Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia

Autores
Meroño, Tomás; Sorroche, Patricia; Rosso, Leonardo A. Gómez; Casañas, Liliana; Boero, Laura Estela; Arbelbide, Jorge A.; Brites, Fernando Daniel
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To characterize the lipid-related atherogenic risk factors in iron deficiency anaemia (IDA) patients. Design and methods: Twenty IDA women were compared to healthy age-matched controls. Lipoprotein profile, cholesteryl ester transfer protein (CETP), paraoxonase (PON) 1 and lipoprotein-associated phospholipase A2 (LpPLA2) activities and plasma levels of oxidized-LDL were evaluated. Results: Triglycerides were higher (median [range]) (1.0 [0.5-1.9] vs. 0.7 [0.5-1.5] mmol/L, p < 0.05) and HDL-C lower (mean ± SD) (1.3 ± 0.3 vs. 1.6 ± 0.4 mmol/L, p < 0.01) in the patients group. CETP (197 ± 29% vs. 151 ± 29% mL- 1 h- 1, p < 0.001), PON 1 (122 ± 17 vs. 140 ± 33 μmol mL- 1 min- 1, p < 0.05) and LpPLA2 (9.6 ± 2.0 vs. 8.1 ± 1.7 μmol mL- 1 h- 1, p < 0.05) activities were different in IDA women. No difference was observed in oxidized-LDL. Haemoglobin correlated negatively with triglycerides (r = - 0.35, p < 0.05), CETP (r = - 0.62, p < 0.001) and LpPLA2 (r = - 0.34, p < 0.05), while ferritin was positively associated with HDL-C (r = 0.39, p < 0.05) and inversely with CETP (r = - 0.49, p < 0.005). Conclusion: The alterations in lipoprotein profile, CETP, PON 1 and LpPLA2 activities described in the present study indicate that non-treated IDA might represent a proatherogenic state.
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sorroche, Patricia. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Rosso, Leonardo A. Gómez. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Casañas, Liliana. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Arbelbide, Jorge A.. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
ATHEROSCLEROSIS
CHOLESTERYL ESTER TRANSFER PROTEIN
IRON
IRON DEFICIENCY ANAEMIA
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
OXIDIZED LDL
PARAOXONASE 1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/112840
Acceder
id CONICETDig_662c4594586867bbd33be6fe7c9a3678
oai_identifier_str oai:ri.conicet.gov.ar:11336/112840
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemiaMeroño, TomásSorroche, PatriciaRosso, Leonardo A. GómezCasañas, LilianaBoero, Laura EstelaArbelbide, Jorge A.Brites, Fernando DanielATHEROSCLEROSISCHOLESTERYL ESTER TRANSFER PROTEINIRONIRON DEFICIENCY ANAEMIALIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2OXIDIZED LDLPARAOXONASE 1https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: To characterize the lipid-related atherogenic risk factors in iron deficiency anaemia (IDA) patients. Design and methods: Twenty IDA women were compared to healthy age-matched controls. Lipoprotein profile, cholesteryl ester transfer protein (CETP), paraoxonase (PON) 1 and lipoprotein-associated phospholipase A2 (LpPLA2) activities and plasma levels of oxidized-LDL were evaluated. Results: Triglycerides were higher (median [range]) (1.0 [0.5-1.9] vs. 0.7 [0.5-1.5] mmol/L, p < 0.05) and HDL-C lower (mean ± SD) (1.3 ± 0.3 vs. 1.6 ± 0.4 mmol/L, p < 0.01) in the patients group. CETP (197 ± 29% vs. 151 ± 29% mL- 1 h- 1, p < 0.001), PON 1 (122 ± 17 vs. 140 ± 33 μmol mL- 1 min- 1, p < 0.05) and LpPLA2 (9.6 ± 2.0 vs. 8.1 ± 1.7 μmol mL- 1 h- 1, p < 0.05) activities were different in IDA women. No difference was observed in oxidized-LDL. Haemoglobin correlated negatively with triglycerides (r = - 0.35, p < 0.05), CETP (r = - 0.62, p < 0.001) and LpPLA2 (r = - 0.34, p < 0.05), while ferritin was positively associated with HDL-C (r = 0.39, p < 0.05) and inversely with CETP (r = - 0.49, p < 0.005). Conclusion: The alterations in lipoprotein profile, CETP, PON 1 and LpPLA2 activities described in the present study indicate that non-treated IDA might represent a proatherogenic state.Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Sorroche, Patricia. Instituto Universitario del Hospital Italiano de Buenos Aires; ArgentinaFil: Rosso, Leonardo A. Gómez. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Casañas, Liliana. Instituto Universitario del Hospital Italiano de Buenos Aires; ArgentinaFil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Arbelbide, Jorge A.. Instituto Universitario del Hospital Italiano de Buenos Aires; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaPergamon-Elsevier Science Ltd2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/112840Meroño, Tomás; Sorroche, Patricia; Rosso, Leonardo A. Gómez; Casañas, Liliana; Boero, Laura Estela; et al.; Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia; Pergamon-Elsevier Science Ltd; Clinical Biochemistry; 43; 4-5; 3-2010; 416-4230009-9120CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.clinbiochem.2009.10.003info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009912009004433info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:28Zoai:ri.conicet.gov.ar:11336/112840instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:28.345CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia
title Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia
spellingShingle Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia
Meroño, Tomás
ATHEROSCLEROSIS
CHOLESTERYL ESTER TRANSFER PROTEIN
IRON
IRON DEFICIENCY ANAEMIA
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
OXIDIZED LDL
PARAOXONASE 1
title_short Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia
title_full Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia
title_fullStr Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia
title_full_unstemmed Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia
title_sort Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia
dc.creator.none.fl_str_mv Meroño, Tomás
Sorroche, Patricia
Rosso, Leonardo A. Gómez
Casañas, Liliana
Boero, Laura Estela
Arbelbide, Jorge A.
Brites, Fernando Daniel
author Meroño, Tomás
author_facet Meroño, Tomás
Sorroche, Patricia
Rosso, Leonardo A. Gómez
Casañas, Liliana
Boero, Laura Estela
Arbelbide, Jorge A.
Brites, Fernando Daniel
author_role author
author2 Sorroche, Patricia
Rosso, Leonardo A. Gómez
Casañas, Liliana
Boero, Laura Estela
Arbelbide, Jorge A.
Brites, Fernando Daniel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ATHEROSCLEROSIS
CHOLESTERYL ESTER TRANSFER PROTEIN
IRON
IRON DEFICIENCY ANAEMIA
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
OXIDIZED LDL
PARAOXONASE 1
topic ATHEROSCLEROSIS
CHOLESTERYL ESTER TRANSFER PROTEIN
IRON
IRON DEFICIENCY ANAEMIA
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
OXIDIZED LDL
PARAOXONASE 1
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To characterize the lipid-related atherogenic risk factors in iron deficiency anaemia (IDA) patients. Design and methods: Twenty IDA women were compared to healthy age-matched controls. Lipoprotein profile, cholesteryl ester transfer protein (CETP), paraoxonase (PON) 1 and lipoprotein-associated phospholipase A2 (LpPLA2) activities and plasma levels of oxidized-LDL were evaluated. Results: Triglycerides were higher (median [range]) (1.0 [0.5-1.9] vs. 0.7 [0.5-1.5] mmol/L, p < 0.05) and HDL-C lower (mean ± SD) (1.3 ± 0.3 vs. 1.6 ± 0.4 mmol/L, p < 0.01) in the patients group. CETP (197 ± 29% vs. 151 ± 29% mL- 1 h- 1, p < 0.001), PON 1 (122 ± 17 vs. 140 ± 33 μmol mL- 1 min- 1, p < 0.05) and LpPLA2 (9.6 ± 2.0 vs. 8.1 ± 1.7 μmol mL- 1 h- 1, p < 0.05) activities were different in IDA women. No difference was observed in oxidized-LDL. Haemoglobin correlated negatively with triglycerides (r = - 0.35, p < 0.05), CETP (r = - 0.62, p < 0.001) and LpPLA2 (r = - 0.34, p < 0.05), while ferritin was positively associated with HDL-C (r = 0.39, p < 0.05) and inversely with CETP (r = - 0.49, p < 0.005). Conclusion: The alterations in lipoprotein profile, CETP, PON 1 and LpPLA2 activities described in the present study indicate that non-treated IDA might represent a proatherogenic state.
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Sorroche, Patricia. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Rosso, Leonardo A. Gómez. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Casañas, Liliana. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Arbelbide, Jorge A.. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Objective: To characterize the lipid-related atherogenic risk factors in iron deficiency anaemia (IDA) patients. Design and methods: Twenty IDA women were compared to healthy age-matched controls. Lipoprotein profile, cholesteryl ester transfer protein (CETP), paraoxonase (PON) 1 and lipoprotein-associated phospholipase A2 (LpPLA2) activities and plasma levels of oxidized-LDL were evaluated. Results: Triglycerides were higher (median [range]) (1.0 [0.5-1.9] vs. 0.7 [0.5-1.5] mmol/L, p < 0.05) and HDL-C lower (mean ± SD) (1.3 ± 0.3 vs. 1.6 ± 0.4 mmol/L, p < 0.01) in the patients group. CETP (197 ± 29% vs. 151 ± 29% mL- 1 h- 1, p < 0.001), PON 1 (122 ± 17 vs. 140 ± 33 μmol mL- 1 min- 1, p < 0.05) and LpPLA2 (9.6 ± 2.0 vs. 8.1 ± 1.7 μmol mL- 1 h- 1, p < 0.05) activities were different in IDA women. No difference was observed in oxidized-LDL. Haemoglobin correlated negatively with triglycerides (r = - 0.35, p < 0.05), CETP (r = - 0.62, p < 0.001) and LpPLA2 (r = - 0.34, p < 0.05), while ferritin was positively associated with HDL-C (r = 0.39, p < 0.05) and inversely with CETP (r = - 0.49, p < 0.005). Conclusion: The alterations in lipoprotein profile, CETP, PON 1 and LpPLA2 activities described in the present study indicate that non-treated IDA might represent a proatherogenic state.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/112840
Meroño, Tomás; Sorroche, Patricia; Rosso, Leonardo A. Gómez; Casañas, Liliana; Boero, Laura Estela; et al.; Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia; Pergamon-Elsevier Science Ltd; Clinical Biochemistry; 43; 4-5; 3-2010; 416-423
0009-9120
CONICET Digital
CONICET
url http://hdl.handle.net/11336/112840
identifier_str_mv Meroño, Tomás; Sorroche, Patricia; Rosso, Leonardo A. Gómez; Casañas, Liliana; Boero, Laura Estela; et al.; Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia; Pergamon-Elsevier Science Ltd; Clinical Biochemistry; 43; 4-5; 3-2010; 416-423
0009-9120
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clinbiochem.2009.10.003
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009912009004433
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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