Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina

Autores
Blanco, Sonia B.; Segura, Elsa Leonor; Cura, Estela N.; Chuit, Roberto; Tulián, Liliana; Flores, Isolina; Garbarino, Gabriela; Villalonga, Juan F.; Gurtler, Ricardo Esteban
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We designed a set of procedures for first-line local health services to detect and treat the congenital transmission of Trypanosoma cruzi at a province-wide scale, and field-tested the programme in the province of Tucumam, northwestern Argentina, from 1992 to 1994. The programme consists of routine screening of pregnant women for seroreactivity to T. cruzi, serological and parasitological follow-up of the newborn at least twice during the first year of age, treatment of the infected infants, and evaluation of the outcome. 927 (5.5%) of 16 842 pregnant women were seroreactive to T. cruzi by indirect haemagglutination assay and ELISA. Twenty-one (6.7%) of 315 newborns to seroreactive mothers were diagnosed as infected with T. cruzi parasites microhaematocrit concentration before 30 days of age. Five newborns who initially tested negative had a T. cruzi infection detected by microhaematocrit and/or serological techniques at 3 or 6 months of age. Thus, congenital infection was diagnosed in 26 (7.1%) infants born to seroreactive women and residing in houses free of triatomine bugs. Four of 6 infants born to seroreactive mothers died during the first year of age and had some evidence of T. cruzi infection; one of the deaths was attributed to T. cruzi based on clinical evidence. After specific treatment with nifurtimox or benznidazole, 30 of 32 infants remained parasitologically and serologically negative. This study shows the feasibility of controlling the incidence of congenitally acquired T. cruzi infections at a province-wide scale by means of a specific screening programme at first-line health services level.
Fil: Blanco, Sonia B.. Servicio Nacional de Chagas; Argentina
Fil: Segura, Elsa Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Cura, Estela N.. Centro de Control de Calidad de Biológicos; Argentina
Fil: Chuit, Roberto. Secretaría de Salud de la Nación; Argentina
Fil: Tulián, Liliana. Servicio Nacional de Chagas; Argentina
Fil: Flores, Isolina. Maternidad de Nuestra Señora de la Merced; Argentina
Fil: Garbarino, Gabriela. Maternidad de Nuestra Señora de la Merced; Argentina
Fil: Villalonga, Juan F.. Hospital Pediátrico del Niño Jesús; Argentina
Fil: Gurtler, Ricardo Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Materia
Benznidazole
Chagas Disease
Congenital
Control
Nifurtimox
Serodiag Nosis
Transmission
Trypanosomiasis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71637
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/71637
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern ArgentinaBlanco, Sonia B.Segura, Elsa LeonorCura, Estela N.Chuit, RobertoTulián, LilianaFlores, IsolinaGarbarino, GabrielaVillalonga, Juan F.Gurtler, Ricardo EstebanBenznidazoleChagas DiseaseCongenitalControlNifurtimoxSerodiag NosisTransmissionTrypanosomiasishttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3We designed a set of procedures for first-line local health services to detect and treat the congenital transmission of Trypanosoma cruzi at a province-wide scale, and field-tested the programme in the province of Tucumam, northwestern Argentina, from 1992 to 1994. The programme consists of routine screening of pregnant women for seroreactivity to T. cruzi, serological and parasitological follow-up of the newborn at least twice during the first year of age, treatment of the infected infants, and evaluation of the outcome. 927 (5.5%) of 16 842 pregnant women were seroreactive to T. cruzi by indirect haemagglutination assay and ELISA. Twenty-one (6.7%) of 315 newborns to seroreactive mothers were diagnosed as infected with T. cruzi parasites microhaematocrit concentration before 30 days of age. Five newborns who initially tested negative had a T. cruzi infection detected by microhaematocrit and/or serological techniques at 3 or 6 months of age. Thus, congenital infection was diagnosed in 26 (7.1%) infants born to seroreactive women and residing in houses free of triatomine bugs. Four of 6 infants born to seroreactive mothers died during the first year of age and had some evidence of T. cruzi infection; one of the deaths was attributed to T. cruzi based on clinical evidence. After specific treatment with nifurtimox or benznidazole, 30 of 32 infants remained parasitologically and serologically negative. This study shows the feasibility of controlling the incidence of congenitally acquired T. cruzi infections at a province-wide scale by means of a specific screening programme at first-line health services level.Fil: Blanco, Sonia B.. Servicio Nacional de Chagas; ArgentinaFil: Segura, Elsa Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Cura, Estela N.. Centro de Control de Calidad de Biológicos; ArgentinaFil: Chuit, Roberto. Secretaría de Salud de la Nación; ArgentinaFil: Tulián, Liliana. Servicio Nacional de Chagas; ArgentinaFil: Flores, Isolina. Maternidad de Nuestra Señora de la Merced; ArgentinaFil: Garbarino, Gabriela. Maternidad de Nuestra Señora de la Merced; ArgentinaFil: Villalonga, Juan F.. Hospital Pediátrico del Niño Jesús; ArgentinaFil: Gurtler, Ricardo Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaWiley Blackwell Publishing, Inc2000-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71637Blanco, Sonia B.; Segura, Elsa Leonor; Cura, Estela N.; Chuit, Roberto; Tulián, Liliana; et al.; Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina; Wiley Blackwell Publishing, Inc; Tropical Medicine And International Health; 5; 4; 5-2000; 293-3011360-2276CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1046/j.1365-3156.2000.00548.xinfo:eu-repo/semantics/altIdentifier/doi/10.1046/j.1365-3156.2000.00548.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:12Zoai:ri.conicet.gov.ar:11336/71637instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:12.675CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina
title Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina
spellingShingle Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina
Blanco, Sonia B.
Benznidazole
Chagas Disease
Congenital
Control
Nifurtimox
Serodiag Nosis
Transmission
Trypanosomiasis
title_short Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina
title_full Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina
title_fullStr Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina
title_full_unstemmed Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina
title_sort Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina
dc.creator.none.fl_str_mv Blanco, Sonia B.
Segura, Elsa Leonor
Cura, Estela N.
Chuit, Roberto
Tulián, Liliana
Flores, Isolina
Garbarino, Gabriela
Villalonga, Juan F.
Gurtler, Ricardo Esteban
author Blanco, Sonia B.
author_facet Blanco, Sonia B.
Segura, Elsa Leonor
Cura, Estela N.
Chuit, Roberto
Tulián, Liliana
Flores, Isolina
Garbarino, Gabriela
Villalonga, Juan F.
Gurtler, Ricardo Esteban
author_role author
author2 Segura, Elsa Leonor
Cura, Estela N.
Chuit, Roberto
Tulián, Liliana
Flores, Isolina
Garbarino, Gabriela
Villalonga, Juan F.
Gurtler, Ricardo Esteban
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Benznidazole
Chagas Disease
Congenital
Control
Nifurtimox
Serodiag Nosis
Transmission
Trypanosomiasis
topic Benznidazole
Chagas Disease
Congenital
Control
Nifurtimox
Serodiag Nosis
Transmission
Trypanosomiasis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We designed a set of procedures for first-line local health services to detect and treat the congenital transmission of Trypanosoma cruzi at a province-wide scale, and field-tested the programme in the province of Tucumam, northwestern Argentina, from 1992 to 1994. The programme consists of routine screening of pregnant women for seroreactivity to T. cruzi, serological and parasitological follow-up of the newborn at least twice during the first year of age, treatment of the infected infants, and evaluation of the outcome. 927 (5.5%) of 16 842 pregnant women were seroreactive to T. cruzi by indirect haemagglutination assay and ELISA. Twenty-one (6.7%) of 315 newborns to seroreactive mothers were diagnosed as infected with T. cruzi parasites microhaematocrit concentration before 30 days of age. Five newborns who initially tested negative had a T. cruzi infection detected by microhaematocrit and/or serological techniques at 3 or 6 months of age. Thus, congenital infection was diagnosed in 26 (7.1%) infants born to seroreactive women and residing in houses free of triatomine bugs. Four of 6 infants born to seroreactive mothers died during the first year of age and had some evidence of T. cruzi infection; one of the deaths was attributed to T. cruzi based on clinical evidence. After specific treatment with nifurtimox or benznidazole, 30 of 32 infants remained parasitologically and serologically negative. This study shows the feasibility of controlling the incidence of congenitally acquired T. cruzi infections at a province-wide scale by means of a specific screening programme at first-line health services level.
Fil: Blanco, Sonia B.. Servicio Nacional de Chagas; Argentina
Fil: Segura, Elsa Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Cura, Estela N.. Centro de Control de Calidad de Biológicos; Argentina
Fil: Chuit, Roberto. Secretaría de Salud de la Nación; Argentina
Fil: Tulián, Liliana. Servicio Nacional de Chagas; Argentina
Fil: Flores, Isolina. Maternidad de Nuestra Señora de la Merced; Argentina
Fil: Garbarino, Gabriela. Maternidad de Nuestra Señora de la Merced; Argentina
Fil: Villalonga, Juan F.. Hospital Pediátrico del Niño Jesús; Argentina
Fil: Gurtler, Ricardo Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
description We designed a set of procedures for first-line local health services to detect and treat the congenital transmission of Trypanosoma cruzi at a province-wide scale, and field-tested the programme in the province of Tucumam, northwestern Argentina, from 1992 to 1994. The programme consists of routine screening of pregnant women for seroreactivity to T. cruzi, serological and parasitological follow-up of the newborn at least twice during the first year of age, treatment of the infected infants, and evaluation of the outcome. 927 (5.5%) of 16 842 pregnant women were seroreactive to T. cruzi by indirect haemagglutination assay and ELISA. Twenty-one (6.7%) of 315 newborns to seroreactive mothers were diagnosed as infected with T. cruzi parasites microhaematocrit concentration before 30 days of age. Five newborns who initially tested negative had a T. cruzi infection detected by microhaematocrit and/or serological techniques at 3 or 6 months of age. Thus, congenital infection was diagnosed in 26 (7.1%) infants born to seroreactive women and residing in houses free of triatomine bugs. Four of 6 infants born to seroreactive mothers died during the first year of age and had some evidence of T. cruzi infection; one of the deaths was attributed to T. cruzi based on clinical evidence. After specific treatment with nifurtimox or benznidazole, 30 of 32 infants remained parasitologically and serologically negative. This study shows the feasibility of controlling the incidence of congenitally acquired T. cruzi infections at a province-wide scale by means of a specific screening programme at first-line health services level.
publishDate 2000
dc.date.none.fl_str_mv 2000-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71637
Blanco, Sonia B.; Segura, Elsa Leonor; Cura, Estela N.; Chuit, Roberto; Tulián, Liliana; et al.; Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina; Wiley Blackwell Publishing, Inc; Tropical Medicine And International Health; 5; 4; 5-2000; 293-301
1360-2276
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71637
identifier_str_mv Blanco, Sonia B.; Segura, Elsa Leonor; Cura, Estela N.; Chuit, Roberto; Tulián, Liliana; et al.; Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina; Wiley Blackwell Publishing, Inc; Tropical Medicine And International Health; 5; 4; 5-2000; 293-301
1360-2276
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1046/j.1365-3156.2000.00548.x
info:eu-repo/semantics/altIdentifier/doi/10.1046/j.1365-3156.2000.00548.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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