Immunomodulatory activity of Apis mellifera propolis from the North of Argentina

Autores
Sampietro, Diego Alejandro; Vattuone, Marta Amelia; Vattuone, Marta Amelia
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Propolis is a bee hive product with complex chemical composition that was used as medicine from ancient times. The immunomodulatory activity of partially purified propolis extracts (PPPEs), galangin and pinocembrin was studied through their in vitro effect on neutrophil chemotactic and phagocytic activities. PPPEs (15 samples from each of 10 different beehives) were more effective (around 45% and 50% for a concentration of 40 μg of PPPEs/mL of active substance) as chemotactic agents than galangin and pinocembrin (around 20 and 25%, respectively) and showed higher neutrophil phagocitic activity (270 ± 10% for beehive 10) than galangin and pinocembrin (180 ± 10 and 135 ± 9%, respectively). The highest effect of PPPEs can be attributed to a synergistic effect among components of PPPEs. The results of this study indicated that PPPEs, galangin and pinocembrin stimulate neutrophil chemotactic activity at various concentrations suggesting their possible use for patients suffering neutrophil disfunction. The nitro blue tetrazolium results indicated that the extracts and isolated flavonoids have the capacity to scavenge active radicals suggesting that they would be valuable in the treatment of diseases associated with free radical damage. Consequently, the in vitro results suggest a potential value of these propolis extracts in the medical field.
Fil: Sampietro, Diego Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Vattuone, Marta Amelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vattuone, Marta Amelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
Propolis
Galangin
Pinocembrin
Immunomodulatory
Apis Mellifera
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44566
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/44566
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Immunomodulatory activity of Apis mellifera propolis from the North of ArgentinaSampietro, Diego AlejandroVattuone, Marta AmeliaVattuone, Marta AmeliaPropolisGalanginPinocembrinImmunomodulatoryApis Melliferahttps://purl.org/becyt/ford/4.4https://purl.org/becyt/ford/4Propolis is a bee hive product with complex chemical composition that was used as medicine from ancient times. The immunomodulatory activity of partially purified propolis extracts (PPPEs), galangin and pinocembrin was studied through their in vitro effect on neutrophil chemotactic and phagocytic activities. PPPEs (15 samples from each of 10 different beehives) were more effective (around 45% and 50% for a concentration of 40 μg of PPPEs/mL of active substance) as chemotactic agents than galangin and pinocembrin (around 20 and 25%, respectively) and showed higher neutrophil phagocitic activity (270 ± 10% for beehive 10) than galangin and pinocembrin (180 ± 10 and 135 ± 9%, respectively). The highest effect of PPPEs can be attributed to a synergistic effect among components of PPPEs. The results of this study indicated that PPPEs, galangin and pinocembrin stimulate neutrophil chemotactic activity at various concentrations suggesting their possible use for patients suffering neutrophil disfunction. The nitro blue tetrazolium results indicated that the extracts and isolated flavonoids have the capacity to scavenge active radicals suggesting that they would be valuable in the treatment of diseases associated with free radical damage. Consequently, the in vitro results suggest a potential value of these propolis extracts in the medical field.Fil: Sampietro, Diego Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Vattuone, Marta Amelia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vattuone, Marta Amelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaElsevier Science2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44566Sampietro, Diego Alejandro; Vattuone, Marta Amelia; Vattuone, Marta Amelia; Immunomodulatory activity of Apis mellifera propolis from the North of Argentina; Elsevier Science; LWT - Food Science and Technology; 70; 7-2016; 9-150023-6438CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.lwt.2016.02.028info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0023643816301074info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:12Zoai:ri.conicet.gov.ar:11336/44566instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:12.663CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immunomodulatory activity of Apis mellifera propolis from the North of Argentina
title Immunomodulatory activity of Apis mellifera propolis from the North of Argentina
spellingShingle Immunomodulatory activity of Apis mellifera propolis from the North of Argentina
Sampietro, Diego Alejandro
Propolis
Galangin
Pinocembrin
Immunomodulatory
Apis Mellifera
title_short Immunomodulatory activity of Apis mellifera propolis from the North of Argentina
title_full Immunomodulatory activity of Apis mellifera propolis from the North of Argentina
title_fullStr Immunomodulatory activity of Apis mellifera propolis from the North of Argentina
title_full_unstemmed Immunomodulatory activity of Apis mellifera propolis from the North of Argentina
title_sort Immunomodulatory activity of Apis mellifera propolis from the North of Argentina
dc.creator.none.fl_str_mv Sampietro, Diego Alejandro
Vattuone, Marta Amelia
Vattuone, Marta Amelia
author Sampietro, Diego Alejandro
author_facet Sampietro, Diego Alejandro
Vattuone, Marta Amelia
author_role author
author2 Vattuone, Marta Amelia
author2_role author
dc.subject.none.fl_str_mv Propolis
Galangin
Pinocembrin
Immunomodulatory
Apis Mellifera
topic Propolis
Galangin
Pinocembrin
Immunomodulatory
Apis Mellifera
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.4
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Propolis is a bee hive product with complex chemical composition that was used as medicine from ancient times. The immunomodulatory activity of partially purified propolis extracts (PPPEs), galangin and pinocembrin was studied through their in vitro effect on neutrophil chemotactic and phagocytic activities. PPPEs (15 samples from each of 10 different beehives) were more effective (around 45% and 50% for a concentration of 40 μg of PPPEs/mL of active substance) as chemotactic agents than galangin and pinocembrin (around 20 and 25%, respectively) and showed higher neutrophil phagocitic activity (270 ± 10% for beehive 10) than galangin and pinocembrin (180 ± 10 and 135 ± 9%, respectively). The highest effect of PPPEs can be attributed to a synergistic effect among components of PPPEs. The results of this study indicated that PPPEs, galangin and pinocembrin stimulate neutrophil chemotactic activity at various concentrations suggesting their possible use for patients suffering neutrophil disfunction. The nitro blue tetrazolium results indicated that the extracts and isolated flavonoids have the capacity to scavenge active radicals suggesting that they would be valuable in the treatment of diseases associated with free radical damage. Consequently, the in vitro results suggest a potential value of these propolis extracts in the medical field.
Fil: Sampietro, Diego Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Vattuone, Marta Amelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vattuone, Marta Amelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Propolis is a bee hive product with complex chemical composition that was used as medicine from ancient times. The immunomodulatory activity of partially purified propolis extracts (PPPEs), galangin and pinocembrin was studied through their in vitro effect on neutrophil chemotactic and phagocytic activities. PPPEs (15 samples from each of 10 different beehives) were more effective (around 45% and 50% for a concentration of 40 μg of PPPEs/mL of active substance) as chemotactic agents than galangin and pinocembrin (around 20 and 25%, respectively) and showed higher neutrophil phagocitic activity (270 ± 10% for beehive 10) than galangin and pinocembrin (180 ± 10 and 135 ± 9%, respectively). The highest effect of PPPEs can be attributed to a synergistic effect among components of PPPEs. The results of this study indicated that PPPEs, galangin and pinocembrin stimulate neutrophil chemotactic activity at various concentrations suggesting their possible use for patients suffering neutrophil disfunction. The nitro blue tetrazolium results indicated that the extracts and isolated flavonoids have the capacity to scavenge active radicals suggesting that they would be valuable in the treatment of diseases associated with free radical damage. Consequently, the in vitro results suggest a potential value of these propolis extracts in the medical field.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44566
Sampietro, Diego Alejandro; Vattuone, Marta Amelia; Vattuone, Marta Amelia; Immunomodulatory activity of Apis mellifera propolis from the North of Argentina; Elsevier Science; LWT - Food Science and Technology; 70; 7-2016; 9-15
0023-6438
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44566
identifier_str_mv Sampietro, Diego Alejandro; Vattuone, Marta Amelia; Vattuone, Marta Amelia; Immunomodulatory activity of Apis mellifera propolis from the North of Argentina; Elsevier Science; LWT - Food Science and Technology; 70; 7-2016; 9-15
0023-6438
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lwt.2016.02.028
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0023643816301074
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613391550775296
score 13.070432

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