A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma

Autores
Lopes Kinouchi, Fernanda; Cardoso Geraldo Maia, Danielle; de Abreu Ribeiro, Lívia Carolina; Campos Polesi Placeres, Marisa; Font, Graciela Maria; Colombo, Lucas Luis; Rossi, Elizeu Antonio; Zeppone Carlos, Iracilda
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: Soy and its fermented products are considered functional foods. The study objective was to assess three functional food - a non-fermented soy product (NFP), fermented soy product (FSP), fermented soy product enriched with isoflavones (FI) - in terms of their ability to reduce the development of adenocarcinoma in mice, as well their ability on modulating immune system. Methods: It was observed tumor volume and to verify correlations with the immune system it was measured levels of the cytokines IL-1β and TNF-α produced by macrophages as well as IFN-γ produced by lymphocytes using ELISA test, and nitric oxide production by macrophages using Griess reagent. Results: All products showed immunological activity, but FSP showed the most effective tumor containment, resulting in smallest tumor volumes. FI animals expressed larger amounts of nitric oxide and IL-1β and exhibited larger tumor sizes than FSP and NFP animals. Conclusions: The results suggested that the ingestion of FSP was most efficient in tumor containment, possibly due to a positive modulation of the immune system by when Enterococcus faecium and Lactobacillus helveticus are added to the soy product.
Fil: Lopes Kinouchi, Fernanda. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Cardoso Geraldo Maia, Danielle. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: de Abreu Ribeiro, Lívia Carolina. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Campos Polesi Placeres, Marisa. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Rossi, Elizeu Antonio. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Zeppone Carlos, Iracilda. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Materia
Cancer
Cytokine
Immune System
Isoflavones
Soy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/78275
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/78275
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinomaLopes Kinouchi, FernandaCardoso Geraldo Maia, Daniellede Abreu Ribeiro, Lívia CarolinaCampos Polesi Placeres, MarisaFont, Graciela MariaColombo, Lucas LuisRossi, Elizeu AntonioZeppone Carlos, IracildaCancerCytokineImmune SystemIsoflavonesSoyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Purpose: Soy and its fermented products are considered functional foods. The study objective was to assess three functional food - a non-fermented soy product (NFP), fermented soy product (FSP), fermented soy product enriched with isoflavones (FI) - in terms of their ability to reduce the development of adenocarcinoma in mice, as well their ability on modulating immune system. Methods: It was observed tumor volume and to verify correlations with the immune system it was measured levels of the cytokines IL-1β and TNF-α produced by macrophages as well as IFN-γ produced by lymphocytes using ELISA test, and nitric oxide production by macrophages using Griess reagent. Results: All products showed immunological activity, but FSP showed the most effective tumor containment, resulting in smallest tumor volumes. FI animals expressed larger amounts of nitric oxide and IL-1β and exhibited larger tumor sizes than FSP and NFP animals. Conclusions: The results suggested that the ingestion of FSP was most efficient in tumor containment, possibly due to a positive modulation of the immune system by when Enterococcus faecium and Lactobacillus helveticus are added to the soy product.Fil: Lopes Kinouchi, Fernanda. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Cardoso Geraldo Maia, Danielle. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: de Abreu Ribeiro, Lívia Carolina. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Campos Polesi Placeres, Marisa. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Rossi, Elizeu Antonio. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Zeppone Carlos, Iracilda. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilPergamon-Elsevier Science Ltd2012-11-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78275Lopes Kinouchi, Fernanda; Cardoso Geraldo Maia, Danielle; de Abreu Ribeiro, Lívia Carolina; Campos Polesi Placeres, Marisa; Font, Graciela Maria; et al.; A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 50; 11; 25-11-2012; 4144-41480278-69151873-6351CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.fct.2012.08.038info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0278691512006187info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:00Zoai:ri.conicet.gov.ar:11336/78275instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:00.906CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma
title A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma
spellingShingle A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma
Lopes Kinouchi, Fernanda
Cancer
Cytokine
Immune System
Isoflavones
Soy
title_short A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma
title_full A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma
title_fullStr A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma
title_full_unstemmed A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma
title_sort A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma
dc.creator.none.fl_str_mv Lopes Kinouchi, Fernanda
Cardoso Geraldo Maia, Danielle
de Abreu Ribeiro, Lívia Carolina
Campos Polesi Placeres, Marisa
Font, Graciela Maria
Colombo, Lucas Luis
Rossi, Elizeu Antonio
Zeppone Carlos, Iracilda
author Lopes Kinouchi, Fernanda
author_facet Lopes Kinouchi, Fernanda
Cardoso Geraldo Maia, Danielle
de Abreu Ribeiro, Lívia Carolina
Campos Polesi Placeres, Marisa
Font, Graciela Maria
Colombo, Lucas Luis
Rossi, Elizeu Antonio
Zeppone Carlos, Iracilda
author_role author
author2 Cardoso Geraldo Maia, Danielle
de Abreu Ribeiro, Lívia Carolina
Campos Polesi Placeres, Marisa
Font, Graciela Maria
Colombo, Lucas Luis
Rossi, Elizeu Antonio
Zeppone Carlos, Iracilda
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cancer
Cytokine
Immune System
Isoflavones
Soy
topic Cancer
Cytokine
Immune System
Isoflavones
Soy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: Soy and its fermented products are considered functional foods. The study objective was to assess three functional food - a non-fermented soy product (NFP), fermented soy product (FSP), fermented soy product enriched with isoflavones (FI) - in terms of their ability to reduce the development of adenocarcinoma in mice, as well their ability on modulating immune system. Methods: It was observed tumor volume and to verify correlations with the immune system it was measured levels of the cytokines IL-1β and TNF-α produced by macrophages as well as IFN-γ produced by lymphocytes using ELISA test, and nitric oxide production by macrophages using Griess reagent. Results: All products showed immunological activity, but FSP showed the most effective tumor containment, resulting in smallest tumor volumes. FI animals expressed larger amounts of nitric oxide and IL-1β and exhibited larger tumor sizes than FSP and NFP animals. Conclusions: The results suggested that the ingestion of FSP was most efficient in tumor containment, possibly due to a positive modulation of the immune system by when Enterococcus faecium and Lactobacillus helveticus are added to the soy product.
Fil: Lopes Kinouchi, Fernanda. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Cardoso Geraldo Maia, Danielle. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: de Abreu Ribeiro, Lívia Carolina. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Campos Polesi Placeres, Marisa. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Rossi, Elizeu Antonio. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Zeppone Carlos, Iracilda. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
description Purpose: Soy and its fermented products are considered functional foods. The study objective was to assess three functional food - a non-fermented soy product (NFP), fermented soy product (FSP), fermented soy product enriched with isoflavones (FI) - in terms of their ability to reduce the development of adenocarcinoma in mice, as well their ability on modulating immune system. Methods: It was observed tumor volume and to verify correlations with the immune system it was measured levels of the cytokines IL-1β and TNF-α produced by macrophages as well as IFN-γ produced by lymphocytes using ELISA test, and nitric oxide production by macrophages using Griess reagent. Results: All products showed immunological activity, but FSP showed the most effective tumor containment, resulting in smallest tumor volumes. FI animals expressed larger amounts of nitric oxide and IL-1β and exhibited larger tumor sizes than FSP and NFP animals. Conclusions: The results suggested that the ingestion of FSP was most efficient in tumor containment, possibly due to a positive modulation of the immune system by when Enterococcus faecium and Lactobacillus helveticus are added to the soy product.
publishDate 2012
dc.date.none.fl_str_mv 2012-11-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/78275
Lopes Kinouchi, Fernanda; Cardoso Geraldo Maia, Danielle; de Abreu Ribeiro, Lívia Carolina; Campos Polesi Placeres, Marisa; Font, Graciela Maria; et al.; A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 50; 11; 25-11-2012; 4144-4148
0278-6915
1873-6351
CONICET Digital
CONICET
url http://hdl.handle.net/11336/78275
identifier_str_mv Lopes Kinouchi, Fernanda; Cardoso Geraldo Maia, Danielle; de Abreu Ribeiro, Lívia Carolina; Campos Polesi Placeres, Marisa; Font, Graciela Maria; et al.; A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 50; 11; 25-11-2012; 4144-4148
0278-6915
1873-6351
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fct.2012.08.038
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0278691512006187
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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