Fluoride inhibition of oxygen consumption and increased oxidative stress in rats

Autores
Fina, Brenda Lorena; Brance, María Lorena; Brun, Lucas Ricardo Martín; Rigalli, Alfredo
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to evaluate the effect of fluoride (F) on oxygen consumption (VO2) in rats and how it might affect the respiratory chain and the levels of reactive oxygen species (ROS). Eighteen Sprague-Dawley rats were divided into three groups: Control, NaF20, and NaF40,which received 0, 20, and 40 µmol F/100 g bw/day for 30 days, respectively. In vivo, VO2 decreased 90 min after treatment with F, whereas TBARS, CAT, and GPx were higher. In vitro, F decreased VO2in liver and in mitochondria. These results support the hypothesis that the bone inflammatory foci observed in treatments with NaF could involve an inhibition of the respiratory chain that would cause increase in reactive oxygen species (ROS).
Fil: Fina, Brenda Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Brance, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Brun, Lucas Ricardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Rigalli, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Materia
LIVER
FLUORIDE AND OXYGEN IN RATS
MITOCHONDRIA
OXIDATIVE STRESS
RAT OXYGEN CONSUMPTION
REACTIVE OXYGEN SPECIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271231
Acceder
id CONICETDig_5f78db4b3050098cc9348979943b09e3
oai_identifier_str oai:ri.conicet.gov.ar:11336/271231
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fluoride inhibition of oxygen consumption and increased oxidative stress in ratsFina, Brenda LorenaBrance, María LorenaBrun, Lucas Ricardo MartínRigalli, AlfredoLIVERFLUORIDE AND OXYGEN IN RATSMITOCHONDRIAOXIDATIVE STRESSRAT OXYGEN CONSUMPTIONREACTIVE OXYGEN SPECIEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of this work was to evaluate the effect of fluoride (F) on oxygen consumption (VO2) in rats and how it might affect the respiratory chain and the levels of reactive oxygen species (ROS). Eighteen Sprague-Dawley rats were divided into three groups: Control, NaF20, and NaF40,which received 0, 20, and 40 µmol F/100 g bw/day for 30 days, respectively. In vivo, VO2 decreased 90 min after treatment with F, whereas TBARS, CAT, and GPx were higher. In vitro, F decreased VO2in liver and in mitochondria. These results support the hypothesis that the bone inflammatory foci observed in treatments with NaF could involve an inhibition of the respiratory chain that would cause increase in reactive oxygen species (ROS).Fil: Fina, Brenda Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Brance, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Brun, Lucas Ricardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Rigalli, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaInternational Society for Fluoride Research2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271231Fina, Brenda Lorena; Brance, María Lorena; Brun, Lucas Ricardo Martín; Rigalli, Alfredo; Fluoride inhibition of oxygen consumption and increased oxidative stress in rats; International Society for Fluoride Research; Fluoride; 45; 4; 12-2012; 343-3480015-4725CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.fluorideresearch.org/454/files/FJ2012_v45_n4_p343-348_sfs.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:19Zoai:ri.conicet.gov.ar:11336/271231instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:19.778CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fluoride inhibition of oxygen consumption and increased oxidative stress in rats
title Fluoride inhibition of oxygen consumption and increased oxidative stress in rats
spellingShingle Fluoride inhibition of oxygen consumption and increased oxidative stress in rats
Fina, Brenda Lorena
LIVER
FLUORIDE AND OXYGEN IN RATS
MITOCHONDRIA
OXIDATIVE STRESS
RAT OXYGEN CONSUMPTION
REACTIVE OXYGEN SPECIES
title_short Fluoride inhibition of oxygen consumption and increased oxidative stress in rats
title_full Fluoride inhibition of oxygen consumption and increased oxidative stress in rats
title_fullStr Fluoride inhibition of oxygen consumption and increased oxidative stress in rats
title_full_unstemmed Fluoride inhibition of oxygen consumption and increased oxidative stress in rats
title_sort Fluoride inhibition of oxygen consumption and increased oxidative stress in rats
dc.creator.none.fl_str_mv Fina, Brenda Lorena
Brance, María Lorena
Brun, Lucas Ricardo Martín
Rigalli, Alfredo
author Fina, Brenda Lorena
author_facet Fina, Brenda Lorena
Brance, María Lorena
Brun, Lucas Ricardo Martín
Rigalli, Alfredo
author_role author
author2 Brance, María Lorena
Brun, Lucas Ricardo Martín
Rigalli, Alfredo
author2_role author
author
author
dc.subject.none.fl_str_mv LIVER
FLUORIDE AND OXYGEN IN RATS
MITOCHONDRIA
OXIDATIVE STRESS
RAT OXYGEN CONSUMPTION
REACTIVE OXYGEN SPECIES
topic LIVER
FLUORIDE AND OXYGEN IN RATS
MITOCHONDRIA
OXIDATIVE STRESS
RAT OXYGEN CONSUMPTION
REACTIVE OXYGEN SPECIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this work was to evaluate the effect of fluoride (F) on oxygen consumption (VO2) in rats and how it might affect the respiratory chain and the levels of reactive oxygen species (ROS). Eighteen Sprague-Dawley rats were divided into three groups: Control, NaF20, and NaF40,which received 0, 20, and 40 µmol F/100 g bw/day for 30 days, respectively. In vivo, VO2 decreased 90 min after treatment with F, whereas TBARS, CAT, and GPx were higher. In vitro, F decreased VO2in liver and in mitochondria. These results support the hypothesis that the bone inflammatory foci observed in treatments with NaF could involve an inhibition of the respiratory chain that would cause increase in reactive oxygen species (ROS).
Fil: Fina, Brenda Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Brance, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Brun, Lucas Ricardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Rigalli, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
description The aim of this work was to evaluate the effect of fluoride (F) on oxygen consumption (VO2) in rats and how it might affect the respiratory chain and the levels of reactive oxygen species (ROS). Eighteen Sprague-Dawley rats were divided into three groups: Control, NaF20, and NaF40,which received 0, 20, and 40 µmol F/100 g bw/day for 30 days, respectively. In vivo, VO2 decreased 90 min after treatment with F, whereas TBARS, CAT, and GPx were higher. In vitro, F decreased VO2in liver and in mitochondria. These results support the hypothesis that the bone inflammatory foci observed in treatments with NaF could involve an inhibition of the respiratory chain that would cause increase in reactive oxygen species (ROS).
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271231
Fina, Brenda Lorena; Brance, María Lorena; Brun, Lucas Ricardo Martín; Rigalli, Alfredo; Fluoride inhibition of oxygen consumption and increased oxidative stress in rats; International Society for Fluoride Research; Fluoride; 45; 4; 12-2012; 343-348
0015-4725
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271231
identifier_str_mv Fina, Brenda Lorena; Brance, María Lorena; Brun, Lucas Ricardo Martín; Rigalli, Alfredo; Fluoride inhibition of oxygen consumption and increased oxidative stress in rats; International Society for Fluoride Research; Fluoride; 45; 4; 12-2012; 343-348
0015-4725
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.fluorideresearch.org/454/files/FJ2012_v45_n4_p343-348_sfs.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Society for Fluoride Research
publisher.none.fl_str_mv International Society for Fluoride Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613447447216128
score 13.070432

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