Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease

Autores
Zold, Camila Lidia; Escande, Mariela Veronica; Pomata, Pablo Ernesto; Riquelme, Luis A.; Murer, Mario Gustavo
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Anomalous patterns of synchronization between basal ganglia and cortex underlie the symptoms of Parkinson´s disease. Computational modeling studies suggest that changes in cortical feedback loops involving trans-striatal and trans-subthalamic circuits bring up this anomalous synchronization. We asked whether striatal outflow synchronizes globus pallidus neurons with cortical activity in a rat model of Parkinson´s disease. We found that striatal firing is highly increased in rats with chronic nigrostriatal lesion and that this hyperactivity can be reduced by locally infusing a competitive NMDA receptor antagonist. Moreover, NMDA receptor-dependent striatal output had frequency dependent effects on distinct pathological patterns of cortico-pallidal coupling. Blockade of striatal NMDA receptors almost completely abolished an anomalous ~ 1 Hz cortico-pallidal anti-phase synchronization induced by nigrostriatal degeneration. Moreover, under striatal NMDA receptor blockade, synchronization with 2.5?5 Hz cortical oscillations falls to negligible levels and oscillations at 10?20 Hz are markedly attenuated, whereas beta synchronization (with a peak at ~ 26 Hz) is marginally reduced. Thus, tonic activation of striatal NMDA receptors allows different forms of anomalous oscillations along the cortico-striato-pallidal axis. Moreover, the frequency dependent effects of NMDA receptors suggest that low and high frequency parkinsonian oscillations stem from partially different mechanisms. Finally, our results may help to reconcile views about the contributions of changes in firing rate and oscillatory synchronization to Parkinson´s disease symptoms by showing that they are related to each other.
Fil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Escande, Mariela Veronica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pomata, Pablo Ernesto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Riquelme, Luis A.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Striatum
Nmda Receptor
Globus Pallidus
Neuronal Synchronization
Parkinson´S Disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22197
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/22197
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's diseaseZold, Camila LidiaEscande, Mariela VeronicaPomata, Pablo ErnestoRiquelme, Luis A.Murer, Mario GustavoStriatumNmda ReceptorGlobus PallidusNeuronal SynchronizationParkinson´S Diseasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Anomalous patterns of synchronization between basal ganglia and cortex underlie the symptoms of Parkinson´s disease. Computational modeling studies suggest that changes in cortical feedback loops involving trans-striatal and trans-subthalamic circuits bring up this anomalous synchronization. We asked whether striatal outflow synchronizes globus pallidus neurons with cortical activity in a rat model of Parkinson´s disease. We found that striatal firing is highly increased in rats with chronic nigrostriatal lesion and that this hyperactivity can be reduced by locally infusing a competitive NMDA receptor antagonist. Moreover, NMDA receptor-dependent striatal output had frequency dependent effects on distinct pathological patterns of cortico-pallidal coupling. Blockade of striatal NMDA receptors almost completely abolished an anomalous ~ 1 Hz cortico-pallidal anti-phase synchronization induced by nigrostriatal degeneration. Moreover, under striatal NMDA receptor blockade, synchronization with 2.5?5 Hz cortical oscillations falls to negligible levels and oscillations at 10?20 Hz are markedly attenuated, whereas beta synchronization (with a peak at ~ 26 Hz) is marginally reduced. Thus, tonic activation of striatal NMDA receptors allows different forms of anomalous oscillations along the cortico-striato-pallidal axis. Moreover, the frequency dependent effects of NMDA receptors suggest that low and high frequency parkinsonian oscillations stem from partially different mechanisms. Finally, our results may help to reconcile views about the contributions of changes in firing rate and oscillatory synchronization to Parkinson´s disease symptoms by showing that they are related to each other.Fil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Escande, Mariela Veronica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pomata, Pablo Ernesto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Riquelme, Luis A.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; ArgentinaFil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Inc2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22197Zold, Camila Lidia; Escande, Mariela Veronica; Pomata, Pablo Ernesto; Riquelme, Luis A.; Murer, Mario Gustavo; Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease; Elsevier Inc; Neurobiology of Disease; 47; 1; 3-2012; 38-480969-99611095-953XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0969996112000939info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nbd.2012.03.022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:49Zoai:ri.conicet.gov.ar:11336/22197instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:49.544CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
title Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
spellingShingle Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
Zold, Camila Lidia
Striatum
Nmda Receptor
Globus Pallidus
Neuronal Synchronization
Parkinson´S Disease
title_short Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
title_full Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
title_fullStr Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
title_full_unstemmed Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
title_sort Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
dc.creator.none.fl_str_mv Zold, Camila Lidia
Escande, Mariela Veronica
Pomata, Pablo Ernesto
Riquelme, Luis A.
Murer, Mario Gustavo
author Zold, Camila Lidia
author_facet Zold, Camila Lidia
Escande, Mariela Veronica
Pomata, Pablo Ernesto
Riquelme, Luis A.
Murer, Mario Gustavo
author_role author
author2 Escande, Mariela Veronica
Pomata, Pablo Ernesto
Riquelme, Luis A.
Murer, Mario Gustavo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Striatum
Nmda Receptor
Globus Pallidus
Neuronal Synchronization
Parkinson´S Disease
topic Striatum
Nmda Receptor
Globus Pallidus
Neuronal Synchronization
Parkinson´S Disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Anomalous patterns of synchronization between basal ganglia and cortex underlie the symptoms of Parkinson´s disease. Computational modeling studies suggest that changes in cortical feedback loops involving trans-striatal and trans-subthalamic circuits bring up this anomalous synchronization. We asked whether striatal outflow synchronizes globus pallidus neurons with cortical activity in a rat model of Parkinson´s disease. We found that striatal firing is highly increased in rats with chronic nigrostriatal lesion and that this hyperactivity can be reduced by locally infusing a competitive NMDA receptor antagonist. Moreover, NMDA receptor-dependent striatal output had frequency dependent effects on distinct pathological patterns of cortico-pallidal coupling. Blockade of striatal NMDA receptors almost completely abolished an anomalous ~ 1 Hz cortico-pallidal anti-phase synchronization induced by nigrostriatal degeneration. Moreover, under striatal NMDA receptor blockade, synchronization with 2.5?5 Hz cortical oscillations falls to negligible levels and oscillations at 10?20 Hz are markedly attenuated, whereas beta synchronization (with a peak at ~ 26 Hz) is marginally reduced. Thus, tonic activation of striatal NMDA receptors allows different forms of anomalous oscillations along the cortico-striato-pallidal axis. Moreover, the frequency dependent effects of NMDA receptors suggest that low and high frequency parkinsonian oscillations stem from partially different mechanisms. Finally, our results may help to reconcile views about the contributions of changes in firing rate and oscillatory synchronization to Parkinson´s disease symptoms by showing that they are related to each other.
Fil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Escande, Mariela Veronica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pomata, Pablo Ernesto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Riquelme, Luis A.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Anomalous patterns of synchronization between basal ganglia and cortex underlie the symptoms of Parkinson´s disease. Computational modeling studies suggest that changes in cortical feedback loops involving trans-striatal and trans-subthalamic circuits bring up this anomalous synchronization. We asked whether striatal outflow synchronizes globus pallidus neurons with cortical activity in a rat model of Parkinson´s disease. We found that striatal firing is highly increased in rats with chronic nigrostriatal lesion and that this hyperactivity can be reduced by locally infusing a competitive NMDA receptor antagonist. Moreover, NMDA receptor-dependent striatal output had frequency dependent effects on distinct pathological patterns of cortico-pallidal coupling. Blockade of striatal NMDA receptors almost completely abolished an anomalous ~ 1 Hz cortico-pallidal anti-phase synchronization induced by nigrostriatal degeneration. Moreover, under striatal NMDA receptor blockade, synchronization with 2.5?5 Hz cortical oscillations falls to negligible levels and oscillations at 10?20 Hz are markedly attenuated, whereas beta synchronization (with a peak at ~ 26 Hz) is marginally reduced. Thus, tonic activation of striatal NMDA receptors allows different forms of anomalous oscillations along the cortico-striato-pallidal axis. Moreover, the frequency dependent effects of NMDA receptors suggest that low and high frequency parkinsonian oscillations stem from partially different mechanisms. Finally, our results may help to reconcile views about the contributions of changes in firing rate and oscillatory synchronization to Parkinson´s disease symptoms by showing that they are related to each other.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22197
Zold, Camila Lidia; Escande, Mariela Veronica; Pomata, Pablo Ernesto; Riquelme, Luis A.; Murer, Mario Gustavo; Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease; Elsevier Inc; Neurobiology of Disease; 47; 1; 3-2012; 38-48
0969-9961
1095-953X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22197
identifier_str_mv Zold, Camila Lidia; Escande, Mariela Veronica; Pomata, Pablo Ernesto; Riquelme, Luis A.; Murer, Mario Gustavo; Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease; Elsevier Inc; Neurobiology of Disease; 47; 1; 3-2012; 38-48
0969-9961
1095-953X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0969996112000939
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nbd.2012.03.022
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.885934

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