The man who feels two hearts: the different pathways of interoception

Autores
Couto, Juan Blas Marcos; Salles, Alejo; Sedeño, Lucas; Peradejordi Lastras, Margarita Ana; Barttfeld, Pablo; Canales Johnson, Andres; Vidal Dos Santos, Hector Yamil; Huepe, David; Bekinschtein, Tristán Andrés; Sigman, Mariano; Favaloro, Roberto; Manes, Facundo Francisco; Ibañez, Agustin Mariano
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Recent advances in neuroscience have provided new insights into the understanding of heart–brain interaction and communication. Cardiac information to the brain relies on two pathways, terminating in the insular cortex (IC) and anterior cingulate cortex (ACC), along with the somatosensory cortex (S1-S2). Interoception relying on these neuroanatomical pathways has been shown to modulate social cognition. We report the case study of C.S., a patient with an external heart (an extracorporeal left-univentricular cardiac assist device, LVAD). The patient was assessed with neural/behavioral measures of cardiac interoception complemented by neuropsychological and social cognition measures. The patients performance on the interoception task (heartbeat detection) seemed to be guided by signals from the artificial LVAD, which provides a somatosensory beat rather than by his endogenous heart. Cortical activity (HEP, heartbeat-evoked potential) was found decreased in comparison with normal volunteers, particularly during interoceptive states. The patient accurately performed several cognitive tasks, except for interoception-related social cognition domains (empathy, theory of mind and decision making). This evidence suggests an imbalance in the patients cardiac interoceptive pathways that enhances sensation driven by the artificial pump over that from the cardiac vagal-IC/ACC pathway. A patient with two hearts, one endogenous and one artificial, presents a unique opportunity to explore models of interoception and heart–brain interaction.
Fil: Couto, Juan Blas Marcos. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salles, Alejo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sedeño, Lucas. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Peradejordi Lastras, Margarita Ana. Universidad Favaloro; Argentina
Fil: Barttfeld, Pablo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina
Fil: Canales Johnson, Andres. Universidad Diego Portales; Chile
Fil: Vidal Dos Santos, Hector Yamil. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina
Fil: Huepe, David. Universidad Diego Portales; Chile
Fil: Bekinschtein, Tristán Andrés. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina. Universidad Torcuato Di Tella; Argentina
Fil: Favaloro, Roberto. Universidad Favaloro; Argentina
Fil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Ibañez, Agustin Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
HEART-BRAIN
HEP
INSULA
INTEROCEPTION
SOCIAL COGNITION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2529
Acceder
id CONICETDig_6f3ce39671770cadafc449a6f02f63fc
oai_identifier_str oai:ri.conicet.gov.ar:11336/2529
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The man who feels two hearts: the different pathways of interoceptionCouto, Juan Blas MarcosSalles, AlejoSedeño, LucasPeradejordi Lastras, Margarita AnaBarttfeld, PabloCanales Johnson, AndresVidal Dos Santos, Hector YamilHuepe, DavidBekinschtein, Tristán AndrésSigman, MarianoFavaloro, RobertoManes, Facundo FranciscoIbañez, Agustin MarianoHEART-BRAINHEPINSULAINTEROCEPTIONSOCIAL COGNITIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Recent advances in neuroscience have provided new insights into the understanding of heart–brain interaction and communication. Cardiac information to the brain relies on two pathways, terminating in the insular cortex (IC) and anterior cingulate cortex (ACC), along with the somatosensory cortex (S1-S2). Interoception relying on these neuroanatomical pathways has been shown to modulate social cognition. We report the case study of C.S., a patient with an external heart (an extracorporeal left-univentricular cardiac assist device, LVAD). The patient was assessed with neural/behavioral measures of cardiac interoception complemented by neuropsychological and social cognition measures. The patients performance on the interoception task (heartbeat detection) seemed to be guided by signals from the artificial LVAD, which provides a somatosensory beat rather than by his endogenous heart. Cortical activity (HEP, heartbeat-evoked potential) was found decreased in comparison with normal volunteers, particularly during interoceptive states. The patient accurately performed several cognitive tasks, except for interoception-related social cognition domains (empathy, theory of mind and decision making). This evidence suggests an imbalance in the patients cardiac interoceptive pathways that enhances sensation driven by the artificial pump over that from the cardiac vagal-IC/ACC pathway. A patient with two hearts, one endogenous and one artificial, presents a unique opportunity to explore models of interoception and heart–brain interaction.Fil: Couto, Juan Blas Marcos. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salles, Alejo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sedeño, Lucas. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Peradejordi Lastras, Margarita Ana. Universidad Favaloro; ArgentinaFil: Barttfeld, Pablo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; ArgentinaFil: Canales Johnson, Andres. Universidad Diego Portales; ChileFil: Vidal Dos Santos, Hector Yamil. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; ArgentinaFil: Huepe, David. Universidad Diego Portales; ChileFil: Bekinschtein, Tristán Andrés. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina. Universidad Torcuato Di Tella; ArgentinaFil: Favaloro, Roberto. Universidad Favaloro; ArgentinaFil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Ibañez, Agustin Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaOxford University Press2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2529Couto, Juan Blas Marcos; Salles, Alejo; Sedeño, Lucas; Peradejordi Lastras, Margarita Ana; Barttfeld, Pablo; et al.; The man who feels two hearts: the different pathways of interoception; Oxford University Press; Social Cognitive and Affective Neuroscience; 9; 9; 7-2013; 1253-12601749-5016enginfo:eu-repo/semantics/altIdentifier/doi/10.1093%2Fscan%2Fnst108info:eu-repo/semantics/altIdentifier/url/http://scan.oxfordjournals.org/content/9/9/1253.shortinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:14Zoai:ri.conicet.gov.ar:11336/2529instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:15.005CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The man who feels two hearts: the different pathways of interoception
title The man who feels two hearts: the different pathways of interoception
spellingShingle The man who feels two hearts: the different pathways of interoception
Couto, Juan Blas Marcos
HEART-BRAIN
HEP
INSULA
INTEROCEPTION
SOCIAL COGNITION
title_short The man who feels two hearts: the different pathways of interoception
title_full The man who feels two hearts: the different pathways of interoception
title_fullStr The man who feels two hearts: the different pathways of interoception
title_full_unstemmed The man who feels two hearts: the different pathways of interoception
title_sort The man who feels two hearts: the different pathways of interoception
dc.creator.none.fl_str_mv Couto, Juan Blas Marcos
Salles, Alejo
Sedeño, Lucas
Peradejordi Lastras, Margarita Ana
Barttfeld, Pablo
Canales Johnson, Andres
Vidal Dos Santos, Hector Yamil
Huepe, David
Bekinschtein, Tristán Andrés
Sigman, Mariano
Favaloro, Roberto
Manes, Facundo Francisco
Ibañez, Agustin Mariano
author Couto, Juan Blas Marcos
author_facet Couto, Juan Blas Marcos
Salles, Alejo
Sedeño, Lucas
Peradejordi Lastras, Margarita Ana
Barttfeld, Pablo
Canales Johnson, Andres
Vidal Dos Santos, Hector Yamil
Huepe, David
Bekinschtein, Tristán Andrés
Sigman, Mariano
Favaloro, Roberto
Manes, Facundo Francisco
Ibañez, Agustin Mariano
author_role author
author2 Salles, Alejo
Sedeño, Lucas
Peradejordi Lastras, Margarita Ana
Barttfeld, Pablo
Canales Johnson, Andres
Vidal Dos Santos, Hector Yamil
Huepe, David
Bekinschtein, Tristán Andrés
Sigman, Mariano
Favaloro, Roberto
Manes, Facundo Francisco
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HEART-BRAIN
HEP
INSULA
INTEROCEPTION
SOCIAL COGNITION
topic HEART-BRAIN
HEP
INSULA
INTEROCEPTION
SOCIAL COGNITION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Recent advances in neuroscience have provided new insights into the understanding of heart–brain interaction and communication. Cardiac information to the brain relies on two pathways, terminating in the insular cortex (IC) and anterior cingulate cortex (ACC), along with the somatosensory cortex (S1-S2). Interoception relying on these neuroanatomical pathways has been shown to modulate social cognition. We report the case study of C.S., a patient with an external heart (an extracorporeal left-univentricular cardiac assist device, LVAD). The patient was assessed with neural/behavioral measures of cardiac interoception complemented by neuropsychological and social cognition measures. The patients performance on the interoception task (heartbeat detection) seemed to be guided by signals from the artificial LVAD, which provides a somatosensory beat rather than by his endogenous heart. Cortical activity (HEP, heartbeat-evoked potential) was found decreased in comparison with normal volunteers, particularly during interoceptive states. The patient accurately performed several cognitive tasks, except for interoception-related social cognition domains (empathy, theory of mind and decision making). This evidence suggests an imbalance in the patients cardiac interoceptive pathways that enhances sensation driven by the artificial pump over that from the cardiac vagal-IC/ACC pathway. A patient with two hearts, one endogenous and one artificial, presents a unique opportunity to explore models of interoception and heart–brain interaction.
Fil: Couto, Juan Blas Marcos. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salles, Alejo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sedeño, Lucas. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Peradejordi Lastras, Margarita Ana. Universidad Favaloro; Argentina
Fil: Barttfeld, Pablo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina
Fil: Canales Johnson, Andres. Universidad Diego Portales; Chile
Fil: Vidal Dos Santos, Hector Yamil. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina
Fil: Huepe, David. Universidad Diego Portales; Chile
Fil: Bekinschtein, Tristán Andrés. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina. Universidad Torcuato Di Tella; Argentina
Fil: Favaloro, Roberto. Universidad Favaloro; Argentina
Fil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Ibañez, Agustin Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Recent advances in neuroscience have provided new insights into the understanding of heart–brain interaction and communication. Cardiac information to the brain relies on two pathways, terminating in the insular cortex (IC) and anterior cingulate cortex (ACC), along with the somatosensory cortex (S1-S2). Interoception relying on these neuroanatomical pathways has been shown to modulate social cognition. We report the case study of C.S., a patient with an external heart (an extracorporeal left-univentricular cardiac assist device, LVAD). The patient was assessed with neural/behavioral measures of cardiac interoception complemented by neuropsychological and social cognition measures. The patients performance on the interoception task (heartbeat detection) seemed to be guided by signals from the artificial LVAD, which provides a somatosensory beat rather than by his endogenous heart. Cortical activity (HEP, heartbeat-evoked potential) was found decreased in comparison with normal volunteers, particularly during interoceptive states. The patient accurately performed several cognitive tasks, except for interoception-related social cognition domains (empathy, theory of mind and decision making). This evidence suggests an imbalance in the patients cardiac interoceptive pathways that enhances sensation driven by the artificial pump over that from the cardiac vagal-IC/ACC pathway. A patient with two hearts, one endogenous and one artificial, presents a unique opportunity to explore models of interoception and heart–brain interaction.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2529
Couto, Juan Blas Marcos; Salles, Alejo; Sedeño, Lucas; Peradejordi Lastras, Margarita Ana; Barttfeld, Pablo; et al.; The man who feels two hearts: the different pathways of interoception; Oxford University Press; Social Cognitive and Affective Neuroscience; 9; 9; 7-2013; 1253-1260
1749-5016
url http://hdl.handle.net/11336/2529
identifier_str_mv Couto, Juan Blas Marcos; Salles, Alejo; Sedeño, Lucas; Peradejordi Lastras, Margarita Ana; Barttfeld, Pablo; et al.; The man who feels two hearts: the different pathways of interoception; Oxford University Press; Social Cognitive and Affective Neuroscience; 9; 9; 7-2013; 1253-1260
1749-5016
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093%2Fscan%2Fnst108
info:eu-repo/semantics/altIdentifier/url/http://scan.oxfordjournals.org/content/9/9/1253.short
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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