Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease

Autores
Hazelton, Jessica L.; Fittipaldi, María Sol; Fraile Vazquez, Matias; Sourty, Marion; Legaz, Agustina; Hudson, Anna L.; García Cordero, Indira Ruth; Salamone, Paula Celeste; Yoris, Adrián Isidro; Ibañez, Agustín; Piguet, Olivier; Kumfor, Fiona
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Disease-specific mechanisms underlying emotion recognition difficulties in behavioural-variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), and Parkinson's disease (PD) are unknown. Interoceptive accuracy, accurately detecting internal cues (e.g., one's heart beating), and cognitive abilities are candidate mechanisms underlying emotion recognition. One hundred and sixty-eight participants (52 bvFTD; 41 AD; 24 PD; 51 controls) were recruited. Emotion recognition was measured via the Facial Affect Selection Task or the Mini-Social and Emotional Assessment Emotion Recognition Task. Interoception was assessed with a heartbeat detection task. Participants pressed a button each time they: 1) felt their heartbeat (Interoception); or 2) heard a recorded heartbeat (Exteroception-control). Cognition was measured via the Addenbrooke's Cognitive Examination-III or the Montreal Cognitive Assessment. Voxel-based morphometry analyses identified neural correlates associated with emotion recognition and interoceptive accuracy. All patient groups showed worse emotion recognition and cognition than controls (all P's ≤ .008). Only the bvFTD showed worse interoceptive accuracy than controls (P < .001). Regression analyses revealed that in bvFTD worse interoceptive accuracy predicted worse emotion recognition (P = .008). Whereas worse cognition predicted worse emotion recognition overall (P < .001). Neuroimaging analyses revealed that the insula, orbitofrontal cortex, and amygdala were involved in emotion recognition and interoceptive accuracy in bvFTD. Here, we provide evidence for disease-specific mechanisms for emotion recognition difficulties. In bvFTD, emotion recognition impairment is driven by inaccurate perception of the internal milieu. Whereas, in AD and PD, cognitive impairment likely underlies emotion recognition deficits. The current study furthers our theoretical understanding of emotion and highlights the need for targeted interventions.
Fil: Hazelton, Jessica L.. University of Sydney; Australia
Fil: Fittipaldi, María Sol. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibáñez; Chile. Universidad Nacional de Córdoba; Argentina
Fil: Fraile Vazquez, Matias. Universidad de San Andrés; Argentina
Fil: Sourty, Marion. Faculty Of Engineering; Australia. The University Of Sydney; Australia
Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Hudson, Anna L.. Unsw Medicine; Australia. The College Of Medicine And Public Health; Australia. Neuroscience Research Australia; Australia
Fil: García Cordero, Indira Ruth. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Tanz Centre For Research In Neurodegenerative Diseases; Canadá
Fil: Salamone, Paula Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Linköping University; Suecia
Fil: Yoris, Adrián Isidro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
Fil: Ibañez, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibáñez; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Reino Unido. University of California; Estados Unidos
Fil: Piguet, Olivier. University of Sydney; Australia
Fil: Kumfor, Fiona. University of Sydney; Australia
Materia
BEHAVIOURAL-VARIANT FRONTOTEMPORAL DEMENTIA
EMOTION
INSULA
INTEROCEPTION
SOCIAL COGNITION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/218689
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/218689
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's diseaseHazelton, Jessica L.Fittipaldi, María SolFraile Vazquez, MatiasSourty, MarionLegaz, AgustinaHudson, Anna L.García Cordero, Indira RuthSalamone, Paula CelesteYoris, Adrián IsidroIbañez, AgustínPiguet, OlivierKumfor, FionaBEHAVIOURAL-VARIANT FRONTOTEMPORAL DEMENTIAEMOTIONINSULAINTEROCEPTIONSOCIAL COGNITIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Disease-specific mechanisms underlying emotion recognition difficulties in behavioural-variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), and Parkinson's disease (PD) are unknown. Interoceptive accuracy, accurately detecting internal cues (e.g., one's heart beating), and cognitive abilities are candidate mechanisms underlying emotion recognition. One hundred and sixty-eight participants (52 bvFTD; 41 AD; 24 PD; 51 controls) were recruited. Emotion recognition was measured via the Facial Affect Selection Task or the Mini-Social and Emotional Assessment Emotion Recognition Task. Interoception was assessed with a heartbeat detection task. Participants pressed a button each time they: 1) felt their heartbeat (Interoception); or 2) heard a recorded heartbeat (Exteroception-control). Cognition was measured via the Addenbrooke's Cognitive Examination-III or the Montreal Cognitive Assessment. Voxel-based morphometry analyses identified neural correlates associated with emotion recognition and interoceptive accuracy. All patient groups showed worse emotion recognition and cognition than controls (all P's ≤ .008). Only the bvFTD showed worse interoceptive accuracy than controls (P < .001). Regression analyses revealed that in bvFTD worse interoceptive accuracy predicted worse emotion recognition (P = .008). Whereas worse cognition predicted worse emotion recognition overall (P < .001). Neuroimaging analyses revealed that the insula, orbitofrontal cortex, and amygdala were involved in emotion recognition and interoceptive accuracy in bvFTD. Here, we provide evidence for disease-specific mechanisms for emotion recognition difficulties. In bvFTD, emotion recognition impairment is driven by inaccurate perception of the internal milieu. Whereas, in AD and PD, cognitive impairment likely underlies emotion recognition deficits. The current study furthers our theoretical understanding of emotion and highlights the need for targeted interventions.Fil: Hazelton, Jessica L.. University of Sydney; AustraliaFil: Fittipaldi, María Sol. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibáñez; Chile. Universidad Nacional de Córdoba; ArgentinaFil: Fraile Vazquez, Matias. Universidad de San Andrés; ArgentinaFil: Sourty, Marion. Faculty Of Engineering; Australia. The University Of Sydney; AustraliaFil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Hudson, Anna L.. Unsw Medicine; Australia. The College Of Medicine And Public Health; Australia. Neuroscience Research Australia; AustraliaFil: García Cordero, Indira Ruth. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Tanz Centre For Research In Neurodegenerative Diseases; CanadáFil: Salamone, Paula Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Linköping University; SueciaFil: Yoris, Adrián Isidro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; ArgentinaFil: Ibañez, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibáñez; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Reino Unido. University of California; Estados UnidosFil: Piguet, Olivier. University of Sydney; AustraliaFil: Kumfor, Fiona. University of Sydney; AustraliaJournal of Pure and Applied Algebra2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218689Hazelton, Jessica L.; Fittipaldi, María Sol; Fraile Vazquez, Matias; Sourty, Marion; Legaz, Agustina; et al.; Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease; Journal of Pure and Applied Algebra; Cortex; 163; 6-2023; 66-790010-9452CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cortex.2023.02.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0010945223000606info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:19Zoai:ri.conicet.gov.ar:11336/218689instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:19.582CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease
title Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease
spellingShingle Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease
Hazelton, Jessica L.
BEHAVIOURAL-VARIANT FRONTOTEMPORAL DEMENTIA
EMOTION
INSULA
INTEROCEPTION
SOCIAL COGNITION
title_short Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease
title_full Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease
title_fullStr Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease
title_full_unstemmed Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease
title_sort Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease
dc.creator.none.fl_str_mv Hazelton, Jessica L.
Fittipaldi, María Sol
Fraile Vazquez, Matias
Sourty, Marion
Legaz, Agustina
Hudson, Anna L.
García Cordero, Indira Ruth
Salamone, Paula Celeste
Yoris, Adrián Isidro
Ibañez, Agustín
Piguet, Olivier
Kumfor, Fiona
author Hazelton, Jessica L.
author_facet Hazelton, Jessica L.
Fittipaldi, María Sol
Fraile Vazquez, Matias
Sourty, Marion
Legaz, Agustina
Hudson, Anna L.
García Cordero, Indira Ruth
Salamone, Paula Celeste
Yoris, Adrián Isidro
Ibañez, Agustín
Piguet, Olivier
Kumfor, Fiona
author_role author
author2 Fittipaldi, María Sol
Fraile Vazquez, Matias
Sourty, Marion
Legaz, Agustina
Hudson, Anna L.
García Cordero, Indira Ruth
Salamone, Paula Celeste
Yoris, Adrián Isidro
Ibañez, Agustín
Piguet, Olivier
Kumfor, Fiona
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BEHAVIOURAL-VARIANT FRONTOTEMPORAL DEMENTIA
EMOTION
INSULA
INTEROCEPTION
SOCIAL COGNITION
topic BEHAVIOURAL-VARIANT FRONTOTEMPORAL DEMENTIA
EMOTION
INSULA
INTEROCEPTION
SOCIAL COGNITION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Disease-specific mechanisms underlying emotion recognition difficulties in behavioural-variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), and Parkinson's disease (PD) are unknown. Interoceptive accuracy, accurately detecting internal cues (e.g., one's heart beating), and cognitive abilities are candidate mechanisms underlying emotion recognition. One hundred and sixty-eight participants (52 bvFTD; 41 AD; 24 PD; 51 controls) were recruited. Emotion recognition was measured via the Facial Affect Selection Task or the Mini-Social and Emotional Assessment Emotion Recognition Task. Interoception was assessed with a heartbeat detection task. Participants pressed a button each time they: 1) felt their heartbeat (Interoception); or 2) heard a recorded heartbeat (Exteroception-control). Cognition was measured via the Addenbrooke's Cognitive Examination-III or the Montreal Cognitive Assessment. Voxel-based morphometry analyses identified neural correlates associated with emotion recognition and interoceptive accuracy. All patient groups showed worse emotion recognition and cognition than controls (all P's ≤ .008). Only the bvFTD showed worse interoceptive accuracy than controls (P < .001). Regression analyses revealed that in bvFTD worse interoceptive accuracy predicted worse emotion recognition (P = .008). Whereas worse cognition predicted worse emotion recognition overall (P < .001). Neuroimaging analyses revealed that the insula, orbitofrontal cortex, and amygdala were involved in emotion recognition and interoceptive accuracy in bvFTD. Here, we provide evidence for disease-specific mechanisms for emotion recognition difficulties. In bvFTD, emotion recognition impairment is driven by inaccurate perception of the internal milieu. Whereas, in AD and PD, cognitive impairment likely underlies emotion recognition deficits. The current study furthers our theoretical understanding of emotion and highlights the need for targeted interventions.
Fil: Hazelton, Jessica L.. University of Sydney; Australia
Fil: Fittipaldi, María Sol. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibáñez; Chile. Universidad Nacional de Córdoba; Argentina
Fil: Fraile Vazquez, Matias. Universidad de San Andrés; Argentina
Fil: Sourty, Marion. Faculty Of Engineering; Australia. The University Of Sydney; Australia
Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Hudson, Anna L.. Unsw Medicine; Australia. The College Of Medicine And Public Health; Australia. Neuroscience Research Australia; Australia
Fil: García Cordero, Indira Ruth. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Tanz Centre For Research In Neurodegenerative Diseases; Canadá
Fil: Salamone, Paula Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Linköping University; Suecia
Fil: Yoris, Adrián Isidro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
Fil: Ibañez, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibáñez; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Reino Unido. University of California; Estados Unidos
Fil: Piguet, Olivier. University of Sydney; Australia
Fil: Kumfor, Fiona. University of Sydney; Australia
description Disease-specific mechanisms underlying emotion recognition difficulties in behavioural-variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), and Parkinson's disease (PD) are unknown. Interoceptive accuracy, accurately detecting internal cues (e.g., one's heart beating), and cognitive abilities are candidate mechanisms underlying emotion recognition. One hundred and sixty-eight participants (52 bvFTD; 41 AD; 24 PD; 51 controls) were recruited. Emotion recognition was measured via the Facial Affect Selection Task or the Mini-Social and Emotional Assessment Emotion Recognition Task. Interoception was assessed with a heartbeat detection task. Participants pressed a button each time they: 1) felt their heartbeat (Interoception); or 2) heard a recorded heartbeat (Exteroception-control). Cognition was measured via the Addenbrooke's Cognitive Examination-III or the Montreal Cognitive Assessment. Voxel-based morphometry analyses identified neural correlates associated with emotion recognition and interoceptive accuracy. All patient groups showed worse emotion recognition and cognition than controls (all P's ≤ .008). Only the bvFTD showed worse interoceptive accuracy than controls (P < .001). Regression analyses revealed that in bvFTD worse interoceptive accuracy predicted worse emotion recognition (P = .008). Whereas worse cognition predicted worse emotion recognition overall (P < .001). Neuroimaging analyses revealed that the insula, orbitofrontal cortex, and amygdala were involved in emotion recognition and interoceptive accuracy in bvFTD. Here, we provide evidence for disease-specific mechanisms for emotion recognition difficulties. In bvFTD, emotion recognition impairment is driven by inaccurate perception of the internal milieu. Whereas, in AD and PD, cognitive impairment likely underlies emotion recognition deficits. The current study furthers our theoretical understanding of emotion and highlights the need for targeted interventions.
publishDate 2023
dc.date.none.fl_str_mv 2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/218689
Hazelton, Jessica L.; Fittipaldi, María Sol; Fraile Vazquez, Matias; Sourty, Marion; Legaz, Agustina; et al.; Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease; Journal of Pure and Applied Algebra; Cortex; 163; 6-2023; 66-79
0010-9452
CONICET Digital
CONICET
url http://hdl.handle.net/11336/218689
identifier_str_mv Hazelton, Jessica L.; Fittipaldi, María Sol; Fraile Vazquez, Matias; Sourty, Marion; Legaz, Agustina; et al.; Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease; Journal of Pure and Applied Algebra; Cortex; 163; 6-2023; 66-79
0010-9452
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cortex.2023.02.009
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0010945223000606
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Journal of Pure and Applied Algebra
publisher.none.fl_str_mv Journal of Pure and Applied Algebra
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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