Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases

Autores
Garcia Bustos, Maria Fernanda; González Prieto, Ana Gabriela; Ramos, Federico; Mora, Maria Celia; Hashiguchi, Yoshihisa; Parodi Ramoneda, Cecilia María; Basombrio, Miguel Angel Manuel; Moreno, Sonia; Monroig, Sibila; Beckar, Josefina; Jaime, Daniela; Sajama, Modesto Jesus; Yeo, Matthew; Marco, Jorge Diego; Locatelli, Fabricio M.; Barrio, Alejandra
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Leishmaniasis is a parasitic disease caused by hemoflagellates of the genus Leishmania and is transmitted to humans by the bite of infected phlebotomine sandflies. Depending on the Leishmania species, the disease has different clinical forms including cutaneous, mucocutaneous, and visceral manifestations. Previous studies performed in endemic zones of northwestern-Argentina, during epidemic outbreaks, have been important for detecting patients suffering from the acute phase of the disease, but have not given a complete representation of the clinical and epidemiological features in the region. Furthermore, due to the resurgence of leishmaniasis worldwide and in particular the large increase of international tourism to the region, it seems pertinent to update the current epidemiological and clinical profile of leishmaniasis in northwestern-Argentina. Here we present a retrospective analysis of 95 Leishmania positive cases, presenting between 2000?2014. Patients were derived from hospitals and diagnosed in our lab at the University of Salta, located in a non-endemic area in Salta, Argentina. We detected numerous extensive mucocutaneous cases (34/95, 35.8%) distinct from mucosal affected patients, some instances originating in locations with no previously reported human cases. Additionally patients suffering from concomitant diseases, besides leishmaniasis, were assessed. These included Chagas disease, syphilis, deep mycoses, tuberculosis, toxoplasmosis and intestinal parasitosis. This study updates the clinical and epidemiological features of leishmaniasis in northwestern-Argentina, and discusses the implications and management strategy for patients who acquire the disease in this region.
Fil: Garcia Bustos, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina
Fil: González Prieto, Ana Gabriela. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramos, Federico. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mora, Maria Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina
Fil: Hashiguchi, Yoshihisa. Kochi University. Kochi Medical School; Japón. Universidad Central del Ecuador y Proyecto Prometeo. Centro de Biomedicina; Ecuador
Fil: Parodi Ramoneda, Cecilia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Basombrio, Miguel Angel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Moreno, Sonia. Provincia de Salta. Ministerio de Salud Publica. Hospital del Milagro; Argentina
Fil: Monroig, Sibila. Provincia de Salta. Ministerio de Salud Publica. Hospital San Bernardo; Argentina
Fil: Beckar, Josefina. Provincia de Salta. Ministerio de Salud Publica. Hospital San Bernardo; Argentina
Fil: Jaime, Daniela. Provincia de Salta. Ministerio de Salud Pública. Hospital Joaquin Castellanos; Argentina
Fil: Sajama, Modesto Jesus. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; Argentina
Fil: Yeo, Matthew. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Marco, Jorge Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Locatelli, Fabricio M.. Kochi University. Kochi Medical School; Japón
Fil: Barrio, Alejandra. Universidad Nacional de Salta; Argentina
Materia
Cutaneous Leishmaniasis
Mucocutaneous Leishmaniasis
Visceral Leishmaniasis
Leishmania (V.) Braziliensis
Leishmania (L.) Amazonensis
Leishmania (L.) Infantum
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7002
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent casesGarcia Bustos, Maria FernandaGonzález Prieto, Ana GabrielaRamos, FedericoMora, Maria CeliaHashiguchi, YoshihisaParodi Ramoneda, Cecilia MaríaBasombrio, Miguel Angel ManuelMoreno, SoniaMonroig, SibilaBeckar, JosefinaJaime, DanielaSajama, Modesto JesusYeo, MatthewMarco, Jorge DiegoLocatelli, Fabricio M.Barrio, AlejandraCutaneous LeishmaniasisMucocutaneous LeishmaniasisVisceral LeishmaniasisLeishmania (V.) BraziliensisLeishmania (L.) AmazonensisLeishmania (L.) Infantumhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Leishmaniasis is a parasitic disease caused by hemoflagellates of the genus Leishmania and is transmitted to humans by the bite of infected phlebotomine sandflies. Depending on the Leishmania species, the disease has different clinical forms including cutaneous, mucocutaneous, and visceral manifestations. Previous studies performed in endemic zones of northwestern-Argentina, during epidemic outbreaks, have been important for detecting patients suffering from the acute phase of the disease, but have not given a complete representation of the clinical and epidemiological features in the region. Furthermore, due to the resurgence of leishmaniasis worldwide and in particular the large increase of international tourism to the region, it seems pertinent to update the current epidemiological and clinical profile of leishmaniasis in northwestern-Argentina. Here we present a retrospective analysis of 95 Leishmania positive cases, presenting between 2000?2014. Patients were derived from hospitals and diagnosed in our lab at the University of Salta, located in a non-endemic area in Salta, Argentina. We detected numerous extensive mucocutaneous cases (34/95, 35.8%) distinct from mucosal affected patients, some instances originating in locations with no previously reported human cases. Additionally patients suffering from concomitant diseases, besides leishmaniasis, were assessed. These included Chagas disease, syphilis, deep mycoses, tuberculosis, toxoplasmosis and intestinal parasitosis. This study updates the clinical and epidemiological features of leishmaniasis in northwestern-Argentina, and discusses the implications and management strategy for patients who acquire the disease in this region.Fil: Garcia Bustos, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; ArgentinaFil: González Prieto, Ana Gabriela. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ramos, Federico. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mora, Maria Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; ArgentinaFil: Hashiguchi, Yoshihisa. Kochi University. Kochi Medical School; Japón. Universidad Central del Ecuador y Proyecto Prometeo. Centro de Biomedicina; EcuadorFil: Parodi Ramoneda, Cecilia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; ArgentinaFil: Basombrio, Miguel Angel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; ArgentinaFil: Moreno, Sonia. Provincia de Salta. Ministerio de Salud Publica. Hospital del Milagro; ArgentinaFil: Monroig, Sibila. Provincia de Salta. Ministerio de Salud Publica. Hospital San Bernardo; ArgentinaFil: Beckar, Josefina. Provincia de Salta. Ministerio de Salud Publica. Hospital San Bernardo; ArgentinaFil: Jaime, Daniela. Provincia de Salta. Ministerio de Salud Pública. Hospital Joaquin Castellanos; ArgentinaFil: Sajama, Modesto Jesus. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; ArgentinaFil: Yeo, Matthew. London School of Hygiene and Tropical Medicine; Reino UnidoFil: Marco, Jorge Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; ArgentinaFil: Locatelli, Fabricio M.. Kochi University. Kochi Medical School; JapónFil: Barrio, Alejandra. Universidad Nacional de Salta; ArgentinaElsevier Science2015-11-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7002Garcia Bustos, Maria Fernanda; González Prieto, Ana Gabriela; Ramos, Federico; Mora, Maria Celia; Hashiguchi, Yoshihisa; et al.; Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases; Elsevier Science; Acta Tropica; 154; 21-11-2015; 125-1320001-706Xenginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actatropica.2015.11.008info:eu-repo/semantics/altIdentifier/pmid/26611809info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0001706X15301558info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/26611809info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:23Zoai:ri.conicet.gov.ar:11336/7002instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:23.437CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases
title Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases
spellingShingle Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases
Garcia Bustos, Maria Fernanda
Cutaneous Leishmaniasis
Mucocutaneous Leishmaniasis
Visceral Leishmaniasis
Leishmania (V.) Braziliensis
Leishmania (L.) Amazonensis
Leishmania (L.) Infantum
title_short Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases
title_full Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases
title_fullStr Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases
title_full_unstemmed Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases
title_sort Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases
dc.creator.none.fl_str_mv Garcia Bustos, Maria Fernanda
González Prieto, Ana Gabriela
Ramos, Federico
Mora, Maria Celia
Hashiguchi, Yoshihisa
Parodi Ramoneda, Cecilia María
Basombrio, Miguel Angel Manuel
Moreno, Sonia
Monroig, Sibila
Beckar, Josefina
Jaime, Daniela
Sajama, Modesto Jesus
Yeo, Matthew
Marco, Jorge Diego
Locatelli, Fabricio M.
Barrio, Alejandra
author Garcia Bustos, Maria Fernanda
author_facet Garcia Bustos, Maria Fernanda
González Prieto, Ana Gabriela
Ramos, Federico
Mora, Maria Celia
Hashiguchi, Yoshihisa
Parodi Ramoneda, Cecilia María
Basombrio, Miguel Angel Manuel
Moreno, Sonia
Monroig, Sibila
Beckar, Josefina
Jaime, Daniela
Sajama, Modesto Jesus
Yeo, Matthew
Marco, Jorge Diego
Locatelli, Fabricio M.
Barrio, Alejandra
author_role author
author2 González Prieto, Ana Gabriela
Ramos, Federico
Mora, Maria Celia
Hashiguchi, Yoshihisa
Parodi Ramoneda, Cecilia María
Basombrio, Miguel Angel Manuel
Moreno, Sonia
Monroig, Sibila
Beckar, Josefina
Jaime, Daniela
Sajama, Modesto Jesus
Yeo, Matthew
Marco, Jorge Diego
Locatelli, Fabricio M.
Barrio, Alejandra
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cutaneous Leishmaniasis
Mucocutaneous Leishmaniasis
Visceral Leishmaniasis
Leishmania (V.) Braziliensis
Leishmania (L.) Amazonensis
Leishmania (L.) Infantum
topic Cutaneous Leishmaniasis
Mucocutaneous Leishmaniasis
Visceral Leishmaniasis
Leishmania (V.) Braziliensis
Leishmania (L.) Amazonensis
Leishmania (L.) Infantum
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Leishmaniasis is a parasitic disease caused by hemoflagellates of the genus Leishmania and is transmitted to humans by the bite of infected phlebotomine sandflies. Depending on the Leishmania species, the disease has different clinical forms including cutaneous, mucocutaneous, and visceral manifestations. Previous studies performed in endemic zones of northwestern-Argentina, during epidemic outbreaks, have been important for detecting patients suffering from the acute phase of the disease, but have not given a complete representation of the clinical and epidemiological features in the region. Furthermore, due to the resurgence of leishmaniasis worldwide and in particular the large increase of international tourism to the region, it seems pertinent to update the current epidemiological and clinical profile of leishmaniasis in northwestern-Argentina. Here we present a retrospective analysis of 95 Leishmania positive cases, presenting between 2000?2014. Patients were derived from hospitals and diagnosed in our lab at the University of Salta, located in a non-endemic area in Salta, Argentina. We detected numerous extensive mucocutaneous cases (34/95, 35.8%) distinct from mucosal affected patients, some instances originating in locations with no previously reported human cases. Additionally patients suffering from concomitant diseases, besides leishmaniasis, were assessed. These included Chagas disease, syphilis, deep mycoses, tuberculosis, toxoplasmosis and intestinal parasitosis. This study updates the clinical and epidemiological features of leishmaniasis in northwestern-Argentina, and discusses the implications and management strategy for patients who acquire the disease in this region.
Fil: Garcia Bustos, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina
Fil: González Prieto, Ana Gabriela. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramos, Federico. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mora, Maria Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina
Fil: Hashiguchi, Yoshihisa. Kochi University. Kochi Medical School; Japón. Universidad Central del Ecuador y Proyecto Prometeo. Centro de Biomedicina; Ecuador
Fil: Parodi Ramoneda, Cecilia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Basombrio, Miguel Angel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Moreno, Sonia. Provincia de Salta. Ministerio de Salud Publica. Hospital del Milagro; Argentina
Fil: Monroig, Sibila. Provincia de Salta. Ministerio de Salud Publica. Hospital San Bernardo; Argentina
Fil: Beckar, Josefina. Provincia de Salta. Ministerio de Salud Publica. Hospital San Bernardo; Argentina
Fil: Jaime, Daniela. Provincia de Salta. Ministerio de Salud Pública. Hospital Joaquin Castellanos; Argentina
Fil: Sajama, Modesto Jesus. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; Argentina
Fil: Yeo, Matthew. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Marco, Jorge Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Locatelli, Fabricio M.. Kochi University. Kochi Medical School; Japón
Fil: Barrio, Alejandra. Universidad Nacional de Salta; Argentina
description Leishmaniasis is a parasitic disease caused by hemoflagellates of the genus Leishmania and is transmitted to humans by the bite of infected phlebotomine sandflies. Depending on the Leishmania species, the disease has different clinical forms including cutaneous, mucocutaneous, and visceral manifestations. Previous studies performed in endemic zones of northwestern-Argentina, during epidemic outbreaks, have been important for detecting patients suffering from the acute phase of the disease, but have not given a complete representation of the clinical and epidemiological features in the region. Furthermore, due to the resurgence of leishmaniasis worldwide and in particular the large increase of international tourism to the region, it seems pertinent to update the current epidemiological and clinical profile of leishmaniasis in northwestern-Argentina. Here we present a retrospective analysis of 95 Leishmania positive cases, presenting between 2000?2014. Patients were derived from hospitals and diagnosed in our lab at the University of Salta, located in a non-endemic area in Salta, Argentina. We detected numerous extensive mucocutaneous cases (34/95, 35.8%) distinct from mucosal affected patients, some instances originating in locations with no previously reported human cases. Additionally patients suffering from concomitant diseases, besides leishmaniasis, were assessed. These included Chagas disease, syphilis, deep mycoses, tuberculosis, toxoplasmosis and intestinal parasitosis. This study updates the clinical and epidemiological features of leishmaniasis in northwestern-Argentina, and discusses the implications and management strategy for patients who acquire the disease in this region.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7002
Garcia Bustos, Maria Fernanda; González Prieto, Ana Gabriela; Ramos, Federico; Mora, Maria Celia; Hashiguchi, Yoshihisa; et al.; Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases; Elsevier Science; Acta Tropica; 154; 21-11-2015; 125-132
0001-706X
url http://hdl.handle.net/11336/7002
identifier_str_mv Garcia Bustos, Maria Fernanda; González Prieto, Ana Gabriela; Ramos, Federico; Mora, Maria Celia; Hashiguchi, Yoshihisa; et al.; Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases; Elsevier Science; Acta Tropica; 154; 21-11-2015; 125-132
0001-706X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actatropica.2015.11.008
info:eu-repo/semantics/altIdentifier/pmid/26611809
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0001706X15301558
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/26611809
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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