Galectins: New agonists of platelet activation

Autores
Schattner, Mirta Ana; Rabinovich, Gabriel Adrián
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article we review recent advances on the role of galectins in platelet physiology. Either in soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through modulation of discrete signaling pathways. We discuss the role of platelet-galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas - CONICET . Instituto de Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas -CONICET. Instituto de Biología y Medicina Experimental (i); Argentina
Materia
Platelet
Hemostasis
Galectins
Glycans
Cancer
Inflammation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2003
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/2003
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Galectins: New agonists of platelet activationSchattner, Mirta AnaRabinovich, Gabriel AdriánPlateletHemostasisGalectinsGlycansCancerInflammationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article we review recent advances on the role of galectins in platelet physiology. Either in soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through modulation of discrete signaling pathways. We discuss the role of platelet-galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas - CONICET . Instituto de Medicina Experimental; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas -CONICET. Instituto de Biología y Medicina Experimental (i); ArgentinaWalter de Gruyter & Co2013-03-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/2003Schattner, Mirta Ana; Rabinovich, Gabriel Adrián; Galectins: New agonists of platelet activation; Walter de Gruyter & Co; Biological Chemistry; 394; 7; 18-3-2013; 857-8631431-6730enginfo:eu-repo/semantics/altIdentifier/doi/10.1515/hsz-2013-0108info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:54Zoai:ri.conicet.gov.ar:11336/2003instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:55.981CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Galectins: New agonists of platelet activation
title Galectins: New agonists of platelet activation
spellingShingle Galectins: New agonists of platelet activation
Schattner, Mirta Ana
Platelet
Hemostasis
Galectins
Glycans
Cancer
Inflammation
title_short Galectins: New agonists of platelet activation
title_full Galectins: New agonists of platelet activation
title_fullStr Galectins: New agonists of platelet activation
title_full_unstemmed Galectins: New agonists of platelet activation
title_sort Galectins: New agonists of platelet activation
dc.creator.none.fl_str_mv Schattner, Mirta Ana
Rabinovich, Gabriel Adrián
author Schattner, Mirta Ana
author_facet Schattner, Mirta Ana
Rabinovich, Gabriel Adrián
author_role author
author2 Rabinovich, Gabriel Adrián
author2_role author
dc.subject.none.fl_str_mv Platelet
Hemostasis
Galectins
Glycans
Cancer
Inflammation
topic Platelet
Hemostasis
Galectins
Glycans
Cancer
Inflammation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article we review recent advances on the role of galectins in platelet physiology. Either in soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through modulation of discrete signaling pathways. We discuss the role of platelet-galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas - CONICET . Instituto de Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas -CONICET. Instituto de Biología y Medicina Experimental (i); Argentina
description Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article we review recent advances on the role of galectins in platelet physiology. Either in soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through modulation of discrete signaling pathways. We discuss the role of platelet-galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-18
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2003
Schattner, Mirta Ana; Rabinovich, Gabriel Adrián; Galectins: New agonists of platelet activation; Walter de Gruyter & Co; Biological Chemistry; 394; 7; 18-3-2013; 857-863
1431-6730
url http://hdl.handle.net/11336/2003
identifier_str_mv Schattner, Mirta Ana; Rabinovich, Gabriel Adrián; Galectins: New agonists of platelet activation; Walter de Gruyter & Co; Biological Chemistry; 394; 7; 18-3-2013; 857-863
1431-6730
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1515/hsz-2013-0108
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Walter de Gruyter & Co
publisher.none.fl_str_mv Walter de Gruyter & Co
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269490208833536
score 13.13397

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