Critical role of dendritic cells in mouse mammary tumor virus in vivo infection

Autores
Courreges, Maria Cecilia; Burzyn, Dalia; Nepomnaschy, Irene; Piazzon, Margarita Isabel; Ross, Susan R.
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mouse mammary tumor virus (MMTV) is a milk-transmitted betaretrovirus that causes mammary tumors in mice. Although mammary epithelial cells are the ultimate targets of MMTV, the virus utilizes components of the host immune system to establish infection. Previous studies indicated that dendritic cells play a role in MMTV infection. Here we show that dendritic cells are the first cells to be infected by MMTV in vivo and that they are capable of producing infectious virus that can be transmitted to other cell types. Moreover, upon contact with the virus, dendritic cells became more mature and migrated in response to the chemokine macrophage inflammatory protein 3β. Finally, we demonstrate that targeted ablation of dendritic cells in vivo dramatically attenuated MMTV infection. These data indicate that MMTV infection of dendritic cells is critical to initial propagation of the virus in vivo. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Fil: Courreges, Maria Cecilia. University of Pennsylvania; Estados Unidos
Fil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Ross, Susan R.. University of Pennsylvania; Estados Unidos
Materia
Mmtv
Dendritic Cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55444
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Critical role of dendritic cells in mouse mammary tumor virus in vivo infectionCourreges, Maria CeciliaBurzyn, DaliaNepomnaschy, IrenePiazzon, Margarita IsabelRoss, Susan R.MmtvDendritic Cellshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Mouse mammary tumor virus (MMTV) is a milk-transmitted betaretrovirus that causes mammary tumors in mice. Although mammary epithelial cells are the ultimate targets of MMTV, the virus utilizes components of the host immune system to establish infection. Previous studies indicated that dendritic cells play a role in MMTV infection. Here we show that dendritic cells are the first cells to be infected by MMTV in vivo and that they are capable of producing infectious virus that can be transmitted to other cell types. Moreover, upon contact with the virus, dendritic cells became more mature and migrated in response to the chemokine macrophage inflammatory protein 3β. Finally, we demonstrate that targeted ablation of dendritic cells in vivo dramatically attenuated MMTV infection. These data indicate that MMTV infection of dendritic cells is critical to initial propagation of the virus in vivo. Copyright © 2007, American Society for Microbiology. All Rights Reserved.Fil: Courreges, Maria Cecilia. University of Pennsylvania; Estados UnidosFil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Ross, Susan R.. University of Pennsylvania; Estados UnidosAmerican Society for Microbiology2007-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55444Courreges, Maria Cecilia; Burzyn, Dalia; Nepomnaschy, Irene; Piazzon, Margarita Isabel; Ross, Susan R.; Critical role of dendritic cells in mouse mammary tumor virus in vivo infection; American Society for Microbiology; Journal of Virology; 81; 8; 4-2007; 3769-37770022-538XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.02728-06info:eu-repo/semantics/altIdentifier/url/http://jvi.asm.org/content/81/8/3769info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:07Zoai:ri.conicet.gov.ar:11336/55444instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:07.74CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Critical role of dendritic cells in mouse mammary tumor virus in vivo infection
title Critical role of dendritic cells in mouse mammary tumor virus in vivo infection
spellingShingle Critical role of dendritic cells in mouse mammary tumor virus in vivo infection
Courreges, Maria Cecilia
Mmtv
Dendritic Cells
title_short Critical role of dendritic cells in mouse mammary tumor virus in vivo infection
title_full Critical role of dendritic cells in mouse mammary tumor virus in vivo infection
title_fullStr Critical role of dendritic cells in mouse mammary tumor virus in vivo infection
title_full_unstemmed Critical role of dendritic cells in mouse mammary tumor virus in vivo infection
title_sort Critical role of dendritic cells in mouse mammary tumor virus in vivo infection
dc.creator.none.fl_str_mv Courreges, Maria Cecilia
Burzyn, Dalia
Nepomnaschy, Irene
Piazzon, Margarita Isabel
Ross, Susan R.
author Courreges, Maria Cecilia
author_facet Courreges, Maria Cecilia
Burzyn, Dalia
Nepomnaschy, Irene
Piazzon, Margarita Isabel
Ross, Susan R.
author_role author
author2 Burzyn, Dalia
Nepomnaschy, Irene
Piazzon, Margarita Isabel
Ross, Susan R.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Mmtv
Dendritic Cells
topic Mmtv
Dendritic Cells
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mouse mammary tumor virus (MMTV) is a milk-transmitted betaretrovirus that causes mammary tumors in mice. Although mammary epithelial cells are the ultimate targets of MMTV, the virus utilizes components of the host immune system to establish infection. Previous studies indicated that dendritic cells play a role in MMTV infection. Here we show that dendritic cells are the first cells to be infected by MMTV in vivo and that they are capable of producing infectious virus that can be transmitted to other cell types. Moreover, upon contact with the virus, dendritic cells became more mature and migrated in response to the chemokine macrophage inflammatory protein 3β. Finally, we demonstrate that targeted ablation of dendritic cells in vivo dramatically attenuated MMTV infection. These data indicate that MMTV infection of dendritic cells is critical to initial propagation of the virus in vivo. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Fil: Courreges, Maria Cecilia. University of Pennsylvania; Estados Unidos
Fil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Ross, Susan R.. University of Pennsylvania; Estados Unidos
description Mouse mammary tumor virus (MMTV) is a milk-transmitted betaretrovirus that causes mammary tumors in mice. Although mammary epithelial cells are the ultimate targets of MMTV, the virus utilizes components of the host immune system to establish infection. Previous studies indicated that dendritic cells play a role in MMTV infection. Here we show that dendritic cells are the first cells to be infected by MMTV in vivo and that they are capable of producing infectious virus that can be transmitted to other cell types. Moreover, upon contact with the virus, dendritic cells became more mature and migrated in response to the chemokine macrophage inflammatory protein 3β. Finally, we demonstrate that targeted ablation of dendritic cells in vivo dramatically attenuated MMTV infection. These data indicate that MMTV infection of dendritic cells is critical to initial propagation of the virus in vivo. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
publishDate 2007
dc.date.none.fl_str_mv 2007-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55444
Courreges, Maria Cecilia; Burzyn, Dalia; Nepomnaschy, Irene; Piazzon, Margarita Isabel; Ross, Susan R.; Critical role of dendritic cells in mouse mammary tumor virus in vivo infection; American Society for Microbiology; Journal of Virology; 81; 8; 4-2007; 3769-3777
0022-538X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55444
identifier_str_mv Courreges, Maria Cecilia; Burzyn, Dalia; Nepomnaschy, Irene; Piazzon, Margarita Isabel; Ross, Susan R.; Critical role of dendritic cells in mouse mammary tumor virus in vivo infection; American Society for Microbiology; Journal of Virology; 81; 8; 4-2007; 3769-3777
0022-538X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.02728-06
info:eu-repo/semantics/altIdentifier/url/http://jvi.asm.org/content/81/8/3769
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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