The eukaryotic linear motif resource - 2018 update

Autores: Gouw, Marc; Michael, Sushama; Sámano Sánchez, Hugo; Kumar, Manjeet; Zeke, András; Lang, Benjamin; Bely, Benoit; Chemes, Lucia Beatriz; Davey, Norman E; Deng, Ziqi; Diella, Francesca; Gürth, Clara Marie; Huber, Ann Kathrin; Kleinsorg, Stefan; Schlegel, Lara S.; Palopoli, Nicolás; Roey, Kim V; Altenberg, Brigitte; Reményi, Attila; Dinkel, Holger; Gibson, Toby J.
Año de publicación: 2018
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome.
Fil: Gouw, Marc. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Michael, Sushama. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Sámano Sánchez, Hugo. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Kumar, Manjeet. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Zeke, András. Hungarian Academy Of Sciences; Hungría
Fil: Lang, Benjamin. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Bely, Benoit. Wellcome Trust; Reino Unido
Fil: Chemes, Lucia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Davey, Norman E. Universidad de Dublin; Irlanda
Fil: Deng, Ziqi. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Diella, Francesca. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Gürth, Clara Marie. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Huber, Ann Kathrin. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Kleinsorg, Stefan. Universitat Heidelberg; Alemania
Fil: Schlegel, Lara S.. Universitat Heidelberg; Alemania
Fil: Palopoli, Nicolás. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Roey, Kim V. Universitat Heidelberg; Alemania
Fil: Altenberg, Brigitte. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Reményi, Attila. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Dinkel, Holger. European Molecular Biology Laboratory Heidelberg; Alemania
Fil: Gibson, Toby J.. European Molecular Biology Laboratory Heidelberg; Alemania
Materia: SHORT LINEAR MOTIFS
SLIMS
ELM
DATABASE ISSUE
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/64451

Acceder

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repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	The eukaryotic linear motif resource - 2018 updateGouw, MarcMichael, SushamaSámano Sánchez, HugoKumar, ManjeetZeke, AndrásLang, BenjaminBely, BenoitChemes, Lucia BeatrizDavey, Norman EDeng, ZiqiDiella, FrancescaGürth, Clara MarieHuber, Ann KathrinKleinsorg, StefanSchlegel, Lara S.Palopoli, NicolásRoey, Kim VAltenberg, BrigitteReményi, AttilaDinkel, HolgerGibson, Toby J.SHORT LINEAR MOTIFSSLIMSELMDATABASE ISSUEhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome.Fil: Gouw, Marc. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Michael, Sushama. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Sámano Sánchez, Hugo. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Kumar, Manjeet. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Zeke, András. Hungarian Academy Of Sciences; HungríaFil: Lang, Benjamin. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Bely, Benoit. Wellcome Trust; Reino UnidoFil: Chemes, Lucia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Davey, Norman E. Universidad de Dublin; IrlandaFil: Deng, Ziqi. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Diella, Francesca. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Gürth, Clara Marie. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Huber, Ann Kathrin. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Kleinsorg, Stefan. Universitat Heidelberg; AlemaniaFil: Schlegel, Lara S.. Universitat Heidelberg; AlemaniaFil: Palopoli, Nicolás. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Roey, Kim V. Universitat Heidelberg; AlemaniaFil: Altenberg, Brigitte. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Reményi, Attila. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Dinkel, Holger. European Molecular Biology Laboratory Heidelberg; AlemaniaFil: Gibson, Toby J.. European Molecular Biology Laboratory Heidelberg; AlemaniaOxford University Press2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64451Gouw, Marc; Michael, Sushama; Sámano Sánchez, Hugo; Kumar, Manjeet; Zeke, András; et al.; The eukaryotic linear motif resource - 2018 update; Oxford University Press; Nucleic Acids Research; 46; D1; 1-2018; D428-D4340305-10481362-4962CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/nar/gkx1077info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/article/46/D1/D428/4612965info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:39Zoai:ri.conicet.gov.ar:11336/64451instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:39.532CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	The eukaryotic linear motif resource - 2018 update
title	The eukaryotic linear motif resource - 2018 update
spellingShingle	The eukaryotic linear motif resource - 2018 update Gouw, Marc SHORT LINEAR MOTIFS SLIMS ELM DATABASE ISSUE
title_short	The eukaryotic linear motif resource - 2018 update
title_full	The eukaryotic linear motif resource - 2018 update
title_fullStr	The eukaryotic linear motif resource - 2018 update
title_full_unstemmed	The eukaryotic linear motif resource - 2018 update
title_sort	The eukaryotic linear motif resource - 2018 update
dc.creator.none.fl_str_mv	Gouw, Marc Michael, Sushama Sámano Sánchez, Hugo Kumar, Manjeet Zeke, András Lang, Benjamin Bely, Benoit Chemes, Lucia Beatriz Davey, Norman E Deng, Ziqi Diella, Francesca Gürth, Clara Marie Huber, Ann Kathrin Kleinsorg, Stefan Schlegel, Lara S. Palopoli, Nicolás Roey, Kim V Altenberg, Brigitte Reményi, Attila Dinkel, Holger Gibson, Toby J.
author	Gouw, Marc
author_facet	Gouw, Marc Michael, Sushama Sámano Sánchez, Hugo Kumar, Manjeet Zeke, András Lang, Benjamin Bely, Benoit Chemes, Lucia Beatriz Davey, Norman E Deng, Ziqi Diella, Francesca Gürth, Clara Marie Huber, Ann Kathrin Kleinsorg, Stefan Schlegel, Lara S. Palopoli, Nicolás Roey, Kim V Altenberg, Brigitte Reményi, Attila Dinkel, Holger Gibson, Toby J.
author_role	author
author2	Michael, Sushama Sámano Sánchez, Hugo Kumar, Manjeet Zeke, András Lang, Benjamin Bely, Benoit Chemes, Lucia Beatriz Davey, Norman E Deng, Ziqi Diella, Francesca Gürth, Clara Marie Huber, Ann Kathrin Kleinsorg, Stefan Schlegel, Lara S. Palopoli, Nicolás Roey, Kim V Altenberg, Brigitte Reményi, Attila Dinkel, Holger Gibson, Toby J.
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	SHORT LINEAR MOTIFS SLIMS ELM DATABASE ISSUE
topic	SHORT LINEAR MOTIFS SLIMS ELM DATABASE ISSUE
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.2 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome. Fil: Gouw, Marc. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Michael, Sushama. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Sámano Sánchez, Hugo. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Kumar, Manjeet. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Zeke, András. Hungarian Academy Of Sciences; Hungría Fil: Lang, Benjamin. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Bely, Benoit. Wellcome Trust; Reino Unido Fil: Chemes, Lucia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Davey, Norman E. Universidad de Dublin; Irlanda Fil: Deng, Ziqi. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Diella, Francesca. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Gürth, Clara Marie. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Huber, Ann Kathrin. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Kleinsorg, Stefan. Universitat Heidelberg; Alemania Fil: Schlegel, Lara S.. Universitat Heidelberg; Alemania Fil: Palopoli, Nicolás. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Roey, Kim V. Universitat Heidelberg; Alemania Fil: Altenberg, Brigitte. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Reményi, Attila. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Dinkel, Holger. European Molecular Biology Laboratory Heidelberg; Alemania Fil: Gibson, Toby J.. European Molecular Biology Laboratory Heidelberg; Alemania
description	Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome.
publishDate	2018
dc.date.none.fl_str_mv	2018-01
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/64451 Gouw, Marc; Michael, Sushama; Sámano Sánchez, Hugo; Kumar, Manjeet; Zeke, András; et al.; The eukaryotic linear motif resource - 2018 update; Oxford University Press; Nucleic Acids Research; 46; D1; 1-2018; D428-D434 0305-1048 1362-4962 CONICET Digital CONICET
url	http://hdl.handle.net/11336/64451
identifier_str_mv	Gouw, Marc; Michael, Sushama; Sámano Sánchez, Hugo; Kumar, Manjeet; Zeke, András; et al.; The eukaryotic linear motif resource - 2018 update; Oxford University Press; Nucleic Acids Research; 46; D1; 1-2018; D428-D434 0305-1048 1362-4962 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/doi/10.1093/nar/gkx1077 info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/article/46/D1/D428/4612965
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf application/pdf
dc.publisher.none.fl_str_mv	Oxford University Press
publisher.none.fl_str_mv	Oxford University Press
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reponame_str	CONICET Digital (CONICET)
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repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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The eukaryotic linear motif resource - 2018 update

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