Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall

Autores
Fernández, Paula Virginia; Arata, Paula Ximena; Ciancia, Marina
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polysaccharides from Codium species have drawn attention due to their high anticoagulant activity. However, many different mechanisms of action have been proposed and the structure of the active compounds was usually not elucidated. Recently, structural determination has been carried out using purified fractions showing the presence of at least three different polysaccharide types, namely: (1) 3-linked B-D-galactans with ramifications on C-6 and terminal B-D-galactopyranose units with pyruvic acid ketal linked to O-3 and O-4 (S-configuration). Sulphation occurs mainly on C-4 and some of the 3-linked galactose units are substituted by pyruvic acid ketals linked to O-4 and O-6 (R-isomer). (2) 3-linked linear pyranosic B-L-arabinans sulphated on C-2 and/or C-4. (3) 4-linked B-D-mannans, partially sulphated on C-2 or on C-6, but to a lesser extent. The backbone of this polysaccharide is similar to that of the fibrillar component of the cell wall. Antiherpetic activity and activity on the immune system were determined for sulphated galactans from Codium fragile, which do not have significant anticoagulant effect, while highly sulphated arabinans have an important anticoagulant activity by mechanisms different to those described for heparin. The utricle cell wall of C. fragile has a sandwich structure of two fibrillar-like layers delimiting a middle amorphouslike zone. Mannans and hydroxyproline-rich glycoprotein-like epitopes are located in two distinct cell-wall layers, whereas sulphated polysaccharides are distributed in the middle area of the wall. The overall cell-wall polymer arrangement in the utricles of different species proved to be somewhat different.
Fil: Fernández, Paula Virginia. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Biologia Aplicada y Alimentos; Argentina
Fil: Arata, Paula Ximena. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Biologia Aplicada y Alimentos; Argentina
Fil: Ciancia, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Biologia Aplicada y Alimentos; Argentina
Materia
Bioactive Compound
Bryopsidales
Cell Wall
Codium
Green Seaweed
Sulphated Polysaccharide
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8173
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/8173
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wallFernández, Paula VirginiaArata, Paula XimenaCiancia, MarinaBioactive CompoundBryopsidalesCell WallCodiumGreen SeaweedSulphated Polysaccharidehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Polysaccharides from Codium species have drawn attention due to their high anticoagulant activity. However, many different mechanisms of action have been proposed and the structure of the active compounds was usually not elucidated. Recently, structural determination has been carried out using purified fractions showing the presence of at least three different polysaccharide types, namely: (1) 3-linked B-D-galactans with ramifications on C-6 and terminal B-D-galactopyranose units with pyruvic acid ketal linked to O-3 and O-4 (S-configuration). Sulphation occurs mainly on C-4 and some of the 3-linked galactose units are substituted by pyruvic acid ketals linked to O-4 and O-6 (R-isomer). (2) 3-linked linear pyranosic B-L-arabinans sulphated on C-2 and/or C-4. (3) 4-linked B-D-mannans, partially sulphated on C-2 or on C-6, but to a lesser extent. The backbone of this polysaccharide is similar to that of the fibrillar component of the cell wall. Antiherpetic activity and activity on the immune system were determined for sulphated galactans from Codium fragile, which do not have significant anticoagulant effect, while highly sulphated arabinans have an important anticoagulant activity by mechanisms different to those described for heparin. The utricle cell wall of C. fragile has a sandwich structure of two fibrillar-like layers delimiting a middle amorphouslike zone. Mannans and hydroxyproline-rich glycoprotein-like epitopes are located in two distinct cell-wall layers, whereas sulphated polysaccharides are distributed in the middle area of the wall. The overall cell-wall polymer arrangement in the utricles of different species proved to be somewhat different.Fil: Fernández, Paula Virginia. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Biologia Aplicada y Alimentos; ArgentinaFil: Arata, Paula Ximena. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Biologia Aplicada y Alimentos; ArgentinaFil: Ciancia, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Biologia Aplicada y Alimentos; ArgentinaElsevier2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8173Fernández, Paula Virginia; Arata, Paula Ximena; Ciancia, Marina; Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall; Elsevier; Advances In Botanical Research; 71; 5-2014; 253-2780065-2296enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/B9780124080621000093info:eu-repo/semantics/altIdentifier/doi/10.1016/B978-0-12-408062-1.00009-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:31Zoai:ri.conicet.gov.ar:11336/8173instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:31.814CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall
title Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall
spellingShingle Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall
Fernández, Paula Virginia
Bioactive Compound
Bryopsidales
Cell Wall
Codium
Green Seaweed
Sulphated Polysaccharide
title_short Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall
title_full Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall
title_fullStr Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall
title_full_unstemmed Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall
title_sort Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall
dc.creator.none.fl_str_mv Fernández, Paula Virginia
Arata, Paula Ximena
Ciancia, Marina
author Fernández, Paula Virginia
author_facet Fernández, Paula Virginia
Arata, Paula Ximena
Ciancia, Marina
author_role author
author2 Arata, Paula Ximena
Ciancia, Marina
author2_role author
author
dc.subject.none.fl_str_mv Bioactive Compound
Bryopsidales
Cell Wall
Codium
Green Seaweed
Sulphated Polysaccharide
topic Bioactive Compound
Bryopsidales
Cell Wall
Codium
Green Seaweed
Sulphated Polysaccharide
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Polysaccharides from Codium species have drawn attention due to their high anticoagulant activity. However, many different mechanisms of action have been proposed and the structure of the active compounds was usually not elucidated. Recently, structural determination has been carried out using purified fractions showing the presence of at least three different polysaccharide types, namely: (1) 3-linked B-D-galactans with ramifications on C-6 and terminal B-D-galactopyranose units with pyruvic acid ketal linked to O-3 and O-4 (S-configuration). Sulphation occurs mainly on C-4 and some of the 3-linked galactose units are substituted by pyruvic acid ketals linked to O-4 and O-6 (R-isomer). (2) 3-linked linear pyranosic B-L-arabinans sulphated on C-2 and/or C-4. (3) 4-linked B-D-mannans, partially sulphated on C-2 or on C-6, but to a lesser extent. The backbone of this polysaccharide is similar to that of the fibrillar component of the cell wall. Antiherpetic activity and activity on the immune system were determined for sulphated galactans from Codium fragile, which do not have significant anticoagulant effect, while highly sulphated arabinans have an important anticoagulant activity by mechanisms different to those described for heparin. The utricle cell wall of C. fragile has a sandwich structure of two fibrillar-like layers delimiting a middle amorphouslike zone. Mannans and hydroxyproline-rich glycoprotein-like epitopes are located in two distinct cell-wall layers, whereas sulphated polysaccharides are distributed in the middle area of the wall. The overall cell-wall polymer arrangement in the utricles of different species proved to be somewhat different.
Fil: Fernández, Paula Virginia. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Biologia Aplicada y Alimentos; Argentina
Fil: Arata, Paula Ximena. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Biologia Aplicada y Alimentos; Argentina
Fil: Ciancia, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Biologia Aplicada y Alimentos; Argentina
description Polysaccharides from Codium species have drawn attention due to their high anticoagulant activity. However, many different mechanisms of action have been proposed and the structure of the active compounds was usually not elucidated. Recently, structural determination has been carried out using purified fractions showing the presence of at least three different polysaccharide types, namely: (1) 3-linked B-D-galactans with ramifications on C-6 and terminal B-D-galactopyranose units with pyruvic acid ketal linked to O-3 and O-4 (S-configuration). Sulphation occurs mainly on C-4 and some of the 3-linked galactose units are substituted by pyruvic acid ketals linked to O-4 and O-6 (R-isomer). (2) 3-linked linear pyranosic B-L-arabinans sulphated on C-2 and/or C-4. (3) 4-linked B-D-mannans, partially sulphated on C-2 or on C-6, but to a lesser extent. The backbone of this polysaccharide is similar to that of the fibrillar component of the cell wall. Antiherpetic activity and activity on the immune system were determined for sulphated galactans from Codium fragile, which do not have significant anticoagulant effect, while highly sulphated arabinans have an important anticoagulant activity by mechanisms different to those described for heparin. The utricle cell wall of C. fragile has a sandwich structure of two fibrillar-like layers delimiting a middle amorphouslike zone. Mannans and hydroxyproline-rich glycoprotein-like epitopes are located in two distinct cell-wall layers, whereas sulphated polysaccharides are distributed in the middle area of the wall. The overall cell-wall polymer arrangement in the utricles of different species proved to be somewhat different.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8173
Fernández, Paula Virginia; Arata, Paula Ximena; Ciancia, Marina; Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall; Elsevier; Advances In Botanical Research; 71; 5-2014; 253-278
0065-2296
url http://hdl.handle.net/11336/8173
identifier_str_mv Fernández, Paula Virginia; Arata, Paula Ximena; Ciancia, Marina; Polysaccharides from Codium species: chemical structure and biological activity. Their role as components of the cell wall; Elsevier; Advances In Botanical Research; 71; 5-2014; 253-278
0065-2296
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/B9780124080621000093
info:eu-repo/semantics/altIdentifier/doi/10.1016/B978-0-12-408062-1.00009-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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