Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis

Autores
Geraldo, Murilo V.; Silber, Ariel Mariano; Pereira, Claudio Alejandro; Uliana, Silvia R.B.
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The metabolism of protozoan parasites of the Leishmania genus is strongly based on amino acid consumption, but little is known about amino acid uptake in these organisms. In the present work, we identified a Leishmania amazonensis gene (La-PAT1) encoding a putative amino acid transporter that belongs to the amino acid/auxin permease family, a group of H +/amino acid symporters. This single copy gene is upregulated in amastigotes, the life cycle stage found in the mammalian host. La-PAT1 putative orthologous sequences were identified in Leishmania infantum, Leishmania donovani, Leishmania major and Trypanosoma.
Fil: Geraldo, Murilo V.. Universidade de Sao Paulo; Brasil
Fil: Silber, Ariel Mariano. Universidade de Sao Paulo; Brasil
Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Uliana, Silvia R.B.. Universidade de Sao Paulo; Brasil
Materia
AMINO ACID PERMEASE
AMINO ACID TRANSPORTER
DIFFERENTIAL GENE EXPRESSION
LEISHMANIA AMAZONENSIS
LEISHMANIASIS
METABOLISM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/148630
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensisGeraldo, Murilo V.Silber, Ariel MarianoPereira, Claudio AlejandroUliana, Silvia R.B.AMINO ACID PERMEASEAMINO ACID TRANSPORTERDIFFERENTIAL GENE EXPRESSIONLEISHMANIA AMAZONENSISLEISHMANIASISMETABOLISMhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The metabolism of protozoan parasites of the Leishmania genus is strongly based on amino acid consumption, but little is known about amino acid uptake in these organisms. In the present work, we identified a Leishmania amazonensis gene (La-PAT1) encoding a putative amino acid transporter that belongs to the amino acid/auxin permease family, a group of H +/amino acid symporters. This single copy gene is upregulated in amastigotes, the life cycle stage found in the mammalian host. La-PAT1 putative orthologous sequences were identified in Leishmania infantum, Leishmania donovani, Leishmania major and Trypanosoma.Fil: Geraldo, Murilo V.. Universidade de Sao Paulo; BrasilFil: Silber, Ariel Mariano. Universidade de Sao Paulo; BrasilFil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Uliana, Silvia R.B.. Universidade de Sao Paulo; BrasilWiley Blackwell Publishing, Inc2005-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/148630Geraldo, Murilo V.; Silber, Ariel Mariano; Pereira, Claudio Alejandro; Uliana, Silvia R.B.; Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis; Wiley Blackwell Publishing, Inc; FEMS Microbiology Letters; 242; 2; 1-2005; 275-2800378-1097CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femsle/article/242/2/275/687340info:eu-repo/semantics/altIdentifier/doi/10.1016/j.femsle.2004.11.030info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:37Zoai:ri.conicet.gov.ar:11336/148630instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:38.08CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis
title Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis
spellingShingle Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis
Geraldo, Murilo V.
AMINO ACID PERMEASE
AMINO ACID TRANSPORTER
DIFFERENTIAL GENE EXPRESSION
LEISHMANIA AMAZONENSIS
LEISHMANIASIS
METABOLISM
title_short Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis
title_full Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis
title_fullStr Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis
title_full_unstemmed Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis
title_sort Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis
dc.creator.none.fl_str_mv Geraldo, Murilo V.
Silber, Ariel Mariano
Pereira, Claudio Alejandro
Uliana, Silvia R.B.
author Geraldo, Murilo V.
author_facet Geraldo, Murilo V.
Silber, Ariel Mariano
Pereira, Claudio Alejandro
Uliana, Silvia R.B.
author_role author
author2 Silber, Ariel Mariano
Pereira, Claudio Alejandro
Uliana, Silvia R.B.
author2_role author
author
author
dc.subject.none.fl_str_mv AMINO ACID PERMEASE
AMINO ACID TRANSPORTER
DIFFERENTIAL GENE EXPRESSION
LEISHMANIA AMAZONENSIS
LEISHMANIASIS
METABOLISM
topic AMINO ACID PERMEASE
AMINO ACID TRANSPORTER
DIFFERENTIAL GENE EXPRESSION
LEISHMANIA AMAZONENSIS
LEISHMANIASIS
METABOLISM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The metabolism of protozoan parasites of the Leishmania genus is strongly based on amino acid consumption, but little is known about amino acid uptake in these organisms. In the present work, we identified a Leishmania amazonensis gene (La-PAT1) encoding a putative amino acid transporter that belongs to the amino acid/auxin permease family, a group of H +/amino acid symporters. This single copy gene is upregulated in amastigotes, the life cycle stage found in the mammalian host. La-PAT1 putative orthologous sequences were identified in Leishmania infantum, Leishmania donovani, Leishmania major and Trypanosoma.
Fil: Geraldo, Murilo V.. Universidade de Sao Paulo; Brasil
Fil: Silber, Ariel Mariano. Universidade de Sao Paulo; Brasil
Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Uliana, Silvia R.B.. Universidade de Sao Paulo; Brasil
description The metabolism of protozoan parasites of the Leishmania genus is strongly based on amino acid consumption, but little is known about amino acid uptake in these organisms. In the present work, we identified a Leishmania amazonensis gene (La-PAT1) encoding a putative amino acid transporter that belongs to the amino acid/auxin permease family, a group of H +/amino acid symporters. This single copy gene is upregulated in amastigotes, the life cycle stage found in the mammalian host. La-PAT1 putative orthologous sequences were identified in Leishmania infantum, Leishmania donovani, Leishmania major and Trypanosoma.
publishDate 2005
dc.date.none.fl_str_mv 2005-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/148630
Geraldo, Murilo V.; Silber, Ariel Mariano; Pereira, Claudio Alejandro; Uliana, Silvia R.B.; Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis; Wiley Blackwell Publishing, Inc; FEMS Microbiology Letters; 242; 2; 1-2005; 275-280
0378-1097
CONICET Digital
CONICET
url http://hdl.handle.net/11336/148630
identifier_str_mv Geraldo, Murilo V.; Silber, Ariel Mariano; Pereira, Claudio Alejandro; Uliana, Silvia R.B.; Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis; Wiley Blackwell Publishing, Inc; FEMS Microbiology Letters; 242; 2; 1-2005; 275-280
0378-1097
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femsle/article/242/2/275/687340
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.femsle.2004.11.030
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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