Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report

Autores
Frilling, A.; Giele, H.; Vrakas, G.; Reddy, S.; Macedo, R.; Al Nahhas, A.; Wassan, H.; Clift, A. K.; Gondolesi, Gabriel Eduardo; Vianna, R. M.; Friend, P.; Vaidya, A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neuroendocrine tumors originating from the small bowel frequently metastasize to the lymph nodes and/or liver. Although surgical extirpation of the primary tumor and locoregional metastases epitomizes the management of patients with such tumors, this is not always possible with conventional surgical techniques. Nonresectable, slow-growing tumors involving the mesenteric root represent a generally accepted indication for deceased donor intestinal and multivisceral transplantation. Furthermore, vascularized sentinel forearm flaps offer opportunities for monitoring graft rejection and tailoring immunosuppression regimens. Here, we report the first documented case of modified liver-free multivisceral transplantation preceded by neoadjuvant 177-lutetium peptide receptor radionuclide therapy in a patient with a small bowel neuroendocrine tumor and extensive lymph node metastases in the mesenterium. At a follow-up of 21 months the patient is biochemically and radiologically disease-free.
Fil: Frilling, A.. Imperial College London; Reino Unido
Fil: Giele, H.. University of Oxford; Reino Unido
Fil: Vrakas, G.. University of Oxford; Reino Unido
Fil: Reddy, S.. University of Oxford; Reino Unido
Fil: Macedo, R.. University of Oxford; Reino Unido
Fil: Al Nahhas, A.. Imperial College London; Reino Unido
Fil: Wassan, H.. Imperial College London; Reino Unido
Fil: Clift, A. K.. Imperial College London; Reino Unido
Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vianna, R. M.. University of Miami; Estados Unidos
Fil: Friend, P.. University of Oxford; Reino Unido
Fil: Vaidya, A.. University of Oxford; Reino Unido
Materia
Trasplante
Tumor Neuroendocrino
Intestino
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38524
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/38524
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case reportFrilling, A.Giele, H.Vrakas, G.Reddy, S.Macedo, R.Al Nahhas, A.Wassan, H.Clift, A. K.Gondolesi, Gabriel EduardoVianna, R. M.Friend, P.Vaidya, A.TrasplanteTumor NeuroendocrinoIntestinohttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Neuroendocrine tumors originating from the small bowel frequently metastasize to the lymph nodes and/or liver. Although surgical extirpation of the primary tumor and locoregional metastases epitomizes the management of patients with such tumors, this is not always possible with conventional surgical techniques. Nonresectable, slow-growing tumors involving the mesenteric root represent a generally accepted indication for deceased donor intestinal and multivisceral transplantation. Furthermore, vascularized sentinel forearm flaps offer opportunities for monitoring graft rejection and tailoring immunosuppression regimens. Here, we report the first documented case of modified liver-free multivisceral transplantation preceded by neoadjuvant 177-lutetium peptide receptor radionuclide therapy in a patient with a small bowel neuroendocrine tumor and extensive lymph node metastases in the mesenterium. At a follow-up of 21 months the patient is biochemically and radiologically disease-free.Fil: Frilling, A.. Imperial College London; Reino UnidoFil: Giele, H.. University of Oxford; Reino UnidoFil: Vrakas, G.. University of Oxford; Reino UnidoFil: Reddy, S.. University of Oxford; Reino UnidoFil: Macedo, R.. University of Oxford; Reino UnidoFil: Al Nahhas, A.. Imperial College London; Reino UnidoFil: Wassan, H.. Imperial College London; Reino UnidoFil: Clift, A. K.. Imperial College London; Reino UnidoFil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vianna, R. M.. University of Miami; Estados UnidosFil: Friend, P.. University of Oxford; Reino UnidoFil: Vaidya, A.. University of Oxford; Reino UnidoElsevier Science Inc2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38524Frilling, A.; Giele, H.; Vrakas, G.; Reddy, S.; Macedo, R.; et al.; Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report; Elsevier Science Inc; Transplantation Proceedings; 47; 3; 4-2015; 858-8620041-1345CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/ 10.1016/j.transproceed.2015.01.007info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0041134515000834info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:14Zoai:ri.conicet.gov.ar:11336/38524instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:15.03CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report
title Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report
spellingShingle Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report
Frilling, A.
Trasplante
Tumor Neuroendocrino
Intestino
title_short Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report
title_full Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report
title_fullStr Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report
title_full_unstemmed Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report
title_sort Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report
dc.creator.none.fl_str_mv Frilling, A.
Giele, H.
Vrakas, G.
Reddy, S.
Macedo, R.
Al Nahhas, A.
Wassan, H.
Clift, A. K.
Gondolesi, Gabriel Eduardo
Vianna, R. M.
Friend, P.
Vaidya, A.
author Frilling, A.
author_facet Frilling, A.
Giele, H.
Vrakas, G.
Reddy, S.
Macedo, R.
Al Nahhas, A.
Wassan, H.
Clift, A. K.
Gondolesi, Gabriel Eduardo
Vianna, R. M.
Friend, P.
Vaidya, A.
author_role author
author2 Giele, H.
Vrakas, G.
Reddy, S.
Macedo, R.
Al Nahhas, A.
Wassan, H.
Clift, A. K.
Gondolesi, Gabriel Eduardo
Vianna, R. M.
Friend, P.
Vaidya, A.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trasplante
Tumor Neuroendocrino
Intestino
topic Trasplante
Tumor Neuroendocrino
Intestino
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neuroendocrine tumors originating from the small bowel frequently metastasize to the lymph nodes and/or liver. Although surgical extirpation of the primary tumor and locoregional metastases epitomizes the management of patients with such tumors, this is not always possible with conventional surgical techniques. Nonresectable, slow-growing tumors involving the mesenteric root represent a generally accepted indication for deceased donor intestinal and multivisceral transplantation. Furthermore, vascularized sentinel forearm flaps offer opportunities for monitoring graft rejection and tailoring immunosuppression regimens. Here, we report the first documented case of modified liver-free multivisceral transplantation preceded by neoadjuvant 177-lutetium peptide receptor radionuclide therapy in a patient with a small bowel neuroendocrine tumor and extensive lymph node metastases in the mesenterium. At a follow-up of 21 months the patient is biochemically and radiologically disease-free.
Fil: Frilling, A.. Imperial College London; Reino Unido
Fil: Giele, H.. University of Oxford; Reino Unido
Fil: Vrakas, G.. University of Oxford; Reino Unido
Fil: Reddy, S.. University of Oxford; Reino Unido
Fil: Macedo, R.. University of Oxford; Reino Unido
Fil: Al Nahhas, A.. Imperial College London; Reino Unido
Fil: Wassan, H.. Imperial College London; Reino Unido
Fil: Clift, A. K.. Imperial College London; Reino Unido
Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vianna, R. M.. University of Miami; Estados Unidos
Fil: Friend, P.. University of Oxford; Reino Unido
Fil: Vaidya, A.. University of Oxford; Reino Unido
description Neuroendocrine tumors originating from the small bowel frequently metastasize to the lymph nodes and/or liver. Although surgical extirpation of the primary tumor and locoregional metastases epitomizes the management of patients with such tumors, this is not always possible with conventional surgical techniques. Nonresectable, slow-growing tumors involving the mesenteric root represent a generally accepted indication for deceased donor intestinal and multivisceral transplantation. Furthermore, vascularized sentinel forearm flaps offer opportunities for monitoring graft rejection and tailoring immunosuppression regimens. Here, we report the first documented case of modified liver-free multivisceral transplantation preceded by neoadjuvant 177-lutetium peptide receptor radionuclide therapy in a patient with a small bowel neuroendocrine tumor and extensive lymph node metastases in the mesenterium. At a follow-up of 21 months the patient is biochemically and radiologically disease-free.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38524
Frilling, A.; Giele, H.; Vrakas, G.; Reddy, S.; Macedo, R.; et al.; Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report; Elsevier Science Inc; Transplantation Proceedings; 47; 3; 4-2015; 858-862
0041-1345
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38524
identifier_str_mv Frilling, A.; Giele, H.; Vrakas, G.; Reddy, S.; Macedo, R.; et al.; Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report; Elsevier Science Inc; Transplantation Proceedings; 47; 3; 4-2015; 858-862
0041-1345
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/ 10.1016/j.transproceed.2015.01.007
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0041134515000834
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269900704317440
score 13.13397

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