High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)

Autores
García, Angelina; Demarchi, Dario; Tovo Rodrigues, Luciana; Pauro, Maia; Callegari Jacques, Sidia M.; Salzano, Francisco M.; Hutz, Mara H.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA) in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs). Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But a most unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.
Fil: García, Angelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; Argentina
Fil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; Argentina
Fil: Tovo Rodrigues, Luciana. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Pauro, Maia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; Argentina
Fil: Callegari Jacques, Sidia M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Hutz, Mara H.. Universidade Federal do Rio Grande do Sul; Brasil
Materia
AIMs
CÓRDOBA
MIGRATIONS
POPULATION STRUCTURE
SAN LUIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11103

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network_name_str CONICET Digital (CONICET)
spelling High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)García, AngelinaDemarchi, DarioTovo Rodrigues, LucianaPauro, MaiaCallegari Jacques, Sidia M.Salzano, Francisco M.Hutz, Mara H.AIMsCÓRDOBAMIGRATIONSPOPULATION STRUCTURESAN LUIShttps://purl.org/becyt/ford/6.5https://purl.org/becyt/ford/6https://purl.org/becyt/ford/6.5https://purl.org/becyt/ford/6The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA) in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs). Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But a most unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.Fil: García, Angelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; ArgentinaFil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; ArgentinaFil: Tovo Rodrigues, Luciana. Universidade Federal do Rio Grande do Sul; BrasilFil: Pauro, Maia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; ArgentinaFil: Callegari Jacques, Sidia M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Hutz, Mara H.. Universidade Federal do Rio Grande do Sul; BrasilSociedade Brasileira de Genética2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11103García, Angelina; Demarchi, Dario; Tovo Rodrigues, Luciana; Pauro, Maia; Callegari Jacques, Sidia M.; et al.; High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs); Sociedade Brasileira de Genética; Genetics And Molecular Biology; 38; 3; 7-2015; 324-3311415-47571678-4685enginfo:eu-repo/semantics/altIdentifier/doi/10.1590/S1415-475738320140260info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/pnsddsinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26500436/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:42:16Zoai:ri.conicet.gov.ar:11336/11103instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:42:16.564CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
spellingShingle High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
García, Angelina
AIMs
CÓRDOBA
MIGRATIONS
POPULATION STRUCTURE
SAN LUIS
title_short High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title_full High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title_fullStr High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title_full_unstemmed High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title_sort High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
dc.creator.none.fl_str_mv García, Angelina
Demarchi, Dario
Tovo Rodrigues, Luciana
Pauro, Maia
Callegari Jacques, Sidia M.
Salzano, Francisco M.
Hutz, Mara H.
author García, Angelina
author_facet García, Angelina
Demarchi, Dario
Tovo Rodrigues, Luciana
Pauro, Maia
Callegari Jacques, Sidia M.
Salzano, Francisco M.
Hutz, Mara H.
author_role author
author2 Demarchi, Dario
Tovo Rodrigues, Luciana
Pauro, Maia
Callegari Jacques, Sidia M.
Salzano, Francisco M.
Hutz, Mara H.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AIMs
CÓRDOBA
MIGRATIONS
POPULATION STRUCTURE
SAN LUIS
topic AIMs
CÓRDOBA
MIGRATIONS
POPULATION STRUCTURE
SAN LUIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/6.5
https://purl.org/becyt/ford/6
https://purl.org/becyt/ford/6.5
https://purl.org/becyt/ford/6
dc.description.none.fl_txt_mv The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA) in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs). Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But a most unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.
Fil: García, Angelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; Argentina
Fil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; Argentina
Fil: Tovo Rodrigues, Luciana. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Pauro, Maia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Antropología de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; Argentina
Fil: Callegari Jacques, Sidia M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Hutz, Mara H.. Universidade Federal do Rio Grande do Sul; Brasil
description The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA) in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs). Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But a most unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11103
García, Angelina; Demarchi, Dario; Tovo Rodrigues, Luciana; Pauro, Maia; Callegari Jacques, Sidia M.; et al.; High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs); Sociedade Brasileira de Genética; Genetics And Molecular Biology; 38; 3; 7-2015; 324-331
1415-4757
1678-4685
url http://hdl.handle.net/11336/11103
identifier_str_mv García, Angelina; Demarchi, Dario; Tovo Rodrigues, Luciana; Pauro, Maia; Callegari Jacques, Sidia M.; et al.; High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs); Sociedade Brasileira de Genética; Genetics And Molecular Biology; 38; 3; 7-2015; 324-331
1415-4757
1678-4685
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1590/S1415-475738320140260
info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/pnsdds
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26500436/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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