Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy

Autores
Rocha, Luisa; Lizette Frías Soria , Christian; Ortiz, José G.; Auzmendi, Jerónimo Andrés; Lazarowski, Alberto
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cannabis has been considered as a therapeutic strategy to control intractable epilepsy. Several cannabis components, especially cannabidiol (CBD), induce antiseizure effects. However, additional information is necessary to identify the types of epilepsies that can be controlled by these components and the mechanisms involved in these effects. This review presents a summary of the discussion carried out during the 2nd Latin American Workshop on Neurobiology of Epilepsy entitled “Cannabinoid and epilepsy: myths and realities.” This event was carried out during the 10th Latin American Epilepsy Congress in San José de Costa Rica (September 28, 2018). The review focuses to discuss the use of CBD as a new therapeutic strategy to control drug-resistant epilepsy. It also indicates the necessity to consider the evaluation of unconventional targets such as P-glycoprotein, to explain the effects of CBD in drug-resistant epilepsy.
Fil: Rocha, Luisa. CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS ; INSTITUTO POLITÉCNICO NACIONAL;
Fil: Lizette Frías Soria , Christian. CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS ; INSTITUTO POLITÉCNICO NACIONAL;
Fil: Ortiz, José G.. Universidad de Puerto Rico; Puerto Rico
Fil: Auzmendi, Jerónimo Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Lazarowski, Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Materia
CANNABIDIOL
CANNABIS
DRUG-RESISTANT EPILEPSY
P-GLYCOPROTEIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/140176
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsyRocha, LuisaLizette Frías Soria , ChristianOrtiz, José G.Auzmendi, Jerónimo AndrésLazarowski, AlbertoCANNABIDIOLCANNABISDRUG-RESISTANT EPILEPSYP-GLYCOPROTEINhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cannabis has been considered as a therapeutic strategy to control intractable epilepsy. Several cannabis components, especially cannabidiol (CBD), induce antiseizure effects. However, additional information is necessary to identify the types of epilepsies that can be controlled by these components and the mechanisms involved in these effects. This review presents a summary of the discussion carried out during the 2nd Latin American Workshop on Neurobiology of Epilepsy entitled “Cannabinoid and epilepsy: myths and realities.” This event was carried out during the 10th Latin American Epilepsy Congress in San José de Costa Rica (September 28, 2018). The review focuses to discuss the use of CBD as a new therapeutic strategy to control drug-resistant epilepsy. It also indicates the necessity to consider the evaluation of unconventional targets such as P-glycoprotein, to explain the effects of CBD in drug-resistant epilepsy.Fil: Rocha, Luisa. CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS ; INSTITUTO POLITÉCNICO NACIONAL;Fil: Lizette Frías Soria , Christian. CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS ; INSTITUTO POLITÉCNICO NACIONAL;Fil: Ortiz, José G.. Universidad de Puerto Rico; Puerto RicoFil: Auzmendi, Jerónimo Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Lazarowski, Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaWiley Blackwell Publishing, Inc2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/140176Rocha, Luisa; Lizette Frías Soria , Christian; Ortiz, José G.; Auzmendi, Jerónimo Andrés; Lazarowski, Alberto; Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy; Wiley Blackwell Publishing, Inc; Epilepsia Open; 5; 1; 1-2020; 36-492470-92392470-9239CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/epi4.12376info:eu-repo/semantics/altIdentifier/doi/10.1002/epi4.12376info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:25:05Zoai:ri.conicet.gov.ar:11336/140176instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:25:05.331CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy
title Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy
spellingShingle Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy
Rocha, Luisa
CANNABIDIOL
CANNABIS
DRUG-RESISTANT EPILEPSY
P-GLYCOPROTEIN
title_short Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy
title_full Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy
title_fullStr Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy
title_full_unstemmed Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy
title_sort Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy
dc.creator.none.fl_str_mv Rocha, Luisa
Lizette Frías Soria , Christian
Ortiz, José G.
Auzmendi, Jerónimo Andrés
Lazarowski, Alberto
author Rocha, Luisa
author_facet Rocha, Luisa
Lizette Frías Soria , Christian
Ortiz, José G.
Auzmendi, Jerónimo Andrés
Lazarowski, Alberto
author_role author
author2 Lizette Frías Soria , Christian
Ortiz, José G.
Auzmendi, Jerónimo Andrés
Lazarowski, Alberto
author2_role author
author
author
author
dc.subject.none.fl_str_mv CANNABIDIOL
CANNABIS
DRUG-RESISTANT EPILEPSY
P-GLYCOPROTEIN
topic CANNABIDIOL
CANNABIS
DRUG-RESISTANT EPILEPSY
P-GLYCOPROTEIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cannabis has been considered as a therapeutic strategy to control intractable epilepsy. Several cannabis components, especially cannabidiol (CBD), induce antiseizure effects. However, additional information is necessary to identify the types of epilepsies that can be controlled by these components and the mechanisms involved in these effects. This review presents a summary of the discussion carried out during the 2nd Latin American Workshop on Neurobiology of Epilepsy entitled “Cannabinoid and epilepsy: myths and realities.” This event was carried out during the 10th Latin American Epilepsy Congress in San José de Costa Rica (September 28, 2018). The review focuses to discuss the use of CBD as a new therapeutic strategy to control drug-resistant epilepsy. It also indicates the necessity to consider the evaluation of unconventional targets such as P-glycoprotein, to explain the effects of CBD in drug-resistant epilepsy.
Fil: Rocha, Luisa. CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS ; INSTITUTO POLITÉCNICO NACIONAL;
Fil: Lizette Frías Soria , Christian. CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS ; INSTITUTO POLITÉCNICO NACIONAL;
Fil: Ortiz, José G.. Universidad de Puerto Rico; Puerto Rico
Fil: Auzmendi, Jerónimo Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Lazarowski, Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
description Cannabis has been considered as a therapeutic strategy to control intractable epilepsy. Several cannabis components, especially cannabidiol (CBD), induce antiseizure effects. However, additional information is necessary to identify the types of epilepsies that can be controlled by these components and the mechanisms involved in these effects. This review presents a summary of the discussion carried out during the 2nd Latin American Workshop on Neurobiology of Epilepsy entitled “Cannabinoid and epilepsy: myths and realities.” This event was carried out during the 10th Latin American Epilepsy Congress in San José de Costa Rica (September 28, 2018). The review focuses to discuss the use of CBD as a new therapeutic strategy to control drug-resistant epilepsy. It also indicates the necessity to consider the evaluation of unconventional targets such as P-glycoprotein, to explain the effects of CBD in drug-resistant epilepsy.
publishDate 2020
dc.date.none.fl_str_mv 2020-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/140176
Rocha, Luisa; Lizette Frías Soria , Christian; Ortiz, José G.; Auzmendi, Jerónimo Andrés; Lazarowski, Alberto; Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy; Wiley Blackwell Publishing, Inc; Epilepsia Open; 5; 1; 1-2020; 36-49
2470-9239
2470-9239
CONICET Digital
CONICET
url http://hdl.handle.net/11336/140176
identifier_str_mv Rocha, Luisa; Lizette Frías Soria , Christian; Ortiz, José G.; Auzmendi, Jerónimo Andrés; Lazarowski, Alberto; Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy; Wiley Blackwell Publishing, Inc; Epilepsia Open; 5; 1; 1-2020; 36-49
2470-9239
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/epi4.12376
info:eu-repo/semantics/altIdentifier/doi/10.1002/epi4.12376
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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