Excessive buccal saliva in patients with Parkinson’s Disease of the French COPARK cohort

• Autores: Rascol, Olivier; Negre-Pages, Laurence; Damier, Philippe; Delval, Arnaud; Derkinderen, Pascal; Destée, Alain; Fabbri, Margherita; Meissner, Wassilios G.; Rachdi, Amine; Tison, François; Pérez Lloret, Santiago
• Año de publicación: 2020
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Postprint del articulo publicado en Journal of Neural Transmission, 2020
• Materia: ENFERMEDAD DE PARKINSON; GLANDULAS SALIVALES; SISTEMA NERVIOSO AUTONOMO; CALIDAD DE VIDA; TRATAMIENTO MEDICO; ENFERMEDADES NEUROGENERATIVAS
• Institución: Pontificia Universidad Católica Argentina

Fil: Rascol, Olivier. Université de Toulouse. NeuroToul COEN Center. Services de Pharmacologie Clinique et Neurosciences. Centre d’Investigation Clinique; Francia
Fil: Negre-Pages, Laurence. LN Pharma; Francia
Fil: Negre-Pages, Laurence. Hôpital la Colombière. Département d’Information Médicale. Unité de Recherche Clinique et Epidémiologie; Francia
Fil: Damier, Philippe. Université de Nantes. Department of Neurology; Francia
Fil: Delval, Arnaud. Université de Lille. Department of Neurology; Francia
Fil: Derkinderen, Pascal. Université de Lille. Department of Neurology; Francia
Fil: Destée, Alain. Université de Lille. Department of Neurology; Francia
Fil: Fabbri, Margherita.University of Turin. Department of Neuroscience; Italia
Fil: Meissner, Wassilios G. NS-Park/FCRIN Network. Service de Neurologie; Francia
Fil: Meissner, Wassilios G. Université de Bordeaux. Institut des Maladies Neurodégénératives; Francia
Fil: Meissner, Wassilios G. University of Otag. Departament Medicine. New Zealand Brain Research Institute; Nueva Zelanda
Fil: Rachdi, Amine. Université de Toulouse. NeuroToul COEN Center. Services de Pharmacologie Clinique et Neurosciences. Centre d’Investigation Clinique; Francia
Fil: Tison, François. University of Otag. Departament Medicine. New Zealand Brain Research Institute; Nueva Zelanda
Fil: Tison, François. Université de Toulouse. NeuroToul COEN Center. Services de Pharmacologie Clinique et Neurosciences. Centre d’Investigation Clinique; Francia
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez Lloret, Santiago. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Abstract: Introduction: We describe excessive buccal saliva (EBS) prevalence in patients with Parkinson’s Disease (PD) and controls of the COPARK study, its changes between “ON” and OFF” conditions and over time, its impact on Health-related Quality of life (HRQoL), and factors associated with this condition. Methods: We studied 671 ambulatory PD patients and 177 age/sex-matched controls. We defined “sialorrhea” as UPDRS item #6 (salivation)=1 or 2; and “drooling” as item #6=3 or 4. SCOPA-Aut drooling score (item #2) was also available in a subset (45%) of the cohort. HRQoL was assessed by the PDQ-39 and SF-36 scales. Twenty-four months follow-up data was available in 401/671 patients. Results: EBS as assessed by UPDRS was present in 38% of PD patients in the “ON” condition (“Sialorrhea”: 35%; “drooling”: 3%). There were also more PD patients reporting “drooling” than controls according to the SCOPA-Aut (49% vs 19%, p<0.01). UPDRS salivation score was worse in the “OFF” vs “ON” condition in PD patients with motor fluctuations (0.90±0.94 vs 0.54±0.79, p<0.01). UPDRS salivation score worsened after 24 months of follow up (0.47±0.70 vs 0.64±0.81, p<0.01). Worse PDQ-39 scores were observed in PD patients with EBS in bivariate but not in multivariate analyses. EBS was directly related to PD duration and severity, male gender, dysphagia, hypomimia, and autonomic dysfunction (logistic regression). Conclusions: EBS was more frequent in PD patients than controls, worsened in the “OFF” condition and after 24 months of follow-up, moderately affected HRQoL and was correlated with indices of bradykinesia, dysphagia, and autonomic dysfunction.