Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats
- Autores
- Arias, Carlos; Mlewski, Estela Cecilia; Molina, Juan Carlos; Spear, Ne
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Heterogeneous rat strains appear to be particularly sensitive to the sedative effects of ethanol as adults and insensitive to ethanol's stimulant effects. Recently, the authors found that ethanol induces stimulant effects in preweanling Sprague-Dawley rats. In adult mice, these effects seem to be governed by the mesocorticolimbic dopaminergic pathway, which can be modulated by means of GABA B agonist (baclofen) or opioid antagonist (naloxone) treatments. This study tested whether these pharmacological treatments might reduce the activating effect of ethanol in preweanling Sprague-Dawley rats. Twelve-day-old pups given naloxone (Experiment 1A) or baclofen (Experiment 1B) before ethanol administration were tested in terms of locomotor activity in a novel environment. Naloxone and baclofen significantly reduced the stimulating effect of ethanol but had no effect on locomotor activity patterns in water-treated controls. Blood ethanol levels were not affected by naloxone or baclofen (Experiment 2). During the preweanling period, opioid and GABA B receptors seem to be involved in the stimulating effect of ethanol. © 2009 American Psychological Association.
Fil: Arias, Carlos. University Of Binghamton; Estados Unidos
Fil: Mlewski, Estela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; Argentina
Fil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. University Of Binghamton; Estados Unidos
Fil: Spear, Ne. University Of Binghamton; Estados Unidos - Materia
-
Baclofen
Ethanol
Infant Rat
Naloxone
Stimulation - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/55922
Ver los metadatos del registro completo
id |
CONICETDig_2f0a8ffc6c5b32e80edeb54c46e4e0ba |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/55922 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley RatsArias, CarlosMlewski, Estela CeciliaMolina, Juan CarlosSpear, NeBaclofenEthanolInfant RatNaloxoneStimulationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Heterogeneous rat strains appear to be particularly sensitive to the sedative effects of ethanol as adults and insensitive to ethanol's stimulant effects. Recently, the authors found that ethanol induces stimulant effects in preweanling Sprague-Dawley rats. In adult mice, these effects seem to be governed by the mesocorticolimbic dopaminergic pathway, which can be modulated by means of GABA B agonist (baclofen) or opioid antagonist (naloxone) treatments. This study tested whether these pharmacological treatments might reduce the activating effect of ethanol in preweanling Sprague-Dawley rats. Twelve-day-old pups given naloxone (Experiment 1A) or baclofen (Experiment 1B) before ethanol administration were tested in terms of locomotor activity in a novel environment. Naloxone and baclofen significantly reduced the stimulating effect of ethanol but had no effect on locomotor activity patterns in water-treated controls. Blood ethanol levels were not affected by naloxone or baclofen (Experiment 2). During the preweanling period, opioid and GABA B receptors seem to be involved in the stimulating effect of ethanol. © 2009 American Psychological Association.Fil: Arias, Carlos. University Of Binghamton; Estados UnidosFil: Mlewski, Estela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. University Of Binghamton; Estados UnidosFil: Spear, Ne. University Of Binghamton; Estados UnidosAmerican Psychological Association2009-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55922Arias, Carlos; Mlewski, Estela Cecilia; Molina, Juan Carlos; Spear, Ne; Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats; American Psychological Association; Behavioral Neuroscience.; 123; 1; 2-2009; 172-1800735-70441939-0084CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://psycnet.apa.org/doiLanding?doi=10.1037%2Fa0014049info:eu-repo/semantics/altIdentifier/doi/10.1037/a0014049info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:01:26Zoai:ri.conicet.gov.ar:11336/55922instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:01:27.133CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats |
title |
Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats |
spellingShingle |
Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats Arias, Carlos Baclofen Ethanol Infant Rat Naloxone Stimulation |
title_short |
Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats |
title_full |
Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats |
title_fullStr |
Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats |
title_full_unstemmed |
Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats |
title_sort |
Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats |
dc.creator.none.fl_str_mv |
Arias, Carlos Mlewski, Estela Cecilia Molina, Juan Carlos Spear, Ne |
author |
Arias, Carlos |
author_facet |
Arias, Carlos Mlewski, Estela Cecilia Molina, Juan Carlos Spear, Ne |
author_role |
author |
author2 |
Mlewski, Estela Cecilia Molina, Juan Carlos Spear, Ne |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Baclofen Ethanol Infant Rat Naloxone Stimulation |
topic |
Baclofen Ethanol Infant Rat Naloxone Stimulation |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Heterogeneous rat strains appear to be particularly sensitive to the sedative effects of ethanol as adults and insensitive to ethanol's stimulant effects. Recently, the authors found that ethanol induces stimulant effects in preweanling Sprague-Dawley rats. In adult mice, these effects seem to be governed by the mesocorticolimbic dopaminergic pathway, which can be modulated by means of GABA B agonist (baclofen) or opioid antagonist (naloxone) treatments. This study tested whether these pharmacological treatments might reduce the activating effect of ethanol in preweanling Sprague-Dawley rats. Twelve-day-old pups given naloxone (Experiment 1A) or baclofen (Experiment 1B) before ethanol administration were tested in terms of locomotor activity in a novel environment. Naloxone and baclofen significantly reduced the stimulating effect of ethanol but had no effect on locomotor activity patterns in water-treated controls. Blood ethanol levels were not affected by naloxone or baclofen (Experiment 2). During the preweanling period, opioid and GABA B receptors seem to be involved in the stimulating effect of ethanol. © 2009 American Psychological Association. Fil: Arias, Carlos. University Of Binghamton; Estados Unidos Fil: Mlewski, Estela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; Argentina Fil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. University Of Binghamton; Estados Unidos Fil: Spear, Ne. University Of Binghamton; Estados Unidos |
description |
Heterogeneous rat strains appear to be particularly sensitive to the sedative effects of ethanol as adults and insensitive to ethanol's stimulant effects. Recently, the authors found that ethanol induces stimulant effects in preweanling Sprague-Dawley rats. In adult mice, these effects seem to be governed by the mesocorticolimbic dopaminergic pathway, which can be modulated by means of GABA B agonist (baclofen) or opioid antagonist (naloxone) treatments. This study tested whether these pharmacological treatments might reduce the activating effect of ethanol in preweanling Sprague-Dawley rats. Twelve-day-old pups given naloxone (Experiment 1A) or baclofen (Experiment 1B) before ethanol administration were tested in terms of locomotor activity in a novel environment. Naloxone and baclofen significantly reduced the stimulating effect of ethanol but had no effect on locomotor activity patterns in water-treated controls. Blood ethanol levels were not affected by naloxone or baclofen (Experiment 2). During the preweanling period, opioid and GABA B receptors seem to be involved in the stimulating effect of ethanol. © 2009 American Psychological Association. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/55922 Arias, Carlos; Mlewski, Estela Cecilia; Molina, Juan Carlos; Spear, Ne; Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats; American Psychological Association; Behavioral Neuroscience.; 123; 1; 2-2009; 172-180 0735-7044 1939-0084 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/55922 |
identifier_str_mv |
Arias, Carlos; Mlewski, Estela Cecilia; Molina, Juan Carlos; Spear, Ne; Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats; American Psychological Association; Behavioral Neuroscience.; 123; 1; 2-2009; 172-180 0735-7044 1939-0084 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://psycnet.apa.org/doiLanding?doi=10.1037%2Fa0014049 info:eu-repo/semantics/altIdentifier/doi/10.1037/a0014049 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Psychological Association |
publisher.none.fl_str_mv |
American Psychological Association |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613808993075200 |
score |
13.069144 |