Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
- Autores
- Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Qian, Xiaoxia; Rojas Villarraga, Adriana; Sun, Celi; Cañas, Carlos; Tobón, Gabriel J.; Matsuda, Koichi; Shen, Nan; Cherñavsky, Alejandra Claudia; Anaya, Juan Manuel; Nath, Swapan K.
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.
Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Qian, Xiaoxia. New York University Shanghai; China
Fil: Rojas Villarraga, Adriana. Universidad del Rosario; Corporación Para Investigaciones Biológicas; Bogotá; Colombia
Fil: Sun, Celi. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Cañas, Carlos. Fundación Valle del Lili; Colombia
Fil: Tobón, Gabriel J.. Fundación Valle del Lili; Colombia
Fil: Matsuda, Koichi. University of Tokyo; Japón
Fil: Shen, Nan. Shanghai Jiao Tong University School Of Medicine; China
Fil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Anaya, Juan Manuel. Universidad del Rosario; Colombia
Fil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados Unidos - Materia
-
ASIA
AUTOIMMUNITY
CD226
LATIN-AMERICA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/178745
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oai:ri.conicet.gov.ar:11336/178745 |
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3498 |
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CONICET Digital (CONICET) |
spelling |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseasesMaiti, Amit K.Kim Howard, XanaViswanathan, ParvathiGuillen, Laura CristinaQian, XiaoxiaRojas Villarraga, AdrianaSun, CeliCañas, CarlosTobón, Gabriel J.Matsuda, KoichiShen, NanCherñavsky, Alejandra ClaudiaAnaya, Juan ManuelNath, Swapan K.ASIAAUTOIMMUNITYCD226LATIN-AMERICAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados UnidosFil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados UnidosFil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados UnidosFil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Qian, Xiaoxia. New York University Shanghai; ChinaFil: Rojas Villarraga, Adriana. Universidad del Rosario; Corporación Para Investigaciones Biológicas; Bogotá; ColombiaFil: Sun, Celi. Oklahoma Medical Research Foundation; Estados UnidosFil: Cañas, Carlos. Fundación Valle del Lili; ColombiaFil: Tobón, Gabriel J.. Fundación Valle del Lili; ColombiaFil: Matsuda, Koichi. University of Tokyo; JapónFil: Shen, Nan. Shanghai Jiao Tong University School Of Medicine; ChinaFil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Anaya, Juan Manuel. Universidad del Rosario; ColombiaFil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados UnidosOxford University Press2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/178745Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Qian, Xiaoxia; et al.; Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases; Oxford University Press; Rheumatology (oxford, England); 49; 7; 3-2010; 1239-12441462-0324CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/doi:10.1093/rheumatology/kep470info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:40Zoai:ri.conicet.gov.ar:11336/178745instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:40.413CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
spellingShingle |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases Maiti, Amit K. ASIA AUTOIMMUNITY CD226 LATIN-AMERICA |
title_short |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title_full |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title_fullStr |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title_full_unstemmed |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title_sort |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
dc.creator.none.fl_str_mv |
Maiti, Amit K. Kim Howard, Xana Viswanathan, Parvathi Guillen, Laura Cristina Qian, Xiaoxia Rojas Villarraga, Adriana Sun, Celi Cañas, Carlos Tobón, Gabriel J. Matsuda, Koichi Shen, Nan Cherñavsky, Alejandra Claudia Anaya, Juan Manuel Nath, Swapan K. |
author |
Maiti, Amit K. |
author_facet |
Maiti, Amit K. Kim Howard, Xana Viswanathan, Parvathi Guillen, Laura Cristina Qian, Xiaoxia Rojas Villarraga, Adriana Sun, Celi Cañas, Carlos Tobón, Gabriel J. Matsuda, Koichi Shen, Nan Cherñavsky, Alejandra Claudia Anaya, Juan Manuel Nath, Swapan K. |
author_role |
author |
author2 |
Kim Howard, Xana Viswanathan, Parvathi Guillen, Laura Cristina Qian, Xiaoxia Rojas Villarraga, Adriana Sun, Celi Cañas, Carlos Tobón, Gabriel J. Matsuda, Koichi Shen, Nan Cherñavsky, Alejandra Claudia Anaya, Juan Manuel Nath, Swapan K. |
author2_role |
author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
ASIA AUTOIMMUNITY CD226 LATIN-AMERICA |
topic |
ASIA AUTOIMMUNITY CD226 LATIN-AMERICA |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados Unidos Fil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados Unidos Fil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados Unidos Fil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Qian, Xiaoxia. New York University Shanghai; China Fil: Rojas Villarraga, Adriana. Universidad del Rosario; Corporación Para Investigaciones Biológicas; Bogotá; Colombia Fil: Sun, Celi. Oklahoma Medical Research Foundation; Estados Unidos Fil: Cañas, Carlos. Fundación Valle del Lili; Colombia Fil: Tobón, Gabriel J.. Fundación Valle del Lili; Colombia Fil: Matsuda, Koichi. University of Tokyo; Japón Fil: Shen, Nan. Shanghai Jiao Tong University School Of Medicine; China Fil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina Fil: Anaya, Juan Manuel. Universidad del Rosario; Colombia Fil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados Unidos |
description |
Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/178745 Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Qian, Xiaoxia; et al.; Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases; Oxford University Press; Rheumatology (oxford, England); 49; 7; 3-2010; 1239-1244 1462-0324 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/178745 |
identifier_str_mv |
Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Qian, Xiaoxia; et al.; Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases; Oxford University Press; Rheumatology (oxford, England); 49; 7; 3-2010; 1239-1244 1462-0324 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/doi:10.1093/rheumatology/kep470 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613314691203072 |
score |
13.070432 |