Falls in ambulatory non-demented patients with Parkinson's disease

• Autores: Rascol, Olivier; Pérez Lloret, Santiago; Damier, Philippe; Delval, Arnaud; Derkinderen, Pascal; Destée, Alain; Meissner, Wassilios G.; Tison, Francois; Negre Pages, Laurence
• Año de publicación: 2015
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Enfermedad de Parkinson; Caidas; Calidad de Vida
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

This study aimed at determining the prevalence of falling in PD patients, to assess generic and disease-specific clinical and pharmacological factors, relationship with health-related quality of life (HR-QoL) and changes in falls from OFF to ON in patients with motor fluctuations. Six-hundred and eighty-three PD patients of the COPARK survey were evaluated (11 had missing data and were excluded from the analysis). Patients with falls were identified as those with a UPDRS Item 13 ¡Ý 1 in the ON condition. All patients were assessed in a standardized manner [demographics, treatments, Unified PD Rating Scale (UPDRS), Hospital Anxiety and Depression Scale, Pittsburg questionnaire and HR-QoL scales (SF36, PDQ39)]. Falling was reported by 108/672 (16 %) PD patients during the ON state and prevalence increased according to PD severity, from 5 % in Hoehn and Yahr stage 1-60 % in stage 4. Falling was significantly related to lower HR-QoL. Falling correlated with (1) generic factors such as female gender, age at the end of academic studies and diuretics consumption, (2) motor PD-specific factors including disease severity, frozen gait, difficulties when arising from a chair, dyskinesia and higher levodopa daily equivalent dose and (3) non-motor PD-specific factors such as orthostatic hypotension and hallucinations. Falling was more frequent in OFF than in ON in 48/74 (64 %) patients with motor fluctuations and remained unchanged in 27 patients (36 %). In summary, falling affected a significant proportion of PD patients, especially in advanced stages. It was associated with a variety of generic and PD-specific factors and was related to reduced HR-QoL.
Fil: Rascol, Olivier. NS-Park Network; Francia. Université Paul Sabatier; Francia. Inserm; Francia
Fil: Pérez Lloret, Santiago. Université Paul Sabatier; Francia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Damier, Philippe. Hôpital Laënnec; Francia. NS-Park Network; Francia. Inserm; Francia
Fil: Delval, Arnaud. Seul Centre Hospitalier Universitaire; Francia
Fil: Derkinderen, Pascal. Hôpital Laënnec; Francia
Fil: Destée, Alain. NS-Park Network; Francia. Inserm; Francia. Seul Centre Hospitalier Universitaire; Francia
Fil: Meissner, Wassilios G.. Universite de Bordeaux; Francia. Institut des Maladies Neurodégénératives; Francia. Centre Hospitalier Universitaire de Bordeaux; Francia
Fil: Tison, Francois. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; Francia. Institut des Maladies Neurodégénératives; Francia. NS-Park Network; Francia
Fil: Negre Pages, Laurence. Inserm; Francia. NS-Park Network; Francia