Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration

Autores
Alberti, Sebastián; Schmidt, Sonja; Hageneder, Simone; Angelome, Paula Cecilia; Soler Illia, Galo Juan de Avila Arturo; Vana, Philipp; Dostalek, Jakub; Azzaroni, Omar; Knoll, Wolfgang
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nanopores have been applied in the development of artificial biocatalytic systems, controlled drug delivery, and solid-state sensing devices. The interaction of biomacromolecules with surfaces show a dependence on the nanopore diameter, crucial in their ability to infiltrate porous materials. In this context, ordered mesoporous materials obtained by evaporation-induced self-assembly are model materials to test pore-biomolecule interactions. Nevertheless, these materials are generally restricted to pore diameters within the 2-10 nm range, therefore, new polymers as templating agents hold potential to provide an easy reproducible route for the synthesis of mesoporous silica thin films (MTF) with pore diameters above 10 nm without the use of swelling or additional structuring agents. Here, we present a novel and simple approach towards large pore MTF through the combination of supramolecular templating and phase separation with tailor-made block co-polymers. Accurate tuning of the oxide pore size distribution (with small mesopores between 13-18 nm diameter) is achieved by controlling the length and the nature of the hydrophilic polymer block used as a template through a simple reversible addition-fragmentation chain transfer (RAFT) polymerization approach. The importance of these features is highlighted by showing the capability that these new materials offer for biomolecule infiltration benchmarked against the widespread MTF prepared using pluronic F127 as a template. Effect of protein to pore diameter ratio, protein location and effect of pH and ionic strength is briefly tested and discussed.
Fil: Alberti, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Schmidt, Sonja. Universität Göttingen; Alemania
Fil: Hageneder, Simone. Austrian Institute Of Technology; Austria
Fil: Angelome, Paula Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Constituyentes | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Constituyentes; Argentina
Fil: Soler Illia, Galo Juan de Avila Arturo. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vana, Philipp. Universität Göttingen; Alemania
Fil: Dostalek, Jakub. Austrian Institute Of Technology; Austria
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Knoll, Wolfgang. Austrian Institute Of Technology; Austria
Materia
RAFT POLYMERIZATION
POROUS MATERIALS
THIN FILMS
PROTEIN INFILTRATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/228546

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network_name_str CONICET Digital (CONICET)
spelling Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltrationAlberti, SebastiánSchmidt, SonjaHageneder, SimoneAngelome, Paula CeciliaSoler Illia, Galo Juan de Avila ArturoVana, PhilippDostalek, JakubAzzaroni, OmarKnoll, WolfgangRAFT POLYMERIZATIONPOROUS MATERIALSTHIN FILMSPROTEIN INFILTRATIONhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Nanopores have been applied in the development of artificial biocatalytic systems, controlled drug delivery, and solid-state sensing devices. The interaction of biomacromolecules with surfaces show a dependence on the nanopore diameter, crucial in their ability to infiltrate porous materials. In this context, ordered mesoporous materials obtained by evaporation-induced self-assembly are model materials to test pore-biomolecule interactions. Nevertheless, these materials are generally restricted to pore diameters within the 2-10 nm range, therefore, new polymers as templating agents hold potential to provide an easy reproducible route for the synthesis of mesoporous silica thin films (MTF) with pore diameters above 10 nm without the use of swelling or additional structuring agents. Here, we present a novel and simple approach towards large pore MTF through the combination of supramolecular templating and phase separation with tailor-made block co-polymers. Accurate tuning of the oxide pore size distribution (with small mesopores between 13-18 nm diameter) is achieved by controlling the length and the nature of the hydrophilic polymer block used as a template through a simple reversible addition-fragmentation chain transfer (RAFT) polymerization approach. The importance of these features is highlighted by showing the capability that these new materials offer for biomolecule infiltration benchmarked against the widespread MTF prepared using pluronic F127 as a template. Effect of protein to pore diameter ratio, protein location and effect of pH and ionic strength is briefly tested and discussed.Fil: Alberti, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Schmidt, Sonja. Universität Göttingen; AlemaniaFil: Hageneder, Simone. Austrian Institute Of Technology; AustriaFil: Angelome, Paula Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Constituyentes | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Constituyentes; ArgentinaFil: Soler Illia, Galo Juan de Avila Arturo. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vana, Philipp. Universität Göttingen; AlemaniaFil: Dostalek, Jakub. Austrian Institute Of Technology; AustriaFil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Knoll, Wolfgang. Austrian Institute Of Technology; AustriaRoyal Society of Chemistry2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/228546Alberti, Sebastián; Schmidt, Sonja; Hageneder, Simone; Angelome, Paula Cecilia; Soler Illia, Galo Juan de Avila Arturo; et al.; Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration; Royal Society of Chemistry; Materials Chemistry Frontiers; 7; 18; 7-2023; 4142-41512052-1537CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2023/QM/D3QM00378Ginfo:eu-repo/semantics/altIdentifier/doi/10.1039/D3QM00378Ginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:57:53Zoai:ri.conicet.gov.ar:11336/228546instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:57:53.592CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration
title Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration
spellingShingle Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration
Alberti, Sebastián
RAFT POLYMERIZATION
POROUS MATERIALS
THIN FILMS
PROTEIN INFILTRATION
title_short Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration
title_full Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration
title_fullStr Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration
title_full_unstemmed Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration
title_sort Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration
dc.creator.none.fl_str_mv Alberti, Sebastián
Schmidt, Sonja
Hageneder, Simone
Angelome, Paula Cecilia
Soler Illia, Galo Juan de Avila Arturo
Vana, Philipp
Dostalek, Jakub
Azzaroni, Omar
Knoll, Wolfgang
author Alberti, Sebastián
author_facet Alberti, Sebastián
Schmidt, Sonja
Hageneder, Simone
Angelome, Paula Cecilia
Soler Illia, Galo Juan de Avila Arturo
Vana, Philipp
Dostalek, Jakub
Azzaroni, Omar
Knoll, Wolfgang
author_role author
author2 Schmidt, Sonja
Hageneder, Simone
Angelome, Paula Cecilia
Soler Illia, Galo Juan de Avila Arturo
Vana, Philipp
Dostalek, Jakub
Azzaroni, Omar
Knoll, Wolfgang
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv RAFT POLYMERIZATION
POROUS MATERIALS
THIN FILMS
PROTEIN INFILTRATION
topic RAFT POLYMERIZATION
POROUS MATERIALS
THIN FILMS
PROTEIN INFILTRATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Nanopores have been applied in the development of artificial biocatalytic systems, controlled drug delivery, and solid-state sensing devices. The interaction of biomacromolecules with surfaces show a dependence on the nanopore diameter, crucial in their ability to infiltrate porous materials. In this context, ordered mesoporous materials obtained by evaporation-induced self-assembly are model materials to test pore-biomolecule interactions. Nevertheless, these materials are generally restricted to pore diameters within the 2-10 nm range, therefore, new polymers as templating agents hold potential to provide an easy reproducible route for the synthesis of mesoporous silica thin films (MTF) with pore diameters above 10 nm without the use of swelling or additional structuring agents. Here, we present a novel and simple approach towards large pore MTF through the combination of supramolecular templating and phase separation with tailor-made block co-polymers. Accurate tuning of the oxide pore size distribution (with small mesopores between 13-18 nm diameter) is achieved by controlling the length and the nature of the hydrophilic polymer block used as a template through a simple reversible addition-fragmentation chain transfer (RAFT) polymerization approach. The importance of these features is highlighted by showing the capability that these new materials offer for biomolecule infiltration benchmarked against the widespread MTF prepared using pluronic F127 as a template. Effect of protein to pore diameter ratio, protein location and effect of pH and ionic strength is briefly tested and discussed.
Fil: Alberti, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Schmidt, Sonja. Universität Göttingen; Alemania
Fil: Hageneder, Simone. Austrian Institute Of Technology; Austria
Fil: Angelome, Paula Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Constituyentes | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Constituyentes; Argentina
Fil: Soler Illia, Galo Juan de Avila Arturo. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vana, Philipp. Universität Göttingen; Alemania
Fil: Dostalek, Jakub. Austrian Institute Of Technology; Austria
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Knoll, Wolfgang. Austrian Institute Of Technology; Austria
description Nanopores have been applied in the development of artificial biocatalytic systems, controlled drug delivery, and solid-state sensing devices. The interaction of biomacromolecules with surfaces show a dependence on the nanopore diameter, crucial in their ability to infiltrate porous materials. In this context, ordered mesoporous materials obtained by evaporation-induced self-assembly are model materials to test pore-biomolecule interactions. Nevertheless, these materials are generally restricted to pore diameters within the 2-10 nm range, therefore, new polymers as templating agents hold potential to provide an easy reproducible route for the synthesis of mesoporous silica thin films (MTF) with pore diameters above 10 nm without the use of swelling or additional structuring agents. Here, we present a novel and simple approach towards large pore MTF through the combination of supramolecular templating and phase separation with tailor-made block co-polymers. Accurate tuning of the oxide pore size distribution (with small mesopores between 13-18 nm diameter) is achieved by controlling the length and the nature of the hydrophilic polymer block used as a template through a simple reversible addition-fragmentation chain transfer (RAFT) polymerization approach. The importance of these features is highlighted by showing the capability that these new materials offer for biomolecule infiltration benchmarked against the widespread MTF prepared using pluronic F127 as a template. Effect of protein to pore diameter ratio, protein location and effect of pH and ionic strength is briefly tested and discussed.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/228546
Alberti, Sebastián; Schmidt, Sonja; Hageneder, Simone; Angelome, Paula Cecilia; Soler Illia, Galo Juan de Avila Arturo; et al.; Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration; Royal Society of Chemistry; Materials Chemistry Frontiers; 7; 18; 7-2023; 4142-4151
2052-1537
CONICET Digital
CONICET
url http://hdl.handle.net/11336/228546
identifier_str_mv Alberti, Sebastián; Schmidt, Sonja; Hageneder, Simone; Angelome, Paula Cecilia; Soler Illia, Galo Juan de Avila Arturo; et al.; Large-pore mesoporous silica: template design, thin film preparation and biomolecules infiltration; Royal Society of Chemistry; Materials Chemistry Frontiers; 7; 18; 7-2023; 4142-4151
2052-1537
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2023/QM/D3QM00378G
info:eu-repo/semantics/altIdentifier/doi/10.1039/D3QM00378G
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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