Reestablishment of sperm quality after long-term deslorelin suppression in tomcats

Autores
Nuñez Favre, Romina de Los Angeles; García, María Florencia; García Mitacek, María Carla; Rearte, Ramiro; Fontaine, Christelle; de la Sota, Rodolfo Luzbel; Stornelli, María Alejandra
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the study was to determine the time after treatment with a 4.7 mg deslorelin implant until Tomcat spermatogenesis activity was restored, and seminal parameters reached pre-implant values. Tomcats (n = 6) were randomly assigned to one of two treatments. Three cats (n = 3) received a deslorelin implant (4.7 mG; Suprelorin®, Virbac, France) in the interscapular subcutaneous region whereas three (n = 3) received no implant and served as control group. Semen samples were collected by electroejaculation every 4 wk from 3 mo before treatment (pretreatment samples) until reestablishment of pre-treatment sperm quality, 32 mo post-implant insertion (PI). Each semen sample was assessed for motility, velocity, concentration, total sperm count, viability, acrosome integrity, plasma membrane integrity and sperm morphology. After semen collection, testicular volume and presence/absence of penile spines were recorded. Additionally, blood samples were taken to measure testosterone concentration. An increase in sperm concentration and total sperm count was present 1 mo PI despite of an abrupt decrease in serum testosterone concentrations after 2–4 weeks. This initial stimulatory effect was followed by a decrease in seminal parameters, reduction of testicular volume and disappearance of penile spines 2 mo PI. A single Suprelorin® 4.7 mg implant suppressed sperm production for 22–25 months. No clinically side effect was observed during the study period. All toms returned to their initial seminal quality 23–28 months after treatment. Therefore, we conclude that Suprelorin® 4.7 mg is a safe option for reversible reproduction control during long periods in tomcats.
Fil: Nuñez Favre, Romina de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; Argentina
Fil: García, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; Argentina
Fil: García Mitacek, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; Argentina
Fil: Rearte, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Fontaine, Christelle. Virbac Laboratory; Francia
Fil: de la Sota, Rodolfo Luzbel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; Argentina
Fil: Stornelli, María Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CONTRACEPTION
DESLORELIN
GNRH AGONIST
SEMEN
TESTICULAR VOLUME
TESTOSTERONE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85344
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/85344
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Reestablishment of sperm quality after long-term deslorelin suppression in tomcatsNuñez Favre, Romina de Los AngelesGarcía, María FlorenciaGarcía Mitacek, María CarlaRearte, RamiroFontaine, Christellede la Sota, Rodolfo LuzbelStornelli, María AlejandraCONTRACEPTIONDESLORELINGNRH AGONISTSEMENTESTICULAR VOLUMETESTOSTERONEhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The aim of the study was to determine the time after treatment with a 4.7 mg deslorelin implant until Tomcat spermatogenesis activity was restored, and seminal parameters reached pre-implant values. Tomcats (n = 6) were randomly assigned to one of two treatments. Three cats (n = 3) received a deslorelin implant (4.7 mG; Suprelorin®, Virbac, France) in the interscapular subcutaneous region whereas three (n = 3) received no implant and served as control group. Semen samples were collected by electroejaculation every 4 wk from 3 mo before treatment (pretreatment samples) until reestablishment of pre-treatment sperm quality, 32 mo post-implant insertion (PI). Each semen sample was assessed for motility, velocity, concentration, total sperm count, viability, acrosome integrity, plasma membrane integrity and sperm morphology. After semen collection, testicular volume and presence/absence of penile spines were recorded. Additionally, blood samples were taken to measure testosterone concentration. An increase in sperm concentration and total sperm count was present 1 mo PI despite of an abrupt decrease in serum testosterone concentrations after 2–4 weeks. This initial stimulatory effect was followed by a decrease in seminal parameters, reduction of testicular volume and disappearance of penile spines 2 mo PI. A single Suprelorin® 4.7 mg implant suppressed sperm production for 22–25 months. No clinically side effect was observed during the study period. All toms returned to their initial seminal quality 23–28 months after treatment. Therefore, we conclude that Suprelorin® 4.7 mg is a safe option for reversible reproduction control during long periods in tomcats.Fil: Nuñez Favre, Romina de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; ArgentinaFil: García, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; ArgentinaFil: García Mitacek, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; ArgentinaFil: Rearte, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Fontaine, Christelle. Virbac Laboratory; FranciaFil: de la Sota, Rodolfo Luzbel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; ArgentinaFil: Stornelli, María Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85344Nuñez Favre, Romina de Los Angeles; García, María Florencia; García Mitacek, María Carla; Rearte, Ramiro; Fontaine, Christelle; et al.; Reestablishment of sperm quality after long-term deslorelin suppression in tomcats; Elsevier Science; Animal Reproduction Science; 195; 8-2018; 302-3080378-4320CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378432018301258info:eu-repo/semantics/altIdentifier/doi/10.1016/j.anireprosci.2018.06.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:51Zoai:ri.conicet.gov.ar:11336/85344instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:52.009CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reestablishment of sperm quality after long-term deslorelin suppression in tomcats
title Reestablishment of sperm quality after long-term deslorelin suppression in tomcats
spellingShingle Reestablishment of sperm quality after long-term deslorelin suppression in tomcats
Nuñez Favre, Romina de Los Angeles
CONTRACEPTION
DESLORELIN
GNRH AGONIST
SEMEN
TESTICULAR VOLUME
TESTOSTERONE
title_short Reestablishment of sperm quality after long-term deslorelin suppression in tomcats
title_full Reestablishment of sperm quality after long-term deslorelin suppression in tomcats
title_fullStr Reestablishment of sperm quality after long-term deslorelin suppression in tomcats
title_full_unstemmed Reestablishment of sperm quality after long-term deslorelin suppression in tomcats
title_sort Reestablishment of sperm quality after long-term deslorelin suppression in tomcats
dc.creator.none.fl_str_mv Nuñez Favre, Romina de Los Angeles
García, María Florencia
García Mitacek, María Carla
Rearte, Ramiro
Fontaine, Christelle
de la Sota, Rodolfo Luzbel
Stornelli, María Alejandra
author Nuñez Favre, Romina de Los Angeles
author_facet Nuñez Favre, Romina de Los Angeles
García, María Florencia
García Mitacek, María Carla
Rearte, Ramiro
Fontaine, Christelle
de la Sota, Rodolfo Luzbel
Stornelli, María Alejandra
author_role author
author2 García, María Florencia
García Mitacek, María Carla
Rearte, Ramiro
Fontaine, Christelle
de la Sota, Rodolfo Luzbel
Stornelli, María Alejandra
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CONTRACEPTION
DESLORELIN
GNRH AGONIST
SEMEN
TESTICULAR VOLUME
TESTOSTERONE
topic CONTRACEPTION
DESLORELIN
GNRH AGONIST
SEMEN
TESTICULAR VOLUME
TESTOSTERONE
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The aim of the study was to determine the time after treatment with a 4.7 mg deslorelin implant until Tomcat spermatogenesis activity was restored, and seminal parameters reached pre-implant values. Tomcats (n = 6) were randomly assigned to one of two treatments. Three cats (n = 3) received a deslorelin implant (4.7 mG; Suprelorin®, Virbac, France) in the interscapular subcutaneous region whereas three (n = 3) received no implant and served as control group. Semen samples were collected by electroejaculation every 4 wk from 3 mo before treatment (pretreatment samples) until reestablishment of pre-treatment sperm quality, 32 mo post-implant insertion (PI). Each semen sample was assessed for motility, velocity, concentration, total sperm count, viability, acrosome integrity, plasma membrane integrity and sperm morphology. After semen collection, testicular volume and presence/absence of penile spines were recorded. Additionally, blood samples were taken to measure testosterone concentration. An increase in sperm concentration and total sperm count was present 1 mo PI despite of an abrupt decrease in serum testosterone concentrations after 2–4 weeks. This initial stimulatory effect was followed by a decrease in seminal parameters, reduction of testicular volume and disappearance of penile spines 2 mo PI. A single Suprelorin® 4.7 mg implant suppressed sperm production for 22–25 months. No clinically side effect was observed during the study period. All toms returned to their initial seminal quality 23–28 months after treatment. Therefore, we conclude that Suprelorin® 4.7 mg is a safe option for reversible reproduction control during long periods in tomcats.
Fil: Nuñez Favre, Romina de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; Argentina
Fil: García, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; Argentina
Fil: García Mitacek, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; Argentina
Fil: Rearte, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Fontaine, Christelle. Virbac Laboratory; Francia
Fil: de la Sota, Rodolfo Luzbel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Cátedra de Reproducción Animal; Argentina
Fil: Stornelli, María Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The aim of the study was to determine the time after treatment with a 4.7 mg deslorelin implant until Tomcat spermatogenesis activity was restored, and seminal parameters reached pre-implant values. Tomcats (n = 6) were randomly assigned to one of two treatments. Three cats (n = 3) received a deslorelin implant (4.7 mG; Suprelorin®, Virbac, France) in the interscapular subcutaneous region whereas three (n = 3) received no implant and served as control group. Semen samples were collected by electroejaculation every 4 wk from 3 mo before treatment (pretreatment samples) until reestablishment of pre-treatment sperm quality, 32 mo post-implant insertion (PI). Each semen sample was assessed for motility, velocity, concentration, total sperm count, viability, acrosome integrity, plasma membrane integrity and sperm morphology. After semen collection, testicular volume and presence/absence of penile spines were recorded. Additionally, blood samples were taken to measure testosterone concentration. An increase in sperm concentration and total sperm count was present 1 mo PI despite of an abrupt decrease in serum testosterone concentrations after 2–4 weeks. This initial stimulatory effect was followed by a decrease in seminal parameters, reduction of testicular volume and disappearance of penile spines 2 mo PI. A single Suprelorin® 4.7 mg implant suppressed sperm production for 22–25 months. No clinically side effect was observed during the study period. All toms returned to their initial seminal quality 23–28 months after treatment. Therefore, we conclude that Suprelorin® 4.7 mg is a safe option for reversible reproduction control during long periods in tomcats.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85344
Nuñez Favre, Romina de Los Angeles; García, María Florencia; García Mitacek, María Carla; Rearte, Ramiro; Fontaine, Christelle; et al.; Reestablishment of sperm quality after long-term deslorelin suppression in tomcats; Elsevier Science; Animal Reproduction Science; 195; 8-2018; 302-308
0378-4320
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85344
identifier_str_mv Nuñez Favre, Romina de Los Angeles; García, María Florencia; García Mitacek, María Carla; Rearte, Ramiro; Fontaine, Christelle; et al.; Reestablishment of sperm quality after long-term deslorelin suppression in tomcats; Elsevier Science; Animal Reproduction Science; 195; 8-2018; 302-308
0378-4320
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378432018301258
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.anireprosci.2018.06.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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