Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility

Autores
Silvero, María Jazmín; Rocca, Diamela María; Artur de la Villarmois, Emilce; Fournier, Kelsey; Lanterna, Anabel Estela; Perez, Mariela Fernanda; Becerra, María Cecilia; Scaiano, Juan Cesar
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 μg/mL) when co-cultures are analyzed. Their stability in biological media, hemocompat-ibility and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility.
Fil: Silvero, María Jazmín. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Rocca, Diamela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Artur de la Villarmois, Emilce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Fournier, Kelsey. University of Ottawa; Canadá
Fil: Lanterna, Anabel Estela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Perez, Mariela Fernanda. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Scaiano, Juan Cesar. Universidad Nacional de Córdoba; Argentina. University of Ottawa; Canadá
Materia
NANOPARTICLES
BACTERIA
AMOXICILLIN
BIOCOMPATIBLE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86564

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network_name_str CONICET Digital (CONICET)
spelling Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibilitySilvero, María JazmínRocca, Diamela MaríaArtur de la Villarmois, EmilceFournier, KelseyLanterna, Anabel EstelaPerez, Mariela FernandaBecerra, María CeciliaScaiano, Juan CesarNANOPARTICLESBACTERIAAMOXICILLINBIOCOMPATIBLEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 μg/mL) when co-cultures are analyzed. Their stability in biological media, hemocompat-ibility and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility.Fil: Silvero, María Jazmín. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Rocca, Diamela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Artur de la Villarmois, Emilce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Fournier, Kelsey. University of Ottawa; CanadáFil: Lanterna, Anabel Estela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Perez, Mariela Fernanda. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Scaiano, Juan Cesar. Universidad Nacional de Córdoba; Argentina. University of Ottawa; CanadáAmerican Chemical Society2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86564Silvero, María Jazmín; Rocca, Diamela María; Artur de la Villarmois, Emilce; Fournier, Kelsey; Lanterna, Anabel Estela; et al.; Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility; American Chemical Society; ACS Omega; 3; 1; 1-2018; 1220-12302470-1343CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsomega.7b01779info:eu-repo/semantics/altIdentifier/doi/10.1021/acsomega.7b01779info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:33Zoai:ri.conicet.gov.ar:11336/86564instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:33.604CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility
title Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility
spellingShingle Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility
Silvero, María Jazmín
NANOPARTICLES
BACTERIA
AMOXICILLIN
BIOCOMPATIBLE
title_short Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility
title_full Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility
title_fullStr Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility
title_full_unstemmed Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility
title_sort Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility
dc.creator.none.fl_str_mv Silvero, María Jazmín
Rocca, Diamela María
Artur de la Villarmois, Emilce
Fournier, Kelsey
Lanterna, Anabel Estela
Perez, Mariela Fernanda
Becerra, María Cecilia
Scaiano, Juan Cesar
author Silvero, María Jazmín
author_facet Silvero, María Jazmín
Rocca, Diamela María
Artur de la Villarmois, Emilce
Fournier, Kelsey
Lanterna, Anabel Estela
Perez, Mariela Fernanda
Becerra, María Cecilia
Scaiano, Juan Cesar
author_role author
author2 Rocca, Diamela María
Artur de la Villarmois, Emilce
Fournier, Kelsey
Lanterna, Anabel Estela
Perez, Mariela Fernanda
Becerra, María Cecilia
Scaiano, Juan Cesar
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NANOPARTICLES
BACTERIA
AMOXICILLIN
BIOCOMPATIBLE
topic NANOPARTICLES
BACTERIA
AMOXICILLIN
BIOCOMPATIBLE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 μg/mL) when co-cultures are analyzed. Their stability in biological media, hemocompat-ibility and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility.
Fil: Silvero, María Jazmín. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Rocca, Diamela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Artur de la Villarmois, Emilce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Fournier, Kelsey. University of Ottawa; Canadá
Fil: Lanterna, Anabel Estela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Perez, Mariela Fernanda. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Scaiano, Juan Cesar. Universidad Nacional de Córdoba; Argentina. University of Ottawa; Canadá
description Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 μg/mL) when co-cultures are analyzed. Their stability in biological media, hemocompat-ibility and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86564
Silvero, María Jazmín; Rocca, Diamela María; Artur de la Villarmois, Emilce; Fournier, Kelsey; Lanterna, Anabel Estela; et al.; Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility; American Chemical Society; ACS Omega; 3; 1; 1-2018; 1220-1230
2470-1343
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86564
identifier_str_mv Silvero, María Jazmín; Rocca, Diamela María; Artur de la Villarmois, Emilce; Fournier, Kelsey; Lanterna, Anabel Estela; et al.; Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility; American Chemical Society; ACS Omega; 3; 1; 1-2018; 1220-1230
2470-1343
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsomega.7b01779
info:eu-repo/semantics/altIdentifier/doi/10.1021/acsomega.7b01779
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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