Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis

Autores
Dvorkin, Julia; Pecenka, Clint; Sosa, Emiliano M.; Sancilio, Andrea; Dueñas, Karina; Rodriguez, Andrea; Rojas Roque, Carlos; Carruitero, Patricia B.; Baral, Ranju; Vodicka, Elisabeth; Polack, Fernando P.; Libster, Romina Paula; Caballero, Mauricio Tomás
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction There is lack of available data on the economic burden of wheezing episodes after severe respiratory syncytial virus (RSV) infection. This study aimed to assess the cost incurred for wheezing episodes after a severe RSV infection in children from Argentina, considering both the public health system and societal perspectives.Methods A prospective cohort was conducted from 2014 to 2022 to assess the cost of illness of wheezing episodes after severe RSV disease in children from Buenos Aires, Argentina. Direct medical and non-medical costs were estimated, along with indirect costs per episode and patient. Data pertaining to healthcare resource utilisation, indirect expenses and parental out-of-pocket costs were obtained. The overall cost per hospitalisation and health visits was calculated. Costs were quantified in US dollars using the average exchange rate on the specific date of data collection.Results A total of 256 infants experienced severe RSV disease during their first year of life and were followed over a 5-year period in Buenos Aires. Overall, 150 children between 12 and 60 months presented 429 wheezing episodes. The median number of wheezing episodes per patient was 5 (IQR 3–7). The mean cost per wheezing episode was US$191.01 (95% CI 166.37 to 215.64). The total cost per episode of wheezing was significantly higher (p<0.001) in infants under 12 months of age (207.43, 95% CI 154.3 to 260.6) compared with older toddler. The average cumulative cost associated to wheezing per patient was US$415.99 (95% CI 313.35 to 518.63). Considering both acute RSV disease and long-term wheezing outcomes, the cumulative mean cost per patient was US$959.56 (95% CI 832.01 to 1087.10).Conclusions This study reveals the economic impact of prolonged wheezing resulting from severe acute RSV infection on Argentina’s public health system and society. The estimates obtained serve as valuable inputs for informing cost-effectiveness analyses of upcoming RSV preventive interventions.
Fil: Dvorkin, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina. Universidad Nacional de San Martín; Argentina
Fil: Pecenka, Clint. No especifíca;
Fil: Sosa, Emiliano M.. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Sancilio, Andrea. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Dueñas, Karina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Rodriguez, Andrea. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Rojas Roque, Carlos. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Carruitero, Patricia B.. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Baral, Ranju. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Vodicka, Elisabeth. No especifíca;
Fil: Polack, Fernando P.. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Libster, Romina Paula. Fundación para la Investigación en Infectología Infantil; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Materia
Virus sincicial respiratorio
costos en salud
asma
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/253906
Acceder
id CONICETDig_72ac8ea168318977989b98add7d00509
oai_identifier_str oai:ri.conicet.gov.ar:11336/253906
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysisDvorkin, JuliaPecenka, ClintSosa, Emiliano M.Sancilio, AndreaDueñas, KarinaRodriguez, AndreaRojas Roque, CarlosCarruitero, Patricia B.Baral, RanjuVodicka, ElisabethPolack, Fernando P.Libster, Romina PaulaCaballero, Mauricio TomásVirus sincicial respiratoriocostos en saludasmahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction There is lack of available data on the economic burden of wheezing episodes after severe respiratory syncytial virus (RSV) infection. This study aimed to assess the cost incurred for wheezing episodes after a severe RSV infection in children from Argentina, considering both the public health system and societal perspectives.Methods A prospective cohort was conducted from 2014 to 2022 to assess the cost of illness of wheezing episodes after severe RSV disease in children from Buenos Aires, Argentina. Direct medical and non-medical costs were estimated, along with indirect costs per episode and patient. Data pertaining to healthcare resource utilisation, indirect expenses and parental out-of-pocket costs were obtained. The overall cost per hospitalisation and health visits was calculated. Costs were quantified in US dollars using the average exchange rate on the specific date of data collection.Results A total of 256 infants experienced severe RSV disease during their first year of life and were followed over a 5-year period in Buenos Aires. Overall, 150 children between 12 and 60 months presented 429 wheezing episodes. The median number of wheezing episodes per patient was 5 (IQR 3–7). The mean cost per wheezing episode was US$191.01 (95% CI 166.37 to 215.64). The total cost per episode of wheezing was significantly higher (p<0.001) in infants under 12 months of age (207.43, 95% CI 154.3 to 260.6) compared with older toddler. The average cumulative cost associated to wheezing per patient was US$415.99 (95% CI 313.35 to 518.63). Considering both acute RSV disease and long-term wheezing outcomes, the cumulative mean cost per patient was US$959.56 (95% CI 832.01 to 1087.10).Conclusions This study reveals the economic impact of prolonged wheezing resulting from severe acute RSV infection on Argentina’s public health system and society. The estimates obtained serve as valuable inputs for informing cost-effectiveness analyses of upcoming RSV preventive interventions.Fil: Dvorkin, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina. Universidad Nacional de San Martín; ArgentinaFil: Pecenka, Clint. No especifíca;Fil: Sosa, Emiliano M.. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Sancilio, Andrea. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Dueñas, Karina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Rodriguez, Andrea. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Rojas Roque, Carlos. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Carruitero, Patricia B.. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Baral, Ranju. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Vodicka, Elisabeth. No especifíca;Fil: Polack, Fernando P.. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Libster, Romina Paula. Fundación para la Investigación en Infectología Infantil; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaBMJ Publishing Group2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/253906Dvorkin, Julia; Pecenka, Clint; Sosa, Emiliano M.; Sancilio, Andrea; Dueñas, Karina; et al.; Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis; BMJ Publishing Group; BMJ Public Health; 2; 1; 7-2024; 1-102753-4294CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmjpublichealth.bmj.com/lookup/doi/10.1136/bmjph-2024-000975info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjph-2024-000975info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:20Zoai:ri.conicet.gov.ar:11336/253906instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:20.306CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis
title Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis
spellingShingle Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis
Dvorkin, Julia
Virus sincicial respiratorio
costos en salud
asma
title_short Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis
title_full Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis
title_fullStr Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis
title_full_unstemmed Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis
title_sort Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis
dc.creator.none.fl_str_mv Dvorkin, Julia
Pecenka, Clint
Sosa, Emiliano M.
Sancilio, Andrea
Dueñas, Karina
Rodriguez, Andrea
Rojas Roque, Carlos
Carruitero, Patricia B.
Baral, Ranju
Vodicka, Elisabeth
Polack, Fernando P.
Libster, Romina Paula
Caballero, Mauricio Tomás
author Dvorkin, Julia
author_facet Dvorkin, Julia
Pecenka, Clint
Sosa, Emiliano M.
Sancilio, Andrea
Dueñas, Karina
Rodriguez, Andrea
Rojas Roque, Carlos
Carruitero, Patricia B.
Baral, Ranju
Vodicka, Elisabeth
Polack, Fernando P.
Libster, Romina Paula
Caballero, Mauricio Tomás
author_role author
author2 Pecenka, Clint
Sosa, Emiliano M.
Sancilio, Andrea
Dueñas, Karina
Rodriguez, Andrea
Rojas Roque, Carlos
Carruitero, Patricia B.
Baral, Ranju
Vodicka, Elisabeth
Polack, Fernando P.
Libster, Romina Paula
Caballero, Mauricio Tomás
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Virus sincicial respiratorio
costos en salud
asma
topic Virus sincicial respiratorio
costos en salud
asma
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction There is lack of available data on the economic burden of wheezing episodes after severe respiratory syncytial virus (RSV) infection. This study aimed to assess the cost incurred for wheezing episodes after a severe RSV infection in children from Argentina, considering both the public health system and societal perspectives.Methods A prospective cohort was conducted from 2014 to 2022 to assess the cost of illness of wheezing episodes after severe RSV disease in children from Buenos Aires, Argentina. Direct medical and non-medical costs were estimated, along with indirect costs per episode and patient. Data pertaining to healthcare resource utilisation, indirect expenses and parental out-of-pocket costs were obtained. The overall cost per hospitalisation and health visits was calculated. Costs were quantified in US dollars using the average exchange rate on the specific date of data collection.Results A total of 256 infants experienced severe RSV disease during their first year of life and were followed over a 5-year period in Buenos Aires. Overall, 150 children between 12 and 60 months presented 429 wheezing episodes. The median number of wheezing episodes per patient was 5 (IQR 3–7). The mean cost per wheezing episode was US$191.01 (95% CI 166.37 to 215.64). The total cost per episode of wheezing was significantly higher (p<0.001) in infants under 12 months of age (207.43, 95% CI 154.3 to 260.6) compared with older toddler. The average cumulative cost associated to wheezing per patient was US$415.99 (95% CI 313.35 to 518.63). Considering both acute RSV disease and long-term wheezing outcomes, the cumulative mean cost per patient was US$959.56 (95% CI 832.01 to 1087.10).Conclusions This study reveals the economic impact of prolonged wheezing resulting from severe acute RSV infection on Argentina’s public health system and society. The estimates obtained serve as valuable inputs for informing cost-effectiveness analyses of upcoming RSV preventive interventions.
Fil: Dvorkin, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina. Universidad Nacional de San Martín; Argentina
Fil: Pecenka, Clint. No especifíca;
Fil: Sosa, Emiliano M.. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Sancilio, Andrea. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Dueñas, Karina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Rodriguez, Andrea. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Rojas Roque, Carlos. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Carruitero, Patricia B.. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Baral, Ranju. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Vodicka, Elisabeth. No especifíca;
Fil: Polack, Fernando P.. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Libster, Romina Paula. Fundación para la Investigación en Infectología Infantil; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
description Introduction There is lack of available data on the economic burden of wheezing episodes after severe respiratory syncytial virus (RSV) infection. This study aimed to assess the cost incurred for wheezing episodes after a severe RSV infection in children from Argentina, considering both the public health system and societal perspectives.Methods A prospective cohort was conducted from 2014 to 2022 to assess the cost of illness of wheezing episodes after severe RSV disease in children from Buenos Aires, Argentina. Direct medical and non-medical costs were estimated, along with indirect costs per episode and patient. Data pertaining to healthcare resource utilisation, indirect expenses and parental out-of-pocket costs were obtained. The overall cost per hospitalisation and health visits was calculated. Costs were quantified in US dollars using the average exchange rate on the specific date of data collection.Results A total of 256 infants experienced severe RSV disease during their first year of life and were followed over a 5-year period in Buenos Aires. Overall, 150 children between 12 and 60 months presented 429 wheezing episodes. The median number of wheezing episodes per patient was 5 (IQR 3–7). The mean cost per wheezing episode was US$191.01 (95% CI 166.37 to 215.64). The total cost per episode of wheezing was significantly higher (p<0.001) in infants under 12 months of age (207.43, 95% CI 154.3 to 260.6) compared with older toddler. The average cumulative cost associated to wheezing per patient was US$415.99 (95% CI 313.35 to 518.63). Considering both acute RSV disease and long-term wheezing outcomes, the cumulative mean cost per patient was US$959.56 (95% CI 832.01 to 1087.10).Conclusions This study reveals the economic impact of prolonged wheezing resulting from severe acute RSV infection on Argentina’s public health system and society. The estimates obtained serve as valuable inputs for informing cost-effectiveness analyses of upcoming RSV preventive interventions.
publishDate 2024
dc.date.none.fl_str_mv 2024-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/253906
Dvorkin, Julia; Pecenka, Clint; Sosa, Emiliano M.; Sancilio, Andrea; Dueñas, Karina; et al.; Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis; BMJ Publishing Group; BMJ Public Health; 2; 1; 7-2024; 1-10
2753-4294
CONICET Digital
CONICET
url http://hdl.handle.net/11336/253906
identifier_str_mv Dvorkin, Julia; Pecenka, Clint; Sosa, Emiliano M.; Sancilio, Andrea; Dueñas, Karina; et al.; Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis; BMJ Publishing Group; BMJ Public Health; 2; 1; 7-2024; 1-10
2753-4294
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmjpublichealth.bmj.com/lookup/doi/10.1136/bmjph-2024-000975
info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjph-2024-000975
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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