Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains

Autores
Negrotto, Soledad; Mena, Hebe A.; Ure, Agustín Enrique; Jaquenod De Giusti, Carolina; Bollati Fogolín, Mariela; Vermeulen, Elba M.; Schattner, Mirta; Gómez, Ricardo Martín
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.
Instituto de Biotecnologia y Biologia Molecular
Materia
Biología
Junin virus
Dendritic Cells
Virology
Arenavirus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/86431
Acceder
id SEDICI_5e603b415d5afd41dcf689005f6cfe7e
oai_identifier_str oai:sedici.unlp.edu.ar:10915/86431
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strainsNegrotto, SoledadMena, Hebe A.Ure, Agustín EnriqueJaquenod De Giusti, CarolinaBollati Fogolín, MarielaVermeulen, Elba M.Schattner, MirtaGómez, Ricardo MartínBiologíaJunin virusDendritic CellsVirologyArenavirusThe arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.Instituto de Biotecnologia y Biologia Molecular2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf7409-7413http://sedici.unlp.edu.ar/handle/10915/86431enginfo:eu-repo/semantics/altIdentifier/issn/0022-538Xinfo:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.01014-15info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-17T09:59:43Zoai:sedici.unlp.edu.ar:10915/86431Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-17 09:59:43.957SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
spellingShingle Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
Negrotto, Soledad
Biología
Junin virus
Dendritic Cells
Virology
Arenavirus
title_short Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title_full Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title_fullStr Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title_full_unstemmed Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title_sort Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
dc.creator.none.fl_str_mv Negrotto, Soledad
Mena, Hebe A.
Ure, Agustín Enrique
Jaquenod De Giusti, Carolina
Bollati Fogolín, Mariela
Vermeulen, Elba M.
Schattner, Mirta
Gómez, Ricardo Martín
author Negrotto, Soledad
author_facet Negrotto, Soledad
Mena, Hebe A.
Ure, Agustín Enrique
Jaquenod De Giusti, Carolina
Bollati Fogolín, Mariela
Vermeulen, Elba M.
Schattner, Mirta
Gómez, Ricardo Martín
author_role author
author2 Mena, Hebe A.
Ure, Agustín Enrique
Jaquenod De Giusti, Carolina
Bollati Fogolín, Mariela
Vermeulen, Elba M.
Schattner, Mirta
Gómez, Ricardo Martín
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Junin virus
Dendritic Cells
Virology
Arenavirus
topic Biología
Junin virus
Dendritic Cells
Virology
Arenavirus
dc.description.none.fl_txt_mv The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.
Instituto de Biotecnologia y Biologia Molecular
description The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/86431
url http://sedici.unlp.edu.ar/handle/10915/86431
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0022-538X
info:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.01014-15
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
7409-7413
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.001348

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