Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus

Autores
De S.F. Tischer, Paula Cristina; Talarico, Laura Beatriz; Noseda, Miguel D.; Pita B. Guimarães, Silvia Maria; Damonte, Elsa Beatriz; Duarte, Maria Eugênia R.
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6–956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections.
Fil: De S.F. Tischer, Paula Cristina. Universidade Federal do Paraná; Brasil
Fil: Talarico, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Noseda, Miguel D.. Universidade Federal do Paraná; Brasil
Fil: Pita B. Guimarães, Silvia Maria. Instituto de Botânica; Brasil
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Duarte, Maria Eugênia R.. Universidade Federal do Paraná; Brasil
Materia
ANTIVIRAL ACTIVITY
CHEMICAL STRUCTURE
DENGUE VIRUS
HERPES SIMPLEX VIRUS
IOTA/KAPPA-CARRAGEENAN
MERISTIELLA GELIDIUM
SOLIERIACEAE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93761
Acceder
id CONICETDig_6da59fd64214e6d3b3a0ee92d77b96b4
oai_identifier_str oai:ri.conicet.gov.ar:11336/93761
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virusDe S.F. Tischer, Paula CristinaTalarico, Laura BeatrizNoseda, Miguel D.Pita B. Guimarães, Silvia MariaDamonte, Elsa BeatrizDuarte, Maria Eugênia R.ANTIVIRAL ACTIVITYCHEMICAL STRUCTUREDENGUE VIRUSHERPES SIMPLEX VIRUSIOTA/KAPPA-CARRAGEENANMERISTIELLA GELIDIUMSOLIERIACEAEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6–956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections.Fil: De S.F. Tischer, Paula Cristina. Universidade Federal do Paraná; BrasilFil: Talarico, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Noseda, Miguel D.. Universidade Federal do Paraná; BrasilFil: Pita B. Guimarães, Silvia Maria. Instituto de Botânica; BrasilFil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Duarte, Maria Eugênia R.. Universidade Federal do Paraná; BrasilElsevier2006-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93761De S.F. Tischer, Paula Cristina; Talarico, Laura Beatriz; Noseda, Miguel D.; Pita B. Guimarães, Silvia Maria; Damonte, Elsa Beatriz; et al.; Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus; Elsevier; Carbohydrate Polymers; 63; 4; 3-2006; 459-4650144-8617CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0144861705004595info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2005.09.020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:46:41Zoai:ri.conicet.gov.ar:11336/93761instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:46:41.894CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
spellingShingle Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
De S.F. Tischer, Paula Cristina
ANTIVIRAL ACTIVITY
CHEMICAL STRUCTURE
DENGUE VIRUS
HERPES SIMPLEX VIRUS
IOTA/KAPPA-CARRAGEENAN
MERISTIELLA GELIDIUM
SOLIERIACEAE
title_short Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title_full Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title_fullStr Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title_full_unstemmed Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
title_sort Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
dc.creator.none.fl_str_mv De S.F. Tischer, Paula Cristina
Talarico, Laura Beatriz
Noseda, Miguel D.
Pita B. Guimarães, Silvia Maria
Damonte, Elsa Beatriz
Duarte, Maria Eugênia R.
author De S.F. Tischer, Paula Cristina
author_facet De S.F. Tischer, Paula Cristina
Talarico, Laura Beatriz
Noseda, Miguel D.
Pita B. Guimarães, Silvia Maria
Damonte, Elsa Beatriz
Duarte, Maria Eugênia R.
author_role author
author2 Talarico, Laura Beatriz
Noseda, Miguel D.
Pita B. Guimarães, Silvia Maria
Damonte, Elsa Beatriz
Duarte, Maria Eugênia R.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTIVIRAL ACTIVITY
CHEMICAL STRUCTURE
DENGUE VIRUS
HERPES SIMPLEX VIRUS
IOTA/KAPPA-CARRAGEENAN
MERISTIELLA GELIDIUM
SOLIERIACEAE
topic ANTIVIRAL ACTIVITY
CHEMICAL STRUCTURE
DENGUE VIRUS
HERPES SIMPLEX VIRUS
IOTA/KAPPA-CARRAGEENAN
MERISTIELLA GELIDIUM
SOLIERIACEAE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6–956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections.
Fil: De S.F. Tischer, Paula Cristina. Universidade Federal do Paraná; Brasil
Fil: Talarico, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Noseda, Miguel D.. Universidade Federal do Paraná; Brasil
Fil: Pita B. Guimarães, Silvia Maria. Instituto de Botânica; Brasil
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Duarte, Maria Eugênia R.. Universidade Federal do Paraná; Brasil
description Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6–956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections.
publishDate 2006
dc.date.none.fl_str_mv 2006-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93761
De S.F. Tischer, Paula Cristina; Talarico, Laura Beatriz; Noseda, Miguel D.; Pita B. Guimarães, Silvia Maria; Damonte, Elsa Beatriz; et al.; Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus; Elsevier; Carbohydrate Polymers; 63; 4; 3-2006; 459-465
0144-8617
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93761
identifier_str_mv De S.F. Tischer, Paula Cristina; Talarico, Laura Beatriz; Noseda, Miguel D.; Pita B. Guimarães, Silvia Maria; Damonte, Elsa Beatriz; et al.; Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus; Elsevier; Carbohydrate Polymers; 63; 4; 3-2006; 459-465
0144-8617
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0144861705004595
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2005.09.020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614508907069440
score 13.070432

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