exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox...

Autores
Peng, Yu Hao; Heintz, Ryan; Wang, Zhuo; Guo,Yumei; Myers, Kalisa G.; Scremin, Oscar Umberto; Maarek, Jean Michel; Holschneider, Daniel P.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Current rodent connectome projects are revealing brain structural connectivity with unprecedented resolution and completeness. How subregional structural connectivity relates to subregional functional interactions is an emerging research topic. We describe a method for standardized, mesoscopic-level data sampling from autoradiographic coronal sections of the rat brain, and for correlation-based analysis and intuitive display of cortico-cortical functional connectivity (FC) on a flattened cortical map. A graphic user interface “Cx-2D” allows for the display of significant correlations of individual regions-of-interest, as well as graph theoretical metrics across the cortex. Cx-2D was tested on an autoradiographic data set of cerebral blood flow (CBF) of rats that had undergone bilateral striatal lesions, followed by 4 weeks of aerobic exercise training or no exercise. Effects of lesioning and exercise on cortico-cortical FC were examined during a locomotor challenge in this rat model of Parkinsonism. Subregional FC analysis revealed a rich functional reorganization of the brain in response to lesioning and exercise that was not apparent in a standard analysis focused on CBF of isolated brain regions. Lesioned rats showed diminished degree centrality of lateral primary motor cortex, as well as neighboring somatosensory cortex—changes that were substantially reversed in lesioned rats following exercise training. Seed analysis revealed that exercise increased positive correlations in motor and somatosensory cortex, with little effect in non-sensorimotor regions such as visual, auditory, and piriform cortex. The current analysis revealed that exercise partially reinstated sensorimotor FC lost following dopaminergic deafferentation. Cx-2D allows for standardized data sampling from images of brain slices, as well as analysis and display of cortico-cortical FC in the rat cerebral cortex with potential applications in a variety of autoradiographic and histologic studies
Fil: Peng, Yu Hao. University of Southern California; Estados Unidos
Fil: Heintz, Ryan. University of Southern California; Estados Unidos
Fil: Wang, Zhuo. University of Southern California; Estados Unidos
Fil: Guo,Yumei. University of Southern California; Estados Unidos
Fil: Myers, Kalisa G.. University of Southern California; Estados Unidos
Fil: Scremin, Oscar Umberto. Veterans Affairs Greater Los Angeles Healthcare System. Los Angeles; Estados Unidos. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Maarek, Jean Michel. University of Southern California; Estados Unidos
Fil: Holschneider, Daniel P.. University of Southern California; Estados Unidos
Materia
Cerebral Cortex
Functional Connectivity
Brain Mapping
Exercise
Motor Training
Parkinson’S Disease
Dopamine
Software
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31027
Acceder
id CONICETDig_6505b732e6fafe61b7cc1c362e59d0a9
oai_identifier_str oai:ri.conicet.gov.ar:11336/31027
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brainPeng, Yu HaoHeintz, RyanWang, ZhuoGuo,YumeiMyers, Kalisa G.Scremin, Oscar UmbertoMaarek, Jean MichelHolschneider, Daniel P.Cerebral CortexFunctional ConnectivityBrain MappingExerciseMotor TrainingParkinson’S DiseaseDopamineSoftwarehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Current rodent connectome projects are revealing brain structural connectivity with unprecedented resolution and completeness. How subregional structural connectivity relates to subregional functional interactions is an emerging research topic. We describe a method for standardized, mesoscopic-level data sampling from autoradiographic coronal sections of the rat brain, and for correlation-based analysis and intuitive display of cortico-cortical functional connectivity (FC) on a flattened cortical map. A graphic user interface “Cx-2D” allows for the display of significant correlations of individual regions-of-interest, as well as graph theoretical metrics across the cortex. Cx-2D was tested on an autoradiographic data set of cerebral blood flow (CBF) of rats that had undergone bilateral striatal lesions, followed by 4 weeks of aerobic exercise training or no exercise. Effects of lesioning and exercise on cortico-cortical FC were examined during a locomotor challenge in this rat model of Parkinsonism. Subregional FC analysis revealed a rich functional reorganization of the brain in response to lesioning and exercise that was not apparent in a standard analysis focused on CBF of isolated brain regions. Lesioned rats showed diminished degree centrality of lateral primary motor cortex, as well as neighboring somatosensory cortex—changes that were substantially reversed in lesioned rats following exercise training. Seed analysis revealed that exercise increased positive correlations in motor and somatosensory cortex, with little effect in non-sensorimotor regions such as visual, auditory, and piriform cortex. The current analysis revealed that exercise partially reinstated sensorimotor FC lost following dopaminergic deafferentation. Cx-2D allows for standardized data sampling from images of brain slices, as well as analysis and display of cortico-cortical FC in the rat cerebral cortex with potential applications in a variety of autoradiographic and histologic studiesFil: Peng, Yu Hao. University of Southern California; Estados UnidosFil: Heintz, Ryan. University of Southern California; Estados UnidosFil: Wang, Zhuo. University of Southern California; Estados UnidosFil: Guo,Yumei. University of Southern California; Estados UnidosFil: Myers, Kalisa G.. University of Southern California; Estados UnidosFil: Scremin, Oscar Umberto. Veterans Affairs Greater Los Angeles Healthcare System. Los Angeles; Estados Unidos. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Maarek, Jean Michel. University of Southern California; Estados UnidosFil: Holschneider, Daniel P.. University of Southern California; Estados UnidosBenjamin-Cummings Publishing Company2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31027Holschneider, Daniel P.; Maarek, Jean Michel; Scremin, Oscar Umberto; Myers, Kalisa G.; Guo,Yumei; Wang, Zhuo; et al.; exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain; Benjamin-Cummings Publishing Company; Frontiers in Physics; 2; 72; 12-20140429-7725CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphy.2014.00072info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphy.2014.00072/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:03Zoai:ri.conicet.gov.ar:11336/31027instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:03.991CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain
title exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain
spellingShingle exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain
Peng, Yu Hao
Cerebral Cortex
Functional Connectivity
Brain Mapping
Exercise
Motor Training
Parkinson’S Disease
Dopamine
Software
title_short exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain
title_full exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain
title_fullStr exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain
title_full_unstemmed exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain
title_sort exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain
dc.creator.none.fl_str_mv Peng, Yu Hao
Heintz, Ryan
Wang, Zhuo
Guo,Yumei
Myers, Kalisa G.
Scremin, Oscar Umberto
Maarek, Jean Michel
Holschneider, Daniel P.
author Peng, Yu Hao
author_facet Peng, Yu Hao
Heintz, Ryan
Wang, Zhuo
Guo,Yumei
Myers, Kalisa G.
Scremin, Oscar Umberto
Maarek, Jean Michel
Holschneider, Daniel P.
author_role author
author2 Heintz, Ryan
Wang, Zhuo
Guo,Yumei
Myers, Kalisa G.
Scremin, Oscar Umberto
Maarek, Jean Michel
Holschneider, Daniel P.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cerebral Cortex
Functional Connectivity
Brain Mapping
Exercise
Motor Training
Parkinson’S Disease
Dopamine
Software
topic Cerebral Cortex
Functional Connectivity
Brain Mapping
Exercise
Motor Training
Parkinson’S Disease
Dopamine
Software
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Current rodent connectome projects are revealing brain structural connectivity with unprecedented resolution and completeness. How subregional structural connectivity relates to subregional functional interactions is an emerging research topic. We describe a method for standardized, mesoscopic-level data sampling from autoradiographic coronal sections of the rat brain, and for correlation-based analysis and intuitive display of cortico-cortical functional connectivity (FC) on a flattened cortical map. A graphic user interface “Cx-2D” allows for the display of significant correlations of individual regions-of-interest, as well as graph theoretical metrics across the cortex. Cx-2D was tested on an autoradiographic data set of cerebral blood flow (CBF) of rats that had undergone bilateral striatal lesions, followed by 4 weeks of aerobic exercise training or no exercise. Effects of lesioning and exercise on cortico-cortical FC were examined during a locomotor challenge in this rat model of Parkinsonism. Subregional FC analysis revealed a rich functional reorganization of the brain in response to lesioning and exercise that was not apparent in a standard analysis focused on CBF of isolated brain regions. Lesioned rats showed diminished degree centrality of lateral primary motor cortex, as well as neighboring somatosensory cortex—changes that were substantially reversed in lesioned rats following exercise training. Seed analysis revealed that exercise increased positive correlations in motor and somatosensory cortex, with little effect in non-sensorimotor regions such as visual, auditory, and piriform cortex. The current analysis revealed that exercise partially reinstated sensorimotor FC lost following dopaminergic deafferentation. Cx-2D allows for standardized data sampling from images of brain slices, as well as analysis and display of cortico-cortical FC in the rat cerebral cortex with potential applications in a variety of autoradiographic and histologic studies
Fil: Peng, Yu Hao. University of Southern California; Estados Unidos
Fil: Heintz, Ryan. University of Southern California; Estados Unidos
Fil: Wang, Zhuo. University of Southern California; Estados Unidos
Fil: Guo,Yumei. University of Southern California; Estados Unidos
Fil: Myers, Kalisa G.. University of Southern California; Estados Unidos
Fil: Scremin, Oscar Umberto. Veterans Affairs Greater Los Angeles Healthcare System. Los Angeles; Estados Unidos. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Maarek, Jean Michel. University of Southern California; Estados Unidos
Fil: Holschneider, Daniel P.. University of Southern California; Estados Unidos
description Current rodent connectome projects are revealing brain structural connectivity with unprecedented resolution and completeness. How subregional structural connectivity relates to subregional functional interactions is an emerging research topic. We describe a method for standardized, mesoscopic-level data sampling from autoradiographic coronal sections of the rat brain, and for correlation-based analysis and intuitive display of cortico-cortical functional connectivity (FC) on a flattened cortical map. A graphic user interface “Cx-2D” allows for the display of significant correlations of individual regions-of-interest, as well as graph theoretical metrics across the cortex. Cx-2D was tested on an autoradiographic data set of cerebral blood flow (CBF) of rats that had undergone bilateral striatal lesions, followed by 4 weeks of aerobic exercise training or no exercise. Effects of lesioning and exercise on cortico-cortical FC were examined during a locomotor challenge in this rat model of Parkinsonism. Subregional FC analysis revealed a rich functional reorganization of the brain in response to lesioning and exercise that was not apparent in a standard analysis focused on CBF of isolated brain regions. Lesioned rats showed diminished degree centrality of lateral primary motor cortex, as well as neighboring somatosensory cortex—changes that were substantially reversed in lesioned rats following exercise training. Seed analysis revealed that exercise increased positive correlations in motor and somatosensory cortex, with little effect in non-sensorimotor regions such as visual, auditory, and piriform cortex. The current analysis revealed that exercise partially reinstated sensorimotor FC lost following dopaminergic deafferentation. Cx-2D allows for standardized data sampling from images of brain slices, as well as analysis and display of cortico-cortical FC in the rat cerebral cortex with potential applications in a variety of autoradiographic and histologic studies
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31027
Holschneider, Daniel P.; Maarek, Jean Michel; Scremin, Oscar Umberto; Myers, Kalisa G.; Guo,Yumei; Wang, Zhuo; et al.; exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain; Benjamin-Cummings Publishing Company; Frontiers in Physics; 2; 72; 12-2014
0429-7725
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31027
identifier_str_mv Holschneider, Daniel P.; Maarek, Jean Michel; Scremin, Oscar Umberto; Myers, Kalisa G.; Guo,Yumei; Wang, Zhuo; et al.; exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain; Benjamin-Cummings Publishing Company; Frontiers in Physics; 2; 72; 12-2014
0429-7725
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fphy.2014.00072
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphy.2014.00072/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Benjamin-Cummings Publishing Company
publisher.none.fl_str_mv Benjamin-Cummings Publishing Company
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614401927151616
score 13.070432

Publicaciones similares