Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia

Autores
Meroño, Tomás; Dauteuille, Carolane; Tetzlaff, Walter Francisco; Martín, Maximiliano; Botta, Eliana Elizabeth; Lhomme, Marie; Saez, María Soledad; Sorroche, Patricia Beatriz; Boero, Laura Estela; Arbelbide, Jorge; Chapman, M. John; Kontush, Anatol; Brites, Fernando Daniel
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background and aimsIron deficiency anemia (IDA) affects around 20?30% of adults worldwide. An association between IDA and cardiovascular disease (CVD) has been reported. Oxidative stress, inflammation and low concentration of high-density lipoproteins (HDL) were implicated on endothelial dysfunction and CVD in IDA. We studied the effects of iron deficiency and of an intravenous iron administration on oxidative stress and HDL characteristics in IDA women.MethodsTwo studies in IDA women are presented: a case-control study, including 18 patients and 18 age-matched healthy women, and a follow-up study 72hr after the administration of intravenous iron (n = 16). Lipids, malondialdehyde, cholesteryl ester transfer protein (CETP), paraoxonase-1 (PON-1) and HDL chemical composition and functionality (cholesterol efflux and antioxidative activity) were measured. Cell cholesterol efflux from iron-deficient macrophages to a reference HDL was also evaluated.ResultsIDA patients showed higher triglycerides and CETP activity and lower HDL-C than controls (all p < 0.001). HDL particles from IDA patients showed higher triglyceride content (+30%,p < 0.05) and lower antioxidative capacity (−23%,p < 0.05). Although HDL-mediated cholesterol efflux was similar between the patients and controls, iron deficiency provoked a significant reduction in macrophage cholesterol efflux (−25%,p < 0.05). Arylesterase activity of PON-1 was significantly lower in IDA patients than controls (−16%,p < 0.05). The intravenous administration of iron was associated with a decrease in malondialdehyde levels and an increase in arylesterase activity of PON-1 (−22% and +18%, respectively, p < 0.05).ConclusionIDA is associated with oxidative stress and functionally deficient HDL particles. It remains to be determined if such alterations suffice to impair endothelial function in IDA.
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Dauteuille, Carolane. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Tetzlaff, Walter Francisco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Martín, Maximiliano. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Botta, Eliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Lhomme, Marie. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Saez, María Soledad. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Sorroche, Patricia Beatriz. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Arbelbide, Jorge. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Chapman, M. John. Inserm; Francia
Fil: Kontush, Anatol. Inserm; Francia
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
IRON DEFICIENCY ANEMIA
HDL
OXIDATIVE STRESS
IRON
LIPOPROTEIS
PARAXONASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/114064
Acceder
id CONICETDig_b3a6f120422a451205b014746ef67879
oai_identifier_str oai:ri.conicet.gov.ar:11336/114064
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemiaMeroño, TomásDauteuille, CarolaneTetzlaff, Walter FranciscoMartín, MaximilianoBotta, Eliana ElizabethLhomme, MarieSaez, María SoledadSorroche, Patricia BeatrizBoero, Laura EstelaArbelbide, JorgeChapman, M. JohnKontush, AnatolBrites, Fernando DanielIRON DEFICIENCY ANEMIAHDLOXIDATIVE STRESSIRONLIPOPROTEISPARAXONASEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background and aimsIron deficiency anemia (IDA) affects around 20?30% of adults worldwide. An association between IDA and cardiovascular disease (CVD) has been reported. Oxidative stress, inflammation and low concentration of high-density lipoproteins (HDL) were implicated on endothelial dysfunction and CVD in IDA. We studied the effects of iron deficiency and of an intravenous iron administration on oxidative stress and HDL characteristics in IDA women.MethodsTwo studies in IDA women are presented: a case-control study, including 18 patients and 18 age-matched healthy women, and a follow-up study 72hr after the administration of intravenous iron (n = 16). Lipids, malondialdehyde, cholesteryl ester transfer protein (CETP), paraoxonase-1 (PON-1) and HDL chemical composition and functionality (cholesterol efflux and antioxidative activity) were measured. Cell cholesterol efflux from iron-deficient macrophages to a reference HDL was also evaluated.ResultsIDA patients showed higher triglycerides and CETP activity and lower HDL-C than controls (all p < 0.001). HDL particles from IDA patients showed higher triglyceride content (+30%,p < 0.05) and lower antioxidative capacity (−23%,p < 0.05). Although HDL-mediated cholesterol efflux was similar between the patients and controls, iron deficiency provoked a significant reduction in macrophage cholesterol efflux (−25%,p < 0.05). Arylesterase activity of PON-1 was significantly lower in IDA patients than controls (−16%,p < 0.05). The intravenous administration of iron was associated with a decrease in malondialdehyde levels and an increase in arylesterase activity of PON-1 (−22% and +18%, respectively, p < 0.05).ConclusionIDA is associated with oxidative stress and functionally deficient HDL particles. It remains to be determined if such alterations suffice to impair endothelial function in IDA.Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Dauteuille, Carolane. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Tetzlaff, Walter Francisco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Martín, Maximiliano. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Botta, Eliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Lhomme, Marie. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Saez, María Soledad. Instituto Universitario del Hospital Italiano de Buenos Aires; ArgentinaFil: Sorroche, Patricia Beatriz. Instituto Universitario del Hospital Italiano de Buenos Aires; ArgentinaFil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Arbelbide, Jorge. Instituto Universitario del Hospital Italiano de Buenos Aires; ArgentinaFil: Chapman, M. John. Inserm; FranciaFil: Kontush, Anatol. Inserm; FranciaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaElsevier2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114064Meroño, Tomás; Dauteuille, Carolane; Tetzlaff, Walter Francisco; Martín, Maximiliano; Botta, Eliana Elizabeth; et al.; Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia; Elsevier; Clinical Nutrition (edinburgh, Lothian); 36; 2; 2-2016; 552-5580261-5614CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0261561416000595info:eu-repo/semantics/altIdentifier/doi/ 10.1016/j.clnu.2016.02.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:14Zoai:ri.conicet.gov.ar:11336/114064instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:15.182CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
title Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
spellingShingle Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
Meroño, Tomás
IRON DEFICIENCY ANEMIA
HDL
OXIDATIVE STRESS
IRON
LIPOPROTEIS
PARAXONASE
title_short Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
title_full Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
title_fullStr Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
title_full_unstemmed Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
title_sort Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
dc.creator.none.fl_str_mv Meroño, Tomás
Dauteuille, Carolane
Tetzlaff, Walter Francisco
Martín, Maximiliano
Botta, Eliana Elizabeth
Lhomme, Marie
Saez, María Soledad
Sorroche, Patricia Beatriz
Boero, Laura Estela
Arbelbide, Jorge
Chapman, M. John
Kontush, Anatol
Brites, Fernando Daniel
author Meroño, Tomás
author_facet Meroño, Tomás
Dauteuille, Carolane
Tetzlaff, Walter Francisco
Martín, Maximiliano
Botta, Eliana Elizabeth
Lhomme, Marie
Saez, María Soledad
Sorroche, Patricia Beatriz
Boero, Laura Estela
Arbelbide, Jorge
Chapman, M. John
Kontush, Anatol
Brites, Fernando Daniel
author_role author
author2 Dauteuille, Carolane
Tetzlaff, Walter Francisco
Martín, Maximiliano
Botta, Eliana Elizabeth
Lhomme, Marie
Saez, María Soledad
Sorroche, Patricia Beatriz
Boero, Laura Estela
Arbelbide, Jorge
Chapman, M. John
Kontush, Anatol
Brites, Fernando Daniel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv IRON DEFICIENCY ANEMIA
HDL
OXIDATIVE STRESS
IRON
LIPOPROTEIS
PARAXONASE
topic IRON DEFICIENCY ANEMIA
HDL
OXIDATIVE STRESS
IRON
LIPOPROTEIS
PARAXONASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background and aimsIron deficiency anemia (IDA) affects around 20?30% of adults worldwide. An association between IDA and cardiovascular disease (CVD) has been reported. Oxidative stress, inflammation and low concentration of high-density lipoproteins (HDL) were implicated on endothelial dysfunction and CVD in IDA. We studied the effects of iron deficiency and of an intravenous iron administration on oxidative stress and HDL characteristics in IDA women.MethodsTwo studies in IDA women are presented: a case-control study, including 18 patients and 18 age-matched healthy women, and a follow-up study 72hr after the administration of intravenous iron (n = 16). Lipids, malondialdehyde, cholesteryl ester transfer protein (CETP), paraoxonase-1 (PON-1) and HDL chemical composition and functionality (cholesterol efflux and antioxidative activity) were measured. Cell cholesterol efflux from iron-deficient macrophages to a reference HDL was also evaluated.ResultsIDA patients showed higher triglycerides and CETP activity and lower HDL-C than controls (all p < 0.001). HDL particles from IDA patients showed higher triglyceride content (+30%,p < 0.05) and lower antioxidative capacity (−23%,p < 0.05). Although HDL-mediated cholesterol efflux was similar between the patients and controls, iron deficiency provoked a significant reduction in macrophage cholesterol efflux (−25%,p < 0.05). Arylesterase activity of PON-1 was significantly lower in IDA patients than controls (−16%,p < 0.05). The intravenous administration of iron was associated with a decrease in malondialdehyde levels and an increase in arylesterase activity of PON-1 (−22% and +18%, respectively, p < 0.05).ConclusionIDA is associated with oxidative stress and functionally deficient HDL particles. It remains to be determined if such alterations suffice to impair endothelial function in IDA.
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Dauteuille, Carolane. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Tetzlaff, Walter Francisco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Martín, Maximiliano. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Botta, Eliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Lhomme, Marie. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Saez, María Soledad. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Sorroche, Patricia Beatriz. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Arbelbide, Jorge. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Chapman, M. John. Inserm; Francia
Fil: Kontush, Anatol. Inserm; Francia
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Background and aimsIron deficiency anemia (IDA) affects around 20?30% of adults worldwide. An association between IDA and cardiovascular disease (CVD) has been reported. Oxidative stress, inflammation and low concentration of high-density lipoproteins (HDL) were implicated on endothelial dysfunction and CVD in IDA. We studied the effects of iron deficiency and of an intravenous iron administration on oxidative stress and HDL characteristics in IDA women.MethodsTwo studies in IDA women are presented: a case-control study, including 18 patients and 18 age-matched healthy women, and a follow-up study 72hr after the administration of intravenous iron (n = 16). Lipids, malondialdehyde, cholesteryl ester transfer protein (CETP), paraoxonase-1 (PON-1) and HDL chemical composition and functionality (cholesterol efflux and antioxidative activity) were measured. Cell cholesterol efflux from iron-deficient macrophages to a reference HDL was also evaluated.ResultsIDA patients showed higher triglycerides and CETP activity and lower HDL-C than controls (all p < 0.001). HDL particles from IDA patients showed higher triglyceride content (+30%,p < 0.05) and lower antioxidative capacity (−23%,p < 0.05). Although HDL-mediated cholesterol efflux was similar between the patients and controls, iron deficiency provoked a significant reduction in macrophage cholesterol efflux (−25%,p < 0.05). Arylesterase activity of PON-1 was significantly lower in IDA patients than controls (−16%,p < 0.05). The intravenous administration of iron was associated with a decrease in malondialdehyde levels and an increase in arylesterase activity of PON-1 (−22% and +18%, respectively, p < 0.05).ConclusionIDA is associated with oxidative stress and functionally deficient HDL particles. It remains to be determined if such alterations suffice to impair endothelial function in IDA.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/114064
Meroño, Tomás; Dauteuille, Carolane; Tetzlaff, Walter Francisco; Martín, Maximiliano; Botta, Eliana Elizabeth; et al.; Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia; Elsevier; Clinical Nutrition (edinburgh, Lothian); 36; 2; 2-2016; 552-558
0261-5614
CONICET Digital
CONICET
url http://hdl.handle.net/11336/114064
identifier_str_mv Meroño, Tomás; Dauteuille, Carolane; Tetzlaff, Walter Francisco; Martín, Maximiliano; Botta, Eliana Elizabeth; et al.; Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia; Elsevier; Clinical Nutrition (edinburgh, Lothian); 36; 2; 2-2016; 552-558
0261-5614
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0261561416000595
info:eu-repo/semantics/altIdentifier/doi/ 10.1016/j.clnu.2016.02.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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