Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions
- Autores
- Morandi, Elena; Adoue, Véronique; Bernard, Isabelle; Friebel, Ekaterina; Núñez, Nicolás; Aubert, Yann; Masson, Frederick; Dejean, Anne S.; Becher, Burkhard; Astier, Anne; Martinet, Ludovic; Saoudi, Abdelhadi
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The rs763361 nonsynonymous variant in the CD226 gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated diseases, including multiple sclerosis (MS). Compelling evidence suggests that this allele may play a significant role in predisposing individuals to MS by decreasing the immune-regulatory capacity of Treg cells and increasing the proinflammatory potential of effector CD4 T cells. However, the impact of this CD226 gene variant on CD8 T-cell functions, a population that also plays a key role in MS, remains to be determined.
Fil: Morandi, Elena. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Adoue, Véronique. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Bernard, Isabelle. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Friebel, Ekaterina. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Núñez, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Aubert, Yann. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Masson, Frederick. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Dejean, Anne S.. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Becher, Burkhard. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Astier, Anne. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Martinet, Ludovic. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Saoudi, Abdelhadi. Université Paul Sabatier; Francia. Universitat Zurich; Suiza - Materia
-
MULTIPLE SCLEROSIS
CD226
RS763361 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/267699
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell FunctionsMorandi, ElenaAdoue, VéroniqueBernard, IsabelleFriebel, EkaterinaNúñez, NicolásAubert, YannMasson, FrederickDejean, Anne S.Becher, BurkhardAstier, AnneMartinet, LudovicSaoudi, AbdelhadiMULTIPLE SCLEROSISCD226RS763361https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The rs763361 nonsynonymous variant in the CD226 gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated diseases, including multiple sclerosis (MS). Compelling evidence suggests that this allele may play a significant role in predisposing individuals to MS by decreasing the immune-regulatory capacity of Treg cells and increasing the proinflammatory potential of effector CD4 T cells. However, the impact of this CD226 gene variant on CD8 T-cell functions, a population that also plays a key role in MS, remains to be determined.Fil: Morandi, Elena. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Adoue, Véronique. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Bernard, Isabelle. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Friebel, Ekaterina. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Núñez, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Aubert, Yann. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Masson, Frederick. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Dejean, Anne S.. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Becher, Burkhard. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Astier, Anne. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Martinet, Ludovic. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Saoudi, Abdelhadi. Université Paul Sabatier; Francia. Universitat Zurich; SuizaWolters Kluwer Health2024-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267699Morandi, Elena; Adoue, Véronique; Bernard, Isabelle; Friebel, Ekaterina; Núñez, Nicolás; et al.; Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions; Wolters Kluwer Health; Neurology Neuroimmunology & Neuroinflammation; 11; 6; 11-2024; 1-122332-7812CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.neurology.org/doi/10.1212/NXI.0000000000200306info:eu-repo/semantics/altIdentifier/doi/10.1212/NXI.0000000000200306info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:23Zoai:ri.conicet.gov.ar:11336/267699instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:23.423CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions |
title |
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions |
spellingShingle |
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions Morandi, Elena MULTIPLE SCLEROSIS CD226 RS763361 |
title_short |
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions |
title_full |
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions |
title_fullStr |
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions |
title_full_unstemmed |
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions |
title_sort |
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions |
dc.creator.none.fl_str_mv |
Morandi, Elena Adoue, Véronique Bernard, Isabelle Friebel, Ekaterina Núñez, Nicolás Aubert, Yann Masson, Frederick Dejean, Anne S. Becher, Burkhard Astier, Anne Martinet, Ludovic Saoudi, Abdelhadi |
author |
Morandi, Elena |
author_facet |
Morandi, Elena Adoue, Véronique Bernard, Isabelle Friebel, Ekaterina Núñez, Nicolás Aubert, Yann Masson, Frederick Dejean, Anne S. Becher, Burkhard Astier, Anne Martinet, Ludovic Saoudi, Abdelhadi |
author_role |
author |
author2 |
Adoue, Véronique Bernard, Isabelle Friebel, Ekaterina Núñez, Nicolás Aubert, Yann Masson, Frederick Dejean, Anne S. Becher, Burkhard Astier, Anne Martinet, Ludovic Saoudi, Abdelhadi |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
MULTIPLE SCLEROSIS CD226 RS763361 |
topic |
MULTIPLE SCLEROSIS CD226 RS763361 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The rs763361 nonsynonymous variant in the CD226 gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated diseases, including multiple sclerosis (MS). Compelling evidence suggests that this allele may play a significant role in predisposing individuals to MS by decreasing the immune-regulatory capacity of Treg cells and increasing the proinflammatory potential of effector CD4 T cells. However, the impact of this CD226 gene variant on CD8 T-cell functions, a population that also plays a key role in MS, remains to be determined. Fil: Morandi, Elena. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Adoue, Véronique. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Bernard, Isabelle. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Friebel, Ekaterina. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Núñez, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Aubert, Yann. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Masson, Frederick. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Dejean, Anne S.. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Becher, Burkhard. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Astier, Anne. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Martinet, Ludovic. Université Paul Sabatier; Francia. Universitat Zurich; Suiza Fil: Saoudi, Abdelhadi. Université Paul Sabatier; Francia. Universitat Zurich; Suiza |
description |
The rs763361 nonsynonymous variant in the CD226 gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated diseases, including multiple sclerosis (MS). Compelling evidence suggests that this allele may play a significant role in predisposing individuals to MS by decreasing the immune-regulatory capacity of Treg cells and increasing the proinflammatory potential of effector CD4 T cells. However, the impact of this CD226 gene variant on CD8 T-cell functions, a population that also plays a key role in MS, remains to be determined. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/267699 Morandi, Elena; Adoue, Véronique; Bernard, Isabelle; Friebel, Ekaterina; Núñez, Nicolás; et al.; Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions; Wolters Kluwer Health; Neurology Neuroimmunology & Neuroinflammation; 11; 6; 11-2024; 1-12 2332-7812 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/267699 |
identifier_str_mv |
Morandi, Elena; Adoue, Véronique; Bernard, Isabelle; Friebel, Ekaterina; Núñez, Nicolás; et al.; Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions; Wolters Kluwer Health; Neurology Neuroimmunology & Neuroinflammation; 11; 6; 11-2024; 1-12 2332-7812 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.neurology.org/doi/10.1212/NXI.0000000000200306 info:eu-repo/semantics/altIdentifier/doi/10.1212/NXI.0000000000200306 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wolters Kluwer Health |
publisher.none.fl_str_mv |
Wolters Kluwer Health |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614324442628096 |
score |
13.070432 |