution of the circulating arboviruses inSalvador, Bahia, Brazil.Methods: From June 2014 to February 2016, 170 patients with suspected viralmeningitis were identified in Couto Maia Hospital, Salvador-BA, Brazil. TheirCSF samples were investigated for possible viral etiology by reversetranscription-PCR (RT-PCR) for different arboviruses: DENV, ZIKV and CHIKV;and for the EV; and by PCR for the HHV1-5 complex (HSV1-2, VZV, EBV andCMV). Also, ELISA was carried out in a subgroup of remaining samples fordetection of DENV IgM and NS1 antigen, CHIKV IgM and ZIKV IgM.Results: Thirty-seven patients were PCR or ELISA positive for at least one of thestudied viruses (overall positivity 21.8%). EV was the agent most frequentlydetected (10 cases; 27.0%), along with all four DENV serotypes (10 cases;27.0%); followed by CHIKV (6 cases; 16.2%), ZIKV (6 cases; 16.2%), and Varicellazoster virus (VZV) (1 case; 2.7%). Four cases (10.8%) presented viral co-infectiondetected: DENV1 + CHIKV, DENV1 + EV, DENV4 + ZIKV, and CHIKV + ZIKV.Arboviruses (DENV, CHIKV and ZIKV) accounted for the great majority of cases(26 cases; 70.3%) of all single and co-infections: DENV has been the mostfrequently detected arbovirus (13 cases; 35.1%). Among non-arboviralmeningitis,the most common etiology was the EV (11 cases; 29.7%).Conclusions: Arboviruses accounted for the majority of identified virusesamong patients with suspected viral meningitis. In areas where they areendemic it is crucial to increase viral surveillance and consider them in thedifferential diagnosis of meningitis.
Fil: Dias, Tamiris T.. Fundación Oswaldo Cruz; Brasil
Fil: Tauro, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; Argentina
Fil: Macêdo, Lara E. N.. Fundación Oswaldo Cruz; Brasil
Fil: Brito, Liz O.. Fundación Oswaldo Cruz; Brasil
Fil: Ribeiro, Victor H. O.. Fundación Oswaldo Cruz; Brasil
Fil: Santos, Cleiton S.. Fundación Oswaldo Cruz; Brasil
Fil: Jacob-Nascimento, Leile C.. Fundación Oswaldo Cruz; Brasil
Fil: Vilas-Boas, Letícia S.. Fundación Oswaldo Cruz; Brasil
Fil: Amado, Caio. Fundación Oswaldo Cruz; Brasil
Fil: Barbosa, Paula S.. Fundación Oswaldo Cruz; Brasil
Fil: Reis, Joice N.. Fundación Oswaldo Cruz; Brasil
Fil: Soares Campos, Gubio. Fundación Oswaldo Cruz; Brasil
Fil: Ribeiro, Guilherme S.. Fundación Oswaldo Cruz; Brasil
Fil: Siqueira, Isadora C.. Fundación Oswaldo Cruz; Brasil
Fil: Silva, Luciano K.. Fundación Oswaldo Cruz; Brasil
Fil: Reis, Mitermayer G.. Fundación Oswaldo Cruz; Brasil - Materia
-
ARBOVIRUS
BRAZIL
TROPICAL DISEASES
EPIDEMIOLOGY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/214356
Ver los metadatos del registro completo
| id |
CONICETDig_73bf3bebbfded863978e5d56e01332ee |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/214356 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case seriesDias, Tamiris T.Tauro, Laura BeatrizMacêdo, Lara E. N.Brito, Liz O.Ribeiro, Victor H. O.Santos, Cleiton S.Jacob-Nascimento, Leile C.Vilas-Boas, Letícia S.Amado, CaioBarbosa, Paula S.Reis, Joice N.Soares Campos, GubioRibeiro, Guilherme S.Siqueira, Isadora C.Silva, Luciano K.Reis, Mitermayer G.ARBOVIRUSBRAZILTROPICAL DISEASESEPIDEMIOLOGYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Recently, different arboviruses became endemic in Brazil mostlycausing acute febrile illnesses, however, neurological manifestations have alsobeen reported. This study aimed to investigate which viruses were involved inthe meningitis etiology and the contribution of the circulating arboviruses inSalvador, Bahia, Brazil.Methods: From June 2014 to February 2016, 170 patients with suspected viralmeningitis were identified in Couto Maia Hospital, Salvador-BA, Brazil. TheirCSF samples were investigated for possible viral etiology by reversetranscription-PCR (RT-PCR) for different arboviruses: DENV, ZIKV and CHIKV;and for the EV; and by PCR for the HHV1-5 complex (HSV1-2, VZV, EBV andCMV). Also, ELISA was carried out in a subgroup of remaining samples fordetection of DENV IgM and NS1 antigen, CHIKV IgM and ZIKV IgM.Results: Thirty-seven patients were PCR or ELISA positive for at least one of thestudied viruses (overall positivity 21.8%). EV was the agent most frequentlydetected (10 cases; 27.0%), along with all four DENV serotypes (10 cases;27.0%); followed by CHIKV (6 cases; 16.2%), ZIKV (6 cases; 16.2%), and Varicellazoster virus (VZV) (1 case; 2.7%). Four cases (10.8%) presented viral co-infectiondetected: DENV1 + CHIKV, DENV1 + EV, DENV4 + ZIKV, and CHIKV + ZIKV.Arboviruses (DENV, CHIKV and ZIKV) accounted for the great majority of cases(26 cases; 70.3%) of all single and co-infections: DENV has been the mostfrequently detected arbovirus (13 cases; 35.1%). Among non-arboviralmeningitis,the most common etiology was the EV (11 cases; 29.7%).Conclusions: Arboviruses accounted for the majority of identified virusesamong patients with suspected viral meningitis. In areas where they areendemic it is crucial to increase viral surveillance and consider them in thedifferential diagnosis of meningitis.Fil: Dias, Tamiris T.. Fundación Oswaldo Cruz; BrasilFil: Tauro, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; ArgentinaFil: Macêdo, Lara E. N.. Fundación Oswaldo Cruz; BrasilFil: Brito, Liz O.. Fundación Oswaldo Cruz; BrasilFil: Ribeiro, Victor H. O.. Fundación Oswaldo Cruz; BrasilFil: Santos, Cleiton S.. Fundación Oswaldo Cruz; BrasilFil: Jacob-Nascimento, Leile C.. Fundación Oswaldo Cruz; BrasilFil: Vilas-Boas, Letícia S.. Fundación Oswaldo Cruz; BrasilFil: Amado, Caio. Fundación Oswaldo Cruz; BrasilFil: Barbosa, Paula S.. Fundación Oswaldo Cruz; BrasilFil: Reis, Joice N.. Fundación Oswaldo Cruz; BrasilFil: Soares Campos, Gubio. Fundación Oswaldo Cruz; BrasilFil: Ribeiro, Guilherme S.. Fundación Oswaldo Cruz; BrasilFil: Siqueira, Isadora C.. Fundación Oswaldo Cruz; BrasilFil: Silva, Luciano K.. Fundación Oswaldo Cruz; BrasilFil: Reis, Mitermayer G.. Fundación Oswaldo Cruz; BrasilFrontiers Media2022-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214356Dias, Tamiris T.; Tauro, Laura Beatriz; Macêdo, Lara E. N.; Brito, Liz O.; Ribeiro, Victor H. O.; et al.; The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series; Frontiers Media; Frontiers in Tropical Diseases; 3; 11-2022; 1-92673-7515CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fitd.2022.1023588/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fitd.2022.1023588info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:49:03Zoai:ri.conicet.gov.ar:11336/214356instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:49:03.956CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series |
| title |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series |
| spellingShingle |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series Dias, Tamiris T. ARBOVIRUS BRAZIL TROPICAL DISEASES EPIDEMIOLOGY |
| title_short |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series |
| title_full |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series |
| title_fullStr |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series |
| title_full_unstemmed |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series |
| title_sort |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series |
| dc.creator.none.fl_str_mv |
Dias, Tamiris T. Tauro, Laura Beatriz Macêdo, Lara E. N. Brito, Liz O. Ribeiro, Victor H. O. Santos, Cleiton S. Jacob-Nascimento, Leile C. Vilas-Boas, Letícia S. Amado, Caio Barbosa, Paula S. Reis, Joice N. Soares Campos, Gubio Ribeiro, Guilherme S. Siqueira, Isadora C. Silva, Luciano K. Reis, Mitermayer G. |
| author |
Dias, Tamiris T. |
| author_facet |
Dias, Tamiris T. Tauro, Laura Beatriz Macêdo, Lara E. N. Brito, Liz O. Ribeiro, Victor H. O. Santos, Cleiton S. Jacob-Nascimento, Leile C. Vilas-Boas, Letícia S. Amado, Caio Barbosa, Paula S. Reis, Joice N. Soares Campos, Gubio Ribeiro, Guilherme S. Siqueira, Isadora C. Silva, Luciano K. Reis, Mitermayer G. |
| author_role |
author |
| author2 |
Tauro, Laura Beatriz Macêdo, Lara E. N. Brito, Liz O. Ribeiro, Victor H. O. Santos, Cleiton S. Jacob-Nascimento, Leile C. Vilas-Boas, Letícia S. Amado, Caio Barbosa, Paula S. Reis, Joice N. Soares Campos, Gubio Ribeiro, Guilherme S. Siqueira, Isadora C. Silva, Luciano K. Reis, Mitermayer G. |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ARBOVIRUS BRAZIL TROPICAL DISEASES EPIDEMIOLOGY |
| topic |
ARBOVIRUS BRAZIL TROPICAL DISEASES EPIDEMIOLOGY |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Background: Recently, different arboviruses became endemic in Brazil mostlycausing acute febrile illnesses, however, neurological manifestations have alsobeen reported. This study aimed to investigate which viruses were involved inthe meningitis etiology and the contribution of the circulating arboviruses inSalvador, Bahia, Brazil.Methods: From June 2014 to February 2016, 170 patients with suspected viralmeningitis were identified in Couto Maia Hospital, Salvador-BA, Brazil. TheirCSF samples were investigated for possible viral etiology by reversetranscription-PCR (RT-PCR) for different arboviruses: DENV, ZIKV and CHIKV;and for the EV; and by PCR for the HHV1-5 complex (HSV1-2, VZV, EBV andCMV). Also, ELISA was carried out in a subgroup of remaining samples fordetection of DENV IgM and NS1 antigen, CHIKV IgM and ZIKV IgM.Results: Thirty-seven patients were PCR or ELISA positive for at least one of thestudied viruses (overall positivity 21.8%). EV was the agent most frequentlydetected (10 cases; 27.0%), along with all four DENV serotypes (10 cases;27.0%); followed by CHIKV (6 cases; 16.2%), ZIKV (6 cases; 16.2%), and Varicellazoster virus (VZV) (1 case; 2.7%). Four cases (10.8%) presented viral co-infectiondetected: DENV1 + CHIKV, DENV1 + EV, DENV4 + ZIKV, and CHIKV + ZIKV.Arboviruses (DENV, CHIKV and ZIKV) accounted for the great majority of cases(26 cases; 70.3%) of all single and co-infections: DENV has been the mostfrequently detected arbovirus (13 cases; 35.1%). Among non-arboviralmeningitis,the most common etiology was the EV (11 cases; 29.7%).Conclusions: Arboviruses accounted for the majority of identified virusesamong patients with suspected viral meningitis. In areas where they areendemic it is crucial to increase viral surveillance and consider them in thedifferential diagnosis of meningitis. Fil: Dias, Tamiris T.. Fundación Oswaldo Cruz; Brasil Fil: Tauro, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; Argentina Fil: Macêdo, Lara E. N.. Fundación Oswaldo Cruz; Brasil Fil: Brito, Liz O.. Fundación Oswaldo Cruz; Brasil Fil: Ribeiro, Victor H. O.. Fundación Oswaldo Cruz; Brasil Fil: Santos, Cleiton S.. Fundación Oswaldo Cruz; Brasil Fil: Jacob-Nascimento, Leile C.. Fundación Oswaldo Cruz; Brasil Fil: Vilas-Boas, Letícia S.. Fundación Oswaldo Cruz; Brasil Fil: Amado, Caio. Fundación Oswaldo Cruz; Brasil Fil: Barbosa, Paula S.. Fundación Oswaldo Cruz; Brasil Fil: Reis, Joice N.. Fundación Oswaldo Cruz; Brasil Fil: Soares Campos, Gubio. Fundación Oswaldo Cruz; Brasil Fil: Ribeiro, Guilherme S.. Fundación Oswaldo Cruz; Brasil Fil: Siqueira, Isadora C.. Fundación Oswaldo Cruz; Brasil Fil: Silva, Luciano K.. Fundación Oswaldo Cruz; Brasil Fil: Reis, Mitermayer G.. Fundación Oswaldo Cruz; Brasil |
| description |
Background: Recently, different arboviruses became endemic in Brazil mostlycausing acute febrile illnesses, however, neurological manifestations have alsobeen reported. This study aimed to investigate which viruses were involved inthe meningitis etiology and the contribution of the circulating arboviruses inSalvador, Bahia, Brazil.Methods: From June 2014 to February 2016, 170 patients with suspected viralmeningitis were identified in Couto Maia Hospital, Salvador-BA, Brazil. TheirCSF samples were investigated for possible viral etiology by reversetranscription-PCR (RT-PCR) for different arboviruses: DENV, ZIKV and CHIKV;and for the EV; and by PCR for the HHV1-5 complex (HSV1-2, VZV, EBV andCMV). Also, ELISA was carried out in a subgroup of remaining samples fordetection of DENV IgM and NS1 antigen, CHIKV IgM and ZIKV IgM.Results: Thirty-seven patients were PCR or ELISA positive for at least one of thestudied viruses (overall positivity 21.8%). EV was the agent most frequentlydetected (10 cases; 27.0%), along with all four DENV serotypes (10 cases;27.0%); followed by CHIKV (6 cases; 16.2%), ZIKV (6 cases; 16.2%), and Varicellazoster virus (VZV) (1 case; 2.7%). Four cases (10.8%) presented viral co-infectiondetected: DENV1 + CHIKV, DENV1 + EV, DENV4 + ZIKV, and CHIKV + ZIKV.Arboviruses (DENV, CHIKV and ZIKV) accounted for the great majority of cases(26 cases; 70.3%) of all single and co-infections: DENV has been the mostfrequently detected arbovirus (13 cases; 35.1%). Among non-arboviralmeningitis,the most common etiology was the EV (11 cases; 29.7%).Conclusions: Arboviruses accounted for the majority of identified virusesamong patients with suspected viral meningitis. In areas where they areendemic it is crucial to increase viral surveillance and consider them in thedifferential diagnosis of meningitis. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/214356 Dias, Tamiris T.; Tauro, Laura Beatriz; Macêdo, Lara E. N.; Brito, Liz O.; Ribeiro, Victor H. O.; et al.; The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series; Frontiers Media; Frontiers in Tropical Diseases; 3; 11-2022; 1-9 2673-7515 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/214356 |
| identifier_str_mv |
Dias, Tamiris T.; Tauro, Laura Beatriz; Macêdo, Lara E. N.; Brito, Liz O.; Ribeiro, Victor H. O.; et al.; The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series; Frontiers Media; Frontiers in Tropical Diseases; 3; 11-2022; 1-9 2673-7515 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fitd.2022.1023588/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fitd.2022.1023588 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1846083012184244224 |
| score |
13.22299 |