Gene therapy for autoimmune diseases: quo vadis?

Autores
Chernajovsky, Yuti; Gould, David J.; Podhajcer, Osvaldo Luis
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Biological therapies using antibodies and cytokines are becoming widespread for the treatment of chronic inflammatory autoimmune diseases. However, these treatments have several limitations - such as expense, the need for repeated injections and unwanted side-effects - that can be overcome by genetic delivery. This review summarizes the ingenuity, sophistication and variety of gene-therapy approaches that have been taken in the design of therapeutic molecules and vectors, the engineering of cells and the regulation of gene expression for the targeting of disease outcome. We focus our attention on multiple sclerosis, type 1 diabetes and rheumatoid arthritis.
Fil: Chernajovsky, Yuti. University of London; Reino Unido
Fil: Gould, David J.. University of London; Reino Unido
Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
Gene
Therapy
Cancer
Autoimmunity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43066
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gene therapy for autoimmune diseases: quo vadis?Chernajovsky, YutiGould, David J.Podhajcer, Osvaldo LuisGeneTherapyCancerAutoimmunityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Biological therapies using antibodies and cytokines are becoming widespread for the treatment of chronic inflammatory autoimmune diseases. However, these treatments have several limitations - such as expense, the need for repeated injections and unwanted side-effects - that can be overcome by genetic delivery. This review summarizes the ingenuity, sophistication and variety of gene-therapy approaches that have been taken in the design of therapeutic molecules and vectors, the engineering of cells and the regulation of gene expression for the targeting of disease outcome. We focus our attention on multiple sclerosis, type 1 diabetes and rheumatoid arthritis.Fil: Chernajovsky, Yuti. University of London; Reino UnidoFil: Gould, David J.. University of London; Reino UnidoFil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaNature Publishing Group2004-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43066Chernajovsky, Yuti; Gould, David J.; Podhajcer, Osvaldo Luis; Gene therapy for autoimmune diseases: quo vadis?; Nature Publishing Group; Nature Reviews Immunology; 4; 10; 10-2004; 800-8111474-1733CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nri1459info:eu-repo/semantics/altIdentifier/doi/10.1038/nri1459info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:46Zoai:ri.conicet.gov.ar:11336/43066instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:47.16CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gene therapy for autoimmune diseases: quo vadis?
title Gene therapy for autoimmune diseases: quo vadis?
spellingShingle Gene therapy for autoimmune diseases: quo vadis?
Chernajovsky, Yuti
Gene
Therapy
Cancer
Autoimmunity
title_short Gene therapy for autoimmune diseases: quo vadis?
title_full Gene therapy for autoimmune diseases: quo vadis?
title_fullStr Gene therapy for autoimmune diseases: quo vadis?
title_full_unstemmed Gene therapy for autoimmune diseases: quo vadis?
title_sort Gene therapy for autoimmune diseases: quo vadis?
dc.creator.none.fl_str_mv Chernajovsky, Yuti
Gould, David J.
Podhajcer, Osvaldo Luis
author Chernajovsky, Yuti
author_facet Chernajovsky, Yuti
Gould, David J.
Podhajcer, Osvaldo Luis
author_role author
author2 Gould, David J.
Podhajcer, Osvaldo Luis
author2_role author
author
dc.subject.none.fl_str_mv Gene
Therapy
Cancer
Autoimmunity
topic Gene
Therapy
Cancer
Autoimmunity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Biological therapies using antibodies and cytokines are becoming widespread for the treatment of chronic inflammatory autoimmune diseases. However, these treatments have several limitations - such as expense, the need for repeated injections and unwanted side-effects - that can be overcome by genetic delivery. This review summarizes the ingenuity, sophistication and variety of gene-therapy approaches that have been taken in the design of therapeutic molecules and vectors, the engineering of cells and the regulation of gene expression for the targeting of disease outcome. We focus our attention on multiple sclerosis, type 1 diabetes and rheumatoid arthritis.
Fil: Chernajovsky, Yuti. University of London; Reino Unido
Fil: Gould, David J.. University of London; Reino Unido
Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description Biological therapies using antibodies and cytokines are becoming widespread for the treatment of chronic inflammatory autoimmune diseases. However, these treatments have several limitations - such as expense, the need for repeated injections and unwanted side-effects - that can be overcome by genetic delivery. This review summarizes the ingenuity, sophistication and variety of gene-therapy approaches that have been taken in the design of therapeutic molecules and vectors, the engineering of cells and the regulation of gene expression for the targeting of disease outcome. We focus our attention on multiple sclerosis, type 1 diabetes and rheumatoid arthritis.
publishDate 2004
dc.date.none.fl_str_mv 2004-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43066
Chernajovsky, Yuti; Gould, David J.; Podhajcer, Osvaldo Luis; Gene therapy for autoimmune diseases: quo vadis?; Nature Publishing Group; Nature Reviews Immunology; 4; 10; 10-2004; 800-811
1474-1733
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43066
identifier_str_mv Chernajovsky, Yuti; Gould, David J.; Podhajcer, Osvaldo Luis; Gene therapy for autoimmune diseases: quo vadis?; Nature Publishing Group; Nature Reviews Immunology; 4; 10; 10-2004; 800-811
1474-1733
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nri1459
info:eu-repo/semantics/altIdentifier/doi/10.1038/nri1459
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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