NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)

Autores
Konigheim, Brenda Salome; Aguilar, Juan Javier; Tauro, Laura Beatriz; Rivarola, María Elisa; Contigiani de Minio, Marta Silvia; Núñez Montoya, Susana Carolina
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Since Nordihydroguaiaretic acid (NDGA), a potent natural antioxidant, can produce oxidation in several cell kinds,mainly by superoxide anion production (O2), the current study was designed to assess its capacity to produce ornot this reactive oxygen species on Vero cell line, with the aim to establish whether this lignan behaves as a pro- orantioxidant. The O2 production was determined by the Nitro Blue Tetrazolium reduction test. Results show that NDGA has a dual-face behavior on this eukaryotic cell model depending on the biological environment and itsconcentration. The NDGA behaved as a pro-oxidant when it was tested single, by means of an increase in O2 production that was directly concentration-dependent. Mixed with an antioxidant (ascorbic acid) or a moderateoxidant (glucose), the NDGA behaved as pro-oxidant at low concentrations and antioxidant at high concentrations.
Fil: Konigheim, Brenda Salome. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aguilar, Juan Javier. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Tauro, Laura Beatriz. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina
Fil: Rivarola, María Elisa. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Núñez Montoya, Susana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Materia
NORDIHYDROGUAUARETIC ACID
VERO CELLS
PRO-OXIDANT
ANTIOXIDANT
LARREA DIVARICATA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/113581
Acceder
id CONICETDig_6f2d34fc6e3c0da8aa46aae9bab74dcc
oai_identifier_str oai:ri.conicet.gov.ar:11336/113581
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)Nordihydroguaiaretic acid: Dual behavior as pro- or antioxidant on a eukaryotic cell model (vero cells)Konigheim, Brenda SalomeAguilar, Juan JavierTauro, Laura BeatrizRivarola, María ElisaContigiani de Minio, Marta SilviaNúñez Montoya, Susana CarolinaNORDIHYDROGUAUARETIC ACIDVERO CELLSPRO-OXIDANTANTIOXIDANTLARREA DIVARICATAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Since Nordihydroguaiaretic acid (NDGA), a potent natural antioxidant, can produce oxidation in several cell kinds,mainly by superoxide anion production (O2), the current study was designed to assess its capacity to produce ornot this reactive oxygen species on Vero cell line, with the aim to establish whether this lignan behaves as a pro- orantioxidant. The O2 production was determined by the Nitro Blue Tetrazolium reduction test. Results show that NDGA has a dual-face behavior on this eukaryotic cell model depending on the biological environment and itsconcentration. The NDGA behaved as a pro-oxidant when it was tested single, by means of an increase in O2 production that was directly concentration-dependent. Mixed with an antioxidant (ascorbic acid) or a moderateoxidant (glucose), the NDGA behaved as pro-oxidant at low concentrations and antioxidant at high concentrations.Fil: Konigheim, Brenda Salome. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aguilar, Juan Javier. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Tauro, Laura Beatriz. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; ArgentinaFil: Rivarola, María Elisa. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Núñez Montoya, Susana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaPharma Scholars Library2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/113581Konigheim, Brenda Salome; Aguilar, Juan Javier; Tauro, Laura Beatriz; Rivarola, María Elisa; Contigiani de Minio, Marta Silvia; et al.; NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS); Pharma Scholars Library; International Journal of Pharmacy; 5; 3; 7-2015; 685-6922249-1848CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.pharmascholars.com/abstractview/nordihydroguaiaretic-acid-dual-behavior-as-pro-or-antioxidant-on-a-eukaryotic-cell-model-vero-cellsinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:55:29Zoai:ri.conicet.gov.ar:11336/113581instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:55:29.844CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)
Nordihydroguaiaretic acid: Dual behavior as pro- or antioxidant on a eukaryotic cell model (vero cells)
title NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)
spellingShingle NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)
Konigheim, Brenda Salome
NORDIHYDROGUAUARETIC ACID
VERO CELLS
PRO-OXIDANT
ANTIOXIDANT
LARREA DIVARICATA
title_short NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)
title_full NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)
title_fullStr NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)
title_full_unstemmed NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)
title_sort NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS)
dc.creator.none.fl_str_mv Konigheim, Brenda Salome
Aguilar, Juan Javier
Tauro, Laura Beatriz
Rivarola, María Elisa
Contigiani de Minio, Marta Silvia
Núñez Montoya, Susana Carolina
author Konigheim, Brenda Salome
author_facet Konigheim, Brenda Salome
Aguilar, Juan Javier
Tauro, Laura Beatriz
Rivarola, María Elisa
Contigiani de Minio, Marta Silvia
Núñez Montoya, Susana Carolina
author_role author
author2 Aguilar, Juan Javier
Tauro, Laura Beatriz
Rivarola, María Elisa
Contigiani de Minio, Marta Silvia
Núñez Montoya, Susana Carolina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv NORDIHYDROGUAUARETIC ACID
VERO CELLS
PRO-OXIDANT
ANTIOXIDANT
LARREA DIVARICATA
topic NORDIHYDROGUAUARETIC ACID
VERO CELLS
PRO-OXIDANT
ANTIOXIDANT
LARREA DIVARICATA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Since Nordihydroguaiaretic acid (NDGA), a potent natural antioxidant, can produce oxidation in several cell kinds,mainly by superoxide anion production (O2), the current study was designed to assess its capacity to produce ornot this reactive oxygen species on Vero cell line, with the aim to establish whether this lignan behaves as a pro- orantioxidant. The O2 production was determined by the Nitro Blue Tetrazolium reduction test. Results show that NDGA has a dual-face behavior on this eukaryotic cell model depending on the biological environment and itsconcentration. The NDGA behaved as a pro-oxidant when it was tested single, by means of an increase in O2 production that was directly concentration-dependent. Mixed with an antioxidant (ascorbic acid) or a moderateoxidant (glucose), the NDGA behaved as pro-oxidant at low concentrations and antioxidant at high concentrations.
Fil: Konigheim, Brenda Salome. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aguilar, Juan Javier. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Tauro, Laura Beatriz. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina
Fil: Rivarola, María Elisa. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Núñez Montoya, Susana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
description Since Nordihydroguaiaretic acid (NDGA), a potent natural antioxidant, can produce oxidation in several cell kinds,mainly by superoxide anion production (O2), the current study was designed to assess its capacity to produce ornot this reactive oxygen species on Vero cell line, with the aim to establish whether this lignan behaves as a pro- orantioxidant. The O2 production was determined by the Nitro Blue Tetrazolium reduction test. Results show that NDGA has a dual-face behavior on this eukaryotic cell model depending on the biological environment and itsconcentration. The NDGA behaved as a pro-oxidant when it was tested single, by means of an increase in O2 production that was directly concentration-dependent. Mixed with an antioxidant (ascorbic acid) or a moderateoxidant (glucose), the NDGA behaved as pro-oxidant at low concentrations and antioxidant at high concentrations.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/113581
Konigheim, Brenda Salome; Aguilar, Juan Javier; Tauro, Laura Beatriz; Rivarola, María Elisa; Contigiani de Minio, Marta Silvia; et al.; NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS); Pharma Scholars Library; International Journal of Pharmacy; 5; 3; 7-2015; 685-692
2249-1848
CONICET Digital
CONICET
url http://hdl.handle.net/11336/113581
identifier_str_mv Konigheim, Brenda Salome; Aguilar, Juan Javier; Tauro, Laura Beatriz; Rivarola, María Elisa; Contigiani de Minio, Marta Silvia; et al.; NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS); Pharma Scholars Library; International Journal of Pharmacy; 5; 3; 7-2015; 685-692
2249-1848
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.pharmascholars.com/abstractview/nordihydroguaiaretic-acid-dual-behavior-as-pro-or-antioxidant-on-a-eukaryotic-cell-model-vero-cells
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pharma Scholars Library
publisher.none.fl_str_mv Pharma Scholars Library
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782258096111616
score 12.982451

Publicaciones similares