Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats

Autores
Polizio, Ariel Héctor; Gonzales, Soledad; Muñoz, Marina Cecilia; Peña, Clara; Tomaro, Maria Lujan
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
1. Addition of fructose to a rat diet for various time periods leads to hypertension, hyperinsulinemia and dyslipidemia and provides a model for testing oxidative stress parameters in the animals. 2. The oxidative stress generation, the soluble and enzymatic defense system and the heme oxygenase-1 protein expression were studied in heart, liver and kidney of fructose-fed rats during one or eight months. 3. In comparison with the control group, fructose-hypertensive rats showed only in heart increased in lipid peroxidation after both periods of fructose treatment. The behavior of soluble and enzymatic defense system and heme oxygenase-1 protein expression changed differently depending on the organ. Increased or unaltered activities of antioxidant enzymes were found in liver and kidney, respectively. The heme oxygenase-1 induction prevented the oxidative stress generation in liver, where the activity of antioxidant defense enzymes was not reduced. Increased heme oxygenase protein expression was not able to avoid the oxidative stress generation in heart where fructose treatment diminished the activity of antioxidant enzymes. 4. The results obtained demonstrated that up-regulation of HO-1 may prevent oxidative stress generation only when the antioxidant defense system remains still operative.
Fil: Polizio, Ariel Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Gonzales, Soledad. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Muñoz, Marina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Peña, Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Tomaro, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias. Grupo Vinculado Al Cipyp - Ffyb; Argentina
Materia
ANTI-OXIDANT ENZYMES
FRUCTOSE HYPERTENSION
HEME OXYGENASE
OXIDATIVE STRESS
RATS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/116948
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/116948
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive ratsPolizio, Ariel HéctorGonzales, SoledadMuñoz, Marina CeciliaPeña, ClaraTomaro, Maria LujanANTI-OXIDANT ENZYMESFRUCTOSE HYPERTENSIONHEME OXYGENASEOXIDATIVE STRESSRATShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/11. Addition of fructose to a rat diet for various time periods leads to hypertension, hyperinsulinemia and dyslipidemia and provides a model for testing oxidative stress parameters in the animals. 2. The oxidative stress generation, the soluble and enzymatic defense system and the heme oxygenase-1 protein expression were studied in heart, liver and kidney of fructose-fed rats during one or eight months. 3. In comparison with the control group, fructose-hypertensive rats showed only in heart increased in lipid peroxidation after both periods of fructose treatment. The behavior of soluble and enzymatic defense system and heme oxygenase-1 protein expression changed differently depending on the organ. Increased or unaltered activities of antioxidant enzymes were found in liver and kidney, respectively. The heme oxygenase-1 induction prevented the oxidative stress generation in liver, where the activity of antioxidant defense enzymes was not reduced. Increased heme oxygenase protein expression was not able to avoid the oxidative stress generation in heart where fructose treatment diminished the activity of antioxidant enzymes. 4. The results obtained demonstrated that up-regulation of HO-1 may prevent oxidative stress generation only when the antioxidant defense system remains still operative.Fil: Polizio, Ariel Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; ArgentinaFil: Gonzales, Soledad. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; ArgentinaFil: Muñoz, Marina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; ArgentinaFil: Peña, Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; ArgentinaFil: Tomaro, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias. Grupo Vinculado Al Cipyp - Ffyb; ArgentinaWiley Blackwell Publishing, Inc2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/116948Polizio, Ariel Héctor; Gonzales, Soledad; Muñoz, Marina Cecilia; Peña, Clara; Tomaro, Maria Lujan; Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats; Wiley Blackwell Publishing, Inc; Clinical and Experimental Pharmacology and Physiology; 33; 8; 12-2006; 734-7390305-1870CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1681.2006.04426.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1440-1681.2006.04426.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:02Zoai:ri.conicet.gov.ar:11336/116948instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:03.13CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
title Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
spellingShingle Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
Polizio, Ariel Héctor
ANTI-OXIDANT ENZYMES
FRUCTOSE HYPERTENSION
HEME OXYGENASE
OXIDATIVE STRESS
RATS
title_short Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
title_full Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
title_fullStr Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
title_full_unstemmed Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
title_sort Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
dc.creator.none.fl_str_mv Polizio, Ariel Héctor
Gonzales, Soledad
Muñoz, Marina Cecilia
Peña, Clara
Tomaro, Maria Lujan
author Polizio, Ariel Héctor
author_facet Polizio, Ariel Héctor
Gonzales, Soledad
Muñoz, Marina Cecilia
Peña, Clara
Tomaro, Maria Lujan
author_role author
author2 Gonzales, Soledad
Muñoz, Marina Cecilia
Peña, Clara
Tomaro, Maria Lujan
author2_role author
author
author
author
dc.subject.none.fl_str_mv ANTI-OXIDANT ENZYMES
FRUCTOSE HYPERTENSION
HEME OXYGENASE
OXIDATIVE STRESS
RATS
topic ANTI-OXIDANT ENZYMES
FRUCTOSE HYPERTENSION
HEME OXYGENASE
OXIDATIVE STRESS
RATS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv 1. Addition of fructose to a rat diet for various time periods leads to hypertension, hyperinsulinemia and dyslipidemia and provides a model for testing oxidative stress parameters in the animals. 2. The oxidative stress generation, the soluble and enzymatic defense system and the heme oxygenase-1 protein expression were studied in heart, liver and kidney of fructose-fed rats during one or eight months. 3. In comparison with the control group, fructose-hypertensive rats showed only in heart increased in lipid peroxidation after both periods of fructose treatment. The behavior of soluble and enzymatic defense system and heme oxygenase-1 protein expression changed differently depending on the organ. Increased or unaltered activities of antioxidant enzymes were found in liver and kidney, respectively. The heme oxygenase-1 induction prevented the oxidative stress generation in liver, where the activity of antioxidant defense enzymes was not reduced. Increased heme oxygenase protein expression was not able to avoid the oxidative stress generation in heart where fructose treatment diminished the activity of antioxidant enzymes. 4. The results obtained demonstrated that up-regulation of HO-1 may prevent oxidative stress generation only when the antioxidant defense system remains still operative.
Fil: Polizio, Ariel Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Gonzales, Soledad. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Muñoz, Marina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Peña, Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Tomaro, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias. Grupo Vinculado Al Cipyp - Ffyb; Argentina
description 1. Addition of fructose to a rat diet for various time periods leads to hypertension, hyperinsulinemia and dyslipidemia and provides a model for testing oxidative stress parameters in the animals. 2. The oxidative stress generation, the soluble and enzymatic defense system and the heme oxygenase-1 protein expression were studied in heart, liver and kidney of fructose-fed rats during one or eight months. 3. In comparison with the control group, fructose-hypertensive rats showed only in heart increased in lipid peroxidation after both periods of fructose treatment. The behavior of soluble and enzymatic defense system and heme oxygenase-1 protein expression changed differently depending on the organ. Increased or unaltered activities of antioxidant enzymes were found in liver and kidney, respectively. The heme oxygenase-1 induction prevented the oxidative stress generation in liver, where the activity of antioxidant defense enzymes was not reduced. Increased heme oxygenase protein expression was not able to avoid the oxidative stress generation in heart where fructose treatment diminished the activity of antioxidant enzymes. 4. The results obtained demonstrated that up-regulation of HO-1 may prevent oxidative stress generation only when the antioxidant defense system remains still operative.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/116948
Polizio, Ariel Héctor; Gonzales, Soledad; Muñoz, Marina Cecilia; Peña, Clara; Tomaro, Maria Lujan; Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats; Wiley Blackwell Publishing, Inc; Clinical and Experimental Pharmacology and Physiology; 33; 8; 12-2006; 734-739
0305-1870
CONICET Digital
CONICET
url http://hdl.handle.net/11336/116948
identifier_str_mv Polizio, Ariel Héctor; Gonzales, Soledad; Muñoz, Marina Cecilia; Peña, Clara; Tomaro, Maria Lujan; Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats; Wiley Blackwell Publishing, Inc; Clinical and Experimental Pharmacology and Physiology; 33; 8; 12-2006; 734-739
0305-1870
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1681.2006.04426.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1440-1681.2006.04426.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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