Novelty modulates the stimulating motor effects of ethanol in preweanling rats

Autores
Arias, Carlos; Mlewski, Estela Cecilia; Miller, Stacie; Molina, Juan Carlos; Spear, Norman E.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
During early ontogeny heterogeneous rats are sensitive to ethanol's stimulating effects. In adulthood locomotor activity in a novel environment is a valuable predictor of acute sensitivity to the activating effects of various drugs, including ethanol. Environmental novelty modulates response to ethanol and other drugs in adult rats. The present study analyzed the role of novelty in the acute locomotor response induced by ethanol earlier in development, during the preweanling period, a stage characterized by enhanced sensitivity to ethanol's reinforcing effects. In Experiment 1 we evaluated the predictive value of baseline locomotor activity upon ethanol-induced locomotor effects in 12-day-old rats. In Experiment 2 we tested whether repeated familiarization with the testing environment would reduce the stimulating effects induced by ethanol on postnatal day 12. Individual differences in response to an inescapable novel environment significantly predicted the locomotor activating effects of ethanol, but not other acute effects of the drug, such as hypothermia, motor impairment or sedation. Behavioral activation induced by ethanol during the preweanling period was attenuated after familiarization with the testing environment, suggesting that environmental novelty is critical for activating effects of ethanol. © 2009 Elsevier Inc. All rights reserved.
Fil: Arias, Carlos. University Of Binghamton; Estados Unidos
Fil: Mlewski, Estela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; Argentina
Fil: Miller, Stacie. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Spear, Norman E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
Ethanol
Novelty
Preweanling Rat
Stimulation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55961
Acceder
id CONICETDig_5a4d798e874e4bea96a8675fd66e3273
oai_identifier_str oai:ri.conicet.gov.ar:11336/55961
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Novelty modulates the stimulating motor effects of ethanol in preweanling ratsArias, CarlosMlewski, Estela CeciliaMiller, StacieMolina, Juan CarlosSpear, Norman E.EthanolNoveltyPreweanling RatStimulationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3During early ontogeny heterogeneous rats are sensitive to ethanol's stimulating effects. In adulthood locomotor activity in a novel environment is a valuable predictor of acute sensitivity to the activating effects of various drugs, including ethanol. Environmental novelty modulates response to ethanol and other drugs in adult rats. The present study analyzed the role of novelty in the acute locomotor response induced by ethanol earlier in development, during the preweanling period, a stage characterized by enhanced sensitivity to ethanol's reinforcing effects. In Experiment 1 we evaluated the predictive value of baseline locomotor activity upon ethanol-induced locomotor effects in 12-day-old rats. In Experiment 2 we tested whether repeated familiarization with the testing environment would reduce the stimulating effects induced by ethanol on postnatal day 12. Individual differences in response to an inescapable novel environment significantly predicted the locomotor activating effects of ethanol, but not other acute effects of the drug, such as hypothermia, motor impairment or sedation. Behavioral activation induced by ethanol during the preweanling period was attenuated after familiarization with the testing environment, suggesting that environmental novelty is critical for activating effects of ethanol. © 2009 Elsevier Inc. All rights reserved.Fil: Arias, Carlos. University Of Binghamton; Estados UnidosFil: Mlewski, Estela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Miller, Stacie. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Spear, Norman E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaPergamon-Elsevier Science Ltd2009-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55961Arias, Carlos; Mlewski, Estela Cecilia; Miller, Stacie; Molina, Juan Carlos; Spear, Norman E.; Novelty modulates the stimulating motor effects of ethanol in preweanling rats; Pergamon-Elsevier Science Ltd; Pharmacology Biochemistry and Behavior; 92; 3; 5-2009; 448-4560091-3057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0091305709000392info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pbb.2009.01.012info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703475/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:20:44Zoai:ri.conicet.gov.ar:11336/55961instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:20:45.051CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novelty modulates the stimulating motor effects of ethanol in preweanling rats
title Novelty modulates the stimulating motor effects of ethanol in preweanling rats
spellingShingle Novelty modulates the stimulating motor effects of ethanol in preweanling rats
Arias, Carlos
Ethanol
Novelty
Preweanling Rat
Stimulation
title_short Novelty modulates the stimulating motor effects of ethanol in preweanling rats
title_full Novelty modulates the stimulating motor effects of ethanol in preweanling rats
title_fullStr Novelty modulates the stimulating motor effects of ethanol in preweanling rats
title_full_unstemmed Novelty modulates the stimulating motor effects of ethanol in preweanling rats
title_sort Novelty modulates the stimulating motor effects of ethanol in preweanling rats
dc.creator.none.fl_str_mv Arias, Carlos
Mlewski, Estela Cecilia
Miller, Stacie
Molina, Juan Carlos
Spear, Norman E.
author Arias, Carlos
author_facet Arias, Carlos
Mlewski, Estela Cecilia
Miller, Stacie
Molina, Juan Carlos
Spear, Norman E.
author_role author
author2 Mlewski, Estela Cecilia
Miller, Stacie
Molina, Juan Carlos
Spear, Norman E.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ethanol
Novelty
Preweanling Rat
Stimulation
topic Ethanol
Novelty
Preweanling Rat
Stimulation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv During early ontogeny heterogeneous rats are sensitive to ethanol's stimulating effects. In adulthood locomotor activity in a novel environment is a valuable predictor of acute sensitivity to the activating effects of various drugs, including ethanol. Environmental novelty modulates response to ethanol and other drugs in adult rats. The present study analyzed the role of novelty in the acute locomotor response induced by ethanol earlier in development, during the preweanling period, a stage characterized by enhanced sensitivity to ethanol's reinforcing effects. In Experiment 1 we evaluated the predictive value of baseline locomotor activity upon ethanol-induced locomotor effects in 12-day-old rats. In Experiment 2 we tested whether repeated familiarization with the testing environment would reduce the stimulating effects induced by ethanol on postnatal day 12. Individual differences in response to an inescapable novel environment significantly predicted the locomotor activating effects of ethanol, but not other acute effects of the drug, such as hypothermia, motor impairment or sedation. Behavioral activation induced by ethanol during the preweanling period was attenuated after familiarization with the testing environment, suggesting that environmental novelty is critical for activating effects of ethanol. © 2009 Elsevier Inc. All rights reserved.
Fil: Arias, Carlos. University Of Binghamton; Estados Unidos
Fil: Mlewski, Estela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; Argentina
Fil: Miller, Stacie. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Spear, Norman E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description During early ontogeny heterogeneous rats are sensitive to ethanol's stimulating effects. In adulthood locomotor activity in a novel environment is a valuable predictor of acute sensitivity to the activating effects of various drugs, including ethanol. Environmental novelty modulates response to ethanol and other drugs in adult rats. The present study analyzed the role of novelty in the acute locomotor response induced by ethanol earlier in development, during the preweanling period, a stage characterized by enhanced sensitivity to ethanol's reinforcing effects. In Experiment 1 we evaluated the predictive value of baseline locomotor activity upon ethanol-induced locomotor effects in 12-day-old rats. In Experiment 2 we tested whether repeated familiarization with the testing environment would reduce the stimulating effects induced by ethanol on postnatal day 12. Individual differences in response to an inescapable novel environment significantly predicted the locomotor activating effects of ethanol, but not other acute effects of the drug, such as hypothermia, motor impairment or sedation. Behavioral activation induced by ethanol during the preweanling period was attenuated after familiarization with the testing environment, suggesting that environmental novelty is critical for activating effects of ethanol. © 2009 Elsevier Inc. All rights reserved.
publishDate 2009
dc.date.none.fl_str_mv 2009-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55961
Arias, Carlos; Mlewski, Estela Cecilia; Miller, Stacie; Molina, Juan Carlos; Spear, Norman E.; Novelty modulates the stimulating motor effects of ethanol in preweanling rats; Pergamon-Elsevier Science Ltd; Pharmacology Biochemistry and Behavior; 92; 3; 5-2009; 448-456
0091-3057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55961
identifier_str_mv Arias, Carlos; Mlewski, Estela Cecilia; Miller, Stacie; Molina, Juan Carlos; Spear, Norman E.; Novelty modulates the stimulating motor effects of ethanol in preweanling rats; Pergamon-Elsevier Science Ltd; Pharmacology Biochemistry and Behavior; 92; 3; 5-2009; 448-456
0091-3057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0091305709000392
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pbb.2009.01.012
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703475/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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