Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release

Autores
Jerez, Susana Josefina; Peral, Maria de Los Angeles; Coviello, Alfredo
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study investigated the modulation of angiotensin II-induced endothelial prostanoid release in rabbit aortic rings. Two cumulative dose response curves with 90-min washing interval were performed. Incubation with l-NG-nitroarginine methyl ester (l-NAME) 10- 4 M increased angiotensin II maximal contractile response (Emax). This effect was reversed by indomethacin 10- 5 M, diphenyliodinum 10- 5 M, Tempol 10- 5 M or ascorbic acid 10- 4 M in both cumulative dose response curves and by SQ 29548 10- 6 M in the second cumulative dose response curve. When segments were treated with tetraethylamonium 10- 3 M but not with glibenclamide 10- 5 M during the washing period, l-NAME recovered its ability to enhance the E max in arteries incubated with SQ 29548. Conclusions: nitric oxide modulates angiotensin II-induced endothelial release of cyclooxygenase-dependent eicosanoids, one of which acts through thromboxane A2/prostaglandin H2 receptors and would decrease KCa channel activity. An increase in free radical production may account for the enhancement of such prostanoid release. Furthermore, it was found that in the present conditions, the release of the hyperpolarizing factor would improve in order to maintain the vascular tone.
Fil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Coviello, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Materia
ANGIOTENSIN II
CYCLOOXYGENASE
CYTOCHROME P 450 EPOXYGENASE
EICOSANOID
NITRIC OXIDE
TXA2/PGH2 RECEPTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95116
Acceder
id CONICETDig_6c0f1f842071da73659482b58b5c8eb2
oai_identifier_str oai:ri.conicet.gov.ar:11336/95116
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid releaseJerez, Susana JosefinaPeral, Maria de Los AngelesCoviello, AlfredoANGIOTENSIN IICYCLOOXYGENASECYTOCHROME P 450 EPOXYGENASEEICOSANOIDNITRIC OXIDETXA2/PGH2 RECEPTORhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This study investigated the modulation of angiotensin II-induced endothelial prostanoid release in rabbit aortic rings. Two cumulative dose response curves with 90-min washing interval were performed. Incubation with l-NG-nitroarginine methyl ester (l-NAME) 10- 4 M increased angiotensin II maximal contractile response (Emax). This effect was reversed by indomethacin 10- 5 M, diphenyliodinum 10- 5 M, Tempol 10- 5 M or ascorbic acid 10- 4 M in both cumulative dose response curves and by SQ 29548 10- 6 M in the second cumulative dose response curve. When segments were treated with tetraethylamonium 10- 3 M but not with glibenclamide 10- 5 M during the washing period, l-NAME recovered its ability to enhance the E max in arteries incubated with SQ 29548. Conclusions: nitric oxide modulates angiotensin II-induced endothelial release of cyclooxygenase-dependent eicosanoids, one of which acts through thromboxane A2/prostaglandin H2 receptors and would decrease KCa channel activity. An increase in free radical production may account for the enhancement of such prostanoid release. Furthermore, it was found that in the present conditions, the release of the hyperpolarizing factor would improve in order to maintain the vascular tone.Fil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Coviello, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaElsevier Science2005-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95116Jerez, Susana Josefina; Peral, Maria de Los Angeles; Coviello, Alfredo; Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release; Elsevier Science; European Journal of Pharmacology; 520; 1-3; 9-2005; 127-1340014-2999CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejphar.2005.07.030info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014299905007491info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:16:35Zoai:ri.conicet.gov.ar:11336/95116instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:16:35.82CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release
title Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release
spellingShingle Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release
Jerez, Susana Josefina
ANGIOTENSIN II
CYCLOOXYGENASE
CYTOCHROME P 450 EPOXYGENASE
EICOSANOID
NITRIC OXIDE
TXA2/PGH2 RECEPTOR
title_short Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release
title_full Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release
title_fullStr Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release
title_full_unstemmed Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release
title_sort Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release
dc.creator.none.fl_str_mv Jerez, Susana Josefina
Peral, Maria de Los Angeles
Coviello, Alfredo
author Jerez, Susana Josefina
author_facet Jerez, Susana Josefina
Peral, Maria de Los Angeles
Coviello, Alfredo
author_role author
author2 Peral, Maria de Los Angeles
Coviello, Alfredo
author2_role author
author
dc.subject.none.fl_str_mv ANGIOTENSIN II
CYCLOOXYGENASE
CYTOCHROME P 450 EPOXYGENASE
EICOSANOID
NITRIC OXIDE
TXA2/PGH2 RECEPTOR
topic ANGIOTENSIN II
CYCLOOXYGENASE
CYTOCHROME P 450 EPOXYGENASE
EICOSANOID
NITRIC OXIDE
TXA2/PGH2 RECEPTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This study investigated the modulation of angiotensin II-induced endothelial prostanoid release in rabbit aortic rings. Two cumulative dose response curves with 90-min washing interval were performed. Incubation with l-NG-nitroarginine methyl ester (l-NAME) 10- 4 M increased angiotensin II maximal contractile response (Emax). This effect was reversed by indomethacin 10- 5 M, diphenyliodinum 10- 5 M, Tempol 10- 5 M or ascorbic acid 10- 4 M in both cumulative dose response curves and by SQ 29548 10- 6 M in the second cumulative dose response curve. When segments were treated with tetraethylamonium 10- 3 M but not with glibenclamide 10- 5 M during the washing period, l-NAME recovered its ability to enhance the E max in arteries incubated with SQ 29548. Conclusions: nitric oxide modulates angiotensin II-induced endothelial release of cyclooxygenase-dependent eicosanoids, one of which acts through thromboxane A2/prostaglandin H2 receptors and would decrease KCa channel activity. An increase in free radical production may account for the enhancement of such prostanoid release. Furthermore, it was found that in the present conditions, the release of the hyperpolarizing factor would improve in order to maintain the vascular tone.
Fil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Coviello, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
description This study investigated the modulation of angiotensin II-induced endothelial prostanoid release in rabbit aortic rings. Two cumulative dose response curves with 90-min washing interval were performed. Incubation with l-NG-nitroarginine methyl ester (l-NAME) 10- 4 M increased angiotensin II maximal contractile response (Emax). This effect was reversed by indomethacin 10- 5 M, diphenyliodinum 10- 5 M, Tempol 10- 5 M or ascorbic acid 10- 4 M in both cumulative dose response curves and by SQ 29548 10- 6 M in the second cumulative dose response curve. When segments were treated with tetraethylamonium 10- 3 M but not with glibenclamide 10- 5 M during the washing period, l-NAME recovered its ability to enhance the E max in arteries incubated with SQ 29548. Conclusions: nitric oxide modulates angiotensin II-induced endothelial release of cyclooxygenase-dependent eicosanoids, one of which acts through thromboxane A2/prostaglandin H2 receptors and would decrease KCa channel activity. An increase in free radical production may account for the enhancement of such prostanoid release. Furthermore, it was found that in the present conditions, the release of the hyperpolarizing factor would improve in order to maintain the vascular tone.
publishDate 2005
dc.date.none.fl_str_mv 2005-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95116
Jerez, Susana Josefina; Peral, Maria de Los Angeles; Coviello, Alfredo; Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release; Elsevier Science; European Journal of Pharmacology; 520; 1-3; 9-2005; 127-134
0014-2999
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95116
identifier_str_mv Jerez, Susana Josefina; Peral, Maria de Los Angeles; Coviello, Alfredo; Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release; Elsevier Science; European Journal of Pharmacology; 520; 1-3; 9-2005; 127-134
0014-2999
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejphar.2005.07.030
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014299905007491
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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