Microenvironment and endocrine resistance in breast cancer: Friend or foe?

Autores
Recouvreux, Sol; Sampayo, Rocío Guadalupe; Díaz Bessone, María Inés; Simian, Marina
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Breast cancer affects one in eight women around the world. Seventy five percent of these patients have tumors that are estrogen receptor positive and as a consequence receive endocrine therapy. However, about one third eventually develop resistance and cancer reappears. In the last decade our vision of cancer has evolved to consider it more of a tissuerelated disease than a cell-centered one. This editorial argues that we are only starting to understand the role the tumor microenvironment plays in therapy resistance in breast cancer. The development of new therapeutic strategies that target the microenvironment will come when we clearly understand this extremely complicated scenario. As such, and as a scientific community, we have extremely challenging work ahead. We share our views regarding these matters.
Fil: Recouvreux, Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Sampayo, Rocío Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Díaz Bessone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Simian, Marina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
AROMATASE INHIBITORS
BREAST CANCER
CANCER STEM CELLS
ENDOCRINE RESISTANCE
ESTROGEN RECEPTOR
STROMA
TAMOXIFEN
TUMOR MICROENVIRONMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/113383
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Microenvironment and endocrine resistance in breast cancer: Friend or foe?Recouvreux, SolSampayo, Rocío GuadalupeDíaz Bessone, María InésSimian, MarinaAROMATASE INHIBITORSBREAST CANCERCANCER STEM CELLSENDOCRINE RESISTANCEESTROGEN RECEPTORSTROMATAMOXIFENTUMOR MICROENVIRONMENThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Breast cancer affects one in eight women around the world. Seventy five percent of these patients have tumors that are estrogen receptor positive and as a consequence receive endocrine therapy. However, about one third eventually develop resistance and cancer reappears. In the last decade our vision of cancer has evolved to consider it more of a tissuerelated disease than a cell-centered one. This editorial argues that we are only starting to understand the role the tumor microenvironment plays in therapy resistance in breast cancer. The development of new therapeutic strategies that target the microenvironment will come when we clearly understand this extremely complicated scenario. As such, and as a scientific community, we have extremely challenging work ahead. We share our views regarding these matters.Fil: Recouvreux, Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Sampayo, Rocío Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Díaz Bessone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Simian, Marina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBaishideng Publishing Group2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/113383Recouvreux, Sol; Sampayo, Rocío Guadalupe; Díaz Bessone, María Inés; Simian, Marina; Microenvironment and endocrine resistance in breast cancer: Friend or foe?; Baishideng Publishing Group; World Journal of Clinical Oncology; 6; 6; 12-2015; 207-2112218-43332218-4333CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675904/info:eu-repo/semantics/altIdentifier/doi/10.5306/wjco.v6.i6.207info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/2218-4333/full/v6/i6/207.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:08:57Zoai:ri.conicet.gov.ar:11336/113383instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:08:57.488CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Microenvironment and endocrine resistance in breast cancer: Friend or foe?
title Microenvironment and endocrine resistance in breast cancer: Friend or foe?
spellingShingle Microenvironment and endocrine resistance in breast cancer: Friend or foe?
Recouvreux, Sol
AROMATASE INHIBITORS
BREAST CANCER
CANCER STEM CELLS
ENDOCRINE RESISTANCE
ESTROGEN RECEPTOR
STROMA
TAMOXIFEN
TUMOR MICROENVIRONMENT
title_short Microenvironment and endocrine resistance in breast cancer: Friend or foe?
title_full Microenvironment and endocrine resistance in breast cancer: Friend or foe?
title_fullStr Microenvironment and endocrine resistance in breast cancer: Friend or foe?
title_full_unstemmed Microenvironment and endocrine resistance in breast cancer: Friend or foe?
title_sort Microenvironment and endocrine resistance in breast cancer: Friend or foe?
dc.creator.none.fl_str_mv Recouvreux, Sol
Sampayo, Rocío Guadalupe
Díaz Bessone, María Inés
Simian, Marina
author Recouvreux, Sol
author_facet Recouvreux, Sol
Sampayo, Rocío Guadalupe
Díaz Bessone, María Inés
Simian, Marina
author_role author
author2 Sampayo, Rocío Guadalupe
Díaz Bessone, María Inés
Simian, Marina
author2_role author
author
author
dc.subject.none.fl_str_mv AROMATASE INHIBITORS
BREAST CANCER
CANCER STEM CELLS
ENDOCRINE RESISTANCE
ESTROGEN RECEPTOR
STROMA
TAMOXIFEN
TUMOR MICROENVIRONMENT
topic AROMATASE INHIBITORS
BREAST CANCER
CANCER STEM CELLS
ENDOCRINE RESISTANCE
ESTROGEN RECEPTOR
STROMA
TAMOXIFEN
TUMOR MICROENVIRONMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Breast cancer affects one in eight women around the world. Seventy five percent of these patients have tumors that are estrogen receptor positive and as a consequence receive endocrine therapy. However, about one third eventually develop resistance and cancer reappears. In the last decade our vision of cancer has evolved to consider it more of a tissuerelated disease than a cell-centered one. This editorial argues that we are only starting to understand the role the tumor microenvironment plays in therapy resistance in breast cancer. The development of new therapeutic strategies that target the microenvironment will come when we clearly understand this extremely complicated scenario. As such, and as a scientific community, we have extremely challenging work ahead. We share our views regarding these matters.
Fil: Recouvreux, Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Sampayo, Rocío Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Díaz Bessone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Simian, Marina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Breast cancer affects one in eight women around the world. Seventy five percent of these patients have tumors that are estrogen receptor positive and as a consequence receive endocrine therapy. However, about one third eventually develop resistance and cancer reappears. In the last decade our vision of cancer has evolved to consider it more of a tissuerelated disease than a cell-centered one. This editorial argues that we are only starting to understand the role the tumor microenvironment plays in therapy resistance in breast cancer. The development of new therapeutic strategies that target the microenvironment will come when we clearly understand this extremely complicated scenario. As such, and as a scientific community, we have extremely challenging work ahead. We share our views regarding these matters.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/113383
Recouvreux, Sol; Sampayo, Rocío Guadalupe; Díaz Bessone, María Inés; Simian, Marina; Microenvironment and endocrine resistance in breast cancer: Friend or foe?; Baishideng Publishing Group; World Journal of Clinical Oncology; 6; 6; 12-2015; 207-211
2218-4333
2218-4333
CONICET Digital
CONICET
url http://hdl.handle.net/11336/113383
identifier_str_mv Recouvreux, Sol; Sampayo, Rocío Guadalupe; Díaz Bessone, María Inés; Simian, Marina; Microenvironment and endocrine resistance in breast cancer: Friend or foe?; Baishideng Publishing Group; World Journal of Clinical Oncology; 6; 6; 12-2015; 207-211
2218-4333
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675904/
info:eu-repo/semantics/altIdentifier/doi/10.5306/wjco.v6.i6.207
info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/2218-4333/full/v6/i6/207.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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