The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection

Autores
Maroli, Gabriel; Abarintos, Vernalyn; Piper, Andrew; Merkoçi, Arben
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nanoscale electrodes have been a topic of intense research for many decades. Their enhanced sensitivities, born out of an improved signal-to-noise ratio as electrode dimensions decrease, make them ideal for the development of low-concentration analyte sensors. However, to date, nanoelectrode fabrication has typically required expensive equipment and exhaustive, time-consuming fabrication methods that have rendered them unsuitable for widespread use and commercialization. Herein, a method of nanoband electrode fabrication using low cost materials and equipment commonly found in research laboratories around the world is reported. The materials´ cost to produce each nanoband is less than €0.01 and fabrication of a batch takes less than 1 h. The devices can be made of flexible plastics and their designs can be quickly and easily iterated. Facile methods of combining these nanobands into powerful devices, such as complete three-electrode systems, are also displayed. As a proof of concept, the electrodes are functionalized for the detection of a DNA sequence specific to SARS-CoV-2 and found to display single molecule sensitivity.
Fil: Maroli, Gabriel. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires. Unidad de Investigación y Desarrollo de las Ingenierías; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones en Ingeniería Eléctrica "Alfredo Desages". Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras. Instituto de Investigaciones en Ingeniería Eléctrica "Alfredo Desages"; Argentina
Fil: Abarintos, Vernalyn. Catalan Institute of Nanoscience and Nanotechnology; España
Fil: Piper, Andrew. Catalan Institute of Nanoscience and Nanotechnology; España
Fil: Merkoçi, Arben. Catalan Institute of Nanoscience and Nanotechnology; España
Materia
BIOSENSORS
ELECTROCHEMISTRY
NANOELECTRODES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/263660
Acceder
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spelling The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of DetectionMaroli, GabrielAbarintos, VernalynPiper, AndrewMerkoçi, ArbenBIOSENSORSELECTROCHEMISTRYNANOELECTRODEShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3https://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Nanoscale electrodes have been a topic of intense research for many decades. Their enhanced sensitivities, born out of an improved signal-to-noise ratio as electrode dimensions decrease, make them ideal for the development of low-concentration analyte sensors. However, to date, nanoelectrode fabrication has typically required expensive equipment and exhaustive, time-consuming fabrication methods that have rendered them unsuitable for widespread use and commercialization. Herein, a method of nanoband electrode fabrication using low cost materials and equipment commonly found in research laboratories around the world is reported. The materials´ cost to produce each nanoband is less than €0.01 and fabrication of a batch takes less than 1 h. The devices can be made of flexible plastics and their designs can be quickly and easily iterated. Facile methods of combining these nanobands into powerful devices, such as complete three-electrode systems, are also displayed. As a proof of concept, the electrodes are functionalized for the detection of a DNA sequence specific to SARS-CoV-2 and found to display single molecule sensitivity.Fil: Maroli, Gabriel. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires. Unidad de Investigación y Desarrollo de las Ingenierías; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones en Ingeniería Eléctrica "Alfredo Desages". Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras. Instituto de Investigaciones en Ingeniería Eléctrica "Alfredo Desages"; ArgentinaFil: Abarintos, Vernalyn. Catalan Institute of Nanoscience and Nanotechnology; EspañaFil: Piper, Andrew. Catalan Institute of Nanoscience and Nanotechnology; EspañaFil: Merkoçi, Arben. Catalan Institute of Nanoscience and Nanotechnology; EspañaWiley VCH Verlag2023-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/263660Maroli, Gabriel; Abarintos, Vernalyn; Piper, Andrew; Merkoçi, Arben; The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection; Wiley VCH Verlag; Small; 19; 51; 8-2023; 1-111613-6810CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/smll.202302136info:eu-repo/semantics/altIdentifier/doi/10.1002/smll.202302136info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:21:19Zoai:ri.conicet.gov.ar:11336/263660instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:21:20.174CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection
title The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection
spellingShingle The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection
Maroli, Gabriel
BIOSENSORS
ELECTROCHEMISTRY
NANOELECTRODES
title_short The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection
title_full The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection
title_fullStr The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection
title_full_unstemmed The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection
title_sort The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection
dc.creator.none.fl_str_mv Maroli, Gabriel
Abarintos, Vernalyn
Piper, Andrew
Merkoçi, Arben
author Maroli, Gabriel
author_facet Maroli, Gabriel
Abarintos, Vernalyn
Piper, Andrew
Merkoçi, Arben
author_role author
author2 Abarintos, Vernalyn
Piper, Andrew
Merkoçi, Arben
author2_role author
author
author
dc.subject.none.fl_str_mv BIOSENSORS
ELECTROCHEMISTRY
NANOELECTRODES
topic BIOSENSORS
ELECTROCHEMISTRY
NANOELECTRODES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Nanoscale electrodes have been a topic of intense research for many decades. Their enhanced sensitivities, born out of an improved signal-to-noise ratio as electrode dimensions decrease, make them ideal for the development of low-concentration analyte sensors. However, to date, nanoelectrode fabrication has typically required expensive equipment and exhaustive, time-consuming fabrication methods that have rendered them unsuitable for widespread use and commercialization. Herein, a method of nanoband electrode fabrication using low cost materials and equipment commonly found in research laboratories around the world is reported. The materials´ cost to produce each nanoband is less than €0.01 and fabrication of a batch takes less than 1 h. The devices can be made of flexible plastics and their designs can be quickly and easily iterated. Facile methods of combining these nanobands into powerful devices, such as complete three-electrode systems, are also displayed. As a proof of concept, the electrodes are functionalized for the detection of a DNA sequence specific to SARS-CoV-2 and found to display single molecule sensitivity.
Fil: Maroli, Gabriel. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires. Unidad de Investigación y Desarrollo de las Ingenierías; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones en Ingeniería Eléctrica "Alfredo Desages". Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras. Instituto de Investigaciones en Ingeniería Eléctrica "Alfredo Desages"; Argentina
Fil: Abarintos, Vernalyn. Catalan Institute of Nanoscience and Nanotechnology; España
Fil: Piper, Andrew. Catalan Institute of Nanoscience and Nanotechnology; España
Fil: Merkoçi, Arben. Catalan Institute of Nanoscience and Nanotechnology; España
description Nanoscale electrodes have been a topic of intense research for many decades. Their enhanced sensitivities, born out of an improved signal-to-noise ratio as electrode dimensions decrease, make them ideal for the development of low-concentration analyte sensors. However, to date, nanoelectrode fabrication has typically required expensive equipment and exhaustive, time-consuming fabrication methods that have rendered them unsuitable for widespread use and commercialization. Herein, a method of nanoband electrode fabrication using low cost materials and equipment commonly found in research laboratories around the world is reported. The materials´ cost to produce each nanoband is less than €0.01 and fabrication of a batch takes less than 1 h. The devices can be made of flexible plastics and their designs can be quickly and easily iterated. Facile methods of combining these nanobands into powerful devices, such as complete three-electrode systems, are also displayed. As a proof of concept, the electrodes are functionalized for the detection of a DNA sequence specific to SARS-CoV-2 and found to display single molecule sensitivity.
publishDate 2023
dc.date.none.fl_str_mv 2023-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/263660
Maroli, Gabriel; Abarintos, Vernalyn; Piper, Andrew; Merkoçi, Arben; The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection; Wiley VCH Verlag; Small; 19; 51; 8-2023; 1-11
1613-6810
CONICET Digital
CONICET
url http://hdl.handle.net/11336/263660
identifier_str_mv Maroli, Gabriel; Abarintos, Vernalyn; Piper, Andrew; Merkoçi, Arben; The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection; Wiley VCH Verlag; Small; 19; 51; 8-2023; 1-11
1613-6810
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/smll.202302136
info:eu-repo/semantics/altIdentifier/doi/10.1002/smll.202302136
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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