Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol

Autores
José, Carla; Briand, Laura Estefania
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The esterification of ibuprofen using ethanol as reactant and solvent was investigated. Additionally, the surface interaction of the isomers of ibuprofen and ethanol with the biocatalyst was screened through conventional adsorption isotherms and temperature programmed surface reaction (TPSR). These investigations evidenced strong alcohol adsorption and dissolution of the biocatalyst which explains its deactivation upon reuses in the esterification reaction.
Fil: José, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina
Fil: Briand, Laura Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina
Materia
Ethanol
Ibuprofen
Novozym 435
Biocatalyst
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/3016
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/3016
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the AlcoholJosé, CarlaBriand, Laura EstefaniaEthanolIbuprofenNovozym 435Biocatalysthttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2The esterification of ibuprofen using ethanol as reactant and solvent was investigated. Additionally, the surface interaction of the isomers of ibuprofen and ethanol with the biocatalyst was screened through conventional adsorption isotherms and temperature programmed surface reaction (TPSR). These investigations evidenced strong alcohol adsorption and dissolution of the biocatalyst which explains its deactivation upon reuses in the esterification reaction.Fil: José, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas; ArgentinaFil: Briand, Laura Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas; ArgentinaSpringer2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3016José, Carla; Briand, Laura Estefania; Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol; Springer; Reaction Kinetics, Mechanism and Catalysis; 99; 1; 2-2010; 17-221878-51901588-2837enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1007/s11144-009-0103-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:26Zoai:ri.conicet.gov.ar:11336/3016instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:26.313CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol
title Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol
spellingShingle Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol
José, Carla
Ethanol
Ibuprofen
Novozym 435
Biocatalyst
title_short Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol
title_full Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol
title_fullStr Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol
title_full_unstemmed Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol
title_sort Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol
dc.creator.none.fl_str_mv José, Carla
Briand, Laura Estefania
author José, Carla
author_facet José, Carla
Briand, Laura Estefania
author_role author
author2 Briand, Laura Estefania
author2_role author
dc.subject.none.fl_str_mv Ethanol
Ibuprofen
Novozym 435
Biocatalyst
topic Ethanol
Ibuprofen
Novozym 435
Biocatalyst
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The esterification of ibuprofen using ethanol as reactant and solvent was investigated. Additionally, the surface interaction of the isomers of ibuprofen and ethanol with the biocatalyst was screened through conventional adsorption isotherms and temperature programmed surface reaction (TPSR). These investigations evidenced strong alcohol adsorption and dissolution of the biocatalyst which explains its deactivation upon reuses in the esterification reaction.
Fil: José, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina
Fil: Briand, Laura Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina
description The esterification of ibuprofen using ethanol as reactant and solvent was investigated. Additionally, the surface interaction of the isomers of ibuprofen and ethanol with the biocatalyst was screened through conventional adsorption isotherms and temperature programmed surface reaction (TPSR). These investigations evidenced strong alcohol adsorption and dissolution of the biocatalyst which explains its deactivation upon reuses in the esterification reaction.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/3016
José, Carla; Briand, Laura Estefania; Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol; Springer; Reaction Kinetics, Mechanism and Catalysis; 99; 1; 2-2010; 17-22
1878-5190
1588-2837
url http://hdl.handle.net/11336/3016
identifier_str_mv José, Carla; Briand, Laura Estefania; Deactivation of Novozym 435 during the Esterification of Ibuprofen with Ethanol: Evidences of the Detrimental Effect of the Alcohol; Springer; Reaction Kinetics, Mechanism and Catalysis; 99; 1; 2-2010; 17-22
1878-5190
1588-2837
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11144-009-0103-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613065867264000
score 13.069144

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