Ebolavirus comparative genomics

Autores
Jun, Se Ran; Leuze, Michael R.; Nookaew, Intawat; Uberbacher, Edward C.; Land, Miriam; Zhang, Qian; Wanchai, Visanu; Chai, Juanjuan; Nielsen, Morten; Trolle, Thomas; Lund, Ole; Buzard, Gregory S.; Pedersen, Thomas D.; Wassenaar, Trudy M.; Ussery, David W.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The 2014 Ebola outbreak in West Africa is the largest documented for this virus. To examine the dynamics of this genome, we compare more than 100 currently available ebolavirus genomes to each other and to other viral genomes. Based on oligomer frequency analysis, the family Filoviridae forms a distinct group from all other sequenced viral genomes. All filovirus genomes sequenced to date encode proteins with similar functions and gene order, although there is considerable divergence in sequences between the three genera Ebolavirus, Cuevavirus and Marburgvirus within the family Filoviridae. Whereas all ebolavirus genomes are quite similar (multiple sequences of the same strain are often identical), variation is most common in the intergenic regions and within specific areas of the genes encoding the glycoprotein (GP), nucleoprotein (NP) and polymerase (L). We predict regions that could contain epitope-binding sites, which might be good vaccine targets. This information, combined with glycosylation sites and experimentally determined epitopes, can identify the most promising regions for the development of therapeutic strategies.This manuscript has been authored by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan).
Fil: Jun, Se Ran. Oak Ridge National Laboratory; Estados Unidos. University of Tennessee; Estados Unidos
Fil: Leuze, Michael R.. Oak Ridge National Laboratory; Estados Unidos
Fil: Nookaew, Intawat. Oak Ridge National Laboratory; Estados Unidos
Fil: Uberbacher, Edward C.. Oak Ridge National Laboratory; Estados Unidos
Fil: Land, Miriam. Oak Ridge National Laboratory; Estados Unidos
Fil: Zhang, Qian. Oak Ridge National Laboratory; Estados Unidos. University of Tennessee; Estados Unidos
Fil: Wanchai, Visanu. Oak Ridge National Laboratory; Estados Unidos
Fil: Chai, Juanjuan. Oak Ridge National Laboratory; Estados Unidos
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina
Fil: Trolle, Thomas. Technical University of Denmark; Dinamarca
Fil: Lund, Ole. Technical University of Denmark; Dinamarca
Fil: Buzard, Gregory S.. Booze Allen Hamilton; Estados Unidos
Fil: Pedersen, Thomas D.. Technical University of Denmark; Dinamarca. Assays; Dinamarca
Fil: Wassenaar, Trudy M.. Molecular Microbiology and Genomics Consultants; Alemania
Fil: Ussery, David W.. Oak Ridge National Laboratory; Estados Unidos. University of Tennessee; Estados Unidos. Technical University of Denmark; Dinamarca
Materia
Comparative Genomics
Ebola
Ebola Virus Disease (Evd)
Epitope Prediction
Filovirus
Viral Genomes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/51236
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/51236
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ebolavirus comparative genomicsJun, Se RanLeuze, Michael R.Nookaew, IntawatUberbacher, Edward C.Land, MiriamZhang, QianWanchai, VisanuChai, JuanjuanNielsen, MortenTrolle, ThomasLund, OleBuzard, Gregory S.Pedersen, Thomas D.Wassenaar, Trudy M.Ussery, David W.Comparative GenomicsEbolaEbola Virus Disease (Evd)Epitope PredictionFilovirusViral Genomeshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The 2014 Ebola outbreak in West Africa is the largest documented for this virus. To examine the dynamics of this genome, we compare more than 100 currently available ebolavirus genomes to each other and to other viral genomes. Based on oligomer frequency analysis, the family Filoviridae forms a distinct group from all other sequenced viral genomes. All filovirus genomes sequenced to date encode proteins with similar functions and gene order, although there is considerable divergence in sequences between the three genera Ebolavirus, Cuevavirus and Marburgvirus within the family Filoviridae. Whereas all ebolavirus genomes are quite similar (multiple sequences of the same strain are often identical), variation is most common in the intergenic regions and within specific areas of the genes encoding the glycoprotein (GP), nucleoprotein (NP) and polymerase (L). We predict regions that could contain epitope-binding sites, which might be good vaccine targets. This information, combined with glycosylation sites and experimentally determined epitopes, can identify the most promising regions for the development of therapeutic strategies.This manuscript has been authored by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan).Fil: Jun, Se Ran. Oak Ridge National Laboratory; Estados Unidos. University of Tennessee; Estados UnidosFil: Leuze, Michael R.. Oak Ridge National Laboratory; Estados UnidosFil: Nookaew, Intawat. Oak Ridge National Laboratory; Estados UnidosFil: Uberbacher, Edward C.. Oak Ridge National Laboratory; Estados UnidosFil: Land, Miriam. Oak Ridge National Laboratory; Estados UnidosFil: Zhang, Qian. Oak Ridge National Laboratory; Estados Unidos. University of Tennessee; Estados UnidosFil: Wanchai, Visanu. Oak Ridge National Laboratory; Estados UnidosFil: Chai, Juanjuan. Oak Ridge National Laboratory; Estados UnidosFil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Trolle, Thomas. Technical University of Denmark; DinamarcaFil: Lund, Ole. Technical University of Denmark; DinamarcaFil: Buzard, Gregory S.. Booze Allen Hamilton; Estados UnidosFil: Pedersen, Thomas D.. Technical University of Denmark; Dinamarca. Assays; DinamarcaFil: Wassenaar, Trudy M.. Molecular Microbiology and Genomics Consultants; AlemaniaFil: Ussery, David W.. Oak Ridge National Laboratory; Estados Unidos. University of Tennessee; Estados Unidos. Technical University of Denmark; DinamarcaWiley Blackwell Publishing, Inc2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/51236Jun, Se Ran; Leuze, Michael R.; Nookaew, Intawat; Uberbacher, Edward C.; Land, Miriam; et al.; Ebolavirus comparative genomics; Wiley Blackwell Publishing, Inc; Fems Microbiology Reviews; 39; 5; 6-2015; 764-7780168-6445CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/femsre/fuv031info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femsre/article/39/5/764/532220info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:34Zoai:ri.conicet.gov.ar:11336/51236instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:35.154CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ebolavirus comparative genomics
title Ebolavirus comparative genomics
spellingShingle Ebolavirus comparative genomics
Jun, Se Ran
Comparative Genomics
Ebola
Ebola Virus Disease (Evd)
Epitope Prediction
Filovirus
Viral Genomes
title_short Ebolavirus comparative genomics
title_full Ebolavirus comparative genomics
title_fullStr Ebolavirus comparative genomics
title_full_unstemmed Ebolavirus comparative genomics
title_sort Ebolavirus comparative genomics
dc.creator.none.fl_str_mv Jun, Se Ran
Leuze, Michael R.
Nookaew, Intawat
Uberbacher, Edward C.
Land, Miriam
Zhang, Qian
Wanchai, Visanu
Chai, Juanjuan
Nielsen, Morten
Trolle, Thomas
Lund, Ole
Buzard, Gregory S.
Pedersen, Thomas D.
Wassenaar, Trudy M.
Ussery, David W.
author Jun, Se Ran
author_facet Jun, Se Ran
Leuze, Michael R.
Nookaew, Intawat
Uberbacher, Edward C.
Land, Miriam
Zhang, Qian
Wanchai, Visanu
Chai, Juanjuan
Nielsen, Morten
Trolle, Thomas
Lund, Ole
Buzard, Gregory S.
Pedersen, Thomas D.
Wassenaar, Trudy M.
Ussery, David W.
author_role author
author2 Leuze, Michael R.
Nookaew, Intawat
Uberbacher, Edward C.
Land, Miriam
Zhang, Qian
Wanchai, Visanu
Chai, Juanjuan
Nielsen, Morten
Trolle, Thomas
Lund, Ole
Buzard, Gregory S.
Pedersen, Thomas D.
Wassenaar, Trudy M.
Ussery, David W.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Comparative Genomics
Ebola
Ebola Virus Disease (Evd)
Epitope Prediction
Filovirus
Viral Genomes
topic Comparative Genomics
Ebola
Ebola Virus Disease (Evd)
Epitope Prediction
Filovirus
Viral Genomes
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The 2014 Ebola outbreak in West Africa is the largest documented for this virus. To examine the dynamics of this genome, we compare more than 100 currently available ebolavirus genomes to each other and to other viral genomes. Based on oligomer frequency analysis, the family Filoviridae forms a distinct group from all other sequenced viral genomes. All filovirus genomes sequenced to date encode proteins with similar functions and gene order, although there is considerable divergence in sequences between the three genera Ebolavirus, Cuevavirus and Marburgvirus within the family Filoviridae. Whereas all ebolavirus genomes are quite similar (multiple sequences of the same strain are often identical), variation is most common in the intergenic regions and within specific areas of the genes encoding the glycoprotein (GP), nucleoprotein (NP) and polymerase (L). We predict regions that could contain epitope-binding sites, which might be good vaccine targets. This information, combined with glycosylation sites and experimentally determined epitopes, can identify the most promising regions for the development of therapeutic strategies.This manuscript has been authored by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan).
Fil: Jun, Se Ran. Oak Ridge National Laboratory; Estados Unidos. University of Tennessee; Estados Unidos
Fil: Leuze, Michael R.. Oak Ridge National Laboratory; Estados Unidos
Fil: Nookaew, Intawat. Oak Ridge National Laboratory; Estados Unidos
Fil: Uberbacher, Edward C.. Oak Ridge National Laboratory; Estados Unidos
Fil: Land, Miriam. Oak Ridge National Laboratory; Estados Unidos
Fil: Zhang, Qian. Oak Ridge National Laboratory; Estados Unidos. University of Tennessee; Estados Unidos
Fil: Wanchai, Visanu. Oak Ridge National Laboratory; Estados Unidos
Fil: Chai, Juanjuan. Oak Ridge National Laboratory; Estados Unidos
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina
Fil: Trolle, Thomas. Technical University of Denmark; Dinamarca
Fil: Lund, Ole. Technical University of Denmark; Dinamarca
Fil: Buzard, Gregory S.. Booze Allen Hamilton; Estados Unidos
Fil: Pedersen, Thomas D.. Technical University of Denmark; Dinamarca. Assays; Dinamarca
Fil: Wassenaar, Trudy M.. Molecular Microbiology and Genomics Consultants; Alemania
Fil: Ussery, David W.. Oak Ridge National Laboratory; Estados Unidos. University of Tennessee; Estados Unidos. Technical University of Denmark; Dinamarca
description The 2014 Ebola outbreak in West Africa is the largest documented for this virus. To examine the dynamics of this genome, we compare more than 100 currently available ebolavirus genomes to each other and to other viral genomes. Based on oligomer frequency analysis, the family Filoviridae forms a distinct group from all other sequenced viral genomes. All filovirus genomes sequenced to date encode proteins with similar functions and gene order, although there is considerable divergence in sequences between the three genera Ebolavirus, Cuevavirus and Marburgvirus within the family Filoviridae. Whereas all ebolavirus genomes are quite similar (multiple sequences of the same strain are often identical), variation is most common in the intergenic regions and within specific areas of the genes encoding the glycoprotein (GP), nucleoprotein (NP) and polymerase (L). We predict regions that could contain epitope-binding sites, which might be good vaccine targets. This information, combined with glycosylation sites and experimentally determined epitopes, can identify the most promising regions for the development of therapeutic strategies.This manuscript has been authored by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan).
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/51236
Jun, Se Ran; Leuze, Michael R.; Nookaew, Intawat; Uberbacher, Edward C.; Land, Miriam; et al.; Ebolavirus comparative genomics; Wiley Blackwell Publishing, Inc; Fems Microbiology Reviews; 39; 5; 6-2015; 764-778
0168-6445
CONICET Digital
CONICET
url http://hdl.handle.net/11336/51236
identifier_str_mv Jun, Se Ran; Leuze, Michael R.; Nookaew, Intawat; Uberbacher, Edward C.; Land, Miriam; et al.; Ebolavirus comparative genomics; Wiley Blackwell Publishing, Inc; Fems Microbiology Reviews; 39; 5; 6-2015; 764-778
0168-6445
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/femsre/fuv031
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femsre/article/39/5/764/532220
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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