Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility
- Autores
- Silvero, María Jazmín; Rocca, Diamela María; Artur de la Villarmois, Emilce; Fournier, Kelsey; Lanterna, Anabel Estela; Perez, Mariela Fernanda; Becerra, María Cecilia; Scaiano, Juan Cesar
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 μg/mL) when co-cultures are analyzed. Their stability in biological media, hemocompat-ibility and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility.
Fil: Silvero, María Jazmín. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Rocca, Diamela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Artur de la Villarmois, Emilce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Fournier, Kelsey. University of Ottawa; Canadá
Fil: Lanterna, Anabel Estela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Perez, Mariela Fernanda. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Scaiano, Juan Cesar. Universidad Nacional de Córdoba; Argentina. University of Ottawa; Canadá - Materia
-
NANOPARTICLES
BACTERIA
AMOXICILLIN
BIOCOMPATIBLE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/86564
Ver los metadatos del registro completo
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Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibilitySilvero, María JazmínRocca, Diamela MaríaArtur de la Villarmois, EmilceFournier, KelseyLanterna, Anabel EstelaPerez, Mariela FernandaBecerra, María CeciliaScaiano, Juan CesarNANOPARTICLESBACTERIAAMOXICILLINBIOCOMPATIBLEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 μg/mL) when co-cultures are analyzed. Their stability in biological media, hemocompat-ibility and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility.Fil: Silvero, María Jazmín. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Rocca, Diamela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Artur de la Villarmois, Emilce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Fournier, Kelsey. University of Ottawa; CanadáFil: Lanterna, Anabel Estela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Perez, Mariela Fernanda. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Scaiano, Juan Cesar. Universidad Nacional de Córdoba; Argentina. University of Ottawa; CanadáAmerican Chemical Society2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86564Silvero, María Jazmín; Rocca, Diamela María; Artur de la Villarmois, Emilce; Fournier, Kelsey; Lanterna, Anabel Estela; et al.; Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility; American Chemical Society; ACS Omega; 3; 1; 1-2018; 1220-12302470-1343CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsomega.7b01779info:eu-repo/semantics/altIdentifier/doi/10.1021/acsomega.7b01779info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:33Zoai:ri.conicet.gov.ar:11336/86564instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:33.604CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility |
title |
Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility |
spellingShingle |
Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility Silvero, María Jazmín NANOPARTICLES BACTERIA AMOXICILLIN BIOCOMPATIBLE |
title_short |
Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility |
title_full |
Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility |
title_fullStr |
Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility |
title_full_unstemmed |
Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility |
title_sort |
Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility |
dc.creator.none.fl_str_mv |
Silvero, María Jazmín Rocca, Diamela María Artur de la Villarmois, Emilce Fournier, Kelsey Lanterna, Anabel Estela Perez, Mariela Fernanda Becerra, María Cecilia Scaiano, Juan Cesar |
author |
Silvero, María Jazmín |
author_facet |
Silvero, María Jazmín Rocca, Diamela María Artur de la Villarmois, Emilce Fournier, Kelsey Lanterna, Anabel Estela Perez, Mariela Fernanda Becerra, María Cecilia Scaiano, Juan Cesar |
author_role |
author |
author2 |
Rocca, Diamela María Artur de la Villarmois, Emilce Fournier, Kelsey Lanterna, Anabel Estela Perez, Mariela Fernanda Becerra, María Cecilia Scaiano, Juan Cesar |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
NANOPARTICLES BACTERIA AMOXICILLIN BIOCOMPATIBLE |
topic |
NANOPARTICLES BACTERIA AMOXICILLIN BIOCOMPATIBLE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 μg/mL) when co-cultures are analyzed. Their stability in biological media, hemocompat-ibility and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility. Fil: Silvero, María Jazmín. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina Fil: Rocca, Diamela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina Fil: Artur de la Villarmois, Emilce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Fournier, Kelsey. University of Ottawa; Canadá Fil: Lanterna, Anabel Estela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Perez, Mariela Fernanda. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina Fil: Scaiano, Juan Cesar. Universidad Nacional de Córdoba; Argentina. University of Ottawa; Canadá |
description |
Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 μg/mL) when co-cultures are analyzed. Their stability in biological media, hemocompat-ibility and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/86564 Silvero, María Jazmín; Rocca, Diamela María; Artur de la Villarmois, Emilce; Fournier, Kelsey; Lanterna, Anabel Estela; et al.; Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility; American Chemical Society; ACS Omega; 3; 1; 1-2018; 1220-1230 2470-1343 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/86564 |
identifier_str_mv |
Silvero, María Jazmín; Rocca, Diamela María; Artur de la Villarmois, Emilce; Fournier, Kelsey; Lanterna, Anabel Estela; et al.; Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: From one-step synthesis to in vivo cytocompatibility; American Chemical Society; ACS Omega; 3; 1; 1-2018; 1220-1230 2470-1343 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsomega.7b01779 info:eu-repo/semantics/altIdentifier/doi/10.1021/acsomega.7b01779 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613507740336128 |
score |
13.070432 |