Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease

Autores
Sookoian, Silvia Cristina; Castaño, Gustavo Osvaldo; Pirola, Carlos Jose
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We read with great interest the article by Kim et al. about the association between nonalcoholic fatty liver disease (NAFLD) and coronary artery calcification (CAC). The authors concluded that NAFLD per se might be a risk factor for coronary artery disease (CAD) as the association was “above and beyond visceral adiposity (VAT).”1 Interestingly, the Framingham Heart Study showed that VAT, body mass index, and pericardial fat (PCF) are associated with CAC, but only PCF remains significant following risk factor adjustment, suggesting a locally toxic effect of PCF on the vasculature.2 Thus, Kim et al. still leave open a key question about whether the contribution of NAFLD to CAC is above and beyond PCF. That would be an interesting hypothesis to test, even though the current evidence linking NAFLD, carotid artery wall thickness, and plaque development strongly suggests so.3
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Castaño, Gustavo Osvaldo. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Pirola, Carlos Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
FATTY LIVER
CARDIOVASCULAR RISK
NASH
ATHEROGENESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/272128
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular diseaseSookoian, Silvia CristinaCastaño, Gustavo OsvaldoPirola, Carlos JoseFATTY LIVERCARDIOVASCULAR RISKNASHATHEROGENESIShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3We read with great interest the article by Kim et al. about the association between nonalcoholic fatty liver disease (NAFLD) and coronary artery calcification (CAC). The authors concluded that NAFLD per se might be a risk factor for coronary artery disease (CAD) as the association was “above and beyond visceral adiposity (VAT).”1 Interestingly, the Framingham Heart Study showed that VAT, body mass index, and pericardial fat (PCF) are associated with CAC, but only PCF remains significant following risk factor adjustment, suggesting a locally toxic effect of PCF on the vasculature.2 Thus, Kim et al. still leave open a key question about whether the contribution of NAFLD to CAC is above and beyond PCF. That would be an interesting hypothesis to test, even though the current evidence linking NAFLD, carotid artery wall thickness, and plaque development strongly suggests so.3Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Castaño, Gustavo Osvaldo. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaFil: Pirola, Carlos Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaJohn Wiley & Sons2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/272128Sookoian, Silvia Cristina; Castaño, Gustavo Osvaldo; Pirola, Carlos Jose; Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease; John Wiley & Sons; Hepatology (Baltimore, Md.); 56; 3; 9-2012; 1185-11860270-9139CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/hep.25785info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.25785info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:03:15Zoai:ri.conicet.gov.ar:11336/272128instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:03:15.403CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease
title Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease
spellingShingle Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease
Sookoian, Silvia Cristina
FATTY LIVER
CARDIOVASCULAR RISK
NASH
ATHEROGENESIS
title_short Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease
title_full Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease
title_fullStr Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease
title_full_unstemmed Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease
title_sort Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease
dc.creator.none.fl_str_mv Sookoian, Silvia Cristina
Castaño, Gustavo Osvaldo
Pirola, Carlos Jose
author Sookoian, Silvia Cristina
author_facet Sookoian, Silvia Cristina
Castaño, Gustavo Osvaldo
Pirola, Carlos Jose
author_role author
author2 Castaño, Gustavo Osvaldo
Pirola, Carlos Jose
author2_role author
author
dc.subject.none.fl_str_mv FATTY LIVER
CARDIOVASCULAR RISK
NASH
ATHEROGENESIS
topic FATTY LIVER
CARDIOVASCULAR RISK
NASH
ATHEROGENESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We read with great interest the article by Kim et al. about the association between nonalcoholic fatty liver disease (NAFLD) and coronary artery calcification (CAC). The authors concluded that NAFLD per se might be a risk factor for coronary artery disease (CAD) as the association was “above and beyond visceral adiposity (VAT).”1 Interestingly, the Framingham Heart Study showed that VAT, body mass index, and pericardial fat (PCF) are associated with CAC, but only PCF remains significant following risk factor adjustment, suggesting a locally toxic effect of PCF on the vasculature.2 Thus, Kim et al. still leave open a key question about whether the contribution of NAFLD to CAC is above and beyond PCF. That would be an interesting hypothesis to test, even though the current evidence linking NAFLD, carotid artery wall thickness, and plaque development strongly suggests so.3
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Castaño, Gustavo Osvaldo. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Pirola, Carlos Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description We read with great interest the article by Kim et al. about the association between nonalcoholic fatty liver disease (NAFLD) and coronary artery calcification (CAC). The authors concluded that NAFLD per se might be a risk factor for coronary artery disease (CAD) as the association was “above and beyond visceral adiposity (VAT).”1 Interestingly, the Framingham Heart Study showed that VAT, body mass index, and pericardial fat (PCF) are associated with CAC, but only PCF remains significant following risk factor adjustment, suggesting a locally toxic effect of PCF on the vasculature.2 Thus, Kim et al. still leave open a key question about whether the contribution of NAFLD to CAC is above and beyond PCF. That would be an interesting hypothesis to test, even though the current evidence linking NAFLD, carotid artery wall thickness, and plaque development strongly suggests so.3
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/272128
Sookoian, Silvia Cristina; Castaño, Gustavo Osvaldo; Pirola, Carlos Jose; Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease; John Wiley & Sons; Hepatology (Baltimore, Md.); 56; 3; 9-2012; 1185-1186
0270-9139
CONICET Digital
CONICET
url http://hdl.handle.net/11336/272128
identifier_str_mv Sookoian, Silvia Cristina; Castaño, Gustavo Osvaldo; Pirola, Carlos Jose; Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease; John Wiley & Sons; Hepatology (Baltimore, Md.); 56; 3; 9-2012; 1185-1186
0270-9139
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/hep.25785
info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.25785
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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