Non-alcoholic fatty liver disease and risk of cardiovascular disease

Autores
Lonardo, Amedeo; Sookoian, Silvia Cristina; Pirola, Carlos José; Targher, Giovanni
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide, causing considerable liver-related mortality and morbidity. During the past decade, it has also become increasingly evident that NAFLD is a multisystem disease that affects many extra-hepatic organ systems, including the heart and the vascular system. In this updated clinical review, we discuss the rapidly expanding body of clinical and epidemiological evidence that supports a strong association of NAFLD with cardiovascular diseases (CVDs) and other functional and structural myocardial abnormalities. We also discuss some recently published data that correlate NAFLD due to specific genetic polymorphisms with the risk of CVDs. Finally, we briefly examine the assessment tools for estimating the global CVD risk in patients with NAFLD as well as the conventional and the more innovative pharmacological approaches for the treatment of CVD risk in this group of patients.
Fil: Lonardo, Amedeo. Università degli studi di Modena e Reggio Emilia; Italia
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Targher, Giovanni. Universita di Verona; Italia
Materia
FATTY LIVER
NASH
CARDIOVASCULAR RISK
CARDIOVASCULAR DISEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/101382
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/101382
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Non-alcoholic fatty liver disease and risk of cardiovascular diseaseLonardo, AmedeoSookoian, Silvia CristinaPirola, Carlos JoséTargher, GiovanniFATTY LIVERNASHCARDIOVASCULAR RISKCARDIOVASCULAR DISEASEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide, causing considerable liver-related mortality and morbidity. During the past decade, it has also become increasingly evident that NAFLD is a multisystem disease that affects many extra-hepatic organ systems, including the heart and the vascular system. In this updated clinical review, we discuss the rapidly expanding body of clinical and epidemiological evidence that supports a strong association of NAFLD with cardiovascular diseases (CVDs) and other functional and structural myocardial abnormalities. We also discuss some recently published data that correlate NAFLD due to specific genetic polymorphisms with the risk of CVDs. Finally, we briefly examine the assessment tools for estimating the global CVD risk in patients with NAFLD as well as the conventional and the more innovative pharmacological approaches for the treatment of CVD risk in this group of patients.Fil: Lonardo, Amedeo. Università degli studi di Modena e Reggio Emilia; ItaliaFil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Targher, Giovanni. Universita di Verona; ItaliaW B Saunders Co-Elsevier Inc2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/101382Lonardo, Amedeo; Sookoian, Silvia Cristina; Pirola, Carlos José; Targher, Giovanni; Non-alcoholic fatty liver disease and risk of cardiovascular disease; W B Saunders Co-Elsevier Inc; Metabolism-clinical And Experimental; 65; 8; 9-2015; 1-150026-0495CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.metabol.2015.09.017info:eu-repo/semantics/altIdentifier/url/https://www.metabolismjournal.com/article/S0026-0495(15)00271-1/fulltextinfo:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)https://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:30Zoai:ri.conicet.gov.ar:11336/101382instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:31.169CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Non-alcoholic fatty liver disease and risk of cardiovascular disease
title Non-alcoholic fatty liver disease and risk of cardiovascular disease
spellingShingle Non-alcoholic fatty liver disease and risk of cardiovascular disease
Lonardo, Amedeo
FATTY LIVER
NASH
CARDIOVASCULAR RISK
CARDIOVASCULAR DISEASE
title_short Non-alcoholic fatty liver disease and risk of cardiovascular disease
title_full Non-alcoholic fatty liver disease and risk of cardiovascular disease
title_fullStr Non-alcoholic fatty liver disease and risk of cardiovascular disease
title_full_unstemmed Non-alcoholic fatty liver disease and risk of cardiovascular disease
title_sort Non-alcoholic fatty liver disease and risk of cardiovascular disease
dc.creator.none.fl_str_mv Lonardo, Amedeo
Sookoian, Silvia Cristina
Pirola, Carlos José
Targher, Giovanni
author Lonardo, Amedeo
author_facet Lonardo, Amedeo
Sookoian, Silvia Cristina
Pirola, Carlos José
Targher, Giovanni
author_role author
author2 Sookoian, Silvia Cristina
Pirola, Carlos José
Targher, Giovanni
author2_role author
author
author
dc.subject.none.fl_str_mv FATTY LIVER
NASH
CARDIOVASCULAR RISK
CARDIOVASCULAR DISEASE
topic FATTY LIVER
NASH
CARDIOVASCULAR RISK
CARDIOVASCULAR DISEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide, causing considerable liver-related mortality and morbidity. During the past decade, it has also become increasingly evident that NAFLD is a multisystem disease that affects many extra-hepatic organ systems, including the heart and the vascular system. In this updated clinical review, we discuss the rapidly expanding body of clinical and epidemiological evidence that supports a strong association of NAFLD with cardiovascular diseases (CVDs) and other functional and structural myocardial abnormalities. We also discuss some recently published data that correlate NAFLD due to specific genetic polymorphisms with the risk of CVDs. Finally, we briefly examine the assessment tools for estimating the global CVD risk in patients with NAFLD as well as the conventional and the more innovative pharmacological approaches for the treatment of CVD risk in this group of patients.
Fil: Lonardo, Amedeo. Università degli studi di Modena e Reggio Emilia; Italia
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Targher, Giovanni. Universita di Verona; Italia
description Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide, causing considerable liver-related mortality and morbidity. During the past decade, it has also become increasingly evident that NAFLD is a multisystem disease that affects many extra-hepatic organ systems, including the heart and the vascular system. In this updated clinical review, we discuss the rapidly expanding body of clinical and epidemiological evidence that supports a strong association of NAFLD with cardiovascular diseases (CVDs) and other functional and structural myocardial abnormalities. We also discuss some recently published data that correlate NAFLD due to specific genetic polymorphisms with the risk of CVDs. Finally, we briefly examine the assessment tools for estimating the global CVD risk in patients with NAFLD as well as the conventional and the more innovative pharmacological approaches for the treatment of CVD risk in this group of patients.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/101382
Lonardo, Amedeo; Sookoian, Silvia Cristina; Pirola, Carlos José; Targher, Giovanni; Non-alcoholic fatty liver disease and risk of cardiovascular disease; W B Saunders Co-Elsevier Inc; Metabolism-clinical And Experimental; 65; 8; 9-2015; 1-15
0026-0495
CONICET Digital
CONICET
url http://hdl.handle.net/11336/101382
identifier_str_mv Lonardo, Amedeo; Sookoian, Silvia Cristina; Pirola, Carlos José; Targher, Giovanni; Non-alcoholic fatty liver disease and risk of cardiovascular disease; W B Saunders Co-Elsevier Inc; Metabolism-clinical And Experimental; 65; 8; 9-2015; 1-15
0026-0495
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.metabol.2015.09.017
info:eu-repo/semantics/altIdentifier/url/https://www.metabolismjournal.com/article/S0026-0495(15)00271-1/fulltext
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv W B Saunders Co-Elsevier Inc
publisher.none.fl_str_mv W B Saunders Co-Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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