Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina

Autores
Pasteran, Fernando; Faccone, Diego Francisco; Gómez, Sonia Alejandra; De Bunder, Sabrina; Spinelli, Federico; Rapoport, Melina; Petroni, Alejandro; Galas, Marcelo Fabián; Corso, Alejandra
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The emergence of Klebsiella pneumoniae carbapenemase (KPC) has now become a global concern. KPC producers are mostly Enterobacteriaceae, but Pseudomonas aeruginosa have also been reported and mostly identified in the American continent.1–4 However, it is unknown if this is due to the spread of epidemic strains, since the multilocus sequence type (ST) has not been provided in most of those reports. The aim of this work was to characterize KPC-producing P. aeruginosa isolated in Argentina from 2006 to June 2011. Since 2005, we designed an algorithm to detect carbapenemases (metallo-β-lactamases, KPC, etc.) in P. aeruginosa at the level of the clinical microbiology laboratory, which was implemented among 432 hospitals. All P. aeruginosa were screened through that algorithm, and KPC production was suspected in isolates with high-level resistance to carbapenems and aztreonam (absence of disc zones) and a negative synergy test result between the carbapenems and EDTA, a phenotype consistent with the reported patterns of KPC-producing P. aeruginosa.
Fil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Faccone, Diego Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Gómez, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: De Bunder, Sabrina. Hospital Zonal de Bariloche "Ramón Carrillo"; Argentina
Fil: Spinelli, Federico. Hospital Privado Regional del Sur; Argentina. Sanatorio del Sol; Argentina
Fil: Rapoport, Melina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Petroni, Alejandro. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Galas, Marcelo Fabián. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Materia
CLONE
MULTIDRUG RESISTANCE
OUTBREAK
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/250775
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in ArgentinaPasteran, FernandoFaccone, Diego FranciscoGómez, Sonia AlejandraDe Bunder, SabrinaSpinelli, FedericoRapoport, MelinaPetroni, AlejandroGalas, Marcelo FabiánCorso, AlejandraCLONEMULTIDRUG RESISTANCEOUTBREAKhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The emergence of Klebsiella pneumoniae carbapenemase (KPC) has now become a global concern. KPC producers are mostly Enterobacteriaceae, but Pseudomonas aeruginosa have also been reported and mostly identified in the American continent.1–4 However, it is unknown if this is due to the spread of epidemic strains, since the multilocus sequence type (ST) has not been provided in most of those reports. The aim of this work was to characterize KPC-producing P. aeruginosa isolated in Argentina from 2006 to June 2011. Since 2005, we designed an algorithm to detect carbapenemases (metallo-β-lactamases, KPC, etc.) in P. aeruginosa at the level of the clinical microbiology laboratory, which was implemented among 432 hospitals. All P. aeruginosa were screened through that algorithm, and KPC production was suspected in isolates with high-level resistance to carbapenems and aztreonam (absence of disc zones) and a negative synergy test result between the carbapenems and EDTA, a phenotype consistent with the reported patterns of KPC-producing P. aeruginosa.Fil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; ArgentinaFil: Faccone, Diego Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; ArgentinaFil: Gómez, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; ArgentinaFil: De Bunder, Sabrina. Hospital Zonal de Bariloche "Ramón Carrillo"; ArgentinaFil: Spinelli, Federico. Hospital Privado Regional del Sur; Argentina. Sanatorio del Sol; ArgentinaFil: Rapoport, Melina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; ArgentinaFil: Petroni, Alejandro. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; ArgentinaFil: Galas, Marcelo Fabián. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; ArgentinaFil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; ArgentinaOxford University Press2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/250775Pasteran, Fernando; Faccone, Diego Francisco; Gómez, Sonia Alejandra; De Bunder, Sabrina; Spinelli, Federico; et al.; Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina; Oxford University Press; Journal of Antimicrobial Chemotherapy; 67; 5; 5-2012; 1291-12930305-7453CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article-abstract/67/5/1291/981209info:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dks032info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:49Zoai:ri.conicet.gov.ar:11336/250775instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:49.53CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina
title Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina
spellingShingle Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina
Pasteran, Fernando
CLONE
MULTIDRUG RESISTANCE
OUTBREAK
title_short Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina
title_full Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina
title_fullStr Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina
title_full_unstemmed Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina
title_sort Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina
dc.creator.none.fl_str_mv Pasteran, Fernando
Faccone, Diego Francisco
Gómez, Sonia Alejandra
De Bunder, Sabrina
Spinelli, Federico
Rapoport, Melina
Petroni, Alejandro
Galas, Marcelo Fabián
Corso, Alejandra
author Pasteran, Fernando
author_facet Pasteran, Fernando
Faccone, Diego Francisco
Gómez, Sonia Alejandra
De Bunder, Sabrina
Spinelli, Federico
Rapoport, Melina
Petroni, Alejandro
Galas, Marcelo Fabián
Corso, Alejandra
author_role author
author2 Faccone, Diego Francisco
Gómez, Sonia Alejandra
De Bunder, Sabrina
Spinelli, Federico
Rapoport, Melina
Petroni, Alejandro
Galas, Marcelo Fabián
Corso, Alejandra
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CLONE
MULTIDRUG RESISTANCE
OUTBREAK
topic CLONE
MULTIDRUG RESISTANCE
OUTBREAK
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The emergence of Klebsiella pneumoniae carbapenemase (KPC) has now become a global concern. KPC producers are mostly Enterobacteriaceae, but Pseudomonas aeruginosa have also been reported and mostly identified in the American continent.1–4 However, it is unknown if this is due to the spread of epidemic strains, since the multilocus sequence type (ST) has not been provided in most of those reports. The aim of this work was to characterize KPC-producing P. aeruginosa isolated in Argentina from 2006 to June 2011. Since 2005, we designed an algorithm to detect carbapenemases (metallo-β-lactamases, KPC, etc.) in P. aeruginosa at the level of the clinical microbiology laboratory, which was implemented among 432 hospitals. All P. aeruginosa were screened through that algorithm, and KPC production was suspected in isolates with high-level resistance to carbapenems and aztreonam (absence of disc zones) and a negative synergy test result between the carbapenems and EDTA, a phenotype consistent with the reported patterns of KPC-producing P. aeruginosa.
Fil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Faccone, Diego Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Gómez, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: De Bunder, Sabrina. Hospital Zonal de Bariloche "Ramón Carrillo"; Argentina
Fil: Spinelli, Federico. Hospital Privado Regional del Sur; Argentina. Sanatorio del Sol; Argentina
Fil: Rapoport, Melina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Petroni, Alejandro. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Galas, Marcelo Fabián. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
description The emergence of Klebsiella pneumoniae carbapenemase (KPC) has now become a global concern. KPC producers are mostly Enterobacteriaceae, but Pseudomonas aeruginosa have also been reported and mostly identified in the American continent.1–4 However, it is unknown if this is due to the spread of epidemic strains, since the multilocus sequence type (ST) has not been provided in most of those reports. The aim of this work was to characterize KPC-producing P. aeruginosa isolated in Argentina from 2006 to June 2011. Since 2005, we designed an algorithm to detect carbapenemases (metallo-β-lactamases, KPC, etc.) in P. aeruginosa at the level of the clinical microbiology laboratory, which was implemented among 432 hospitals. All P. aeruginosa were screened through that algorithm, and KPC production was suspected in isolates with high-level resistance to carbapenems and aztreonam (absence of disc zones) and a negative synergy test result between the carbapenems and EDTA, a phenotype consistent with the reported patterns of KPC-producing P. aeruginosa.
publishDate 2012
dc.date.none.fl_str_mv 2012-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/250775
Pasteran, Fernando; Faccone, Diego Francisco; Gómez, Sonia Alejandra; De Bunder, Sabrina; Spinelli, Federico; et al.; Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina; Oxford University Press; Journal of Antimicrobial Chemotherapy; 67; 5; 5-2012; 1291-1293
0305-7453
CONICET Digital
CONICET
url http://hdl.handle.net/11336/250775
identifier_str_mv Pasteran, Fernando; Faccone, Diego Francisco; Gómez, Sonia Alejandra; De Bunder, Sabrina; Spinelli, Federico; et al.; Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina; Oxford University Press; Journal of Antimicrobial Chemotherapy; 67; 5; 5-2012; 1291-1293
0305-7453
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article-abstract/67/5/1291/981209
info:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dks032
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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