Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs
- Autores
- Castillo, Victor Alejandro; Giacomini, Damiana Paula; Páez Pereda, Marcelo; Stalla, Johanna; Labeur, Marta; Theodoropoulou, Marily; Holsboer, Florian; Grossman, Ashley B.; Stalla, Günter K.; Arzt, Eduardo Simon
- Año de publicación
- 2006
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cushing's disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy is currently limited. Because retinoic acid has been shown to be potentially useful in decreasing corticotroph secretion and proliferation in rodent models, we have studied its action in dogs with Cushing's disease. A randomized treatment with retinoic acid (n = 22) vs. ketoconazole (n = 20) in dogs with Cushing's disease was assigned for a period of 180 d. Clinical signs, plasma ACTH and alpha-MSH, the cortisol/creatinine urine ratio, and pituitary magnetic resonance imaging were assessed and compared at different time points. We recorded a significant reduction in plasma ACTH and alpha-MSH, and also in the cortisol/creatinine urine ratio, of the dogs treated with retinoic acid. Pituitary adenoma size was also significantly reduced at the end of retinoic acid treatment. Survival time and all the clinical signs evaluated showed an improvement in the retinoic-acid-treated dogs. No adverse events or signs of hepatotoxicity were observed, suggesting that the drug is not only effective but also safe. Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype. This study highlights the possibility of using retinoic acid as a novel therapy in the treatment of ACTH-secreting tumors in humans with Cushing's disease.
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Giacomini, Damiana Paula. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; Alemania
Fil: Stalla, Johanna. Max Planck Institute of Psychiatry; Alemania
Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania
Fil: Theodoropoulou, Marily. Max Planck Institute of Psychiatry; Alemania
Fil: Holsboer, Florian. Max Planck Institute of Psychiatry; Alemania
Fil: Grossman, Ashley B.. Max Planck Institute of Psychiatry; Alemania
Fil: Stalla, Günter K.. Max Planck Institute of Psychiatry; Alemania
Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina - Materia
-
.Retinoic Acid
Cushing'S Disease - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/44644
Ver los metadatos del registro completo
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Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in DogsCastillo, Victor AlejandroGiacomini, Damiana PaulaPáez Pereda, MarceloStalla, JohannaLabeur, MartaTheodoropoulou, MarilyHolsboer, FlorianGrossman, Ashley B.Stalla, Günter K.Arzt, Eduardo Simon.Retinoic AcidCushing'S DiseaseCushing's disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy is currently limited. Because retinoic acid has been shown to be potentially useful in decreasing corticotroph secretion and proliferation in rodent models, we have studied its action in dogs with Cushing's disease. A randomized treatment with retinoic acid (n = 22) vs. ketoconazole (n = 20) in dogs with Cushing's disease was assigned for a period of 180 d. Clinical signs, plasma ACTH and alpha-MSH, the cortisol/creatinine urine ratio, and pituitary magnetic resonance imaging were assessed and compared at different time points. We recorded a significant reduction in plasma ACTH and alpha-MSH, and also in the cortisol/creatinine urine ratio, of the dogs treated with retinoic acid. Pituitary adenoma size was also significantly reduced at the end of retinoic acid treatment. Survival time and all the clinical signs evaluated showed an improvement in the retinoic-acid-treated dogs. No adverse events or signs of hepatotoxicity were observed, suggesting that the drug is not only effective but also safe. Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype. This study highlights the possibility of using retinoic acid as a novel therapy in the treatment of ACTH-secreting tumors in humans with Cushing's disease.Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Giacomini, Damiana Paula. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; AlemaniaFil: Stalla, Johanna. Max Planck Institute of Psychiatry; AlemaniaFil: Labeur, Marta. Max Planck Institute of Psychiatry; AlemaniaFil: Theodoropoulou, Marily. Max Planck Institute of Psychiatry; AlemaniaFil: Holsboer, Florian. Max Planck Institute of Psychiatry; AlemaniaFil: Grossman, Ashley B.. Max Planck Institute of Psychiatry; AlemaniaFil: Stalla, Günter K.. Max Planck Institute of Psychiatry; AlemaniaFil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaEndocrine Society2006-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44644Castillo, Victor Alejandro; Giacomini, Damiana Paula; Páez Pereda, Marcelo; Stalla, Johanna; Labeur, Marta; et al.; Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs; Endocrine Society; Endocrinology; 147; 9; 9-2006; 4438-44440013-72271945-7170CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/147/9/4438/2528350info:eu-repo/semantics/altIdentifier/doi/10.1210/en.2006-0414info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:10Zoai:ri.conicet.gov.ar:11336/44644instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:10.833CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs |
| title |
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs |
| spellingShingle |
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs Castillo, Victor Alejandro .Retinoic Acid Cushing'S Disease |
| title_short |
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs |
| title_full |
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs |
| title_fullStr |
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs |
| title_full_unstemmed |
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs |
| title_sort |
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs |
| dc.creator.none.fl_str_mv |
Castillo, Victor Alejandro Giacomini, Damiana Paula Páez Pereda, Marcelo Stalla, Johanna Labeur, Marta Theodoropoulou, Marily Holsboer, Florian Grossman, Ashley B. Stalla, Günter K. Arzt, Eduardo Simon |
| author |
Castillo, Victor Alejandro |
| author_facet |
Castillo, Victor Alejandro Giacomini, Damiana Paula Páez Pereda, Marcelo Stalla, Johanna Labeur, Marta Theodoropoulou, Marily Holsboer, Florian Grossman, Ashley B. Stalla, Günter K. Arzt, Eduardo Simon |
| author_role |
author |
| author2 |
Giacomini, Damiana Paula Páez Pereda, Marcelo Stalla, Johanna Labeur, Marta Theodoropoulou, Marily Holsboer, Florian Grossman, Ashley B. Stalla, Günter K. Arzt, Eduardo Simon |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
.Retinoic Acid Cushing'S Disease |
| topic |
.Retinoic Acid Cushing'S Disease |
| dc.description.none.fl_txt_mv |
Cushing's disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy is currently limited. Because retinoic acid has been shown to be potentially useful in decreasing corticotroph secretion and proliferation in rodent models, we have studied its action in dogs with Cushing's disease. A randomized treatment with retinoic acid (n = 22) vs. ketoconazole (n = 20) in dogs with Cushing's disease was assigned for a period of 180 d. Clinical signs, plasma ACTH and alpha-MSH, the cortisol/creatinine urine ratio, and pituitary magnetic resonance imaging were assessed and compared at different time points. We recorded a significant reduction in plasma ACTH and alpha-MSH, and also in the cortisol/creatinine urine ratio, of the dogs treated with retinoic acid. Pituitary adenoma size was also significantly reduced at the end of retinoic acid treatment. Survival time and all the clinical signs evaluated showed an improvement in the retinoic-acid-treated dogs. No adverse events or signs of hepatotoxicity were observed, suggesting that the drug is not only effective but also safe. Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype. This study highlights the possibility of using retinoic acid as a novel therapy in the treatment of ACTH-secreting tumors in humans with Cushing's disease. Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Giacomini, Damiana Paula. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; Alemania Fil: Stalla, Johanna. Max Planck Institute of Psychiatry; Alemania Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania Fil: Theodoropoulou, Marily. Max Planck Institute of Psychiatry; Alemania Fil: Holsboer, Florian. Max Planck Institute of Psychiatry; Alemania Fil: Grossman, Ashley B.. Max Planck Institute of Psychiatry; Alemania Fil: Stalla, Günter K.. Max Planck Institute of Psychiatry; Alemania Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina |
| description |
Cushing's disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy is currently limited. Because retinoic acid has been shown to be potentially useful in decreasing corticotroph secretion and proliferation in rodent models, we have studied its action in dogs with Cushing's disease. A randomized treatment with retinoic acid (n = 22) vs. ketoconazole (n = 20) in dogs with Cushing's disease was assigned for a period of 180 d. Clinical signs, plasma ACTH and alpha-MSH, the cortisol/creatinine urine ratio, and pituitary magnetic resonance imaging were assessed and compared at different time points. We recorded a significant reduction in plasma ACTH and alpha-MSH, and also in the cortisol/creatinine urine ratio, of the dogs treated with retinoic acid. Pituitary adenoma size was also significantly reduced at the end of retinoic acid treatment. Survival time and all the clinical signs evaluated showed an improvement in the retinoic-acid-treated dogs. No adverse events or signs of hepatotoxicity were observed, suggesting that the drug is not only effective but also safe. Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype. This study highlights the possibility of using retinoic acid as a novel therapy in the treatment of ACTH-secreting tumors in humans with Cushing's disease. |
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2006 |
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2006-09 |
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http://hdl.handle.net/11336/44644 Castillo, Victor Alejandro; Giacomini, Damiana Paula; Páez Pereda, Marcelo; Stalla, Johanna; Labeur, Marta; et al.; Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs; Endocrine Society; Endocrinology; 147; 9; 9-2006; 4438-4444 0013-7227 1945-7170 CONICET Digital CONICET |
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http://hdl.handle.net/11336/44644 |
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Castillo, Victor Alejandro; Giacomini, Damiana Paula; Páez Pereda, Marcelo; Stalla, Johanna; Labeur, Marta; et al.; Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs; Endocrine Society; Endocrinology; 147; 9; 9-2006; 4438-4444 0013-7227 1945-7170 CONICET Digital CONICET |
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eng |
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