Why Deprivation Makes Food Taste Better?

Autores
Blanco, Maria Gabriela; Florman, Jeremy; Lacour, Ailin; de Rosa, Maria Jose; Alkema, Mark; Rayes, Diego Hernán
Año de publicación
2025
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The phenomenon of food tasting better after deprivation is conserved across many species. In C. elegans, an enhanced slowing response is ob- served when encountering food after 30 minutes of food deprivation (Sawin et al., 2000). This response is mediated by a large increase in serotonin (5-HT) release from the NSM and ADF neurons (Iwanir et al., 2016; Rhoades et al, 2019). We found that this slowing response and the activity of serotonergic neurons upon food exposure are further enhanced in tyramine (TA)-deficient mutants. TA levels decrease during fasting, and C. elegans reduces its locomotion rate after prolonged fasting (>30 minutes). This reduction in locomotion can be counteracted by the addition of exogenous TA, highlighting the role of TA in regulating movement. In contrast, serotonin (5-HT) decreases locomotion, indicating an antagonistic relationship between 5-HT and TA. We found that tyramine exerts an inhibitory effect on the NSM neuron by activating the tyramine GPCR receptors SER-2 and TYRA-2 Downregulation of tyramine during food deprivation leads to the disinhibition of serotonergic signaling and increased NSM activity upon re-encountering food. This disinhibition provides molecular and neural insights into the enhanced slowing response, enabling the worm to efficiently exploit a new food source. The antagonistic crosstalk between TA and 5-HT illustrates how the nervous system controls discrete behavioral state transitions during foraging. This mechanism may explain why food is perceived as more rewarding or appealing in states of hunger, offering a neural basis for the enhanced sensory experience of food after deprivation.
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
25th International Worm meeting
Davis
Estados Unidos
Genetics Society of America
Materia
neuronal activity
feeding
hunger
serotonin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/282485
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Why Deprivation Makes Food Taste Better?Blanco, Maria GabrielaFlorman, JeremyLacour, Ailinde Rosa, Maria JoseAlkema, MarkRayes, Diego Hernánneuronal activityfeedinghungerserotoninhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The phenomenon of food tasting better after deprivation is conserved across many species. In C. elegans, an enhanced slowing response is ob- served when encountering food after 30 minutes of food deprivation (Sawin et al., 2000). This response is mediated by a large increase in serotonin (5-HT) release from the NSM and ADF neurons (Iwanir et al., 2016; Rhoades et al, 2019). We found that this slowing response and the activity of serotonergic neurons upon food exposure are further enhanced in tyramine (TA)-deficient mutants. TA levels decrease during fasting, and C. elegans reduces its locomotion rate after prolonged fasting (>30 minutes). This reduction in locomotion can be counteracted by the addition of exogenous TA, highlighting the role of TA in regulating movement. In contrast, serotonin (5-HT) decreases locomotion, indicating an antagonistic relationship between 5-HT and TA. We found that tyramine exerts an inhibitory effect on the NSM neuron by activating the tyramine GPCR receptors SER-2 and TYRA-2 Downregulation of tyramine during food deprivation leads to the disinhibition of serotonergic signaling and increased NSM activity upon re-encountering food. This disinhibition provides molecular and neural insights into the enhanced slowing response, enabling the worm to efficiently exploit a new food source. The antagonistic crosstalk between TA and 5-HT illustrates how the nervous system controls discrete behavioral state transitions during foraging. This mechanism may explain why food is perceived as more rewarding or appealing in states of hunger, offering a neural basis for the enhanced sensory experience of food after deprivation.Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Florman, Jeremy. University Of Massachussets. Medical School. Department Of Neurobiology; Estados UnidosFil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Alkema, Mark. University Of Massachussets. Medical School. Department Of Neurobiology; Estados UnidosFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina25th International Worm meetingDavisEstados UnidosGenetics Society of AmericaGenetics Society of America2025info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/282485Why Deprivation Makes Food Taste Better?; 25th International Worm meeting; Davis; Estados Unidos; 2025; 51-51CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/worm-2025/download-program-and-abstract-books/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-05-13T11:22:12Zoai:ri.conicet.gov.ar:11336/282485instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-05-13 11:22:12.497CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Why Deprivation Makes Food Taste Better?
title Why Deprivation Makes Food Taste Better?
spellingShingle Why Deprivation Makes Food Taste Better?
Blanco, Maria Gabriela
neuronal activity
feeding
hunger
serotonin
title_short Why Deprivation Makes Food Taste Better?
title_full Why Deprivation Makes Food Taste Better?
title_fullStr Why Deprivation Makes Food Taste Better?
title_full_unstemmed Why Deprivation Makes Food Taste Better?
title_sort Why Deprivation Makes Food Taste Better?
dc.creator.none.fl_str_mv Blanco, Maria Gabriela
Florman, Jeremy
Lacour, Ailin
de Rosa, Maria Jose
Alkema, Mark
Rayes, Diego Hernán
author Blanco, Maria Gabriela
author_facet Blanco, Maria Gabriela
Florman, Jeremy
Lacour, Ailin
de Rosa, Maria Jose
Alkema, Mark
Rayes, Diego Hernán
author_role author
author2 Florman, Jeremy
Lacour, Ailin
de Rosa, Maria Jose
Alkema, Mark
Rayes, Diego Hernán
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv neuronal activity
feeding
hunger
serotonin
topic neuronal activity
feeding
hunger
serotonin
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The phenomenon of food tasting better after deprivation is conserved across many species. In C. elegans, an enhanced slowing response is ob- served when encountering food after 30 minutes of food deprivation (Sawin et al., 2000). This response is mediated by a large increase in serotonin (5-HT) release from the NSM and ADF neurons (Iwanir et al., 2016; Rhoades et al, 2019). We found that this slowing response and the activity of serotonergic neurons upon food exposure are further enhanced in tyramine (TA)-deficient mutants. TA levels decrease during fasting, and C. elegans reduces its locomotion rate after prolonged fasting (>30 minutes). This reduction in locomotion can be counteracted by the addition of exogenous TA, highlighting the role of TA in regulating movement. In contrast, serotonin (5-HT) decreases locomotion, indicating an antagonistic relationship between 5-HT and TA. We found that tyramine exerts an inhibitory effect on the NSM neuron by activating the tyramine GPCR receptors SER-2 and TYRA-2 Downregulation of tyramine during food deprivation leads to the disinhibition of serotonergic signaling and increased NSM activity upon re-encountering food. This disinhibition provides molecular and neural insights into the enhanced slowing response, enabling the worm to efficiently exploit a new food source. The antagonistic crosstalk between TA and 5-HT illustrates how the nervous system controls discrete behavioral state transitions during foraging. This mechanism may explain why food is perceived as more rewarding or appealing in states of hunger, offering a neural basis for the enhanced sensory experience of food after deprivation.
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
25th International Worm meeting
Davis
Estados Unidos
Genetics Society of America
description The phenomenon of food tasting better after deprivation is conserved across many species. In C. elegans, an enhanced slowing response is ob- served when encountering food after 30 minutes of food deprivation (Sawin et al., 2000). This response is mediated by a large increase in serotonin (5-HT) release from the NSM and ADF neurons (Iwanir et al., 2016; Rhoades et al, 2019). We found that this slowing response and the activity of serotonergic neurons upon food exposure are further enhanced in tyramine (TA)-deficient mutants. TA levels decrease during fasting, and C. elegans reduces its locomotion rate after prolonged fasting (>30 minutes). This reduction in locomotion can be counteracted by the addition of exogenous TA, highlighting the role of TA in regulating movement. In contrast, serotonin (5-HT) decreases locomotion, indicating an antagonistic relationship between 5-HT and TA. We found that tyramine exerts an inhibitory effect on the NSM neuron by activating the tyramine GPCR receptors SER-2 and TYRA-2 Downregulation of tyramine during food deprivation leads to the disinhibition of serotonergic signaling and increased NSM activity upon re-encountering food. This disinhibition provides molecular and neural insights into the enhanced slowing response, enabling the worm to efficiently exploit a new food source. The antagonistic crosstalk between TA and 5-HT illustrates how the nervous system controls discrete behavioral state transitions during foraging. This mechanism may explain why food is perceived as more rewarding or appealing in states of hunger, offering a neural basis for the enhanced sensory experience of food after deprivation.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
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Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/282485
Why Deprivation Makes Food Taste Better?; 25th International Worm meeting; Davis; Estados Unidos; 2025; 51-51
CONICET Digital
CONICET
url http://hdl.handle.net/11336/282485
identifier_str_mv Why Deprivation Makes Food Taste Better?; 25th International Worm meeting; Davis; Estados Unidos; 2025; 51-51
CONICET Digital
CONICET
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language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/worm-2025/download-program-and-abstract-books/
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Genetics Society of America
publisher.none.fl_str_mv Genetics Society of America
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