Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?

Autores
Rocha, Sandra Patricia; Pérez, Ana Rosa; Beloscar, Juan; Bottasso, Oscar Adelmo; Silber, Ariel Mariano
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Trypanosoma cruzi, the etiological agent of Chagas disease, is dependent on proline for a variety of processes, such as energy metabolism, host cell invasion, differentiation, and resistance to osmotic, metabolic, and oxidative stress. On this basis, we investigated a possible relationship between prolinemia and severity of T. cruzi infection in chronic patients, as reported here. The study population consisted of 112 subjects, separated into 83 chronically T. cruzi‐infected patients and 29 age‐matched healthy volunteers (control) of both sexes, recruited at the Chagas Disease Service from the Department of Cardiology, Hospital Provincial del Centenario de Rosario (Rosario, Argentina). Chagasic patients were separated into three groups: chronic asymptomatic, mild/moderate, and severe chronic chagasic cardiomyopathy (CCC) subjects. We observed a significant decrease of 11.7% in prolinemia in chagasic patients when compared to controls. Further analysis within the three groups of chagasic patients also revealed a statistically significant decrease of prolinemia in severe CCC patients compared to controls, showing a relative difference of 13.6% in proline concentrations. These data point to the possibility that collagen—which participates in the healing process of cardiac tissue—and proline metabolism in the myocardium could constitute new factors affecting the evolution of Chagas disease.
Fil: Rocha, Sandra Patricia. Universidade de Sao Paulo; Brasil
Fil: Pérez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Beloscar, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Silber, Ariel Mariano. Universidade de Sao Paulo; Brasil
Materia
CARDIOMYOPATHY
CHAGAS DISEASE
COLLAGEN
FIBROSIS
METABOLISM
PATHOLOGY
PROLINE
PROLINEMIA
SEVERE
TRYPANOSOMA CRUZI
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/149468
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/149468
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?Rocha, Sandra PatriciaPérez, Ana RosaBeloscar, JuanBottasso, Oscar AdelmoSilber, Ariel MarianoCARDIOMYOPATHYCHAGAS DISEASECOLLAGENFIBROSISMETABOLISMPATHOLOGYPROLINEPROLINEMIASEVERETRYPANOSOMA CRUZIhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Trypanosoma cruzi, the etiological agent of Chagas disease, is dependent on proline for a variety of processes, such as energy metabolism, host cell invasion, differentiation, and resistance to osmotic, metabolic, and oxidative stress. On this basis, we investigated a possible relationship between prolinemia and severity of T. cruzi infection in chronic patients, as reported here. The study population consisted of 112 subjects, separated into 83 chronically T. cruzi‐infected patients and 29 age‐matched healthy volunteers (control) of both sexes, recruited at the Chagas Disease Service from the Department of Cardiology, Hospital Provincial del Centenario de Rosario (Rosario, Argentina). Chagasic patients were separated into three groups: chronic asymptomatic, mild/moderate, and severe chronic chagasic cardiomyopathy (CCC) subjects. We observed a significant decrease of 11.7% in prolinemia in chagasic patients when compared to controls. Further analysis within the three groups of chagasic patients also revealed a statistically significant decrease of prolinemia in severe CCC patients compared to controls, showing a relative difference of 13.6% in proline concentrations. These data point to the possibility that collagen—which participates in the healing process of cardiac tissue—and proline metabolism in the myocardium could constitute new factors affecting the evolution of Chagas disease.Fil: Rocha, Sandra Patricia. Universidade de Sao Paulo; BrasilFil: Pérez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Beloscar, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Silber, Ariel Mariano. Universidade de Sao Paulo; BrasilMDPI2019-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/149468Rocha, Sandra Patricia; Pérez, Ana Rosa; Beloscar, Juan; Bottasso, Oscar Adelmo; Silber, Ariel Mariano; Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?; MDPI; Molecules; 24; 17; 8-2019; 1-61420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/24/17/3167info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules24173167info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:21Zoai:ri.conicet.gov.ar:11336/149468instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:10:22.006CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
title Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
spellingShingle Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
Rocha, Sandra Patricia
CARDIOMYOPATHY
CHAGAS DISEASE
COLLAGEN
FIBROSIS
METABOLISM
PATHOLOGY
PROLINE
PROLINEMIA
SEVERE
TRYPANOSOMA CRUZI
title_short Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
title_full Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
title_fullStr Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
title_full_unstemmed Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
title_sort Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
dc.creator.none.fl_str_mv Rocha, Sandra Patricia
Pérez, Ana Rosa
Beloscar, Juan
Bottasso, Oscar Adelmo
Silber, Ariel Mariano
author Rocha, Sandra Patricia
author_facet Rocha, Sandra Patricia
Pérez, Ana Rosa
Beloscar, Juan
Bottasso, Oscar Adelmo
Silber, Ariel Mariano
author_role author
author2 Pérez, Ana Rosa
Beloscar, Juan
Bottasso, Oscar Adelmo
Silber, Ariel Mariano
author2_role author
author
author
author
dc.subject.none.fl_str_mv CARDIOMYOPATHY
CHAGAS DISEASE
COLLAGEN
FIBROSIS
METABOLISM
PATHOLOGY
PROLINE
PROLINEMIA
SEVERE
TRYPANOSOMA CRUZI
topic CARDIOMYOPATHY
CHAGAS DISEASE
COLLAGEN
FIBROSIS
METABOLISM
PATHOLOGY
PROLINE
PROLINEMIA
SEVERE
TRYPANOSOMA CRUZI
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Trypanosoma cruzi, the etiological agent of Chagas disease, is dependent on proline for a variety of processes, such as energy metabolism, host cell invasion, differentiation, and resistance to osmotic, metabolic, and oxidative stress. On this basis, we investigated a possible relationship between prolinemia and severity of T. cruzi infection in chronic patients, as reported here. The study population consisted of 112 subjects, separated into 83 chronically T. cruzi‐infected patients and 29 age‐matched healthy volunteers (control) of both sexes, recruited at the Chagas Disease Service from the Department of Cardiology, Hospital Provincial del Centenario de Rosario (Rosario, Argentina). Chagasic patients were separated into three groups: chronic asymptomatic, mild/moderate, and severe chronic chagasic cardiomyopathy (CCC) subjects. We observed a significant decrease of 11.7% in prolinemia in chagasic patients when compared to controls. Further analysis within the three groups of chagasic patients also revealed a statistically significant decrease of prolinemia in severe CCC patients compared to controls, showing a relative difference of 13.6% in proline concentrations. These data point to the possibility that collagen—which participates in the healing process of cardiac tissue—and proline metabolism in the myocardium could constitute new factors affecting the evolution of Chagas disease.
Fil: Rocha, Sandra Patricia. Universidade de Sao Paulo; Brasil
Fil: Pérez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Beloscar, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Silber, Ariel Mariano. Universidade de Sao Paulo; Brasil
description Trypanosoma cruzi, the etiological agent of Chagas disease, is dependent on proline for a variety of processes, such as energy metabolism, host cell invasion, differentiation, and resistance to osmotic, metabolic, and oxidative stress. On this basis, we investigated a possible relationship between prolinemia and severity of T. cruzi infection in chronic patients, as reported here. The study population consisted of 112 subjects, separated into 83 chronically T. cruzi‐infected patients and 29 age‐matched healthy volunteers (control) of both sexes, recruited at the Chagas Disease Service from the Department of Cardiology, Hospital Provincial del Centenario de Rosario (Rosario, Argentina). Chagasic patients were separated into three groups: chronic asymptomatic, mild/moderate, and severe chronic chagasic cardiomyopathy (CCC) subjects. We observed a significant decrease of 11.7% in prolinemia in chagasic patients when compared to controls. Further analysis within the three groups of chagasic patients also revealed a statistically significant decrease of prolinemia in severe CCC patients compared to controls, showing a relative difference of 13.6% in proline concentrations. These data point to the possibility that collagen—which participates in the healing process of cardiac tissue—and proline metabolism in the myocardium could constitute new factors affecting the evolution of Chagas disease.
publishDate 2019
dc.date.none.fl_str_mv 2019-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/149468
Rocha, Sandra Patricia; Pérez, Ana Rosa; Beloscar, Juan; Bottasso, Oscar Adelmo; Silber, Ariel Mariano; Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?; MDPI; Molecules; 24; 17; 8-2019; 1-6
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/149468
identifier_str_mv Rocha, Sandra Patricia; Pérez, Ana Rosa; Beloscar, Juan; Bottasso, Oscar Adelmo; Silber, Ariel Mariano; Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?; MDPI; Molecules; 24; 17; 8-2019; 1-6
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/24/17/3167
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules24173167
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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