Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission

Autores
Volta, Bibiana; Bustos, Patricia Laura; González, Carolina; Natale, Maria Ailen; Perrone, Alina Elizabeth; Milduberger, Natalia Ayelen; Laucella, Susana Adriana; Bua, Jacqueline Elena
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Trypanosoma cruzi, the causative agent of Chagas disease, can be transmitted to the offspring of infected women, which constitutes an epidemiologically significant parasite transmission route in non-endemic areas. It is relevant to evaluate differentially expressed factors in T. cruzi-infected pregnant women as potential markers of Chagas congenital transmission.MethodsCirculating levels of twelve cytokines and chemokines were measured by ELISA or cytometric bead array in T. cruzi-infected and uninfected pregnant women in their second trimester of pregnancy, and control groups of T. cruzi-infected and uninfected non-pregnant women.ResultsT. cruzi-infected women showed a pro-inflammatory Th1-biased profile, with increased levels of TNF-α, IL-12p70, IL-15 and MIG. Uninfected pregnant women presented a biased response towards Th2/Th17/Treg profiles, with increased plasma levels of IL-5, IL-6, IL-1β, IL-17A and IL-10. Finally, we identified that high parasitemia together with low levels of TNF-α, IL-15, and IL-17, low TNF-α/IL-10 ratio, and high IL-12p70 levels are factors associated with an increased probability of Chagas congenital transmission.ConclusionsT. cruzi-infected pregnant women who did not transmit the infection to their babies exhibited a distinct pro-inflammatory cytokine profile that might serve as a potential predictive marker of congenital transmission.
Fil: Volta, Bibiana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Bustos, Patricia Laura. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: González, Carolina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Natale, Maria Ailen. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Milduberger, Natalia Ayelen. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Laucella, Susana Adriana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Materia
TRYPANOSOMA CRUZI
PREGNANCY
CYTOKINES
CONGENITAL TRANSMISSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/157695
Acceder
id CONICETDig_6054ad11e79ef3616dac2bd54c9ae256
oai_identifier_str oai:ri.conicet.gov.ar:11336/157695
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmissionVolta, BibianaBustos, Patricia LauraGonzález, CarolinaNatale, Maria AilenPerrone, Alina ElizabethMilduberger, Natalia AyelenLaucella, Susana AdrianaBua, Jacqueline ElenaTRYPANOSOMA CRUZIPREGNANCYCYTOKINESCONGENITAL TRANSMISSIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Trypanosoma cruzi, the causative agent of Chagas disease, can be transmitted to the offspring of infected women, which constitutes an epidemiologically significant parasite transmission route in non-endemic areas. It is relevant to evaluate differentially expressed factors in T. cruzi-infected pregnant women as potential markers of Chagas congenital transmission.MethodsCirculating levels of twelve cytokines and chemokines were measured by ELISA or cytometric bead array in T. cruzi-infected and uninfected pregnant women in their second trimester of pregnancy, and control groups of T. cruzi-infected and uninfected non-pregnant women.ResultsT. cruzi-infected women showed a pro-inflammatory Th1-biased profile, with increased levels of TNF-α, IL-12p70, IL-15 and MIG. Uninfected pregnant women presented a biased response towards Th2/Th17/Treg profiles, with increased plasma levels of IL-5, IL-6, IL-1β, IL-17A and IL-10. Finally, we identified that high parasitemia together with low levels of TNF-α, IL-15, and IL-17, low TNF-α/IL-10 ratio, and high IL-12p70 levels are factors associated with an increased probability of Chagas congenital transmission.ConclusionsT. cruzi-infected pregnant women who did not transmit the infection to their babies exhibited a distinct pro-inflammatory cytokine profile that might serve as a potential predictive marker of congenital transmission.Fil: Volta, Bibiana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Bustos, Patricia Laura. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: González, Carolina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Natale, Maria Ailen. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Milduberger, Natalia Ayelen. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Laucella, Susana Adriana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaUniversity of Chicago Press2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/157695Volta, Bibiana; Bustos, Patricia Laura; González, Carolina; Natale, Maria Ailen; Perrone, Alina Elizabeth; et al.; Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission; University of Chicago Press; Journal Of Infectious Diseases; 2; 6; 1-2021; 1086–10950022-1899CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article-abstract/224/6/1086/6126505info:eu-repo/semantics/altIdentifier/doi/10.1093/infdis/jiab057info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:18Zoai:ri.conicet.gov.ar:11336/157695instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:18.31CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission
title Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission
spellingShingle Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission
Volta, Bibiana
TRYPANOSOMA CRUZI
PREGNANCY
CYTOKINES
CONGENITAL TRANSMISSION
title_short Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission
title_full Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission
title_fullStr Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission
title_full_unstemmed Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission
title_sort Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission
dc.creator.none.fl_str_mv Volta, Bibiana
Bustos, Patricia Laura
González, Carolina
Natale, Maria Ailen
Perrone, Alina Elizabeth
Milduberger, Natalia Ayelen
Laucella, Susana Adriana
Bua, Jacqueline Elena
author Volta, Bibiana
author_facet Volta, Bibiana
Bustos, Patricia Laura
González, Carolina
Natale, Maria Ailen
Perrone, Alina Elizabeth
Milduberger, Natalia Ayelen
Laucella, Susana Adriana
Bua, Jacqueline Elena
author_role author
author2 Bustos, Patricia Laura
González, Carolina
Natale, Maria Ailen
Perrone, Alina Elizabeth
Milduberger, Natalia Ayelen
Laucella, Susana Adriana
Bua, Jacqueline Elena
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TRYPANOSOMA CRUZI
PREGNANCY
CYTOKINES
CONGENITAL TRANSMISSION
topic TRYPANOSOMA CRUZI
PREGNANCY
CYTOKINES
CONGENITAL TRANSMISSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Trypanosoma cruzi, the causative agent of Chagas disease, can be transmitted to the offspring of infected women, which constitutes an epidemiologically significant parasite transmission route in non-endemic areas. It is relevant to evaluate differentially expressed factors in T. cruzi-infected pregnant women as potential markers of Chagas congenital transmission.MethodsCirculating levels of twelve cytokines and chemokines were measured by ELISA or cytometric bead array in T. cruzi-infected and uninfected pregnant women in their second trimester of pregnancy, and control groups of T. cruzi-infected and uninfected non-pregnant women.ResultsT. cruzi-infected women showed a pro-inflammatory Th1-biased profile, with increased levels of TNF-α, IL-12p70, IL-15 and MIG. Uninfected pregnant women presented a biased response towards Th2/Th17/Treg profiles, with increased plasma levels of IL-5, IL-6, IL-1β, IL-17A and IL-10. Finally, we identified that high parasitemia together with low levels of TNF-α, IL-15, and IL-17, low TNF-α/IL-10 ratio, and high IL-12p70 levels are factors associated with an increased probability of Chagas congenital transmission.ConclusionsT. cruzi-infected pregnant women who did not transmit the infection to their babies exhibited a distinct pro-inflammatory cytokine profile that might serve as a potential predictive marker of congenital transmission.
Fil: Volta, Bibiana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Bustos, Patricia Laura. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: González, Carolina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Natale, Maria Ailen. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Milduberger, Natalia Ayelen. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Laucella, Susana Adriana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
description Trypanosoma cruzi, the causative agent of Chagas disease, can be transmitted to the offspring of infected women, which constitutes an epidemiologically significant parasite transmission route in non-endemic areas. It is relevant to evaluate differentially expressed factors in T. cruzi-infected pregnant women as potential markers of Chagas congenital transmission.MethodsCirculating levels of twelve cytokines and chemokines were measured by ELISA or cytometric bead array in T. cruzi-infected and uninfected pregnant women in their second trimester of pregnancy, and control groups of T. cruzi-infected and uninfected non-pregnant women.ResultsT. cruzi-infected women showed a pro-inflammatory Th1-biased profile, with increased levels of TNF-α, IL-12p70, IL-15 and MIG. Uninfected pregnant women presented a biased response towards Th2/Th17/Treg profiles, with increased plasma levels of IL-5, IL-6, IL-1β, IL-17A and IL-10. Finally, we identified that high parasitemia together with low levels of TNF-α, IL-15, and IL-17, low TNF-α/IL-10 ratio, and high IL-12p70 levels are factors associated with an increased probability of Chagas congenital transmission.ConclusionsT. cruzi-infected pregnant women who did not transmit the infection to their babies exhibited a distinct pro-inflammatory cytokine profile that might serve as a potential predictive marker of congenital transmission.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/157695
Volta, Bibiana; Bustos, Patricia Laura; González, Carolina; Natale, Maria Ailen; Perrone, Alina Elizabeth; et al.; Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission; University of Chicago Press; Journal Of Infectious Diseases; 2; 6; 1-2021; 1086–1095
0022-1899
CONICET Digital
CONICET
url http://hdl.handle.net/11336/157695
identifier_str_mv Volta, Bibiana; Bustos, Patricia Laura; González, Carolina; Natale, Maria Ailen; Perrone, Alina Elizabeth; et al.; Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission; University of Chicago Press; Journal Of Infectious Diseases; 2; 6; 1-2021; 1086–1095
0022-1899
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article-abstract/224/6/1086/6126505
info:eu-repo/semantics/altIdentifier/doi/10.1093/infdis/jiab057
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269630258741248
score 13.13397

Publicaciones similares