Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection

Autores
Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; Gibbons, Luz; Herrera, Claudia; Sosa-Estani, Sergio Alejandro; Buekens, Pierre
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases.
Fil: Truyens, Carine. Université Libre de Bruxelles; Bélgica
Fil: Dumonteil, Eric. University of Tulane; Estados Unidos
Fil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; Honduras
Fil: Cafferata, Maria Luisa. No especifíca;
Fil: Ciganda, Alvaro. No especifíca;
Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Herrera, Claudia. University of Tulane; Estados Unidos
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
Materia
CHAGAS DISEASE
DIAGNOSTIC PERFORMANCE
DIAGNOSTICS
ELISA
RAPID TEST
REACTIVITY
SEROLOGY
STRAIN DIVERSITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/175516

id CONICETDig_5b7a51dffd703a9d060c06772dd8e8bd
oai_identifier_str oai:ri.conicet.gov.ar:11336/175516
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi InfectionTruyens, CarineDumonteil, EricAlger, JackelineCafferata, Maria LuisaCiganda, AlvaroGibbons, LuzHerrera, ClaudiaSosa-Estani, Sergio AlejandroBuekens, PierreCHAGAS DISEASEDIAGNOSTIC PERFORMANCEDIAGNOSTICSELISARAPID TESTREACTIVITYSEROLOGYSTRAIN DIVERSITYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases.Fil: Truyens, Carine. Université Libre de Bruxelles; BélgicaFil: Dumonteil, Eric. University of Tulane; Estados UnidosFil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; HondurasFil: Cafferata, Maria Luisa. No especifíca;Fil: Ciganda, Alvaro. No especifíca;Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Herrera, Claudia. University of Tulane; Estados UnidosFil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Buekens, Pierre. University of Tulane; Estados UnidosAmerican Society for Microbiology2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/175516Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; et al.; Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection; American Society for Microbiology; Journal of Clinical Microbiology; 59; 12; 11-2021; 1-80095-1137CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/JCM.01062-21info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:36:35Zoai:ri.conicet.gov.ar:11336/175516instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:36:35.309CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
title Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
spellingShingle Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
Truyens, Carine
CHAGAS DISEASE
DIAGNOSTIC PERFORMANCE
DIAGNOSTICS
ELISA
RAPID TEST
REACTIVITY
SEROLOGY
STRAIN DIVERSITY
title_short Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
title_full Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
title_fullStr Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
title_full_unstemmed Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
title_sort Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
dc.creator.none.fl_str_mv Truyens, Carine
Dumonteil, Eric
Alger, Jackeline
Cafferata, Maria Luisa
Ciganda, Alvaro
Gibbons, Luz
Herrera, Claudia
Sosa-Estani, Sergio Alejandro
Buekens, Pierre
author Truyens, Carine
author_facet Truyens, Carine
Dumonteil, Eric
Alger, Jackeline
Cafferata, Maria Luisa
Ciganda, Alvaro
Gibbons, Luz
Herrera, Claudia
Sosa-Estani, Sergio Alejandro
Buekens, Pierre
author_role author
author2 Dumonteil, Eric
Alger, Jackeline
Cafferata, Maria Luisa
Ciganda, Alvaro
Gibbons, Luz
Herrera, Claudia
Sosa-Estani, Sergio Alejandro
Buekens, Pierre
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHAGAS DISEASE
DIAGNOSTIC PERFORMANCE
DIAGNOSTICS
ELISA
RAPID TEST
REACTIVITY
SEROLOGY
STRAIN DIVERSITY
topic CHAGAS DISEASE
DIAGNOSTIC PERFORMANCE
DIAGNOSTICS
ELISA
RAPID TEST
REACTIVITY
SEROLOGY
STRAIN DIVERSITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases.
Fil: Truyens, Carine. Université Libre de Bruxelles; Bélgica
Fil: Dumonteil, Eric. University of Tulane; Estados Unidos
Fil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; Honduras
Fil: Cafferata, Maria Luisa. No especifíca;
Fil: Ciganda, Alvaro. No especifíca;
Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Herrera, Claudia. University of Tulane; Estados Unidos
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
description Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/175516
Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; et al.; Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection; American Society for Microbiology; Journal of Clinical Microbiology; 59; 12; 11-2021; 1-8
0095-1137
CONICET Digital
CONICET
url http://hdl.handle.net/11336/175516
identifier_str_mv Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; et al.; Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection; American Society for Microbiology; Journal of Clinical Microbiology; 59; 12; 11-2021; 1-8
0095-1137
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1128/JCM.01062-21
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083488793493504
score 13.22299