Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
- Autores
- Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; Gibbons, Luz; Herrera, Claudia; Sosa-Estani, Sergio Alejandro; Buekens, Pierre
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases.
Fil: Truyens, Carine. Université Libre de Bruxelles; Bélgica
Fil: Dumonteil, Eric. University of Tulane; Estados Unidos
Fil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; Honduras
Fil: Cafferata, Maria Luisa. No especifíca;
Fil: Ciganda, Alvaro. No especifíca;
Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Herrera, Claudia. University of Tulane; Estados Unidos
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Buekens, Pierre. University of Tulane; Estados Unidos - Materia
-
CHAGAS DISEASE
DIAGNOSTIC PERFORMANCE
DIAGNOSTICS
ELISA
RAPID TEST
REACTIVITY
SEROLOGY
STRAIN DIVERSITY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/175516
Ver los metadatos del registro completo
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Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi InfectionTruyens, CarineDumonteil, EricAlger, JackelineCafferata, Maria LuisaCiganda, AlvaroGibbons, LuzHerrera, ClaudiaSosa-Estani, Sergio AlejandroBuekens, PierreCHAGAS DISEASEDIAGNOSTIC PERFORMANCEDIAGNOSTICSELISARAPID TESTREACTIVITYSEROLOGYSTRAIN DIVERSITYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases.Fil: Truyens, Carine. Université Libre de Bruxelles; BélgicaFil: Dumonteil, Eric. University of Tulane; Estados UnidosFil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; HondurasFil: Cafferata, Maria Luisa. No especifíca;Fil: Ciganda, Alvaro. No especifíca;Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Herrera, Claudia. University of Tulane; Estados UnidosFil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Buekens, Pierre. University of Tulane; Estados UnidosAmerican Society for Microbiology2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/175516Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; et al.; Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection; American Society for Microbiology; Journal of Clinical Microbiology; 59; 12; 11-2021; 1-80095-1137CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/JCM.01062-21info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:36:35Zoai:ri.conicet.gov.ar:11336/175516instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:36:35.309CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection |
title |
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection |
spellingShingle |
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection Truyens, Carine CHAGAS DISEASE DIAGNOSTIC PERFORMANCE DIAGNOSTICS ELISA RAPID TEST REACTIVITY SEROLOGY STRAIN DIVERSITY |
title_short |
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection |
title_full |
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection |
title_fullStr |
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection |
title_full_unstemmed |
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection |
title_sort |
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection |
dc.creator.none.fl_str_mv |
Truyens, Carine Dumonteil, Eric Alger, Jackeline Cafferata, Maria Luisa Ciganda, Alvaro Gibbons, Luz Herrera, Claudia Sosa-Estani, Sergio Alejandro Buekens, Pierre |
author |
Truyens, Carine |
author_facet |
Truyens, Carine Dumonteil, Eric Alger, Jackeline Cafferata, Maria Luisa Ciganda, Alvaro Gibbons, Luz Herrera, Claudia Sosa-Estani, Sergio Alejandro Buekens, Pierre |
author_role |
author |
author2 |
Dumonteil, Eric Alger, Jackeline Cafferata, Maria Luisa Ciganda, Alvaro Gibbons, Luz Herrera, Claudia Sosa-Estani, Sergio Alejandro Buekens, Pierre |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
CHAGAS DISEASE DIAGNOSTIC PERFORMANCE DIAGNOSTICS ELISA RAPID TEST REACTIVITY SEROLOGY STRAIN DIVERSITY |
topic |
CHAGAS DISEASE DIAGNOSTIC PERFORMANCE DIAGNOSTICS ELISA RAPID TEST REACTIVITY SEROLOGY STRAIN DIVERSITY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases. Fil: Truyens, Carine. Université Libre de Bruxelles; Bélgica Fil: Dumonteil, Eric. University of Tulane; Estados Unidos Fil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; Honduras Fil: Cafferata, Maria Luisa. No especifíca; Fil: Ciganda, Alvaro. No especifíca; Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Herrera, Claudia. University of Tulane; Estados Unidos Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Buekens, Pierre. University of Tulane; Estados Unidos |
description |
Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/175516 Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; et al.; Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection; American Society for Microbiology; Journal of Clinical Microbiology; 59; 12; 11-2021; 1-8 0095-1137 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/175516 |
identifier_str_mv |
Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; et al.; Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection; American Society for Microbiology; Journal of Clinical Microbiology; 59; 12; 11-2021; 1-8 0095-1137 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1128/JCM.01062-21 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.22299 |