Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions

Autores
Morandi, Elena; Adoue, Véronique; Bernard, Isabelle; Friebel, Ekaterina; Núñez, Nicolás; Aubert, Yann; Masson, Frederick; Dejean, Anne S.; Becher, Burkhard; Astier, Anne; Martinet, Ludovic; Saoudi, Abdelhadi
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The rs763361 nonsynonymous variant in the CD226 gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated diseases, including multiple sclerosis (MS). Compelling evidence suggests that this allele may play a significant role in predisposing individuals to MS by decreasing the immune-regulatory capacity of Treg cells and increasing the proinflammatory potential of effector CD4 T cells. However, the impact of this CD226 gene variant on CD8 T-cell functions, a population that also plays a key role in MS, remains to be determined.
Fil: Morandi, Elena. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Adoue, Véronique. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Bernard, Isabelle. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Friebel, Ekaterina. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Núñez, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Aubert, Yann. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Masson, Frederick. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Dejean, Anne S.. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Becher, Burkhard. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Astier, Anne. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Martinet, Ludovic. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Saoudi, Abdelhadi. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Materia
MULTIPLE SCLEROSIS
CD226
RS763361
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267699
Acceder
id CONICETDig_ee8238dd63735cc8459ecb5c73c56f57
oai_identifier_str oai:ri.conicet.gov.ar:11336/267699
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell FunctionsMorandi, ElenaAdoue, VéroniqueBernard, IsabelleFriebel, EkaterinaNúñez, NicolásAubert, YannMasson, FrederickDejean, Anne S.Becher, BurkhardAstier, AnneMartinet, LudovicSaoudi, AbdelhadiMULTIPLE SCLEROSISCD226RS763361https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The rs763361 nonsynonymous variant in the CD226 gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated diseases, including multiple sclerosis (MS). Compelling evidence suggests that this allele may play a significant role in predisposing individuals to MS by decreasing the immune-regulatory capacity of Treg cells and increasing the proinflammatory potential of effector CD4 T cells. However, the impact of this CD226 gene variant on CD8 T-cell functions, a population that also plays a key role in MS, remains to be determined.Fil: Morandi, Elena. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Adoue, Véronique. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Bernard, Isabelle. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Friebel, Ekaterina. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Núñez, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Aubert, Yann. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Masson, Frederick. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Dejean, Anne S.. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Becher, Burkhard. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Astier, Anne. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Martinet, Ludovic. Université Paul Sabatier; Francia. Universitat Zurich; SuizaFil: Saoudi, Abdelhadi. Université Paul Sabatier; Francia. Universitat Zurich; SuizaWolters Kluwer Health2024-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267699Morandi, Elena; Adoue, Véronique; Bernard, Isabelle; Friebel, Ekaterina; Núñez, Nicolás; et al.; Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions; Wolters Kluwer Health; Neurology Neuroimmunology & Neuroinflammation; 11; 6; 11-2024; 1-122332-7812CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.neurology.org/doi/10.1212/NXI.0000000000200306info:eu-repo/semantics/altIdentifier/doi/10.1212/NXI.0000000000200306info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:03:49Zoai:ri.conicet.gov.ar:11336/267699instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:03:49.393CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions
title Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions
spellingShingle Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions
Morandi, Elena
MULTIPLE SCLEROSIS
CD226
RS763361
title_short Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions
title_full Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions
title_fullStr Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions
title_full_unstemmed Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions
title_sort Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions
dc.creator.none.fl_str_mv Morandi, Elena
Adoue, Véronique
Bernard, Isabelle
Friebel, Ekaterina
Núñez, Nicolás
Aubert, Yann
Masson, Frederick
Dejean, Anne S.
Becher, Burkhard
Astier, Anne
Martinet, Ludovic
Saoudi, Abdelhadi
author Morandi, Elena
author_facet Morandi, Elena
Adoue, Véronique
Bernard, Isabelle
Friebel, Ekaterina
Núñez, Nicolás
Aubert, Yann
Masson, Frederick
Dejean, Anne S.
Becher, Burkhard
Astier, Anne
Martinet, Ludovic
Saoudi, Abdelhadi
author_role author
author2 Adoue, Véronique
Bernard, Isabelle
Friebel, Ekaterina
Núñez, Nicolás
Aubert, Yann
Masson, Frederick
Dejean, Anne S.
Becher, Burkhard
Astier, Anne
Martinet, Ludovic
Saoudi, Abdelhadi
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MULTIPLE SCLEROSIS
CD226
RS763361
topic MULTIPLE SCLEROSIS
CD226
RS763361
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The rs763361 nonsynonymous variant in the CD226 gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated diseases, including multiple sclerosis (MS). Compelling evidence suggests that this allele may play a significant role in predisposing individuals to MS by decreasing the immune-regulatory capacity of Treg cells and increasing the proinflammatory potential of effector CD4 T cells. However, the impact of this CD226 gene variant on CD8 T-cell functions, a population that also plays a key role in MS, remains to be determined.
Fil: Morandi, Elena. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Adoue, Véronique. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Bernard, Isabelle. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Friebel, Ekaterina. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Núñez, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Aubert, Yann. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Masson, Frederick. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Dejean, Anne S.. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Becher, Burkhard. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Astier, Anne. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Martinet, Ludovic. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
Fil: Saoudi, Abdelhadi. Université Paul Sabatier; Francia. Universitat Zurich; Suiza
description The rs763361 nonsynonymous variant in the CD226 gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated diseases, including multiple sclerosis (MS). Compelling evidence suggests that this allele may play a significant role in predisposing individuals to MS by decreasing the immune-regulatory capacity of Treg cells and increasing the proinflammatory potential of effector CD4 T cells. However, the impact of this CD226 gene variant on CD8 T-cell functions, a population that also plays a key role in MS, remains to be determined.
publishDate 2024
dc.date.none.fl_str_mv 2024-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267699
Morandi, Elena; Adoue, Véronique; Bernard, Isabelle; Friebel, Ekaterina; Núñez, Nicolás; et al.; Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions; Wolters Kluwer Health; Neurology Neuroimmunology & Neuroinflammation; 11; 6; 11-2024; 1-12
2332-7812
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267699
identifier_str_mv Morandi, Elena; Adoue, Véronique; Bernard, Isabelle; Friebel, Ekaterina; Núñez, Nicolás; et al.; Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions; Wolters Kluwer Health; Neurology Neuroimmunology & Neuroinflammation; 11; 6; 11-2024; 1-12
2332-7812
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.neurology.org/doi/10.1212/NXI.0000000000200306
info:eu-repo/semantics/altIdentifier/doi/10.1212/NXI.0000000000200306
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Health
publisher.none.fl_str_mv Wolters Kluwer Health
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782382795915264
score 12.982451

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