Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

Autores
Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Qian, Xiaoxia; Rojas Villarraga, Adriana; Sun, Celi; Cañas, Carlos; Tobón, Gabriel J.; Matsuda, Koichi; Shen, Nan; Cherñavsky, Alejandra Claudia; Anaya, Juan Manuel; Nath, Swapan K.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.
Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Qian, Xiaoxia. New York University Shanghai; China
Fil: Rojas Villarraga, Adriana. Universidad del Rosario; Corporación Para Investigaciones Biológicas; Bogotá; Colombia
Fil: Sun, Celi. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Cañas, Carlos. Fundación Valle del Lili; Colombia
Fil: Tobón, Gabriel J.. Fundación Valle del Lili; Colombia
Fil: Matsuda, Koichi. University of Tokyo; Japón
Fil: Shen, Nan. Shanghai Jiao Tong University School Of Medicine; China
Fil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Anaya, Juan Manuel. Universidad del Rosario; Colombia
Fil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados Unidos
Materia
ASIA
AUTOIMMUNITY
CD226
LATIN-AMERICA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/178745

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseasesMaiti, Amit K.Kim Howard, XanaViswanathan, ParvathiGuillen, Laura CristinaQian, XiaoxiaRojas Villarraga, AdrianaSun, CeliCañas, CarlosTobón, Gabriel J.Matsuda, KoichiShen, NanCherñavsky, Alejandra ClaudiaAnaya, Juan ManuelNath, Swapan K.ASIAAUTOIMMUNITYCD226LATIN-AMERICAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados UnidosFil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados UnidosFil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados UnidosFil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Qian, Xiaoxia. New York University Shanghai; ChinaFil: Rojas Villarraga, Adriana. Universidad del Rosario; Corporación Para Investigaciones Biológicas; Bogotá; ColombiaFil: Sun, Celi. Oklahoma Medical Research Foundation; Estados UnidosFil: Cañas, Carlos. Fundación Valle del Lili; ColombiaFil: Tobón, Gabriel J.. Fundación Valle del Lili; ColombiaFil: Matsuda, Koichi. University of Tokyo; JapónFil: Shen, Nan. Shanghai Jiao Tong University School Of Medicine; ChinaFil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Anaya, Juan Manuel. Universidad del Rosario; ColombiaFil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados UnidosOxford University Press2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/178745Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Qian, Xiaoxia; et al.; Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases; Oxford University Press; Rheumatology (oxford, England); 49; 7; 3-2010; 1239-12441462-0324CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/doi:10.1093/rheumatology/kep470info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:40Zoai:ri.conicet.gov.ar:11336/178745instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:40.413CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
spellingShingle Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
Maiti, Amit K.
ASIA
AUTOIMMUNITY
CD226
LATIN-AMERICA
title_short Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title_full Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title_fullStr Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title_full_unstemmed Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title_sort Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
dc.creator.none.fl_str_mv Maiti, Amit K.
Kim Howard, Xana
Viswanathan, Parvathi
Guillen, Laura Cristina
Qian, Xiaoxia
Rojas Villarraga, Adriana
Sun, Celi
Cañas, Carlos
Tobón, Gabriel J.
Matsuda, Koichi
Shen, Nan
Cherñavsky, Alejandra Claudia
Anaya, Juan Manuel
Nath, Swapan K.
author Maiti, Amit K.
author_facet Maiti, Amit K.
Kim Howard, Xana
Viswanathan, Parvathi
Guillen, Laura Cristina
Qian, Xiaoxia
Rojas Villarraga, Adriana
Sun, Celi
Cañas, Carlos
Tobón, Gabriel J.
Matsuda, Koichi
Shen, Nan
Cherñavsky, Alejandra Claudia
Anaya, Juan Manuel
Nath, Swapan K.
author_role author
author2 Kim Howard, Xana
Viswanathan, Parvathi
Guillen, Laura Cristina
Qian, Xiaoxia
Rojas Villarraga, Adriana
Sun, Celi
Cañas, Carlos
Tobón, Gabriel J.
Matsuda, Koichi
Shen, Nan
Cherñavsky, Alejandra Claudia
Anaya, Juan Manuel
Nath, Swapan K.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ASIA
AUTOIMMUNITY
CD226
LATIN-AMERICA
topic ASIA
AUTOIMMUNITY
CD226
LATIN-AMERICA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.
Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Qian, Xiaoxia. New York University Shanghai; China
Fil: Rojas Villarraga, Adriana. Universidad del Rosario; Corporación Para Investigaciones Biológicas; Bogotá; Colombia
Fil: Sun, Celi. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Cañas, Carlos. Fundación Valle del Lili; Colombia
Fil: Tobón, Gabriel J.. Fundación Valle del Lili; Colombia
Fil: Matsuda, Koichi. University of Tokyo; Japón
Fil: Shen, Nan. Shanghai Jiao Tong University School Of Medicine; China
Fil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Anaya, Juan Manuel. Universidad del Rosario; Colombia
Fil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados Unidos
description Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/178745
Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Qian, Xiaoxia; et al.; Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases; Oxford University Press; Rheumatology (oxford, England); 49; 7; 3-2010; 1239-1244
1462-0324
CONICET Digital
CONICET
url http://hdl.handle.net/11336/178745
identifier_str_mv Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Qian, Xiaoxia; et al.; Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases; Oxford University Press; Rheumatology (oxford, England); 49; 7; 3-2010; 1239-1244
1462-0324
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/doi:10.1093/rheumatology/kep470
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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