Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses

Autores
Blanco, Pablo Javier; Santos, Gabriela H. Vargas dos; Bulant, Carlos Alberto; Alvarez, Alonso M.; Oliveira, Fredric A. P.; Cunha Lima, Gabriella; Lemos, Pedro A.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The geometry of coronary arteries is believed to play the role as an atherosclerotic risk factor on its own. The full characterization of the normal coronary network has been reported in the literature. Reports on the integration of geometry and functional data for normal coronary vessels started to proliferate more recently. In this work, we analyze and integrate the geometric data retrieved from angiography images of the left main coronary bifurcation in angiographically normal patients and hemodynamic data generated from blood flow models to analyze the role of allometric laws and the connection between flow distribution and wall shear stress loads on the left anterior descending and left circumflex arteries. This in-silico study contributes to the characterization of normal coronary anatomy and its impact on the hemodynamic shear stresses acting over the vessel wall, shedding light on the impact of geometry-based versus simulation-based hypotheses to define boundary conditions for numerical simulations. We discuss the role of the wall shear stress corresponding to scenarios adopted by the scientific community and the ones proposed in this study. For the simulation-based hypothesis, we propose an iterative strategy to define boundary conditions at the main left coronary bifurcation, such that wall shear stresses are matched between the left descending and left circumflex arteries. From this study, we conclude that a one-fits-all power law exponent of results in an good trade-off between computational cost and wall shear stress balance between daughter vessels.
Fil: Blanco, Pablo Javier. National Laboratory for Scientific Computing; Brasil. National Institute of Science and Technology in Medicine; Brasil
Fil: Santos, Gabriela H. Vargas dos. Hospital Israelita Albert Einstein; Brasil
Fil: Bulant, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. National Institute of Science and Technology in Medicine; Brasil
Fil: Alvarez, Alonso M.. National Laboratory for Scientific Computing; Brasil. National Institute of Science and Technology in Medicine; Brasil
Fil: Oliveira, Fredric A. P.. Hospital Israelita Albert Einstein; Brasil
Fil: Cunha Lima, Gabriella. Hospital Israelita Albert Einstein; Brasil
Fil: Lemos, Pedro A.. Hospital Israelita Albert Einstein; Brasil. University of São Paulo Medical School. Heart Institute. Department of Interventional Cardiology; Brasil. National Institute of Science and Technology in Medicine; Brasil
Materia
ALLOMETRIC LAWS
ANGIOGRAPHY
BLOOD FLOW
CORONARY ARTERIES
SIMULATION
VASCULAR GEOMETRY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/164375
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/164375
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analysesBlanco, Pablo JavierSantos, Gabriela H. Vargas dosBulant, Carlos AlbertoAlvarez, Alonso M.Oliveira, Fredric A. P.Cunha Lima, GabriellaLemos, Pedro A.ALLOMETRIC LAWSANGIOGRAPHYBLOOD FLOWCORONARY ARTERIESSIMULATIONVASCULAR GEOMETRYhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2The geometry of coronary arteries is believed to play the role as an atherosclerotic risk factor on its own. The full characterization of the normal coronary network has been reported in the literature. Reports on the integration of geometry and functional data for normal coronary vessels started to proliferate more recently. In this work, we analyze and integrate the geometric data retrieved from angiography images of the left main coronary bifurcation in angiographically normal patients and hemodynamic data generated from blood flow models to analyze the role of allometric laws and the connection between flow distribution and wall shear stress loads on the left anterior descending and left circumflex arteries. This in-silico study contributes to the characterization of normal coronary anatomy and its impact on the hemodynamic shear stresses acting over the vessel wall, shedding light on the impact of geometry-based versus simulation-based hypotheses to define boundary conditions for numerical simulations. We discuss the role of the wall shear stress corresponding to scenarios adopted by the scientific community and the ones proposed in this study. For the simulation-based hypothesis, we propose an iterative strategy to define boundary conditions at the main left coronary bifurcation, such that wall shear stresses are matched between the left descending and left circumflex arteries. From this study, we conclude that a one-fits-all power law exponent of results in an good trade-off between computational cost and wall shear stress balance between daughter vessels.Fil: Blanco, Pablo Javier. National Laboratory for Scientific Computing; Brasil. National Institute of Science and Technology in Medicine; BrasilFil: Santos, Gabriela H. Vargas dos. Hospital Israelita Albert Einstein; BrasilFil: Bulant, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. National Institute of Science and Technology in Medicine; BrasilFil: Alvarez, Alonso M.. National Laboratory for Scientific Computing; Brasil. National Institute of Science and Technology in Medicine; BrasilFil: Oliveira, Fredric A. P.. Hospital Israelita Albert Einstein; BrasilFil: Cunha Lima, Gabriella. Hospital Israelita Albert Einstein; BrasilFil: Lemos, Pedro A.. Hospital Israelita Albert Einstein; Brasil. University of São Paulo Medical School. Heart Institute. Department of Interventional Cardiology; Brasil. National Institute of Science and Technology in Medicine; BrasilElsevier2022-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/164375Blanco, Pablo Javier; Santos, Gabriela H. Vargas dos; Bulant, Carlos Alberto; Alvarez, Alonso M.; Oliveira, Fredric A. P.; et al.; Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses; Elsevier; Medical Engineering & Physics; 99; 1-2022; 1-321350-4533CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1350453321001016info:eu-repo/semantics/altIdentifier/doi/10.1016/j.medengphy.2021.08.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:55:10Zoai:ri.conicet.gov.ar:11336/164375instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:55:10.496CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses
title Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses
spellingShingle Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses
Blanco, Pablo Javier
ALLOMETRIC LAWS
ANGIOGRAPHY
BLOOD FLOW
CORONARY ARTERIES
SIMULATION
VASCULAR GEOMETRY
title_short Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses
title_full Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses
title_fullStr Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses
title_full_unstemmed Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses
title_sort Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses
dc.creator.none.fl_str_mv Blanco, Pablo Javier
Santos, Gabriela H. Vargas dos
Bulant, Carlos Alberto
Alvarez, Alonso M.
Oliveira, Fredric A. P.
Cunha Lima, Gabriella
Lemos, Pedro A.
author Blanco, Pablo Javier
author_facet Blanco, Pablo Javier
Santos, Gabriela H. Vargas dos
Bulant, Carlos Alberto
Alvarez, Alonso M.
Oliveira, Fredric A. P.
Cunha Lima, Gabriella
Lemos, Pedro A.
author_role author
author2 Santos, Gabriela H. Vargas dos
Bulant, Carlos Alberto
Alvarez, Alonso M.
Oliveira, Fredric A. P.
Cunha Lima, Gabriella
Lemos, Pedro A.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ALLOMETRIC LAWS
ANGIOGRAPHY
BLOOD FLOW
CORONARY ARTERIES
SIMULATION
VASCULAR GEOMETRY
topic ALLOMETRIC LAWS
ANGIOGRAPHY
BLOOD FLOW
CORONARY ARTERIES
SIMULATION
VASCULAR GEOMETRY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The geometry of coronary arteries is believed to play the role as an atherosclerotic risk factor on its own. The full characterization of the normal coronary network has been reported in the literature. Reports on the integration of geometry and functional data for normal coronary vessels started to proliferate more recently. In this work, we analyze and integrate the geometric data retrieved from angiography images of the left main coronary bifurcation in angiographically normal patients and hemodynamic data generated from blood flow models to analyze the role of allometric laws and the connection between flow distribution and wall shear stress loads on the left anterior descending and left circumflex arteries. This in-silico study contributes to the characterization of normal coronary anatomy and its impact on the hemodynamic shear stresses acting over the vessel wall, shedding light on the impact of geometry-based versus simulation-based hypotheses to define boundary conditions for numerical simulations. We discuss the role of the wall shear stress corresponding to scenarios adopted by the scientific community and the ones proposed in this study. For the simulation-based hypothesis, we propose an iterative strategy to define boundary conditions at the main left coronary bifurcation, such that wall shear stresses are matched between the left descending and left circumflex arteries. From this study, we conclude that a one-fits-all power law exponent of results in an good trade-off between computational cost and wall shear stress balance between daughter vessels.
Fil: Blanco, Pablo Javier. National Laboratory for Scientific Computing; Brasil. National Institute of Science and Technology in Medicine; Brasil
Fil: Santos, Gabriela H. Vargas dos. Hospital Israelita Albert Einstein; Brasil
Fil: Bulant, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. National Institute of Science and Technology in Medicine; Brasil
Fil: Alvarez, Alonso M.. National Laboratory for Scientific Computing; Brasil. National Institute of Science and Technology in Medicine; Brasil
Fil: Oliveira, Fredric A. P.. Hospital Israelita Albert Einstein; Brasil
Fil: Cunha Lima, Gabriella. Hospital Israelita Albert Einstein; Brasil
Fil: Lemos, Pedro A.. Hospital Israelita Albert Einstein; Brasil. University of São Paulo Medical School. Heart Institute. Department of Interventional Cardiology; Brasil. National Institute of Science and Technology in Medicine; Brasil
description The geometry of coronary arteries is believed to play the role as an atherosclerotic risk factor on its own. The full characterization of the normal coronary network has been reported in the literature. Reports on the integration of geometry and functional data for normal coronary vessels started to proliferate more recently. In this work, we analyze and integrate the geometric data retrieved from angiography images of the left main coronary bifurcation in angiographically normal patients and hemodynamic data generated from blood flow models to analyze the role of allometric laws and the connection between flow distribution and wall shear stress loads on the left anterior descending and left circumflex arteries. This in-silico study contributes to the characterization of normal coronary anatomy and its impact on the hemodynamic shear stresses acting over the vessel wall, shedding light on the impact of geometry-based versus simulation-based hypotheses to define boundary conditions for numerical simulations. We discuss the role of the wall shear stress corresponding to scenarios adopted by the scientific community and the ones proposed in this study. For the simulation-based hypothesis, we propose an iterative strategy to define boundary conditions at the main left coronary bifurcation, such that wall shear stresses are matched between the left descending and left circumflex arteries. From this study, we conclude that a one-fits-all power law exponent of results in an good trade-off between computational cost and wall shear stress balance between daughter vessels.
publishDate 2022
dc.date.none.fl_str_mv 2022-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/164375
Blanco, Pablo Javier; Santos, Gabriela H. Vargas dos; Bulant, Carlos Alberto; Alvarez, Alonso M.; Oliveira, Fredric A. P.; et al.; Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses; Elsevier; Medical Engineering & Physics; 99; 1-2022; 1-32
1350-4533
CONICET Digital
CONICET
url http://hdl.handle.net/11336/164375
identifier_str_mv Blanco, Pablo Javier; Santos, Gabriela H. Vargas dos; Bulant, Carlos Alberto; Alvarez, Alonso M.; Oliveira, Fredric A. P.; et al.; Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses; Elsevier; Medical Engineering & Physics; 99; 1-2022; 1-32
1350-4533
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1350453321001016
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.medengphy.2021.08.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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