Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations

Autores
Grunhut, Marcos; Martins, Valdomiro L.; Centurión, María Eugenia; Araújo, Mário Cesar Ugulino de; Fernández Band, Beatriz Susana
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A novel, simple, cheap, flexible, versatile, and highly sensitivity flow-batch analyzer (FBA) with chemiluminescence detection was developed for determination of dopamine, norepinephrine, and epinephrine in pharmaceutical preparations. The method was based on the inhibitory effect of the mentioned catecholamines on a luminol-potassium hexacyanoferrate (III) chemiluminescence system in alkaline medium. The optimization of the chemical variables affecting this chemiluminescence inhibition effect has been carried out using a Box-Behnken experimental design. The sample throughput was 28 h-1. The system allowed the automatic preparation of standard solutions and analytical process can be accomplished just by changing the operational parameters in FBA control software.
Fil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Martins, Valdomiro L.. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Centurión, María Eugenia. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Araújo, Mário Cesar Ugulino de. Universidade Federal da Paraiba; Brasil
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
BOX-BEHNKEN DESIGN
CATECHOLAMINES
CHEMILUMINESCENCE
FLOW-BATCH ANALYZER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95351
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/95351
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparationsGrunhut, MarcosMartins, Valdomiro L.Centurión, María EugeniaAraújo, Mário Cesar Ugulino deFernández Band, Beatriz SusanaBOX-BEHNKEN DESIGNCATECHOLAMINESCHEMILUMINESCENCEFLOW-BATCH ANALYZERhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A novel, simple, cheap, flexible, versatile, and highly sensitivity flow-batch analyzer (FBA) with chemiluminescence detection was developed for determination of dopamine, norepinephrine, and epinephrine in pharmaceutical preparations. The method was based on the inhibitory effect of the mentioned catecholamines on a luminol-potassium hexacyanoferrate (III) chemiluminescence system in alkaline medium. The optimization of the chemical variables affecting this chemiluminescence inhibition effect has been carried out using a Box-Behnken experimental design. The sample throughput was 28 h-1. The system allowed the automatic preparation of standard solutions and analytical process can be accomplished just by changing the operational parameters in FBA control software.Fil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Martins, Valdomiro L.. Universidad Nacional del Sur. Departamento de Química; ArgentinaFil: Centurión, María Eugenia. Universidad Nacional del Sur. Departamento de Química; ArgentinaFil: Araújo, Mário Cesar Ugulino de. Universidade Federal da Paraiba; BrasilFil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaTaylor & Francis2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95351Grunhut, Marcos; Martins, Valdomiro L.; Centurión, María Eugenia; Araújo, Mário Cesar Ugulino de; Fernández Band, Beatriz Susana; Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations; Taylor & Francis; Analytical Letters; 44; 1-3; 1-2011; 67-810003-2719CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/00032719.2010.500765info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/00032719.2010.500765info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:20Zoai:ri.conicet.gov.ar:11336/95351instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:21.016CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations
title Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations
spellingShingle Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations
Grunhut, Marcos
BOX-BEHNKEN DESIGN
CATECHOLAMINES
CHEMILUMINESCENCE
FLOW-BATCH ANALYZER
title_short Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations
title_full Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations
title_fullStr Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations
title_full_unstemmed Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations
title_sort Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations
dc.creator.none.fl_str_mv Grunhut, Marcos
Martins, Valdomiro L.
Centurión, María Eugenia
Araújo, Mário Cesar Ugulino de
Fernández Band, Beatriz Susana
author Grunhut, Marcos
author_facet Grunhut, Marcos
Martins, Valdomiro L.
Centurión, María Eugenia
Araújo, Mário Cesar Ugulino de
Fernández Band, Beatriz Susana
author_role author
author2 Martins, Valdomiro L.
Centurión, María Eugenia
Araújo, Mário Cesar Ugulino de
Fernández Band, Beatriz Susana
author2_role author
author
author
author
dc.subject.none.fl_str_mv BOX-BEHNKEN DESIGN
CATECHOLAMINES
CHEMILUMINESCENCE
FLOW-BATCH ANALYZER
topic BOX-BEHNKEN DESIGN
CATECHOLAMINES
CHEMILUMINESCENCE
FLOW-BATCH ANALYZER
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A novel, simple, cheap, flexible, versatile, and highly sensitivity flow-batch analyzer (FBA) with chemiluminescence detection was developed for determination of dopamine, norepinephrine, and epinephrine in pharmaceutical preparations. The method was based on the inhibitory effect of the mentioned catecholamines on a luminol-potassium hexacyanoferrate (III) chemiluminescence system in alkaline medium. The optimization of the chemical variables affecting this chemiluminescence inhibition effect has been carried out using a Box-Behnken experimental design. The sample throughput was 28 h-1. The system allowed the automatic preparation of standard solutions and analytical process can be accomplished just by changing the operational parameters in FBA control software.
Fil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Martins, Valdomiro L.. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Centurión, María Eugenia. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Araújo, Mário Cesar Ugulino de. Universidade Federal da Paraiba; Brasil
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description A novel, simple, cheap, flexible, versatile, and highly sensitivity flow-batch analyzer (FBA) with chemiluminescence detection was developed for determination of dopamine, norepinephrine, and epinephrine in pharmaceutical preparations. The method was based on the inhibitory effect of the mentioned catecholamines on a luminol-potassium hexacyanoferrate (III) chemiluminescence system in alkaline medium. The optimization of the chemical variables affecting this chemiluminescence inhibition effect has been carried out using a Box-Behnken experimental design. The sample throughput was 28 h-1. The system allowed the automatic preparation of standard solutions and analytical process can be accomplished just by changing the operational parameters in FBA control software.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95351
Grunhut, Marcos; Martins, Valdomiro L.; Centurión, María Eugenia; Araújo, Mário Cesar Ugulino de; Fernández Band, Beatriz Susana; Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations; Taylor & Francis; Analytical Letters; 44; 1-3; 1-2011; 67-81
0003-2719
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95351
identifier_str_mv Grunhut, Marcos; Martins, Valdomiro L.; Centurión, María Eugenia; Araújo, Mário Cesar Ugulino de; Fernández Band, Beatriz Susana; Flow-batch analyzer for the chemiluminescence determination of catecholamines in pharmaceutical preparations; Taylor & Francis; Analytical Letters; 44; 1-3; 1-2011; 67-81
0003-2719
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/00032719.2010.500765
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/00032719.2010.500765
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269691162132480
score 13.13397

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